C S Elangbam

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. ncbi request reprint Endocardial myxomatous change in Harlan Sprague-Dawley rats (Hsd:S-D) and CD-1 mice: its microscopic resemblance to drug-induced valvulopathy in humans
    Chandikumar S Elangbam
    Department of Pathology, GlaxoSmithKline Inc, Research Triangle Park, North Carolina 27709 3398, USA
    Toxicol Pathol 30:483-91. 2002
  2. ncbi request reprint 5-Hydroxytryptamine (5HT) receptors in the heart valves of cynomolgus monkeys and Sprague-Dawley rats
    Chandikumar S Elangbam
    Pathology Department, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    J Histochem Cytochem 53:671-7. 2005
  3. doi request reprint 5-hydroxytryptamine (5HT)-induced valvulopathy: compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats
    Chandikumar S Elangbam
    Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC 27709 3398, USA
    Exp Toxicol Pathol 60:253-62. 2008
  4. ncbi request reprint Evaluation of glycosaminoglycans content and 5-hydroxytryptamine 2B receptor in the heart valves of Sprague-Dawley rats with spontaneous mitral valvulopathy--a possible exacerbation by dl-amphetamine sulfate in Fischer 344 rats?
    Chandikumar S Elangbam
    Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Exp Toxicol Pathol 58:89-99. 2006
  5. doi request reprint Review paper: Current strategies in the development of anti-obesity drugs and their safety concerns
    C S Elangbam
    Department of Pathology, Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Vet Pathol 46:10-24. 2009
  6. doi request reprint Drug-induced valvulopathy: an update
    Chandikumar S Elangbam
    Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC27709 3398, USA
    Toxicol Pathol 38:837-48. 2010
  7. ncbi request reprint Vascular effects of GI262570X (PPAR-gamma agonist) in the brown adipose tissue of Han Wistar rats: a review of 1-month, 13-week, 27-week and 2-year oral toxicity studies
    Chandikumar S Elangbam
    Department of Pathology, GlaxoSmithKline Inc, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:420-6. 2002

Detail Information

Publications7

  1. ncbi request reprint Endocardial myxomatous change in Harlan Sprague-Dawley rats (Hsd:S-D) and CD-1 mice: its microscopic resemblance to drug-induced valvulopathy in humans
    Chandikumar S Elangbam
    Department of Pathology, GlaxoSmithKline Inc, Research Triangle Park, North Carolina 27709 3398, USA
    Toxicol Pathol 30:483-91. 2002
    ..However, additional research is needed to confirm a relationship between EMC and MPC in rats and/or mice...
  2. ncbi request reprint 5-Hydroxytryptamine (5HT) receptors in the heart valves of cynomolgus monkeys and Sprague-Dawley rats
    Chandikumar S Elangbam
    Pathology Department, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    J Histochem Cytochem 53:671-7. 2005
    ....
  3. doi request reprint 5-hydroxytryptamine (5HT)-induced valvulopathy: compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats
    Chandikumar S Elangbam
    Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC 27709 3398, USA
    Exp Toxicol Pathol 60:253-62. 2008
    ..Thus, these findings further highlight the necessity and/or utilization of animal models to screen potential valvular effects of serotonergic compounds...
  4. ncbi request reprint Evaluation of glycosaminoglycans content and 5-hydroxytryptamine 2B receptor in the heart valves of Sprague-Dawley rats with spontaneous mitral valvulopathy--a possible exacerbation by dl-amphetamine sulfate in Fischer 344 rats?
    Chandikumar S Elangbam
    Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Exp Toxicol Pathol 58:89-99. 2006
    ..However, additional research is needed to confirm a role for 5HT2BR in the pathogenesis of SMV in SD rats, and to further characterize the relationship between dl-amphetamine treatment and exacerbation of SMV in F344 rats...
  5. doi request reprint Review paper: Current strategies in the development of anti-obesity drugs and their safety concerns
    C S Elangbam
    Department of Pathology, Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Vet Pathol 46:10-24. 2009
    ....
  6. doi request reprint Drug-induced valvulopathy: an update
    Chandikumar S Elangbam
    Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC27709 3398, USA
    Toxicol Pathol 38:837-48. 2010
    ....
  7. ncbi request reprint Vascular effects of GI262570X (PPAR-gamma agonist) in the brown adipose tissue of Han Wistar rats: a review of 1-month, 13-week, 27-week and 2-year oral toxicity studies
    Chandikumar S Elangbam
    Department of Pathology, GlaxoSmithKline Inc, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:420-6. 2002
    ..These results suggest that the possibility of generating atherosclerotic-like lesions through prolonged treatment of GI262570X (PPAR-gamma agonist) is highly unlikely in rats...