William A Lee

Summary

Affiliation: Gilead Sciences
Country: USA

Publications

  1. pmc Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue
    William A Lee
    Gilead Sciences, Inc, 333 Lakeside Dr, Foster City, CA 94404, USA
    Antimicrob Agents Chemother 49:1898-906. 2005
  2. pmc Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication
    Kathy A Keith
    University of Alabama School of Medicine, Birmingham, Alabama 35233, USA
    Antimicrob Agents Chemother 47:2193-8. 2003
  3. ncbi request reprint Perspectives on the development of acyclic nucleotide analogs as antiviral drugs
    William A Lee
    Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
    Antiviral Res 71:254-9. 2006
  4. pmc GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions
    Grushenka H I Wolfgang
    Gilead Sciences, 333 Lakeside Drive, Foster City, CA, USA
    Antimicrob Agents Chemother 53:2777-84. 2009
  5. doi request reprint Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340
    Darius Babusis
    Gilead Sciences, Inc, Foster City, California 94404, United States
    Mol Pharm 10:459-66. 2013
  6. pmc Nucleotide analogue prodrug tenofovir disoproxil enhances lymphoid cell loading following oral administration in monkeys
    Lucie Durand-Gasselin
    Gilead Sciences, Inc, Foster City, California 94404, USA
    Mol Pharm 6:1145-51. 2009
  7. ncbi request reprint Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring
    Tomas Cihlar
    Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
    J Mol Biol 363:635-47. 2006
  8. ncbi request reprint Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH
    William J Watkins
    Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
    Bioorg Med Chem Lett 16:3479-83. 2006
  9. doi request reprint GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma
    Hans Reiser
    Department of Research and Development, Gilead Sciences, Inc, Foster City, California 94404, USA
    Clin Cancer Res 14:2824-32. 2008
  10. pmc Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase
    I Hung Shih
    Gilead Sciences, Inc, 333 Lakeside Dr, Foster City, CA 94404, USA
    Antimicrob Agents Chemother 55:4196-203. 2011

Collaborators

Detail Information

Publications11

  1. pmc Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue
    William A Lee
    Gilead Sciences, Inc, 333 Lakeside Dr, Foster City, CA 94404, USA
    Antimicrob Agents Chemother 49:1898-906. 2005
    ..2 microg-eq/ml in plasma. A radiolabeled distribution study with dogs resulted in an increased distribution of tenofovir to tissues of lymphatic origin compared to the commercially available prodrug tenofovir DF (Viread)...
  2. pmc Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication
    Kathy A Keith
    University of Alabama School of Medicine, Birmingham, Alabama 35233, USA
    Antimicrob Agents Chemother 47:2193-8. 2003
    ..These data indicate that a number of these ANP derivatives have activity against vaccinia virus and cowpox virus in vitro and should be evaluated for their efficacies in animal models...
  3. ncbi request reprint Perspectives on the development of acyclic nucleotide analogs as antiviral drugs
    William A Lee
    Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
    Antiviral Res 71:254-9. 2006
    ....
  4. pmc GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions
    Grushenka H I Wolfgang
    Gilead Sciences, 333 Lakeside Drive, Foster City, CA, USA
    Antimicrob Agents Chemother 53:2777-84. 2009
    ..At the highest dose (0.1%), cures were evident at the end of 5 weeks, and lesions did not recur in a 30-day follow-up period. These data suggest that GS-9191 may have utility in the treatment of HPV-induced lesions...
  5. doi request reprint Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340
    Darius Babusis
    Gilead Sciences, Inc, Foster City, California 94404, United States
    Mol Pharm 10:459-66. 2013
    ....
  6. pmc Nucleotide analogue prodrug tenofovir disoproxil enhances lymphoid cell loading following oral administration in monkeys
    Lucie Durand-Gasselin
    Gilead Sciences, Inc, Foster City, California 94404, USA
    Mol Pharm 6:1145-51. 2009
    ..These results illustrate that administration of even a fleeting prodrug can increase target tissue loading and give valuable insight for future prodrug development...
  7. ncbi request reprint Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring
    Tomas Cihlar
    Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
    J Mol Biol 363:635-47. 2006
    ..This strategy, which is applicable to various PI scaffolds, should facilitate the design of novel PIs and potentially other antiviral therapeutics...
  8. ncbi request reprint Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH
    William J Watkins
    Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
    Bioorg Med Chem Lett 16:3479-83. 2006
    ..The design, synthesis, and IMPDH inhibitory activity of a series of phosphonic acid-containing analogues of mycophenolic acid are described...
  9. doi request reprint GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma
    Hans Reiser
    Department of Research and Development, Gilead Sciences, Inc, Foster City, California 94404, USA
    Clin Cancer Res 14:2824-32. 2008
    ..Our objective was to characterize the antiproliferative activity, pharmacokinetics, pharmacodynamics, and safety of GS-9219...
  10. pmc Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase
    I Hung Shih
    Gilead Sciences, Inc, 333 Lakeside Dr, Foster City, CA 94404, USA
    Antimicrob Agents Chemother 55:4196-203. 2011
    ..Collectively, these data demonstrate that GS-9190 represents a novel class of nonnucleoside polymerase inhibitors that interact with NS5B likely through involvement of the ╬▓-hairpin in the thumb subdomain...
  11. ncbi request reprint Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency virus
    Koen K A Van Rompay
    California National Primate Research Center, University of California, Davis, CA 95616 8542, USA
    J Acquir Immune Defic Syndr 43:6-14. 2006
    ..These prophylactic results further underscore the relevance of the current tenofovir DF prevention trials in pediatric and adult populations...