Todd C Appleby

Summary

Affiliation: Gilead Sciences
Country: USA

Publications

  1. doi request reprint Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase
    Todd C Appleby
    Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, USA
    Science 347:771-5. 2015
  2. pmc Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV
    Todd C Appleby
    Department of Structural Chemistry, Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
    J Mol Biol 405:1139-53. 2011
  3. pmc Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase
    Martijn Fenaux
    Gilead Sciences, Foster City, California, USA
    Antimicrob Agents Chemother 57:804-10. 2013
  4. doi request reprint An adaptive mutation in NS2 is essential for efficient production of infectious 1b/2a chimeric hepatitis C virus in cell culture
    Katie Chan
    Gilead Sciences, Inc, Foster City, CA 94404, USA
    Virology 422:224-34. 2012

Collaborators

Detail Information

Publications4

  1. doi request reprint Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase
    Todd C Appleby
    Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, USA
    Science 347:771-5. 2015
    ..We investigated the incorporation of nucleotide analog inhibitors, including the clinically active metabolite formed by sofosbuvir, to elucidate key molecular interactions in the active site. ..
  2. pmc Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV
    Todd C Appleby
    Department of Structural Chemistry, Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
    J Mol Biol 405:1139-53. 2011
    ....
  3. pmc Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase
    Martijn Fenaux
    Gilead Sciences, Foster City, California, USA
    Antimicrob Agents Chemother 57:804-10. 2013
    ..This study has been registered at ClinicalTrials.gov under registration number NCT01431898.)...
  4. doi request reprint An adaptive mutation in NS2 is essential for efficient production of infectious 1b/2a chimeric hepatitis C virus in cell culture
    Katie Chan
    Gilead Sciences, Inc, Foster City, CA 94404, USA
    Virology 422:224-34. 2012
    ..Overall, the efficient production of infectious 1b/2a virus particles will facilitate the discovery and characterization of inhibitors targeting steps that involve the structural genes of genotype 1b HCV...