Arlene R Hughes

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. doi request reprint Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utility
    A R Hughes
    GlaxoSmithKline Pharmacogenetics, Research Triangle Park, NC 27709, USA
    Pharmacogenomics J 8:365-74. 2008
  2. doi request reprint Genetic association studies to detect adverse drug reactions: abacavir hypersensitivity as an example
    Arlene R Hughes
    GlaxoSmithKline Genetics, 5 Moore Drive, PO Box 13398, Research Triangle Park, NC 27709, USA
    Pharmacogenomics 10:225-33. 2009
  3. ncbi request reprint Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations
    Arlene R Hughes
    GlaxoSmithKline, NC 27709, USA
    Pharmacogenomics 5:203-11. 2004
  4. ncbi request reprint Genetic variations in HLA-B region and hypersensitivity reactions to abacavir
    Seth Hetherington
    HIV Clinical Development and Medical Affairs, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Lancet 359:1121-2. 2002

Collaborators

  • Allen D Roses
  • Clive Bowman
  • David J Dow
  • Seth Hetherington
  • Kirstie Davies
  • Michael Stocum
  • Eric Lai
  • Denise Shortino
  • Abigail Handley
  • Linda M Thurmond
  • Mary E Fling
  • Michael Mosteller
  • William Spreen
  • Katherine L Baker

Detail Information

Publications4

  1. doi request reprint Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utility
    A R Hughes
    GlaxoSmithKline Pharmacogenetics, Research Triangle Park, NC 27709, USA
    Pharmacogenomics J 8:365-74. 2008
    ..Prospective HLA-B*5701 screening should greatly reduce the incidence of ABC HSR by identifying patients at high risk for ABC HSR before they are treated...
  2. doi request reprint Genetic association studies to detect adverse drug reactions: abacavir hypersensitivity as an example
    Arlene R Hughes
    GlaxoSmithKline Genetics, 5 Moore Drive, PO Box 13398, Research Triangle Park, NC 27709, USA
    Pharmacogenomics 10:225-33. 2009
    ..Important lessons from this pharmacogenetics program will be discussed in this paper...
  3. ncbi request reprint Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations
    Arlene R Hughes
    GlaxoSmithKline, NC 27709, USA
    Pharmacogenomics 5:203-11. 2004
    ..Even after a marker set is identified, appropriate clinical identification and management of hypersensitivity to abacavir must remain the cornerstone of clinical practice...
  4. ncbi request reprint Genetic variations in HLA-B region and hypersensitivity reactions to abacavir
    Seth Hetherington
    HIV Clinical Development and Medical Affairs, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Lancet 359:1121-2. 2002
    ..Clinical monitoring and management of hypersensitivity reactions among patients receiving abacavir must remain unchanged...