Charles H Large

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. doi request reprint The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat
    Charles H Large
    epartment of Molecular and Cellular Biology, Neuroscience Centre of Excellence for Drug Discovery, Medicines Research Centre, GlaxoSmithKline S p A, Via Fleming 4, Verona 37135, Italy
    Epilepsy Res 85:96-106. 2009
  2. doi request reprint Neural network dysfunction in bipolar depression: clues from the efficacy of lamotrigine
    Charles H Large
    Neurosciences Centre of Excellence for Drug Discovery, Medicines Research Centre, GlaxoSmithKline S p A, Via Fleming 4, 37135, Verona, Italy
    Biochem Soc Trans 37:1080-4. 2009
  3. ncbi request reprint The potential role of lamotrigine in schizophrenia
    Charles H Large
    Department of Neuropharmacology, Psychiatry CEDD, GlaxoSmithKline SpA, Via Fleming 4, 37135, Verona, Italy
    Psychopharmacology (Berl) 181:415-36. 2005
  4. ncbi request reprint Do NMDA receptor antagonist models of schizophrenia predict the clinical efficacy of antipsychotic drugs?
    Charles H Large
    Psychiatry CEDD, GlaxoSmithKline, Via Fleming 4, 37135 Verona, Italy
    J Psychopharmacol 21:283-301. 2007
  5. doi request reprint The relationship between lamotrigine concentration and change in resting motor threshold in a rodent model of motor cortex stimulation
    David M Sokal
    Department of Biology, Neurosciences Centre of Excellence for Drug Discovery, Medicines Research Centre, GlaxoSmithKline SpA, Verona, Italy
    Epilepsy Res 83:103-11. 2009
  6. doi request reprint The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: implications for clinical use
    Charles H Large
    Medicines Research Centre, GlaxoSmithKline S p A, Verona, Italy
    Epilepsia 53:425-36. 2012
  7. doi request reprint Effects of lamotrigine on PCP-evoked elevations in monoamine levels in the medial prefrontal cortex of freely moving rats
    Davide Quarta
    Mood and Anxiety DPU, Neurosciences CEDD, GlaxoSmithKline Medicines Research Centre, Verona, Italy
    J Psychopharmacol 25:1703-11. 2011
  8. doi request reprint The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia
    Charles H Large
    Neuroscience Centre of Excellence for Drug Discovery, Medicines Research Centre, GlaxoSmithKline SpA, Verona, Italy
    J Pharmacol Exp Ther 338:100-13. 2011
  9. doi request reprint AMN082, an allosteric mGluR7 agonist that inhibits afferent glutamatergic transmission in rat basolateral amygdala
    Annarosa Ugolini
    Department of Biology, Neuroscience Centre of Excellence for Drug Discovery, Psychiatry CEDD, GlaxoSmithKline Medicines Research Centre S p A, Via Fleming 4, 37135 Verona, Italy
    Neuropharmacology 55:532-6. 2008
  10. ncbi request reprint Effects of GABA(B), 5-HT(1A), and 5-HT(2) receptor stimulation on activation and inhibition of the rat lateral amygdala following medial geniculate nucleus stimulation in vivo
    David M Sokal
    Psychiatry CEDD, GlaxoSmithKline S p A, Via A Fleming 4, Verona 37135, Italy
    Brain Res 1031:141-50. 2005

