M H Selina Mok
Affiliation: GlaxoSmithKline Research and Development
- Excitation of rat hippocampal interneurons via modulation of endogenous agonist activity at the alpha7 nicotinic ACh receptorM H Selina Mok
Schizophrenia and Bipolar Neurophysiology and Pharmacology, Psychiatry CEDD, GlaxoSmithKline, Harlow, Essex CM19 5AW, UK
J Physiol 574:699-710. 2006....
- Electrophysiological characterisation of the actions of kynurenic acid at ligand-gated ion channelsM H Selina Mok
Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex CM19 5AW, United Kingdom
Neuropharmacology 57:242-9. 2009..In conclusion, kynA is an antagonist at NMDA, AMPA and glycine receptors and a modulator of GABA(A) receptors, but we find no evidence for any effect of kynA at the alpha7 nAChR...
- Evaluation of expression and function of the H+/myo-inositol transporter HMITElena Di Daniel
Psychiatry Discovery Technology Group, GlaxoSmithKline, New Frontiers Science Park, Harlow, UK
BMC Cell Biol 10:54. 2009..Here, we describe analyses of expression and function of the recently identified H+/myo-inositol transporter (HMIT) investigated as a potential regulator of PIns signalling...
- Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDARAnne Cécile Fricker
Psychiatry Discovery Technology Group, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM195AW, United Kingdom
Neuropharmacology 56:1060-7. 2009..Taken together, these findings do not support a rationale for targeting NAALADase and increasing extracellular NAAG levels as a therapeutic strategy for the treatment of schizophrenia...