Research Topics
Species | A RosesSummaryAffiliation: GlaxoSmithKline Research and Development Country: USA Publications
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Detail Information
Publications
Pharmacogenetics and drug development: the path to safer and more effective drugsAllen D Roses
Genetics Research, GlaxoSmithKline, Five Moore Drive, Research Triangle Park, North Carolina 27709, USA
Nat Rev Genet 5:645-56. 2004..The rapid identification of adverse events during and after drug development using genomic mapping tools is also reviewed...
Genome-wide screening for drug discovery and companion diagnosticsAllen D Roses
Senior Vice President, Pharmacogenetics, GlaxoSmithKline, Five Moore Drive, Research Triangle Park, NC 27709, USA
Expert Opin Drug Discov 2:489-501. 2007..The anticipated successes are effective and safe medicines for unmet medical needs, with a framework for sustaining drug pipelines...- "Personalized medicine: elusive dream or imminent reality?": A commentaryA Roses
Genetics Research and Development, GlaxoSmithKline, Research Triangle Park, North Carolina, USA
Clin Pharmacol Ther 81:801-5. 2007..One is to simply answer the question as directly and succinctly as possible; another is to expand on the questions. For the purpose of this Commentary, I try to do both... - On the discovery of the genetic association of Apolipoprotein E genotypes and common late-onset Alzheimer diseaseAllen D Roses
Genetic Research, GlaxoSmithKline Research and Development, Five Moore Drive, 5 5616, Research Triangle Park, NC 27709, USA
J Alzheimers Dis 9:361-6. 2006..Rosiglitazone, a PPARgamma agonist which also leads to mitochondrial proliferation shown efficacy as a monotherapy in a Phase IIB clinical trial of 511 patients in an APOE allele-specific analysis... - Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease)A D Roses
Genetics Research, GlaxoSmithKline Research and Development, NC 27709, USA
Pharmacogenomics J 7:10-28. 2007..Pharmacogenetics is currently being used across the pipeline to prevent attrition and to create safer and more effective medicines... - Applying technologies towards safe and effective medicinesAllen D Roses
GlaxoSmithKline, Research Triangle Park, NC 27709, USA
Biotechniques 39:563-4. 2005 - Disease-specific target selection: a critical first step down the right roadAllen D Roses
GlaxoSmithKline R and D, Research Triangle Park, NC 27709, USA
Drug Discov Today 10:177-89. 2005..This review summarizes the methods and intensive data analyses leading to target gene identification for type 2 diabetes mellitus, including the statistical permutation methodology used to correct for many variables... - Drug development and Alzheimer diseaseAllen D Roses
GlaxoSmithKline Research and Development, Genetics Research, Neurology Centre for Excellence in Drug Discovery, Research Triangle Park, NC 27709, USA
Am J Geriatr Psychiatry 11:123-30. 2003 
A microsphere-based assay for multiplexed single nucleotide polymorphism analysis using single base chain extensionJ Chen
Department of Genomic Sciences, Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709 3398, USA
Genome Res 10:549-57. 2000..It can be readily adapted to an automated, high-throughput genotyping system. [Primer sequences used in this study are available as online supplementary materials at www.genome.org.]..- Pharmacogenetics and obesity: common gene variants influence weight loss response of the norepinephrine/dopamine transporter inhibitor GW320659 in obese subjectsColin F Spraggs
Genetics Research, GlaxoSmithKline Research and Development, Medicines Research Centre, Stevenage, UK
Pharmacogenet Genomics 15:883-9. 2005.... - On the utility of data from the International HapMap Project for Australian association studiesJim Stankovich
Division of Genetics and Bioinformatics, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 3050 Parkville, Victoria, Australia
Hum Genet 119:220-2. 2006..Patterns of LD in the Australian and HapMap samples are similar, and tag SNPs chosen using HapMap genotypes perform almost as well on Australian samples as tags chosen using Australian genotypes... - Genetic variations in HLA-B region and hypersensitivity reactions to abacavirSeth Hetherington
HIV Clinical Development and Medical Affairs, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
Lancet 359:1121-2. 2002..Clinical monitoring and management of hypersensitivity reactions among patients receiving abacavir must remain unchanged... - Pharmacogenetics place in modern medical science and practiceAllen D Roses
Genetics Research, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
Life Sci 70:1471-80. 2002..Pharmacogenetics has the potential of changing the pipeline model of drug discovery, clinical development, and mass customization marketing... - Age at onset in two common neurodegenerative diseases is genetically controlledYi-Ju Li
Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
Am J Hum Genet 70:985-93. 2002..62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases... - Use of whole-genome association scans in disease gene identification, drug discovery and developmentAllen D Roses
Duke University, R David Thomas Center, 1 Towerview Drive, Suite 343, Box 90120, Durham, NC 27708, USA
IDrugs 10:797-804. 2007..This feature article discusses the use of whole-genome association scans in disease gene identification, drug discovery and development... - Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer diseaseHao Li
GlaxoSmithKline, Research Triangle Park, North Carolina, USA
Arch Neurol 65:45-53. 2008..To identify single-nucleotide polymorphisms (SNPs) associated with risk and age at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs... - Replication study of the insulin receptor gene in migraine with auraChristian Netzer
Institute of Human Genetics, University of Cologne, 50931 Cologne, Germany
Genomics 91:503-7. 2008..005. In conclusion, further association studies for rs2860174 with even larger numbers of individuals are required to exclude or confirm definitely a small effect of this SNP on migraine susceptibility... - Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathwaysJohn P Cogswell
Department of Pharmacogenetics, GlaxoSmithKline Inc, Research Triangle Park, NC 27709, USA
