Affiliation: GlaxoSmithKline Research and Development
Bax B, Carter P, Lewis C, Guy A, Bridges A, Tanner R, et al. The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. Structure. 2001;9:1143-52 pubmed
..Pre-phosphorylated substrate peptides can be modeled into the active site of the enzyme, with the P1 residue occupying a pocket partially formed by phosphotyrosine 216 and the P4 phosphoserine occupying the 'primed' binding site. ..