Lianhong Xu

Summary

Affiliation: Gilead Sciences
Country: USA

Publications

  1. ncbi Pharmacokinetic enhancers for HIV drugs
    Lianhong Xu
    Gilead Sciences Inc, Department of Medicinal Chemistry, 333 Lakeside Drive, Foster City, CA 94404, USA
    Curr Opin Investig Drugs 10:775-86. 2009
  2. ncbi SAR studies on dihydropyrimidinone antibiotics
    Lianhong Xu
    Gilead Sciences Inc, Foster City, CA 94404, USA
    Bioorg Med Chem Lett 21:1670-4. 2011
  3. ncbi N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase
    Michael L Mitchell
    Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
    Bioorg Med Chem Lett 20:1585-8. 2010
  4. ncbi N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase
    Michael L Mitchell
    Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
    Bioorg Med Chem Lett 20:1589-92. 2010
  5. ncbi In vitro characterization of GS-8374, a novel phosphonate-containing inhibitor of HIV-1 protease with a favorable resistance profile
    Christian Callebaut
    Gilead Sciences, 333 Lakeside Dr, Foster City, CA 94404, USA
    Antimicrob Agents Chemother 55:1366-76. 2011
  6. ncbi Characterization of a novel antibacterial agent that inhibits bacterial translation
    Nina Boddeker
    Gilead Sciences, Foster City, California 94404, USA
    RNA 8:1120-8. 2002

Collaborators

  • James M Chen
  • Michael L Mitchell
  • Eric B Lansdon
  • Tomas Cihlar
  • N T Parkin
  • Christian Callebaut
  • Nina Boddeker
  • Marcos Hatada
  • Tina Priskich
  • Matt Williams
  • Zheng Yu Yang
  • Swami Swaminathan
  • Bernard P Murray
  • Luong Tsai
  • Xiaohong Liu
  • William Lee
  • Gong Xin He
  • Kirsten Stray
  • Stephanie A Leavitt
  • Kelly Wang
  • Carina Cannizzaro
  • Andrew Mulato
  • Gina Bahador
  • Julia Watson
  • Eric Mabery
  • Craig Gibbs
  • John Wolf

Detail Information

Publications6

  1. ncbi Pharmacokinetic enhancers for HIV drugs
    Lianhong Xu
    Gilead Sciences Inc, Department of Medicinal Chemistry, 333 Lakeside Drive, Foster City, CA 94404, USA
    Curr Opin Investig Drugs 10:775-86. 2009
    ..This review summarizes salient features and limitations associated with the use of ritonavir as a PK enhancer, and briefly describes novel PK enhancers that are in development...
  2. ncbi SAR studies on dihydropyrimidinone antibiotics
    Lianhong Xu
    Gilead Sciences Inc, Foster City, CA 94404, USA
    Bioorg Med Chem Lett 21:1670-4. 2011
    ..Several novel dihydropyrimidinone antibiotics demonstrating comparable antibiotic efficacy while possessing favorable selectivity were identified...
  3. ncbi N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase
    Michael L Mitchell
    Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
    Bioorg Med Chem Lett 20:1585-8. 2010
    ..Efforts to improve the suboptimal pharmacokinetic profile of 1 resulted in the discovery of compound 13, which represents the lead compound in this series with improved pharmacokinetics and similar potency as inhibitor 1...
  4. ncbi N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase
    Michael L Mitchell
    Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
    Bioorg Med Chem Lett 20:1589-92. 2010
    ..Our efforts identified compound 10b, which represents the lead compound in this series with pharmacokinetics and antiviral potency that may support once-daily dosing...
  5. ncbi In vitro characterization of GS-8374, a novel phosphonate-containing inhibitor of HIV-1 protease with a favorable resistance profile
    Christian Callebaut
    Gilead Sciences, 333 Lakeside Dr, Foster City, CA 94404, USA
    Antimicrob Agents Chemother 55:1366-76. 2011
    ....
  6. ncbi Characterization of a novel antibacterial agent that inhibits bacterial translation
    Nina Boddeker
    Gilead Sciences, Foster City, California 94404, USA
    RNA 8:1120-8. 2002
    ..Selection and analysis of drug-resistant mutants of S. aureus suggests that drug uptake may be mediated by a dipeptide transport mechanism...