Lluis Ballell

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. pmc Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis
    Lluis Ballell
    Tres Cantos Medicines Development Campus TCMDC, GlaxoSmithKline GSK, Severo Ochoa 2, Tres Cantos, Madrid, Spain
    ChemMedChem 8:313-21. 2013
  2. ncbi request reprint New thiopyrazolo[3,4-d]pyrimidine derivatives as anti-mycobacterial agents
    Lluis Ballell
    Centre for Carbohydrate Chemistry, School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, NR4 7TJ, UK
    Bioorg Med Chem Lett 17:1736-40. 2007
  3. pmc Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3
    Modesto J Remuiñán
    Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
    PLoS ONE 8:e60933. 2013
  4. doi request reprint 4-Substituted thioquinolines and thiazoloquinolines: potent, selective, and Tween-80 in vitro dependent families of antitubercular agents with moderate in vivo activity
    Jaime Escribano
    Diseases of the Developing World DDW, Tres Cantos Medicines Development Campus TCMDC, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos Madrid, Spain
    ChemMedChem 6:2252-63. 2011
  5. ncbi request reprint Synthesis and evaluation of mimetics of UDP and UDP-alpha-D-galactose, dTDP and dTDP-alpha-D-glucose with monosaccharides replacing the key pyrophosphate unit
    Lluis Ballell
    Centre for Carbohydrate Chemistry, School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UK NR4 7TJ
    Org Biomol Chem 3:1109-15. 2005
  6. pmc New small-molecule synthetic antimycobacterials
    Lluis Ballell
    Pharmaceutical Sciences Faculty, Medicinal Chemistry Group, Sorbonnelaan 16, Utrecht University, Utrecht 3584 CA, The Netherlands
    Antimicrob Agents Chemother 49:2153-63. 2005
  7. ncbi request reprint A new chemical probe for the detection of the cancer-linked galectin-3
    Lluis Ballell
    Department of Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB, Utrecht, The Netherlands
    Org Biomol Chem 4:4387-94. 2006

Collaborators

  • Robert A Field
  • Robert J Young
  • Gurdyal S Besra
  • Douglas J Minick
  • David J Dow
  • Ken Duncan
  • Modesto J Remuiñán
  • David Barros
  • Inigo Angulo-Barturen
  • Alfonso Mendoza-Losana
  • Esther Pérez-Herrán
  • Jaime Escribano
  • Monica Cacho
  • Nicholas J Loman
  • Vickey L Spivey
  • Carolina Gonzalez
  • Verónica Sousa
  • Nicholas Cammack
  • Elena Jimenez
  • María Martínez-Hoyos
  • María José Rebollo-Lopez
  • Mark J Pallen
  • María Teresa Fraile-Gabaldón
  • Nalini Mehta
  • Chrystala Constantinidou
  • Joaquín Rullas
  • Jorge Esquivias
  • Johnson Afari
  • Carlos Alemparte
  • Fátima Ortega-Muro
  • Elena Jiménez-Navarro
  • Hilda Rivera
  • Julia Castro-Pichel
  • Santiago Ferrer-Bazaga
  • Cristina Rivero-Hernández

Detail Information

Publications7

  1. pmc Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis
    Lluis Ballell
    Tres Cantos Medicines Development Campus TCMDC, GlaxoSmithKline GSK, Severo Ochoa 2, Tres Cantos, Madrid, Spain
    ChemMedChem 8:313-21. 2013
    ..Two additional drug-discovery-relevant datasets are included: a) a drug-like property analysis reflecting the latest lead-like guidelines and b) an early lead-generation package of the most promising hits within the clusters identified...
  2. ncbi request reprint New thiopyrazolo[3,4-d]pyrimidine derivatives as anti-mycobacterial agents
    Lluis Ballell
    Centre for Carbohydrate Chemistry, School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, NR4 7TJ, UK
    Bioorg Med Chem Lett 17:1736-40. 2007
    ..These compounds showed significant anti-mycobacterial activity (MICs down to 2mug/ml) and their potential as significant drug-like leads is substantiated through cytotoxicity evaluation and in silico profiling...
  3. pmc Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3
    Modesto J Remuiñán
    Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
    PLoS ONE 8:e60933. 2013
    ..In vivo efficacy evaluation of two optimized THPP and Spiro leads showed how the compounds were able to reduce >2 logs bacterial cfu counts in the lungs of infected mice...
  4. doi request reprint 4-Substituted thioquinolines and thiazoloquinolines: potent, selective, and Tween-80 in vitro dependent families of antitubercular agents with moderate in vivo activity
    Jaime Escribano
    Diseases of the Developing World DDW, Tres Cantos Medicines Development Campus TCMDC, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos Madrid, Spain
    ChemMedChem 6:2252-63. 2011
    ..Although the final compounds showed only limited levels of systemic exposure in mice, modest levels of efficacy in vivo at nontoxic doses were observed...
  5. ncbi request reprint Synthesis and evaluation of mimetics of UDP and UDP-alpha-D-galactose, dTDP and dTDP-alpha-D-glucose with monosaccharides replacing the key pyrophosphate unit
    Lluis Ballell
    Centre for Carbohydrate Chemistry, School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UK NR4 7TJ
    Org Biomol Chem 3:1109-15. 2005
    ..These compounds proved not to be inhibitors of bovine beta-1,4-galactosyltransferase although some showed moderate inhibition of Salmonella dTDP-alpha-D-glucose 4,6-dehydratase (RmlB)...
  6. pmc New small-molecule synthetic antimycobacterials
    Lluis Ballell
    Pharmaceutical Sciences Faculty, Medicinal Chemistry Group, Sorbonnelaan 16, Utrecht University, Utrecht 3584 CA, The Netherlands
    Antimicrob Agents Chemother 49:2153-63. 2005
  7. ncbi request reprint A new chemical probe for the detection of the cancer-linked galectin-3
    Lluis Ballell
    Department of Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB, Utrecht, The Netherlands
    Org Biomol Chem 4:4387-94. 2006
    ..Introduction of a fluorescent label via'click' chemistry allows the labelled proteins to be visualized in a gel. With the probe, selective visualization of galectin-3 in protein mixtures was shown and remarkably even in cell lysates...