- Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptorsSebastien Guery
Novartis Institutes for BioMedical Research, Neuroscience, Novartis Pharma A G, Basel, Switzerland
Bioorg Med Chem Lett 17:6206-11. 2007..The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABA(B) receptors is presented...
- Discovery and structure-activity relationship of a novel spirocarbamate series of NPY Y5 antagonistsColin P Leslie
Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline SpA, Medicines Research Centre, Verona, Italy
Bioorg Med Chem Lett 20:6103-7. 2010..Both compounds significantly inhibited the food intake induced by a Y5 selective agonist with minimal effective doses of 3mg/kg po...