Sebastien Guery

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. pmc Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors
    Sebastien Guery
    Novartis Institutes for BioMedical Research, Neuroscience, Novartis Pharma A G, Basel, Switzerland
    Bioorg Med Chem Lett 17:6206-11. 2007
  2. doi request reprint Discovery and structure-activity relationship of a novel spirocarbamate series of NPY Y5 antagonists
    Colin P Leslie
    Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline SpA, Medicines Research Centre, Verona, Italy
    Bioorg Med Chem Lett 20:6103-7. 2010

Detail Information

Publications2

  1. pmc Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors
    Sebastien Guery
    Novartis Institutes for BioMedical Research, Neuroscience, Novartis Pharma A G, Basel, Switzerland
    Bioorg Med Chem Lett 17:6206-11. 2007
    ..The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABA(B) receptors is presented...
  2. doi request reprint Discovery and structure-activity relationship of a novel spirocarbamate series of NPY Y5 antagonists
    Colin P Leslie
    Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline SpA, Medicines Research Centre, Verona, Italy
    Bioorg Med Chem Lett 20:6103-7. 2010
    ..Both compounds significantly inhibited the food intake induced by a Y5 selective agonist with minimal effective doses of 3mg/kg po...