Gordon Bruton

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. ncbi request reprint Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to alpha-ketoamide inhibitors
    Gordon Bruton
    GlaxoSmithKline, New Frontiers Science Park, Essex CM19 5AW, Harlow, UK
    Eur J Med Chem 38:351-6. 2003
  2. ncbi request reprint Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats
    Andrew D Medhurst
    Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Avenue, Harlow, Essex CM19 5AW, UK
    Biochem Pharmacol 73:1182-94. 2007
  3. ncbi request reprint A versatile stereoselective synthesis of endo,exo-furofuranones: application to the enantioselective synthesis of furofuran lignans
    Nigel A Swain
    Department of Chemistry, The University of Southampton, Highfield, Southampton SO17 1BJ, U K
    J Org Chem 69:122-9. 2004

Detail Information

Publications3

  1. ncbi request reprint Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to alpha-ketoamide inhibitors
    Gordon Bruton
    GlaxoSmithKline, New Frontiers Science Park, Essex CM19 5AW, Harlow, UK
    Eur J Med Chem 38:351-6. 2003
    ..3x10(6) M(-1)s(-1) at pH 8.5. Insertion of proline at P1' converted substrates to competitive inhibitors, whilst the incorporation of an alpha-ketoamide at the cleavage site transformed substrates to time dependent inhibitors of SpsB...
  2. ncbi request reprint Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats
    Andrew D Medhurst
    Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Avenue, Harlow, Essex CM19 5AW, UK
    Biochem Pharmacol 73:1182-94. 2007
    ..Novel H(3) receptor antagonists such as GSK207040 and GSK334429 may therefore have therapeutic potential not only in dementia but also in neuropathic pain...
  3. ncbi request reprint A versatile stereoselective synthesis of endo,exo-furofuranones: application to the enantioselective synthesis of furofuran lignans
    Nigel A Swain
    Department of Chemistry, The University of Southampton, Highfield, Southampton SO17 1BJ, U K
    J Org Chem 69:122-9. 2004
    ....