Lina Yao

Summary

Affiliation: Gilead Sciences
Country: USA

Publications

  1. doi request reprint Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice
    Lina Yao
    Department of Biology, Gilead Sciences, Palo Alto, California 94304, USA
    Am J Physiol Cell Physiol 301:C577-86. 2011
  2. pmc Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis
    Lina Yao
    Gilead Sciences, Palo Alto, California, USA
    Nat Med 16:1024-8. 2010
  3. doi request reprint Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor
    Maria P Arolfo
    CV Therapeutics, Palo Alto, CA, USA
    Alcohol Clin Exp Res 33:1935-44. 2009
  4. ncbi request reprint Nicotine and ethanol activate protein kinase A synergistically via G(i) betagamma subunits in nucleus accumbens/ventral tegmental cocultures: the role of dopamine D(1)/D(2) and adenosine A(2A) receptors
    Yuichiro Inoue
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
    J Pharmacol Exp Ther 322:23-9. 2007
  5. pmc Up-regulation of AGS3 during morphine withdrawal promotes cAMP superactivation via adenylyl cyclase 5 and 7 in rat nucleus accumbens/striatal neurons
    Peidong Fan
    Gilead Sciences, Inc, 3172 Porter Drive, Palo Alto, California 94304, USA
    Mol Pharmacol 76:526-33. 2009
  6. ncbi request reprint Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists
    Ming Yang
    Department of Pharmacology, CV Therapeutics, Inc, Palo Alto, CA 94304, USA
    Naunyn Schmiedebergs Arch Pharmacol 375:133-44. 2007
  7. pmc Dopamine and ethanol cause translocation of epsilonPKC associated with epsilonRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways
    Lina Yao
    CV Therapeutics, Inc, 3172 Porter Drive, Palo Alto, CA 94304, USA
    Mol Pharmacol 73:1105-12. 2008
  8. doi request reprint A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias
    Luiz Belardinelli
    Department of Biology, MD Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
    J Pharmacol Exp Ther 344:23-32. 2013
  9. doi request reprint Ambrisentan and tadalafil synergistically relax endothelin-induced contraction of rat pulmonary arteries
    Faquan Liang
    Department of Biology, Gilead Sciences, Inc, 1651 Page Mill Rd, Palo Alto, CA 94304, USA
    Hypertension 59:705-11. 2012
  10. pmc Adenosine A2a blockade prevents synergy between mu-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats
    Lina Yao
    CV Therapeutics, Inc, 3172 Porter Drive, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 103:7877-82. 2006

Collaborators

Detail Information

Publications10

  1. doi request reprint Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice
    Lina Yao
    Department of Biology, Gilead Sciences, Palo Alto, California 94304, USA
    Am J Physiol Cell Physiol 301:C577-86. 2011
    ..5, further promoting Na(+) influx. Pharmacological inhibition of either CaMKII or Na(v)1.5 can ameliorate cardiac dysfunction caused by excessive Na(+) influx...
  2. pmc Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis
    Lina Yao
    Gilead Sciences, Palo Alto, California, USA
    Nat Med 16:1024-8. 2010
    ..Selective inhibition of ALDH-2 may have therapeutic potential for treating human cocaine addiction and preventing relapse...
  3. doi request reprint Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor
    Maria P Arolfo
    CV Therapeutics, Palo Alto, CA, USA
    Alcohol Clin Exp Res 33:1935-44. 2009
    ..However, daidzin can reduce drinking in some rodents without necessarily increasing acetaldehyde. Therefore, a selective ALDH-2 inhibitor might affect other metabolic factors involved in regulating drinking...
  4. ncbi request reprint Nicotine and ethanol activate protein kinase A synergistically via G(i) betagamma subunits in nucleus accumbens/ventral tegmental cocultures: the role of dopamine D(1)/D(2) and adenosine A(2A) receptors
    Yuichiro Inoue
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
    J Pharmacol Exp Ther 322:23-9. 2007
    ....
  5. pmc Up-regulation of AGS3 during morphine withdrawal promotes cAMP superactivation via adenylyl cyclase 5 and 7 in rat nucleus accumbens/striatal neurons
    Peidong Fan
    Gilead Sciences, Inc, 3172 Porter Drive, Palo Alto, California 94304, USA
    Mol Pharmacol 76:526-33. 2009
    ..Our findings identify a critical role for AC 5 and 7 and A2A receptors for up-regulation of AGS3 in morphine withdrawal-induced cAMP superactivation...
  6. ncbi request reprint Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists
    Ming Yang
    Department of Pharmacology, CV Therapeutics, Inc, Palo Alto, CA 94304, USA
    Naunyn Schmiedebergs Arch Pharmacol 375:133-44. 2007
    ..Among the six A2A-antagonists, KW-6002 is the best for use in in vivo animal studies, particularly for a CNS target, based on its bioavailability, half life, and brain penetration...
  7. pmc Dopamine and ethanol cause translocation of epsilonPKC associated with epsilonRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways
    Lina Yao
    CV Therapeutics, Inc, 3172 Porter Drive, Palo Alto, CA 94304, USA
    Mol Pharmacol 73:1105-12. 2008
    ..PKA and PKC signaling have been implicated in alcohol rewarding properties in the mesolimbic dopamine system. Cross-talk between PKA and PKC may underlie some of the behaviors associated with alcoholism...
  8. doi request reprint A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias
    Luiz Belardinelli
    Department of Biology, MD Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
    J Pharmacol Exp Ther 344:23-32. 2013
    ..In summary, GS967 selectively suppressed late I(Na) and prevented and/or reduced the incidence of experimentally induced arrhythmias in rabbit myocytes and hearts...
  9. doi request reprint Ambrisentan and tadalafil synergistically relax endothelin-induced contraction of rat pulmonary arteries
    Faquan Liang
    Department of Biology, Gilead Sciences, Inc, 1651 Page Mill Rd, Palo Alto, CA 94304, USA
    Hypertension 59:705-11. 2012
    ....
  10. pmc Adenosine A2a blockade prevents synergy between mu-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats
    Lina Yao
    CV Therapeutics, Inc, 3172 Porter Drive, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 103:7877-82. 2006
    ..These findings suggest that A2a antagonists might be effective therapeutic agents in the management of abstinent heroin addicts...