B A Chizh

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. ncbi Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathways
    Boris A Chizh
    GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, UK
    J Psychopharmacol 21:259-71. 2007
  2. ncbi Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers
    B A Chizh
    Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2GG, UK
    Br J Anaesth 98:246-54. 2007
  3. ncbi NMDA receptor antagonists as analgesics: focus on the NR2B subtype
    B A Chizh
    Dept of Pharmacology, Grünenthal GmbH Research and Development, Zieglerstr 6, 52078, Aachen, Germany
    Trends Pharmacol Sci 22:636-42. 2001
  4. ncbi Novel approaches to targeting glutamate receptors for the treatment of chronic pain: review article
    B A Chizh
    Department of Pharmacology, Grünenthal GmbH R and D, Aachen, Germany
    Amino Acids 23:169-76. 2002
  5. ncbi The effect of intravenous infusion of adenosine on electrically evoked hyperalgesia in a healthy volunteer model of central sensitization
    Boris A Chizh
    GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Hills Road, Cambridge CB2 2GG, UK
    Anesth Analg 99:816-22, table of contents. 2004
  6. ncbi NMDA antagonists and neuropathic pain--multiple drug targets and multiple uses
    B A Chizh
    GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2GG, UK
    Curr Pharm Des 11:2977-94. 2005
  7. ncbi Antinociception and (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid antagonism by gabapentin in the rat spinal cord in vivo
    B A Chizh
    Department of Pharmacology, Grünenthal GmbH Research and Development, Aachen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 362:197-200. 2000
  8. ncbi The N-methyl-D-aspartate antagonistic and opioid components of d-methadone antinociception in the rat spinal cord
    B A Chizh
    Grunenthal GmbH, Research Centre, Zieglerstrasse 6, 52078, Aachen, Germany
    Neurosci Lett 296:117-20. 2000
  9. doi Use of sensory methods for detecting target engagement in clinical trials of new analgesics
    Boris A Chizh
    GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge CB2 2GG, United Kingdom
    Neurotherapeutics 6:749-54. 2009
  10. doi Predictors of placebo response in pooled lamotrigine neuropathic pain clinical trials
    Michael C Irizarry
    WW Epidemiology, GlaxoSmithKline, Research Triangle Park, NC, USA
    Clin J Pain 25:469-76. 2009

