J R Brown
Affiliation: GlaxoSmithKline Research and Development
- Universal trees based on large combined protein sequence data setsJ R Brown
Anti Microbial Bioinformatics Group, GlaxoSmithKline, 1250 South Collegeville Road, UP1345 P O Box 5089, Collegeville, Pennsylvania 19426 0989, USA
Nat Genet 28:281-5. 2001..Thus, combined protein universal trees are highly congruent with SSU rRNA trees in their strong support for the separate monophyly of domains as well as the early evolution of thermophilic Bacteria...
- Genomic and phylogenetic perspectives on the evolution of prokaryotesJ R Brown
Microbial Bioinformatics Department, Division of Bioinformatics, Glaxo SmithKline Pharmaceuticals, 1250 South Collegeville Road, P O Box 5089, UP1345, Collegeville, Pennsylvania 19426 0989, USA
Syst Biol 50:497-512. 2001..Promising new approaches to genomic analyses, which could add to our understanding prokaryotic evolution and help in their classification, are discussed...
- Systematic identification of selective essential genes in Helicobacter pylori by genome prioritization and allelic replacement mutagenesisA F Chalker
Department of Anti Infective Research, SmithKline Beecham Pharmaceuticals, Collegeville, Pennsylvania 19426, USA
J Bacteriol 183:1259-68. 2001..We propose that the products of a number of these H. pylori-specific essential genes may be suitable targets for novel anti-H. pylori therapies...
- Gene descent, duplication, and horizontal transfer in the evolution of glutamyl- and glutaminyl-tRNA synthetasesJ R Brown
Department of Bioinformatics, SmithKline Beecham Pharmaceuticals, 1250 South Collegeville Road, UP1345, Collegeville PA 19426 0989, USA
J Mol Evol 49:485-95. 1999..Although all bacterial GlnRS form a monophyletic group, the broad phyletic distribution of this tRNA synthetase suggests that multiple gene transfers from eukaryotes to bacteria occurred shortly after the Archaea-eukaryote divergence...
- Phylogenetic analyses do not support horizontal gene transfers from bacteria to vertebratesM J Stanhope
Bioinformatics, GlaxoSmithKline, Collegeville, PA 19426, USA
Nature 411:940-4. 2001..They are, therefore, unlikely to be examples of direct HGT from bacteria to vertebrates...
- Lipid modification of prelipoproteins is dispensable for growth in vitro but essential for virulence in Streptococcus pneumoniaeC M Petit
GlaxoSmithKline Pharmaceuticals, Anti Microbial and Host Defense, Collegeville, PA 19426 0989, USA
FEMS Microbiol Lett 200:229-33. 2001..Our findings suggest a major difference in the role of lipoproteins in Gram-positive bacteria versus the proteobacteria...