Research Topics
Species | B A ChizhSummaryAffiliation: GlaxoSmithKline Research and Development Country: USA Publications
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Detail Information
Publications
Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathwaysBoris A Chizh
GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, UK
J Psychopharmacol 21:259-71. 2007..Some of the new compounds of this class, particularly those acting at the NR2B subtype of the NMDA receptor, have shown promise in preclinical and clinical studies...- Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteersB A Chizh
Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2GG, UK
Br J Anaesth 98:246-54. 2007..Furthermore, we explored if combinations of either of these drugs with the COX-2 inhibitor parecoxib could improve its efficacy... - NMDA receptor antagonists as analgesics: focus on the NR2B subtypeB A Chizh
Dept of Pharmacology, Grünenthal GmbH Research and Development, Zieglerstr 6, 52078, Aachen, Germany
Trends Pharmacol Sci 22:636-42. 2001..Human trials have so far confirmed the good tolerability of these subtype-selective NMDA receptor antagonists; however, whether they are as effective as other NMDA receptor antagonists in pain patients remains to be demonstrated... - Novel approaches to targeting glutamate receptors for the treatment of chronic pain: review articleB A Chizh
Department of Pharmacology, Grünenthal GmbH R and D, Aachen, Germany
Amino Acids 23:169-76. 2002..These recent advances are reviewed in the present work... - The effect of intravenous infusion of adenosine on electrically evoked hyperalgesia in a healthy volunteer model of central sensitizationBoris A Chizh
GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Hills Road, Cambridge CB2 2GG, UK
Anesth Analg 99:816-22, table of contents. 2004..However, adenosine did not have the long-term effects seen in patients. The model can investigate mechanisms of drugs for the treatment of chronic pain... - NMDA antagonists and neuropathic pain--multiple drug targets and multiple usesB A Chizh
GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2GG, UK
Curr Pharm Des 11:2977-94. 2005.... - Antinociception and (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid antagonism by gabapentin in the rat spinal cord in vivoB A Chizh
Department of Pharmacology, Grünenthal GmbH Research and Development, Aachen, Germany
Naunyn Schmiedebergs Arch Pharmacol 362:197-200. 2000..We conclude that gabapentin acts as an AMPA antagonist in the rat spinal cord, and that this mechanism is likely to substantially contribute to the antinociceptive effect of the drug... - The N-methyl-D-aspartate antagonistic and opioid components of d-methadone antinociception in the rat spinal cordB A Chizh
Grunenthal GmbH, Research Centre, Zieglerstrasse 6, 52078, Aachen, Germany
Neurosci Lett 296:117-20. 2000..Thus, in the antinociceptive dose range, the NMDA antagonism does not appear to contribute to the mechanism of d-methadone antinociception... 
Use of sensory methods for detecting target engagement in clinical trials of new analgesicsBoris A Chizh
GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge CB2 2GG, United Kingdom
Neurotherapeutics 6:749-54. 2009..The emphasis is on the TRPV1 antagonists, but some other target mechanisms are also discussed in examining the validity of this approach...- Predictors of placebo response in pooled lamotrigine neuropathic pain clinical trialsMichael C Irizarry
WW Epidemiology, GlaxoSmithKline, Research Triangle Park, NC, USA
Clin J Pain 25:469-76. 2009..The 574 patients in the pooled lamotrigine treatment arms were used as a replication dataset... - Predicting therapeutic efficacy - experimental pain in human subjectsBoris A Chizh
GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Hills Road, Cambridge CB2 2GG, UK
Brain Res Rev 60:243-54. 2009.... - Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathwayMartin J Gunthorpe
Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park North, Third Avenue, Harlow, Essex CM19 5AW, UK
Drug Discov Today 14:56-67. 2009..In this article we will discuss recent progress and challenges in the field in this highly competitive area of drug discovery... - The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humansBoris A Chizh
Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Cambridge and Harlow, UK
Pain 132:132-41. 2007..These data provide the first clinical evidence that a TRPV1 antagonist may alleviate pain and hyperalgesia associated with inflammation and tissue injury... - The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonismThomas Christoph
Department of Pharmacology, , Zieglerstrasse 6, 52078 Aachen, Germany
Neuropharmacology 51:12-7. 2006..Development of short-acting NMDA antagonists could represent a strategy for improving their tolerability... - Antiallodynic effects of NMDA glycine(B) antagonists in neuropathic pain: possible peripheral mechanismsThomas Christoph
Department of Pharmacology, , Zieglerstr. 6, 52078 Aachen, Germany
Brain Res 1048:218-27. 2005..Thus, peripheral NMDA receptors may substantially contribute to the efficacy of NMDA antagonists in neuropathic pain... - P2X receptors and nociceptionB A Chizh
Department of Pharmacology, , Aachen, Germany
Pharmacol Rev 53:553-68. 2001..The development of selective antagonists of these receptors, suitable for a systemic in vivo use although apparently difficult, may prove a useful strategy to generate analgesics with a novel mechanism of action... - Chronic oral gabapentin reduces elements of central sensitization in human experimental hyperalgesiaHanne Gottrup
Danish Pain Research Center, Department of Neurology and Danish Pain Research Center, University of Aarhus
Anesthesiology 101:1400-8. 2004..The aims were to determine whether gabapentin, dosed in a manner similar to that used in the clinic, affected the various components of central sensitization and to assess the utility of this model for characterizing novel analgesics... - Using objective markers and imaging in the development of novel treatments of chronic painBoris A Chizh
Expert Rev Neurother 7:443-7. 2007 
Use of the novel Contact Heat Evoked Potential Stimulator (CHEPS) for the assessment of small fibre neuropathy: correlations with skin flare responses and intra-epidermal nerve fibre countsDuncan D Atherton
Peripheral Neuropathy Unit, Hammersmith Hospital and Imperial College London, UK
BMC Neurol 7:21. 2007..e. the histamine-induced skin flare response and intra-epidermal fibres (IEF), and also quantitative sensory testing (QST), a subjective measure...- Potentiation of nociceptive responses to low pH injections in humans by prostaglandin E2Roman Rukwied
Department of Anesthesiology and Intensive Care Medicine, Clinical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
J Pain 8:443-51. 2007..This can be best explained by TRPV1 sensitization in the presence of PGE2, a mechanism potentially relevant for inflammatory and injury-induced pain... - Fibromyalgia patients show an abnormal dopamine response to painPatrick B Wood
McGill University Centre for Research on Pain, Faculty of Dentistry, 3640 University Street, Strathcona Building, Montreal, QC, Canada, H3A 2B2
Eur J Neurosci 25:3576-82. 2007....