Todd C Appleby
Affiliation: Gilead Sciences
- Viral replication. Structural basis for RNA replication by the hepatitis C virus polymeraseTodd C Appleby
Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, USA
Science 347:771-5. 2015..We investigated the incorporation of nucleotide analog inhibitors, including the clinically active metabolite formed by sofosbuvir, to elucidate key molecular interactions in the active site. ..
- Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCVTodd C Appleby
Department of Structural Chemistry, Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA 94404, USA
J Mol Biol 405:1139-53. 2011....
- Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymeraseMartijn Fenaux
Gilead Sciences, Foster City, California, USA
Antimicrob Agents Chemother 57:804-10. 2013..This study has been registered at ClinicalTrials.gov under registration number NCT01431898.)...
- An adaptive mutation in NS2 is essential for efficient production of infectious 1b/2a chimeric hepatitis C virus in cell cultureKatie Chan
Gilead Sciences, Inc, Foster City, CA 94404, USA
Virology 422:224-34. 2012..Overall, the efficient production of infectious 1b/2a virus particles will facilitate the discovery and characterization of inhibitors targeting steps that involve the structural genes of genotype 1b HCV...