Richard A Peterson

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. doi request reprint Regulatory T-cells: diverse phenotypes integral to immune homeostasis and suppression
    Richard A Peterson
    GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 40:186-204. 2012
  2. pmc Continuing education course #1: non-invasive imaging as a problem-solving tool and translational biomarker strategy in toxicologic pathology
    Richard A Peterson
    GlaxoSmithKline Safety Assessment, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 39:267-72. 2011
  3. doi request reprint Applications of laser scanning cytometry in immunohistochemistry and routine histopathology
    Richard A Peterson
    Molecular and Ultrastructural Pathology Group, Safety Assessment, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:117-32. 2008
  4. ncbi request reprint Morphologic characterization of PhoenixBio (uPA+/+/SCID) humanized liver chimeric mouse model
    Richard A Peterson
    Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Drug Metab Lett 4:180-4. 2010
  5. doi request reprint Preclinical applications of quantitative imaging cytometry to support drug discovery
    David L Krull
    GlaxoSmithKline, Safety Assessment, Investigative Pathology Laboratory, Research Triangle Park, North Carolina, USA
    Methods Cell Biol 102:291-308. 2011
  6. doi request reprint Acute ANIT toxicity in male IL-10 knockout and wild-type mice
    Brenda Faiola
    RTI International, Discovery Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 38:745-55. 2010
  7. doi request reprint PPAR alpha, more than PPAR delta, mediates the hepatic and skeletal muscle alterations induced by the PPAR agonist GW0742
    Brenda Faiola
    Safety Assessment Department, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 105:384-94. 2008
  8. ncbi request reprint Lymphocyte loss and immunosuppression following acetaminophen-induced hepatotoxicity in mice as a potential mechanism of tolerance
    Mary Jane Masson
    Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Chem Res Toxicol 20:20-6. 2007
  9. ncbi request reprint NADPH oxidase involvement in the pathology of Helicobacter pylori infection
    Jacqueline I Keenan
    Department of Surgery, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Free Radic Biol Med 38:1188-96. 2005
  10. ncbi request reprint Adoptive transfer of splenocytes in SCID mice implicates CD4+ T cells in apoptosis and epithelial proliferation associated with Helicobacter pylori-induced gastritis
    Richard A Peterson
    The Ohio State University, College of Veterinary Medicine, Department of Veterinary Biosciences, Columbus, Ohio 43210, USA
    Comp Med 53:498-509. 2003

Detail Information

Publications10

  1. doi request reprint Regulatory T-cells: diverse phenotypes integral to immune homeostasis and suppression
    Richard A Peterson
    GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 40:186-204. 2012
    ..The role of T(REG) in mucosal sites, inflammation/infection, pregnancy, and cancer as well as a review of T(REG) as a modulatory target in drug development will be covered...
  2. pmc Continuing education course #1: non-invasive imaging as a problem-solving tool and translational biomarker strategy in toxicologic pathology
    Richard A Peterson
    GlaxoSmithKline Safety Assessment, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 39:267-72. 2011
    ..The choice of imaging modality will depend on the research question and the needed resolution...
  3. doi request reprint Applications of laser scanning cytometry in immunohistochemistry and routine histopathology
    Richard A Peterson
    Molecular and Ultrastructural Pathology Group, Safety Assessment, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:117-32. 2008
    ..Examples of LSC use in chromogenic IHC, routine histopathology, and Qdot labeling will be reviewed, and advantages and disadvantages of this technology will be discussed...
  4. ncbi request reprint Morphologic characterization of PhoenixBio (uPA+/+/SCID) humanized liver chimeric mouse model
    Richard A Peterson
    Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Drug Metab Lett 4:180-4. 2010
    ....
  5. doi request reprint Preclinical applications of quantitative imaging cytometry to support drug discovery
    David L Krull
    GlaxoSmithKline, Safety Assessment, Investigative Pathology Laboratory, Research Triangle Park, North Carolina, USA
    Methods Cell Biol 102:291-308. 2011
    ..More recently, IHC and LSC have been taken to the next level to quantify biopharmaceutical drug and target co-localization in tissue sections...
  6. doi request reprint Acute ANIT toxicity in male IL-10 knockout and wild-type mice
    Brenda Faiola
    RTI International, Discovery Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 38:745-55. 2010
    ..Overall, our data suggest that IL-10 KO mice have less hepatocellular injury than WT mice following a toxic dose of ANIT and that biliary epithelial injury is accentuated in the KO mice...
  7. doi request reprint PPAR alpha, more than PPAR delta, mediates the hepatic and skeletal muscle alterations induced by the PPAR agonist GW0742
    Brenda Faiola
    Safety Assessment Department, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 105:384-94. 2008
    ....
  8. ncbi request reprint Lymphocyte loss and immunosuppression following acetaminophen-induced hepatotoxicity in mice as a potential mechanism of tolerance
    Mary Jane Masson
    Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Chem Res Toxicol 20:20-6. 2007
    ..Similar regulatory pathways may inhibit other hepatotoxic drugs from causing allergic reactions...
  9. ncbi request reprint NADPH oxidase involvement in the pathology of Helicobacter pylori infection
    Jacqueline I Keenan
    Department of Surgery, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Free Radic Biol Med 38:1188-96. 2005
    ..This is exacerbated by the absence of a functional NADPH oxidase, and is consistent with this enzyme complex having an important role in dampening the inflammatory response...
  10. ncbi request reprint Adoptive transfer of splenocytes in SCID mice implicates CD4+ T cells in apoptosis and epithelial proliferation associated with Helicobacter pylori-induced gastritis
    Richard A Peterson
    The Ohio State University, College of Veterinary Medicine, Department of Veterinary Biosciences, Columbus, Ohio 43210, USA
    Comp Med 53:498-509. 2003
    ..Influx of CD4 cells and gastritis are correlated with epithelial proliferation and apoptosis, and suggest that CD4-dependent H. pylori gastritis leads to epithelial damage with attendant proliferative and metaplastic responses...