Richard A Graham

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. ncbi request reprint Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes
    Richard A Graham
    Division of Molecular Pharmaceutics, School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Biochem Mol Toxicol 20:69-78. 2006
  2. ncbi request reprint Cloning, tissue expression, and regulation of beagle dog CYP4A genes
    Richard A Graham
    Division of Molecular Pharmaceutics, School of Pharmacy, The University of North Carolina at Chapel Hill, 27599, USA
    Toxicol Sci 92:356-67. 2006
  3. ncbi request reprint Differential UGT1A1 induction by chrysin in primary human hepatocytes and HepG2 Cells
    Cornelia M Smith
    Division of Drug Delivery and Disposition, School of Pharmacy, CB 7360, Kerr Hall, Room 2319, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
    J Pharmacol Exp Ther 315:1256-64. 2005
  4. ncbi request reprint In vivo and in vitro induction of cytochrome P450 enzymes in beagle dogs
    Richard A Graham
    XenoTech, LLC, Lenexa, Kansas 66219, USA
    Drug Metab Dispos 30:1206-13. 2002
  5. ncbi request reprint Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes
    Ajay Madan
    XenoTech, LLC, 16825 West 116th Street, Lenexa, KS 66219, USA
    Drug Metab Dispos 31:421-31. 2003

Collaborators

  • Edward L LeCluyse
  • Masahiko Negishi
  • Bryan Goodwin
  • Andrew Parkinson
  • Cornelia M Smith
  • Ajay Madan
  • Hongbing Wang
  • Wojciech L Krol
  • Ivin S Silver
  • April D Downey
  • Liang Shang Gan
  • Linda A Krueger
  • Maria D Ribadeneira
  • Li Yu
  • Maciej Czerwinski
  • Lida Antonian
  • Kathleen M Carroll
  • L Alayne Burton
  • Karl Zech
  • Greg Wagner
  • Patrick Koch
  • Daniel R Mudra
  • Jameson Forster
  • Philmore Robertson

Detail Information

Publications5

  1. ncbi request reprint Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes
    Richard A Graham
    Division of Molecular Pharmaceutics, School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Biochem Mol Toxicol 20:69-78. 2006
    ..Overall, the induction of dog CYP1A, CYP2B, and CYP3A exhibits characteristics that are intermediate to those of rodent and human...
  2. ncbi request reprint Cloning, tissue expression, and regulation of beagle dog CYP4A genes
    Richard A Graham
    Division of Molecular Pharmaceutics, School of Pharmacy, The University of North Carolina at Chapel Hill, 27599, USA
    Toxicol Sci 92:356-67. 2006
    ..These results suggest that dog CYP4A37, CYP4A38, and CYP4A39 are expressed in a tissue-dependent manner and that beagle dog CYP4A is not highly inducible by PPARalpha agonists, similar to the human CYP4A11 gene...
  3. ncbi request reprint Differential UGT1A1 induction by chrysin in primary human hepatocytes and HepG2 Cells
    Cornelia M Smith
    Division of Drug Delivery and Disposition, School of Pharmacy, CB 7360, Kerr Hall, Room 2319, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
    J Pharmacol Exp Ther 315:1256-64. 2005
    ..In conclusion, this study suggests that the metabolic stability of chrysin likely would limit its ability to induce UGT1A1 in vivo...
  4. ncbi request reprint In vivo and in vitro induction of cytochrome P450 enzymes in beagle dogs
    Richard A Graham
    XenoTech, LLC, Lenexa, Kansas 66219, USA
    Drug Metab Dispos 30:1206-13. 2002
    ..e., ex vivo rates). These results suggest that beagle dogs have CYP1A, CYP2B, CYP2E, and CYP3A enzymes and that the induction profile resembles the profile observed in humans more than in rats...
  5. ncbi request reprint Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes
    Ajay Madan
    XenoTech, LLC, 16825 West 116th Street, Lenexa, KS 66219, USA
    Drug Metab Dispos 31:421-31. 2003
    ....