Arlene R Hughes
Affiliation: GlaxoSmithKline Research and Development
- Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utilityA R Hughes
GlaxoSmithKline Pharmacogenetics, Research Triangle Park, NC 27709, USA
Pharmacogenomics J 8:365-74. 2008..Prospective HLA-B*5701 screening should greatly reduce the incidence of ABC HSR by identifying patients at high risk for ABC HSR before they are treated...
- Genetic association studies to detect adverse drug reactions: abacavir hypersensitivity as an exampleArlene R Hughes
GlaxoSmithKline Genetics, 5 Moore Drive, PO Box 13398, Research Triangle Park, NC 27709, USA
Pharmacogenomics 10:225-33. 2009..Important lessons from this pharmacogenetics program will be discussed in this paper...
- Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populationsArlene R Hughes
GlaxoSmithKline, NC 27709, USA
Pharmacogenomics 5:203-11. 2004..Even after a marker set is identified, appropriate clinical identification and management of hypersensitivity to abacavir must remain the cornerstone of clinical practice...
- Genetic variations in HLA-B region and hypersensitivity reactions to abacavirSeth Hetherington
HIV Clinical Development and Medical Affairs, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
Lancet 359:1121-2. 2002..Clinical monitoring and management of hypersensitivity reactions among patients receiving abacavir must remain unchanged...