Affiliation: GlaxoSmithKline Research and Development
- Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to alpha-ketoamide inhibitorsGordon Bruton
GlaxoSmithKline, New Frontiers Science Park, Essex CM19 5AW, Harlow, UK
Eur J Med Chem 38:351-6. 2003..3x10(6) M(-1)s(-1) at pH 8.5. Insertion of proline at P1' converted substrates to competitive inhibitors, whilst the incorporation of an alpha-ketoamide at the cleavage site transformed substrates to time dependent inhibitors of SpsB...
- Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in ratsAndrew D Medhurst
Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Avenue, Harlow, Essex CM19 5AW, UK
Biochem Pharmacol 73:1182-94. 2007..Novel H(3) receptor antagonists such as GSK207040 and GSK334429 may therefore have therapeutic potential not only in dementia but also in neuropathic pain...
- A versatile stereoselective synthesis of endo,exo-furofuranones: application to the enantioselective synthesis of furofuran lignansNigel A Swain
Department of Chemistry, The University of Southampton, Highfield, Southampton SO17 1BJ, U K
J Org Chem 69:122-9. 2004....