J R Brown

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. ncbi request reprint Universal trees based on large combined protein sequence data sets
    J R Brown
    Anti Microbial Bioinformatics Group, GlaxoSmithKline, 1250 South Collegeville Road, UP1345 P O Box 5089, Collegeville, Pennsylvania 19426 0989, USA
    Nat Genet 28:281-5. 2001
  2. ncbi request reprint Genomic and phylogenetic perspectives on the evolution of prokaryotes
    J R Brown
    Microbial Bioinformatics Department, Division of Bioinformatics, Glaxo SmithKline Pharmaceuticals, 1250 South Collegeville Road, P O Box 5089, UP1345, Collegeville, Pennsylvania 19426 0989, USA
    Syst Biol 50:497-512. 2001
  3. pmc Systematic identification of selective essential genes in Helicobacter pylori by genome prioritization and allelic replacement mutagenesis
    A F Chalker
    Department of Anti Infective Research, SmithKline Beecham Pharmaceuticals, Collegeville, Pennsylvania 19426, USA
    J Bacteriol 183:1259-68. 2001
  4. ncbi request reprint Gene descent, duplication, and horizontal transfer in the evolution of glutamyl- and glutaminyl-tRNA synthetases
    J R Brown
    Department of Bioinformatics, SmithKline Beecham Pharmaceuticals, 1250 South Collegeville Road, UP1345, Collegeville PA 19426 0989, USA
    J Mol Evol 49:485-95. 1999
  5. ncbi request reprint Phylogenetic analyses do not support horizontal gene transfers from bacteria to vertebrates
    M J Stanhope
    Bioinformatics, GlaxoSmithKline, Collegeville, PA 19426, USA
    Nature 411:940-4. 2001
  6. ncbi request reprint Lipid modification of prelipoproteins is dispensable for growth in vitro but essential for virulence in Streptococcus pneumoniae
    C M Petit
    GlaxoSmithKline Pharmaceuticals, Anti Microbial and Host Defense, Collegeville, PA 19426 0989, USA
    FEMS Microbiol Lett 200:229-33. 2001

Detail Information

Publications6

  1. ncbi request reprint Universal trees based on large combined protein sequence data sets
    J R Brown
    Anti Microbial Bioinformatics Group, GlaxoSmithKline, 1250 South Collegeville Road, UP1345 P O Box 5089, Collegeville, Pennsylvania 19426 0989, USA
    Nat Genet 28:281-5. 2001
    ..Thus, combined protein universal trees are highly congruent with SSU rRNA trees in their strong support for the separate monophyly of domains as well as the early evolution of thermophilic Bacteria...
  2. ncbi request reprint Genomic and phylogenetic perspectives on the evolution of prokaryotes
    J R Brown
    Microbial Bioinformatics Department, Division of Bioinformatics, Glaxo SmithKline Pharmaceuticals, 1250 South Collegeville Road, P O Box 5089, UP1345, Collegeville, Pennsylvania 19426 0989, USA
    Syst Biol 50:497-512. 2001
    ..Promising new approaches to genomic analyses, which could add to our understanding prokaryotic evolution and help in their classification, are discussed...
  3. pmc Systematic identification of selective essential genes in Helicobacter pylori by genome prioritization and allelic replacement mutagenesis
    A F Chalker
    Department of Anti Infective Research, SmithKline Beecham Pharmaceuticals, Collegeville, Pennsylvania 19426, USA
    J Bacteriol 183:1259-68. 2001
    ..We propose that the products of a number of these H. pylori-specific essential genes may be suitable targets for novel anti-H. pylori therapies...
  4. ncbi request reprint Gene descent, duplication, and horizontal transfer in the evolution of glutamyl- and glutaminyl-tRNA synthetases
    J R Brown
    Department of Bioinformatics, SmithKline Beecham Pharmaceuticals, 1250 South Collegeville Road, UP1345, Collegeville PA 19426 0989, USA
    J Mol Evol 49:485-95. 1999
    ..Although all bacterial GlnRS form a monophyletic group, the broad phyletic distribution of this tRNA synthetase suggests that multiple gene transfers from eukaryotes to bacteria occurred shortly after the Archaea-eukaryote divergence...
  5. ncbi request reprint Phylogenetic analyses do not support horizontal gene transfers from bacteria to vertebrates
    M J Stanhope
    Bioinformatics, GlaxoSmithKline, Collegeville, PA 19426, USA
    Nature 411:940-4. 2001
    ..They are, therefore, unlikely to be examples of direct HGT from bacteria to vertebrates...
  6. ncbi request reprint Lipid modification of prelipoproteins is dispensable for growth in vitro but essential for virulence in Streptococcus pneumoniae
    C M Petit
    GlaxoSmithKline Pharmaceuticals, Anti Microbial and Host Defense, Collegeville, PA 19426 0989, USA
    FEMS Microbiol Lett 200:229-33. 2001
    ..Our findings suggest a major difference in the role of lipoproteins in Gram-positive bacteria versus the proteobacteria...