Aili L Lazaar

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. pmc The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma
    Dave Singh
    The University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester M23 9LT, UK
    Respir Res 11:26. 2010
  2. ncbi request reprint Airway smooth muscle as a regulator of immune responses and bronchomotor tone
    Aili L Lazaar
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Clin Chest Med 27:53-69, vi. 2006
  3. pmc SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans
    Aili L Lazaar
    COPD Clinical Discovery, GlaxoSmithKline, King of Prussia, PA, USA
    Br J Clin Pharmacol 72:282-93. 2011
  4. ncbi request reprint Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent
    Altaf S Kazi
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 286:L539-45. 2004
  5. ncbi request reprint Is airway remodeling clinically relevant in asthma?
    Aili L Lazaar
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Med 115:652-9. 2003
  6. ncbi request reprint Airway smooth muscle: new targets for asthma pharmacotherapy
    Aili L Lazaar
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, 852 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Expert Opin Ther Targets 6:447-59. 2002
  7. ncbi request reprint IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway
    Yassine Amrani
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1063-71. 2003
  8. ncbi request reprint Technology evaluation: omalizumab, Genentech/Novartis/Tanox
    Aili L Lazaar
    University of Pennsylvania Medical Center, Pulmonary, Allergy and Critical Care Division, 852 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Curr Opin Mol Ther 5:81-9. 2003
  9. ncbi request reprint Airway smooth muscle: a modulator of airway remodeling in asthma
    Aili L Lazaar
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine
    J Allergy Clin Immunol 116:488-95; quiz 496. 2005

Collaborators

Detail Information

Publications9

  1. pmc The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma
    Dave Singh
    The University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester M23 9LT, UK
    Respir Res 11:26. 2010
    ..GSK256066 is a selective phosphodiesterase 4 inhibitor that can be given by inhalation, minimising the potential for side effects. We evaluated the effects of GSK256066 on airway responses to allergen challenge in mild asthmatics...
  2. ncbi request reprint Airway smooth muscle as a regulator of immune responses and bronchomotor tone
    Aili L Lazaar
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Clin Chest Med 27:53-69, vi. 2006
    ..This article also discusses how altered synthetic function contributes to airway remodeling...
  3. pmc SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans
    Aili L Lazaar
    COPD Clinical Discovery, GlaxoSmithKline, King of Prussia, PA, USA
    Br J Clin Pharmacol 72:282-93. 2011
    ..A CXCR1/2 receptor antagonist has shown activity in an ozone challenge model in humans...
  4. ncbi request reprint Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent
    Altaf S Kazi
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 286:L539-45. 2004
    ..We conclude that ASM-derived VEGF, through modulation of the extracellular matrix, may play an important role in airway remodeling seen in asthma...
  5. ncbi request reprint Is airway remodeling clinically relevant in asthma?
    Aili L Lazaar
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Med 115:652-9. 2003
    ....
  6. ncbi request reprint Airway smooth muscle: new targets for asthma pharmacotherapy
    Aili L Lazaar
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, 852 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Expert Opin Ther Targets 6:447-59. 2002
    ..Finally, the efficacy of established asthma therapies in modifying the synthetic function of ASM cells are compared and novel targets for pharmacological intervention are discussed...
  7. ncbi request reprint IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway
    Yassine Amrani
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1063-71. 2003
    ....
  8. ncbi request reprint Technology evaluation: omalizumab, Genentech/Novartis/Tanox
    Aili L Lazaar
    University of Pennsylvania Medical Center, Pulmonary, Allergy and Critical Care Division, 852 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Curr Opin Mol Ther 5:81-9. 2003
    ..Omalizumab is at the pre-registration stage for both indications in the US, New Zealand, Switzerland and Western Europe, and is currently registered for both indications in Australia...
  9. ncbi request reprint Airway smooth muscle: a modulator of airway remodeling in asthma
    Aili L Lazaar
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine
    J Allergy Clin Immunol 116:488-95; quiz 496. 2005
    ..These ASM cell functions might directly or indirectly modulate submucosal airway inflammation and promote airway remodeling...