David R Howlett

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. ncbi Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes
    David R Howlett
    Neurology and GI CEDD, GlaxoSmithKline Research and Development Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK
    Brain Res 1017:130-6. 2004
  2. ncbi MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease
    Ainsley A Culbert
    Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development Limited, New Frontiers Science Park, Third Avenue, Harlow CM19 5AW, Essex, United Kingdom
    J Biol Chem 281:23658-67. 2006
  3. ncbi Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability
    Kwok Fai Lau
    Department of Neuroscience, The Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, United Kingdom
    Mol Cell Neurosci 20:13-20. 2002
  4. ncbi Imaging and spatial distribution of beta-amyloid peptide and metal ions in Alzheimer's plaques by laser ablation-inductively coupled plasma-mass spectrometry
    Robert W Hutchinson
    Centre for Analytical Sciences, The University of Sheffield, Sheffield, UK
    Anal Biochem 346:225-33. 2005
  5. ncbi Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors
    Jonathan J Abbott
    King s College London, Wolfson Centre for Age Related Diseases, Guy s Campus, St Thomas Street, London SE1 1UL, UK
    Neurobiol Aging 29:992-1001. 2008

Collaborators

Detail Information

Publications5

  1. ncbi Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes
    David R Howlett
    Neurology and GI CEDD, GlaxoSmithKline Research and Development Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK
    Brain Res 1017:130-6. 2004
    ..These results suggest that the cognitive impairment in TASTPM mice is related to the disruption of neural connectivity and not simply Abeta deposition, which first occurs 3 months earlier...
  2. ncbi MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease
    Ainsley A Culbert
    Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development Limited, New Frontiers Science Park, Third Avenue, Harlow CM19 5AW, Essex, United Kingdom
    J Biol Chem 281:23658-67. 2006
    ..Our data propose a role for MK2 in AD brain pathology, for which neuroinflammation involving cytokines and chemokines and overt neuronal loss have been documented...
  3. ncbi Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability
    Kwok Fai Lau
    Department of Neuroscience, The Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, United Kingdom
    Mol Cell Neurosci 20:13-20. 2002
    ..Threonine(354) phosphorylation functions to selectively stabilize C-PS1. Our results demonstrate that cdk5/p35 is a regulator of PS1 metabolism...
  4. ncbi Imaging and spatial distribution of beta-amyloid peptide and metal ions in Alzheimer's plaques by laser ablation-inductively coupled plasma-mass spectrometry
    Robert W Hutchinson
    Centre for Analytical Sciences, The University of Sheffield, Sheffield, UK
    Anal Biochem 346:225-33. 2005
    ..We also report the combination of laser capture microdissection with LA-ICP-MS as an alternative strategy for microanalysis of immunohistochemical sections...
  5. ncbi Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors
    Jonathan J Abbott
    King s College London, Wolfson Centre for Age Related Diseases, Guy s Campus, St Thomas Street, London SE1 1UL, UK
    Neurobiol Aging 29:992-1001. 2008
    ....