Brenda Faiola

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. ncbi Variations in Prkdc and susceptibility to benzene-induced toxicity in mice
    Brenda Faiola
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 75:321-32. 2003
  2. ncbi Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity
    Alison K Bauer
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 72:201-9. 2003
  3. ncbi Exposure of hematopoietic stem cells to benzene or 1,4-benzoquinone induces gender-specific gene expression
    Brenda Faiola
    CIIT Centers for Health Research, Research Triangle Park, NC, USA
    Stem Cells 22:750-8. 2004
  4. ncbi Gene expression profile in bone marrow and hematopoietic stem cells in mice exposed to inhaled benzene
    Brenda Faiola
    CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
    Mutat Res 549:195-212. 2004
  5. ncbi Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1
    Alison K Bauer
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 63:929-35. 2003
  6. ncbi Use of genetically modified mouse models to assess pathways of benzene-induced bone marrow cytotoxicity and genotoxicity
    Leslie Recio
    Integrated Laboratory Systems Inc, Genetic Toxicology Program, P O Box 13501, Research Triangle Park, NC 27709, USA
    Chem Biol Interact 153:159-64. 2005
  7. ncbi Human CD34+ hematopoietic progenitor cells are sensitive targets for toxicity induced by 1,4-benzoquinone
    Diane J Abernethy
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 79:82-9. 2004
  8. doi PPAR alpha, more than PPAR delta, mediates the hepatic and skeletal muscle alterations induced by the PPAR agonist GW0742
    Brenda Faiola
    Safety Assessment Department, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 105:384-94. 2008
  9. doi Effects of Solutol (Kolliphor) and cremophor in polyethylene glycol 400 vehicle formulations in Sprague-Dawley rats and Beagle dogs
    Alan H Stokes
    GlaxoSmithKline Research and Development Safety Assessment, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    Int J Toxicol 32:189-97. 2013
  10. doi Acute ANIT toxicity in male IL-10 knockout and wild-type mice
    Brenda Faiola
    RTI International, Discovery Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 38:745-55. 2010

Collaborators

Detail Information

Publications11

  1. ncbi Variations in Prkdc and susceptibility to benzene-induced toxicity in mice
    Brenda Faiola
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 75:321-32. 2003
    ..Prkdc does not appear to be a significant genetic susceptibility factor for acute benzene toxicity. Moreover, the role of NHEJ, mediated by DNA-PK, in restoring genomic integrity following benzene-induced DSB remains equivocal...
  2. ncbi Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity
    Alison K Bauer
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 72:201-9. 2003
    ..Thus mEH appears to be critical in benzene-induced toxicity in male, but not female, mice...
  3. ncbi Exposure of hematopoietic stem cells to benzene or 1,4-benzoquinone induces gender-specific gene expression
    Brenda Faiola
    CIIT Centers for Health Research, Research Triangle Park, NC, USA
    Stem Cells 22:750-8. 2004
    ..HSC culture systems such as the one used here will be useful for testing the hematotoxicity of various substances, including other benzene metabolites...
  4. ncbi Gene expression profile in bone marrow and hematopoietic stem cells in mice exposed to inhaled benzene
    Brenda Faiola
    CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
    Mutat Res 549:195-212. 2004
    ....
  5. ncbi Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1
    Alison K Bauer
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 63:929-35. 2003
    ..These results indicate that NQO1 deficiency results in substantially greater benzene-induced toxicity. However, the specific patterns of toxicity differed between the male and female mice...
  6. ncbi Use of genetically modified mouse models to assess pathways of benzene-induced bone marrow cytotoxicity and genotoxicity
    Leslie Recio
    Integrated Laboratory Systems Inc, Genetic Toxicology Program, P O Box 13501, Research Triangle Park, NC 27709, USA
    Chem Biol Interact 153:159-64. 2005
    ..These studies show that benzene toxicity is regulated by a number of genetic pathways that affect the production of reactive metabolites and DNA damage response pathways in a target tissue...
  7. ncbi Human CD34+ hematopoietic progenitor cells are sensitive targets for toxicity induced by 1,4-benzoquinone
    Diane J Abernethy
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 79:82-9. 2004
    ..Human CD34(+) HPC will be useful for testing the toxicity of other benzene metabolites and various hematotoxic chemicals...
  8. doi PPAR alpha, more than PPAR delta, mediates the hepatic and skeletal muscle alterations induced by the PPAR agonist GW0742
    Brenda Faiola
    Safety Assessment Department, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 105:384-94. 2008
    ....
  9. doi Effects of Solutol (Kolliphor) and cremophor in polyethylene glycol 400 vehicle formulations in Sprague-Dawley rats and Beagle dogs
    Alan H Stokes
    GlaxoSmithKline Research and Development Safety Assessment, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    Int J Toxicol 32:189-97. 2013
    ..Generally, lower dose volumes minimized the severity and/or incidence of findings...
  10. doi Acute ANIT toxicity in male IL-10 knockout and wild-type mice
    Brenda Faiola
    RTI International, Discovery Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 38:745-55. 2010
    ..Overall, our data suggest that IL-10 KO mice have less hepatocellular injury than WT mice following a toxic dose of ANIT and that biliary epithelial injury is accentuated in the KO mice...
  11. pmc Influence of CD4 T cells and the source of major histocompatibility complex class II-restricted peptides on cytotoxic T-cell priming by dendritic cells
    Brenda Faiola
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunology 105:47-55. 2002
    ..These observations provide convincing evidence that efficient CTL induction by DC in vivo requires concomitant presentation of class II epitopes for CD4(+) T-cell induction...