Detail Information

Publications21

  1. ncbi Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathways
    Boris A Chizh
    GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, UK
    J Psychopharmacol 21:259-71. 2007
    ..Some of the new compounds of this class, particularly those acting at the NR2B subtype of the NMDA receptor, have shown promise in preclinical and clinical studies...
  2. ncbi Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers
    B A Chizh
    Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2GG, UK
    Br J Anaesth 98:246-54. 2007
    ..Furthermore, we explored if combinations of either of these drugs with the COX-2 inhibitor parecoxib could improve its efficacy...
  3. ncbi NMDA receptor antagonists as analgesics: focus on the NR2B subtype
    B A Chizh
    Dept of Pharmacology, Grünenthal GmbH Research and Development, Zieglerstr 6, 52078, Aachen, Germany
    Trends Pharmacol Sci 22:636-42. 2001
    ..Human trials have so far confirmed the good tolerability of these subtype-selective NMDA receptor antagonists; however, whether they are as effective as other NMDA receptor antagonists in pain patients remains to be demonstrated...
  4. ncbi Novel approaches to targeting glutamate receptors for the treatment of chronic pain: review article
    B A Chizh
    Department of Pharmacology, Grünenthal GmbH R and D, Aachen, Germany
    Amino Acids 23:169-76. 2002
    ..These recent advances are reviewed in the present work...
  5. ncbi The effect of intravenous infusion of adenosine on electrically evoked hyperalgesia in a healthy volunteer model of central sensitization
    Boris A Chizh
    GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Hills Road, Cambridge CB2 2GG, UK
    Anesth Analg 99:816-22, table of contents. 2004
    ..However, adenosine did not have the long-term effects seen in patients. The model can investigate mechanisms of drugs for the treatment of chronic pain...
  6. ncbi NMDA antagonists and neuropathic pain--multiple drug targets and multiple uses
    B A Chizh
    GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2GG, UK
    Curr Pharm Des 11:2977-94. 2005
    ....
  7. ncbi Antinociception and (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid antagonism by gabapentin in the rat spinal cord in vivo
    B A Chizh
    Department of Pharmacology, Grünenthal GmbH Research and Development, Aachen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 362:197-200. 2000
    ..We conclude that gabapentin acts as an AMPA antagonist in the rat spinal cord, and that this mechanism is likely to substantially contribute to the antinociceptive effect of the drug...
  8. ncbi The N-methyl-D-aspartate antagonistic and opioid components of d-methadone antinociception in the rat spinal cord
    B A Chizh
    Grunenthal GmbH, Research Centre, Zieglerstrasse 6, 52078, Aachen, Germany
    Neurosci Lett 296:117-20. 2000
    ..Thus, in the antinociceptive dose range, the NMDA antagonism does not appear to contribute to the mechanism of d-methadone antinociception...
  9. doi Use of sensory methods for detecting target engagement in clinical trials of new analgesics
    Boris A Chizh
    GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge CB2 2GG, United Kingdom
    Neurotherapeutics 6:749-54. 2009
    ..The emphasis is on the TRPV1 antagonists, but some other target mechanisms are also discussed in examining the validity of this approach...
  10. doi Predictors of placebo response in pooled lamotrigine neuropathic pain clinical trials
    Michael C Irizarry
    WW Epidemiology, GlaxoSmithKline, Research Triangle Park, NC, USA
    Clin J Pain 25:469-76. 2009
    ..The 574 patients in the pooled lamotrigine treatment arms were used as a replication dataset...
  11. doi Predicting therapeutic efficacy - experimental pain in human subjects
    Boris A Chizh
    GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Hills Road, Cambridge CB2 2GG, UK
    Brain Res Rev 60:243-54. 2009
    ....
  12. doi Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway
    Martin J Gunthorpe
    Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park North, Third Avenue, Harlow, Essex CM19 5AW, UK
    Drug Discov Today 14:56-67. 2009
    ..In this article we will discuss recent progress and challenges in the field in this highly competitive area of drug discovery...
  13. ncbi The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans
    Boris A Chizh
    Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Cambridge and Harlow, UK
    Pain 132:132-41. 2007
    ..These data provide the first clinical evidence that a TRPV1 antagonist may alleviate pain and hyperalgesia associated with inflammation and tissue injury...
  14. ncbi The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonism
    Thomas Christoph
    Department of Pharmacology, Grünenthal GmbH Research Centre, Zieglerstrasse 6, 52078 Aachen, Germany
    Neuropharmacology 51:12-7. 2006
    ..Development of short-acting NMDA antagonists could represent a strategy for improving their tolerability...
  15. ncbi Antiallodynic effects of NMDA glycine(B) antagonists in neuropathic pain: possible peripheral mechanisms
    Thomas Christoph
    Department of Pharmacology, Grünenthal GmbH R and D, Zieglerstr 6, 52078 Aachen, Germany
    Brain Res 1048:218-27. 2005
    ..Thus, peripheral NMDA receptors may substantially contribute to the efficacy of NMDA antagonists in neuropathic pain...
  16. ncbi P2X receptors and nociception
    B A Chizh
    Department of Pharmacology, , Aachen, Germany
    Pharmacol Rev 53:553-68. 2001
    ..The development of selective antagonists of these receptors, suitable for a systemic in vivo use although apparently difficult, may prove a useful strategy to generate analgesics with a novel mechanism of action...
  17. ncbi Chronic oral gabapentin reduces elements of central sensitization in human experimental hyperalgesia
    Hanne Gottrup
    Danish Pain Research Center, Department of Neurology and Danish Pain Research Center, University of Aarhus
    Anesthesiology 101:1400-8. 2004
    ..The aims were to determine whether gabapentin, dosed in a manner similar to that used in the clinic, affected the various components of central sensitization and to assess the utility of this model for characterizing novel analgesics...
  18. ncbi Using objective markers and imaging in the development of novel treatments of chronic pain
    Boris A Chizh
    Expert Rev Neurother 7:443-7. 2007
  19. pmc Use of the novel Contact Heat Evoked Potential Stimulator (CHEPS) for the assessment of small fibre neuropathy: correlations with skin flare responses and intra-epidermal nerve fibre counts
    Duncan D Atherton
    Peripheral Neuropathy Unit, Hammersmith Hospital and Imperial College London, UK
    BMC Neurol 7:21. 2007
    ..e. the histamine-induced skin flare response and intra-epidermal fibres (IEF), and also quantitative sensory testing (QST), a subjective measure...
  20. ncbi Potentiation of nociceptive responses to low pH injections in humans by prostaglandin E2
    Roman Rukwied
    Department of Anesthesiology and Intensive Care Medicine, Clinical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Pain 8:443-51. 2007
    ..This can be best explained by TRPV1 sensitization in the presence of PGE2, a mechanism potentially relevant for inflammatory and injury-induced pain...
  21. ncbi Fibromyalgia patients show an abnormal dopamine response to pain
    Patrick B Wood
    McGill University Centre for Research on Pain, Faculty of Dentistry, 3640 University Street, Strathcona Building, Montreal, QC, Canada, H3A 2B2
    Eur J Neurosci 25:3576-82. 2007
    ....