Jeffrey J Legos
Affiliation: GlaxoSmithKline Research and Development
- Update on pharmacological strategies for stroke: prevention, acute intervention and regenerationJeffrey J Legos
GlaxoSmithKline, PO Box 1539, 709 Swedeland Road, King of Prussia, Pa 19406 0939, USA
Curr Opin Investig Drugs 4:847-58. 2003..e., neurobehavioral recovery) following brain damage...
- Programmable microchip monitoring of post-stroke pyrexia: effects of aspirin and paracetamol on temperature and infarct size in the ratJeffrey J Legos
GlaxoSmithKline, High Throughput Biology, Discovery Research, 709 Swedeland Road, PO Box 1539, King of Prussia, PA 19406, USA
J Neurosci Methods 113:159-66. 2002..However, a full characterization of these pyretic changes and the effects of anti-pyretic drugs on outcome is not available...
- Pharmacological interventions for stroke: failures and futureJeffrey J Legos
High Throughput Biology, Discovery Research, GlaxoSmithKline, King of Prussia, PA, USA
Expert Opin Investig Drugs 11:603-14. 2002..The scope of this review will focus on recent clinical failures in addition to agents currently in clinical development, comparing vascular targets to the common neuroprotective strategies...
- The selective p38 inhibitor SB-239063 protects primary neurons from mild to moderate excitotoxic injuryJeffrey J Legos
High Throughput Biology, Discovery Research, GlaxoSmithKline, PO Box 1539, Mail Code UW 2523, 709 Swedeland Road, 19406, King of Prussia, PA, USA
Eur J Pharmacol 447:37-42. 2002....
- SB 234551 selective ET(A) receptor antagonism: perfusion/diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protectionJeffrey J Legos
High Throughput Biology, Discovery Research, King of Prussia, PA, USA
Exp Neurol 212:53-62. 2008..In addition, tissue perfusion information obtained under these conditions might clarify mechanism of protection in the evaluation of protective compounds for focal stroke...
- Selective CETP inhibition and PPARalpha agonism increase HDL cholesterol and reduce LDL cholesterol in human ApoB100/human CETP transgenic miceMichael K Hansen
Discovery Research, GlaxoSmithKline, King of Prussia, PA, USA
J Cardiovasc Pharmacol Ther 15:196-202. 2010..In addition, these data demonstrate the use of hApoB100/hCETP transgenic mice to identify, characterize, and screen compounds that increase HDL cholesterol...
- Non-surgical management of spinal cord injuryJeffrey J Legos
Hign Throughput Biology, Discovery Research, GlaxoSmithKline, King of Prussia, PA, USA
Expert Opin Investig Drugs 11:469-82. 2002..This review summarises recent advances in the development of pharmacological agents targeting the acute phase of spinal cord injury as well as potential strategies to facilitate regeneration of the spinal cord...
- Selective PPARdelta agonist treatment increases skeletal muscle lipid metabolism without altering mitochondrial energy coupling: an in vivo magnetic resonance spectroscopy studyBeat M Jucker
Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline, UW2510, King of Prussia, PA 19406, USA
Am J Physiol Endocrinol Metab 293:E1256-64. 2007..However, the mitochondrial-energy coupling efficiency was not altered in the presence of increased uncoupling protein expression...
- Inhibition of phosphodiesterase type 4 decreases stress-induced defecation in rats and miceFrank C Barone
Discovery Research, High Throughput Biology, GlaxoSmithKline, King of Prussia, PA 19406, USA
Pharmacology 81:11-7. 2008..In this study, the effects of PDE4 inhibition were assessed in a model of stress-induced defecation previously demonstrated to be due to increased colonic transit/evacuation...
- LEX032, a novel recombinant serpin, protects the brain after transient focal ischemiaMichael Weaver
Department of Physiology, Temple University School of Medicine, 3420 N Broad St, Philadelphia, Pennsylvania 19140, USA
Microvasc Res 63:327-34. 2002..6 +/- 0.7). This data demonstrates that LEX032 reduces brain injury and suggests that serine protease inhibitors may reduce ischemia/reperfusion injury by decreasing leukocyte activation and migration...
- Caspase 3 activation is essential for neuroprotection in preconditioningBethAnn McLaughlin
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Proc Natl Acad Sci U S A 100:715-20. 2003..We outline a neuroprotective pathway where events normally associated with apoptotic cell death are critical for cell survival...