Research Topics
| R J GlassockSummaryCountry: USA Publications
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Publications
The emergence of the discipline of renal immunopathologyRichard J Glassock
UCLA School of Medicine, Los Angeles, California, USA
Am J Nephrol 22:248-53. 2002
The treatment of idiopathic membranous nephropathy: a dilemma or a conundrum?Richard J Glassock
Am J Kidney Dis 44:562-6. 2004
Uremic toxins: what are they? An integrated overview of pathobiology and classificationRichard J Glassock
Department of Internal Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
J Ren Nutr 18:2-6. 2008..In addition, this article will attempt to integrate these disparate phenomena into a systems biology approach as to how such toxins lead to the diverse clinical manifestations so characteristic of the uremic state...
IgA nephropathy: challenges and opportunitiesRichard J Glassock
David Geffen School of Medicine, The University of California at Los Angeles, USA
Cleve Clin J Med 75:569-76. 2008..But at the same time, opportunities abound for new tests and treatments that may eventually lead to control of this common form of chronic kidney disease...
Therapy of relapsing minimal-change disease in adults: a new approach?Richard J Glassock
David Geffen School of Medicine at UCLA, 8 Bethany, Laguna Niguel, Los Angeles, California 92677, USA
Kidney Int 83:343-5. 2013..However, the optimal dosing regimen and mechanism of action remain unclear. Thus, randomized controlled trials are warranted in both adults and children to better define the role of rituximab in multiple-relapsing MCD...
Idiopathic membranoproliferative glomerulonephritis: does it exist?Fernando C Fervenza
Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
Nephrol Dial Transplant 27:4288-94. 2012..Idiopathic MPGN remains an 'endangered species' after its separation from these known causes...
The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruliRichard J Glassock
Geffen School of Medicine at UCLA, Los Angeles, California 92677, USA
Kidney Int 82:270-7. 2012..This review describes important shortcomings and deficiencies with our current approach and understanding of CKD in the older and elderly adult...
The pathogenesis of membranous nephropathy: evolution and revolutionRichard J Glassock
Geffen School of Medicine, University of California, Los Angeles, California, USA
Curr Opin Nephrol Hypertens 21:235-42. 2012..This review analyzes the recent developments in understanding the pathogenesis of the primary and secondary forms of membranous nephropathy...
Attending rounds: an older patient with nephrotic syndromeRichard J Glassock
David Geffen School of Medicine, University of California, Los Angeles, USA
Clin J Am Soc Nephrol 7:665-70. 2012....
Uremia (end-stage renal disease): how cost-effective are preventive strategies?Richard J Glassock
Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Ren Nutr 20:S131-4. 2010..Newer strategies involving statins and new combinations of agents are emerging but have not yet been tested for their cost-effectiveness in preventing ESRD cost-effectiveness...
Glomerular disease in the elderlyRichard J Glassock
The David Geffen School of Medicine at UCLA, 8 Bethany, Laguna Niguel, Los Angeles, CA 92677, USA
Clin Geriatr Med 25:413-22. 2009..This article briefly outlines the common presentations of glomerular disease in the elderly and discusses the clinical features, prognosis, and management of the primary and secondary glomerular diseases in this population of patients...
Analyzing antibody activity in IgA nephropathyRichard J Glassock
UCLA David Geffen School of Medicine, Los Angeles, California, USA
J Clin Invest 119:1450-2. 2009..These IgG autoantibodies displayed remarkably restricted heterogeneity. These observations offer new insights into disease pathogenesis and may lead to new methods of diagnosis, monitoring, and therapy for patients with IgA nephropathy...
Estimated glomerular filtration rate: time for a performance review?Richard J Glassock
Geffen School of Medicine at UCLA, Los Angeles, California, USA
Kidney Int 75:1001-3. 2009..eGFR formulae also contain variables that independently influence the risk of CKD and cardiovascular disease. eGFR needs a performance review to foster its evolution as a clinically useful tool...
Left ventricular mass in chronic kidney disease and ESRDRichard J Glassock
The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Clin J Am Soc Nephrol 4:S79-91. 2009..In the meantime, key management principles designed to ameliorate LVH and its complications should become a routine part of the care of the patients with CKD and ESRD...
Ageing and the glomerular filtration rate: truths and consequencesRichard J Glassock
8 Bethany, Laguna Niguel, CA 92677, USA
Trans Am Clin Climatol Assoc 120:419-28. 2009..This paper discusses the known effects of ageing on GFR and the consequences of using a classification system for defining CKD that does not take into account the normal decline of GFR with ageing...
Diagnosing chronic kidney diseaseRichard J Glassock
David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Curr Opin Nephrol Hypertens 19:123-8. 2010..The presence and magnitude of albuminuria has important diagnostic and prognostic significance...
The pathogenesis of idiopathic membranous nephropathy: a 50-year odysseyRichard J Glassock
David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Am J Kidney Dis 56:157-67. 2010..It is hoped that this 50-year odyssey will culminate in real progress in the diagnosis, prognosis, and therapy for the human disease...
Health care reforms in America: perspectives, comparisons and realitiesR J Glassock
David Geffen School of Medicine, Los Angeles, CA, USA
QJM 103:709-14. 2010....
Is the presence of microalbuminuria a relevant marker of kidney disease?Richard J Glassock
David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Curr Hypertens Rep 12:364-8. 2010..This article reviews the current evidence concerning MA as a marker of kidney disease or kidney damage...
The pathogenesis of IgA nephropathyRichard J Glassock
David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Curr Opin Nephrol Hypertens 20:153-60. 2011..This review will analyze contemporary information concerning the possible pathogenetic mechanisms involved in IgA nephropathy, emphasizing studies in humans rather than experimental animals...