Detail Information

Publications18

  1. doi request reprint The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat
    Charles H Large
    epartment of Molecular and Cellular Biology, Neuroscience Centre of Excellence for Drug Discovery, Medicines Research Centre, GlaxoSmithKline S p A, Via Fleming 4, Verona 37135, Italy
    Epilepsy Res 85:96-106. 2009
    ..We found that a higher unbound concentration of the drug in the brain was required for anticonvulsant efficacy than would be expected given its sodium channel blocking potency...
  2. doi request reprint Neural network dysfunction in bipolar depression: clues from the efficacy of lamotrigine
    Charles H Large
    Neurosciences Centre of Excellence for Drug Discovery, Medicines Research Centre, GlaxoSmithKline S p A, Via Fleming 4, 37135, Verona, Italy
    Biochem Soc Trans 37:1080-4. 2009
    ..The results are also consistent with the notion of corticolimbic network dysfunction in bipolar disorder...
  3. ncbi request reprint The potential role of lamotrigine in schizophrenia
    Charles H Large
    Department of Neuropharmacology, Psychiatry CEDD, GlaxoSmithKline SpA, Via Fleming 4, 37135, Verona, Italy
    Psychopharmacology (Berl) 181:415-36. 2005
    ..Furthermore, lamotrigine, which can modulate glutamate release, may add to or synergise with atypical antipsychotic drugs, some of which may themselves modulate glutamate transmission...
  4. ncbi request reprint Do NMDA receptor antagonist models of schizophrenia predict the clinical efficacy of antipsychotic drugs?
    Charles H Large
    Psychiatry CEDD, GlaxoSmithKline, Via Fleming 4, 37135 Verona, Italy
    J Psychopharmacol 21:283-301. 2007
    ....
  5. doi request reprint The relationship between lamotrigine concentration and change in resting motor threshold in a rodent model of motor cortex stimulation
    David M Sokal
    Department of Biology, Neurosciences Centre of Excellence for Drug Discovery, Medicines Research Centre, GlaxoSmithKline SpA, Verona, Italy
    Epilepsy Res 83:103-11. 2009
    ....
  6. doi request reprint The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: implications for clinical use
    Charles H Large
    Medicines Research Centre, GlaxoSmithKline S p A, Verona, Italy
    Epilepsia 53:425-36. 2012
    ....
  7. doi request reprint Effects of lamotrigine on PCP-evoked elevations in monoamine levels in the medial prefrontal cortex of freely moving rats
    Davide Quarta
    Mood and Anxiety DPU, Neurosciences CEDD, GlaxoSmithKline Medicines Research Centre, Verona, Italy
    J Psychopharmacol 25:1703-11. 2011
    ..The dissociation between monoamine overflow and locomotor activity suggests the involvement of different brain circuits; relevance to the treatment of schizophrenia is also discussed...
  8. doi request reprint The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia
    Charles H Large
    Neuroscience Centre of Excellence for Drug Discovery, Medicines Research Centre, GlaxoSmithKline SpA, Verona, Italy
    J Pharmacol Exp Ther 338:100-13. 2011
    ....
  9. doi request reprint AMN082, an allosteric mGluR7 agonist that inhibits afferent glutamatergic transmission in rat basolateral amygdala
    Annarosa Ugolini
    Department of Biology, Neuroscience Centre of Excellence for Drug Discovery, Psychiatry CEDD, GlaxoSmithKline Medicines Research Centre S p A, Via Fleming 4, 37135 Verona, Italy
    Neuropharmacology 55:532-6. 2008
    ..These results suggest that mGLUR7 has a unique role in regulating neuronal activity in the BLA and may be a target for novel drugs for the treatment of anxiety...
  10. ncbi request reprint Effects of GABA(B), 5-HT(1A), and 5-HT(2) receptor stimulation on activation and inhibition of the rat lateral amygdala following medial geniculate nucleus stimulation in vivo
    David M Sokal
    Psychiatry CEDD, GlaxoSmithKline S p A, Via A Fleming 4, Verona 37135, Italy
    Brain Res 1031:141-50. 2005
    ..The results support the use of in vivo field potential recording within the MGN-lateral amygdala pathway to evaluate this as a possible site of action for novel anxiolytic drugs...
  11. ncbi request reprint Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model
    Sharon C Stratton
    Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK
    Epilepsy Res 53:95-106. 2003
    ..These results suggest that lamotrigine, like levetiracetam, possesses the ability to counteract kindling acquisition, which differentiates it from other drugs with sodium channel blocking activity...
  12. doi request reprint The CB1 receptor antagonist, SR141716A, prevents high-frequency stimulation-induced reduction of feedback inhibition in the rat dentate gyrus following perforant path stimulation in vivo
    David M Sokal
    Department of Biology, Psychiatry CEDD, GlaxoSmithKline Medicines Research Centre, Via A Fleming 4, Verona, Italy
    Brain Res 1223:50-8. 2008
    ..We suggest that CB(1) activation during HFS of the medial perforant path increases glutamate release from perforant path synapses, but inhibits release of GABA from local circuit interneurons...
  13. doi request reprint The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy
    Martin J Gunthorpe
    New Frontiers Science Park, GlaxoSmithKline plc, Harlow, Essex, United Kingdom
    Epilepsia 53:412-24. 2012
    ....
  14. ncbi request reprint Differential effects of antipsychotic and glutamatergic agents on the phMRI response to phencyclidine
    Alessandro Gozzi
    Department of Biology, Psychiatry CEDD, GlaxoSmithKline Medicines Research Centre, Verona, Italy
    Neuropsychopharmacology 33:1690-703. 2008
    ..Finally, the thalamic effect of clozapine could be key to elucidating the functional basis of its pharmacological action...
  15. doi request reprint Modulation of high-frequency oscillations associated with NMDA receptor hypofunction in the rodent nucleus accumbens by lamotrigine
    Mark J Hunt
    Laboratory of the Limbic System, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Prog Neuropsychopharmacol Biol Psychiatry 32:1312-9. 2008
    ....
  16. ncbi request reprint Lamotrigine prevents ketamine but not amphetamine-induced deficits in prepulse inhibition in mice
    Suzanne A Brody
    Department of Psychiatry and Neurosciences, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093 0804, USA
    Psychopharmacology (Berl) 169:240-6. 2003
    ..Acutely manic bipolar patients, like persons with schizophrenia, Tourette's, and obsessive compulsive disorder, exhibit decreases in sensorimotor gating, as measured by prepulse inhibition of the startle response (PPI)...
  17. pmc An investigation of the efficacy of mood stabilizers in rodent models of prepulse inhibition
    Jacob C Ong
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    J Pharmacol Exp Ther 315:1163-71. 2005
    ..Hence, further studies using these dopaminergic and glutamatergic models of deficient PPI may provide valuable insights into the mechanisms underlying the differential therapeutic effects of antimanic and mood-stabilizing treatments...
  18. ncbi request reprint Effect of lamotrigine treatment on epileptogenesis: an experimental study in rat
    Jari Nissinen
    A I Virtanen Institute, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Epilepsy Res 58:119-32. 2004
    ..These data, together with earlier studies of other antiepileptic drugs, suggest that strategies other than Na(+)-channel blockade should be explored to modulate the molecular cascades leading to epileptogenesis after SE...