J Alzheimers Dis 14:27-41. 2008..We additionally recovered miRNAs from cerebrospinal fluid and discovered AD-specific miRNA changes consistent with their role as potential biomarkers of disease... - The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics researchMatthew R Nelson
GlaxoSmithKline, Research Triangle Park, NC 27709, USA
Am J Hum Genet 83:347-58. 2008..The genotype and demographic data from this reference sample are freely available through the NCBI database of Genotypes and Phenotypes (dbGaP)... - Pharmacogenetics in drug discovery and development: a translational perspectiveAllen D Roses
Deane Drug Discovery Institute, Duke University Medical Center and Fuqua School of Business, Durham, North Carolina 27708, USA
Nat Rev Drug Discov 7:807-17. 2008.... - Genome-based pharmacogenetics and the pharmaceutical industryAllen D Roses
GlaxoSmithKline, Five Moore Drive, Research Triangle Park, North Carolina 27709, USA
Nat Rev Drug Discov 1:541-9. 2002.... - Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populationsArlene R Hughes
GlaxoSmithKline, NC 27709, USA
Pharmacogenomics 5:203-11. 2004..Even after a marker set is identified, appropriate clinical identification and management of hypersensitivity to abacavir must remain the cornerstone of clinical practice... - ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memoryOfir Levi
The Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, 69978, Ramat Aviv, Israel
Neurobiol Dis 13:273-82. 2003..This provides a novel mechanism by which environmental factors can modulate the function and phenotypic expression of the apoE genotype... - Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson diseaseYi Ju Li
Department of Medicine, Center for Human Genetics, Institute for Genome Science and Policy, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
Hum Mol Genet 12:3259-67. 2003..This is provocative given reports of the possible role of inflammation in these two neurodegenerative disorders... - Pharmacogenetics to predict drug-related adverse eventsDavid A Hosford
Department of Genetics Research, GlaxoSmithKline R and D, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 32:9-12. 2004..Together, these studies demonstrate in a stepwise manner the feasibility of using pharmacogenetic approaches to predict DRAEs... - Analysis of European mitochondrial haplogroups with Alzheimer disease riskJoelle M van der Walt
Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
Neurosci Lett 365:28-32. 2004..We suggest that variations within haplogroup U may be involved in AD expression in combination with environmental exposures or nuclear proteins other than APOE... - A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD StudyElizabeth R Hauser
Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
Am J Hum Genet 75:436-47. 2004..These data provide initial areas of the human genome where further investigation may reveal susceptibility genes for early-onset CAD... - The Q7R Saitohin gene polymorphism is not associated with Alzheimer diseaseSofia A Oliveira
Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
Neurosci Lett 347:143-6. 2003..We found no evidence of significant association of this polymorphism with risk of AD using family-based and case-control tests of association... - SNPs--where's the beef?Allen D Roses
GlaxoSmithKline, Genetics Research, Research Triangle Park, NC 27709, USA
Pharmacogenomics J 2:277-83. 2002 - Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer diseaseKristin K Nicodemus
Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
Neurogenetics 5:201-8. 2004..In conclusion, SNPs +5361, or a SNP in strong linkage disequilibrium, may confer some additional risk for developing AD beyond the risk due to APOE-4; however, the effect independent of APOE-4 is likely to be small... - Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22William K Scott
Department of Medicine, Duke University Medical Center, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
Am J Hum Genet 73:1041-51. 2003..These results indicate that linkage to chromosome 9p is strongest in late-onset AD and that regions on chromosome 2q34 and 15q22 are linked to early-onset AD and very-late-onset AD, respectively... - Commentary on "a roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." An impending prevention clinical trial for Alzheimer's disease: roadmaps and realitiesAllen D Roses
Duke University Medical Center and the Fuqua School of Business, Durham, NC, USA
Alzheimers Dement 4:164-6. 2008 - Pharmacogenetics and pharmacogenomics: recent developments, their clinical relevance and some ethical, social, and legal implicationsPaul W Norbert
J Mol Med 81:135-40. 2003..Finally, we provide a framework for the analysis of social accountability that can be used for technology development and technology assessment with regard to pharmacogenomics in particular and molecular medicine in general... - Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neuronsJens Brodbeck
Gladstone Institute of Neurological Disease and Gladstone Institute of Cardiovascular Disease, The J David Gladstone Institutes, 1650 Owens Street, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 105:1343-6. 2008..Rosiglitazone rescued this detrimental effect. Thus, rosiglitazone might improve cognition in AD patients by increasing dendritic spine density... - A single-nucleotide polymorphism tagging set for human drug metabolism and transportKourosh R Ahmadi
Department of Biology (Galton Lab, University College London, The Darwin Building, Gower Street, London WC1E 6BT, UK
Nat Genet 37:84-9. 2005..The analyses also suggest that rare variation is not amenable to tagging strategies... - The knockout mouse projectChristopher P Austin
National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, Bethesda, Maryland 20892, USA
Nat Genet 36:921-4. 2004..It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain... - Medical applications of haplotype-based SNP maps: learning to walk before we runEric Lai
Nat Genet 32:353. 2002 - Design of the Genetics of Early Onset Cardiovascular Disease (GENECARD) studyElizabeth R Hauser
Duke University Medical Center, Durham, NC 27710, USA
Am Heart J 145:602-13. 2003..CONCLUSIONS: Analyses such as these will have implications for stratifying populations for the statistical analysis of the genome scan and on the choice of covariates for the follow-up studies of the initial genome screen analysis...