Alison M Ray

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. ncbi Capsazepine protects against neuronal injury caused by oxygen glucose deprivation by inhibiting I(h)
    Alison M Ray
    Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, Essex, CM19 5AW, United Kingdom
    J Neurosci 23:10146-53. 2003
  2. doi The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase
    Andrew K Takle
    Department of Medicinal Chemistry, Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Bioorg Med Chem Lett 18:4373-6. 2008
  3. doi Tricyclic azepine derivatives as selective brain penetrant 5-HT6 receptor antagonists
    Giancarlo Trani
    Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Bioorg Med Chem Lett 18:5698-700. 2008
  4. doi Identification of a novel 5-HT(4) receptor splice variant (r5-HT(4c1)) and preliminary characterisation of specific 5-HT(4a) and 5-HT(4b) receptor antibodies
    Alison M Ray
    Neuroscience Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Eur J Pharmacol 604:1-11. 2009
  5. ncbi Complex interactions between mGluR1 and mGluR5 shape neuronal network activity in the rat hippocampus
    Christophe Lanneau
    Neurology CEDD, GlaxoSmithKline, Third Avenue, Harlow Essex CM19 5AW, UK
    Neuropharmacology 43:131-40. 2002

Collaborators

  • D M Wilson
  • Tania O Stean
  • Mark J Bamford
  • Christopher N Johnson
  • Helen M Cox
  • Stuart Cobb
  • E A Irving
  • Giancarlo Trani
  • Andrew K Takle
  • Christophe Lanneau
  • Stuart M Baddeley
  • Jon G A Steadman
  • Leann P Quinn
  • Peter H Milner
  • Geoffrey Stemp
  • Antoinette Naylor
  • Frank D King
  • Alastair D Reith
  • David R Witty
  • Tania L Mead
  • Dean A Rivers
  • Alessandra Gaiba
  • Tsu T Chuang
  • Robert P Davis
  • Andrew D Medhurst
  • Brenda K Trail
  • David K Dean
  • Susannah Davies
  • Michael A Briggs
  • Abir A Khazragi
  • Penelope C Staton
  • Beverley B Smith
  • Christopher A Parr
  • Nigel J Deeks
  • Mark H Harries
  • Andrew Randall
  • Ceri H Davies

Detail Information

Publications5

  1. ncbi Capsazepine protects against neuronal injury caused by oxygen glucose deprivation by inhibiting I(h)
    Alison M Ray
    Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, Essex, CM19 5AW, United Kingdom
    J Neurosci 23:10146-53. 2003
    ..These results demonstrate that capsazepine affords neuroprotection through inhibition of I(h) rather than inhibition of VR1...
  2. doi The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase
    Andrew K Takle
    Department of Medicinal Chemistry, Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Bioorg Med Chem Lett 18:4373-6. 2008
    ..One such compound, SB-699393 (17), was examined in vivo to challenge the hypothesis that selective B-Raf inhibitors may be of value in the treatment of stroke...
  3. doi Tricyclic azepine derivatives as selective brain penetrant 5-HT6 receptor antagonists
    Giancarlo Trani
    Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Bioorg Med Chem Lett 18:5698-700. 2008
    ....
  4. doi Identification of a novel 5-HT(4) receptor splice variant (r5-HT(4c1)) and preliminary characterisation of specific 5-HT(4a) and 5-HT(4b) receptor antibodies
    Alison M Ray
    Neuroscience Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Eur J Pharmacol 604:1-11. 2009
    ..Only r5-HT(4b) immunoreactivity was observed on endocrine cells in the duodenum. These data could have implications in rat models and aid understanding of 5-HT(4) splice variant function...
  5. ncbi Complex interactions between mGluR1 and mGluR5 shape neuronal network activity in the rat hippocampus
    Christophe Lanneau
    Neurology CEDD, GlaxoSmithKline, Third Avenue, Harlow Essex CM19 5AW, UK
    Neuropharmacology 43:131-40. 2002
    ..However, mGluR5 appears to be the principal mGluR subtype that initiates bursting activity irrespective of the inhibitory synaptic tone within the neuronal network...