The 2010 nephrology quiz and questionnaire: part 1Richard J Glassock
David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Clin J Am Soc Nephrol 6:2318-27. 2011..These articles try to recapitulate the session and reproduce its educational value for a larger audience--the readers of the Clinical Journal of the American Society of Nephrology. Have fun...
The global burden of chronic kidney disease: how valid are the estimates?Richard J Glassock
David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Nephron Clin Pract 110:c39-46; discussion c47. 2008..Current classification schemas may overstate the prevalance of CKD. This minireview analyzes the pitfalls in the use of current classification approaches for identifying CKD on a global basis...
Diagnosis and natural course of membranous nephropathyRichard J Glassock
Geffen School of Medicine at UCLA, Los Angeles, CA 92677, USA
Semin Nephrol 23:324-32. 2003....
The 2010 nephrology quiz and questionnaire: part 2Richard J Glassock
David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Clin J Am Soc Nephrol 6:2534-47. 2011..These articles try to recapitulate the session and reproduce its educational value for a larger audience--that of the readers of the Clinical Journal of the American Society of Nephrology. Have fun...
Secondary minimal change diseaseRichard J Glassock
The Geffen School of Medicine at UCLA, California, USA
Nephrol Dial Transplant 18:vi52-8. 2003..The predisposing conditions include neoplastic diseases, toxic or allergic reactions to drugs, infections, auto-immune disorders and other miscellaneous entities. These disorders are reviewed and catalogued in this contribution...
The rising tide of end-stage renal disease: what can be done?Richard J Glassock
8 Bethany, Laguna Niguel, CA 92677, USA
Clin Exp Nephrol 8:291-6. 2004..If these strategies can be implemented at the societal level and compliance with the interventions is robust, it is entirely possible that the rising tide of ESRD can be converted into a receding tide of ESRD in the future...
The early history of chemical immunosuppression: 1900-1965Richard J Glassock
J Nephrol 19:S132-6. 2006..The paper discusses the role of serendipity in the advent of 6-mercapthopurine (6-MP) therapy and the productivity in the field through Nobel Prize recipients...
Concluding remarksRichard J Glassock
The David Geffen School of Medicine at UCLA, Los Angeles, Calif, USA
Contrib Nephrol 157:169-73. 2007
Screening for CKD with eGFR: doubts and dangersRichard J Glassock
David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Clin J Am Soc Nephrol 3:1563-8. 2008....
Prophylactic anticoagulation in nephrotic syndrome: a clinical conundrumRichard J Glassock
University of California Los Angeles, USA
J Am Soc Nephrol 18:2221-5. 2007..The optimal duration of prophylactic anticoagulation is unknown but very likely extends to the duration of the nephrotic state per se...
An epidemic of chronic kidney disease: fact or fiction?Richard J Glassock
David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Nephrol Dial Transplant 23:1117-21. 2008
Routine reporting of estimated glomerular filtration rate: not ready for prime timeRichard J Glassock
David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Nat Clin Pract Nephrol 4:422-3. 2008
Glomerular therapeutics: looking back, looking forwardR J Glassock
UCLA School of Medicine, Los Angeles, California 92677, USA
Heart Dis 3:276-81. 2001..Eventually, the understanding of the genetic basis of susceptibility to glomerular disease and its progression will allow a preventative and curative, rather than palliative, strategy to emerge...
Nephrology in the 21st century: revolutionary changesR J Glassock
UCLA School of Medicine, Los Angeles, CA, USA
Am J Kidney Dis 35:S90-2. 2000..The disparity between the "haves" and the "have-nots" will widen. Profound challenges and opportunities await nephrology in the new millennium...
Posttransplant recurrence of primary glomerulonephritisClaudio Ponticelli
Division of Nephrology, Scientific Institute Humanitas, Milan, Italy
Clin J Am Soc Nephrol 5:2363-72. 2010....
Recurrence of secondary glomerular disease after renal transplantationClaudio Ponticelli
Division of Nephrology, Scientific Institute Humanitas, Rozzano, Milano, Italy
Clin J Am Soc Nephrol 6:1214-21. 2011..The main issues in transplantation of patients with secondary GN are the infectious, cardiovascular, or hepatic complications associated with the original disease or its treatment...
CKD in the elderlyRichard J Glassock
Am J Kidney Dis 52:803; author reply 803-4. 2008
L-carnitine use in dialysis patients: is national coverage for supplementation justified? What were CMS regulators thinking--or were they?Theodore I Steinman
Nephrol News Issues 17:28-30, 32-4, 36 passim. 2003..Until there is scientific evidence to support use of L-carnitine supplementation, and it proves to be cost-effective, reimbursement is not justified. Therefore, the current CMS reimbursement decision for L-carnitine appears to be flawed...
Circulating permeability factors in the nephrotic syndrome: a fresh look at an old problemRichard J Glassock
J Am Soc Nephrol 14:541-3. 2003
Rosuvastatin: an independent analysis of risks and benefitsDouglas P Zipes
Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
MedGenMed 8:73. 2006..Although the effectiveness of statins is well established, analyses of spontaneous adverse event reports have recently questioned the safety of rosuvastatin...
Prevention of microalbuminuria in type 2 diabetes: millimeters or milligrams?Richard J Glassock
J Am Soc Nephrol 17:3276-8. 2006
Multitarget therapy of lupus nephritis: base hit or home run?Richard J Glassock
J Am Soc Nephrol 19:1842-4. 2008
