Christopher Arico-Muendel

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. pmc Antiparasitic activities of novel, orally available fumagillin analogs
    Christopher Arico-Muendel
    PRAECIS Pharmaceuticals, 830 Winter Street, Waltham, MA 02451, USA
    Bioorg Med Chem Lett 19:5128-31. 2009
  2. doi request reprint Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity
    Christopher C Arico-Muendel
    GlaxoSmithKline, 830 Winter Street, Waltham, MA 02451 1420, USA
    Drug Metab Dispos 41:814-26. 2013
  3. doi request reprint Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2
    Christopher C Arico-Muendel
    PRAECIS Pharmaceuticals, Inc, Waltham, MA 02451 1420, USA
    J Med Chem 52:8047-56. 2009

Detail Information

Publications3

  1. pmc Antiparasitic activities of novel, orally available fumagillin analogs
    Christopher Arico-Muendel
    PRAECIS Pharmaceuticals, 830 Winter Street, Waltham, MA 02451, USA
    Bioorg Med Chem Lett 19:5128-31. 2009
    ..A subset of the compounds showed efficacy in a murine malaria model. The observed SAR forms a basis for further optimization of fumagillin based inhibitors against parasitic targets by inhibition of MetAP2...
  2. doi request reprint Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity
    Christopher C Arico-Muendel
    GlaxoSmithKline, 830 Winter Street, Waltham, MA 02451 1420, USA
    Drug Metab Dispos 41:814-26. 2013
    ..5]octan-6-yl] N-(2-chloroacetyl)carbamate). The high level of MetAP2 inhibition achieved in vivo supports the value of fumagillin-derived therapeutics for angiogenic diseases...
  3. doi request reprint Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2
    Christopher C Arico-Muendel
    PRAECIS Pharmaceuticals, Inc, Waltham, MA 02451 1420, USA
    J Med Chem 52:8047-56. 2009
    ....