Azzudin E Gharavi

Summary

Country: USA

Publications

  1. ncbi request reprint The molecular basis of antiphospholipid syndrome
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Lupus 12:579-83. 2003
  2. ncbi request reprint Origin of antiphospholipid antibodies: induction of aPL by viral peptides
    A E Gharavi
    Morehouse School of Medicine, Department of Medicine, Atlanta, GA 30310 1495, USA
    Lupus 7:S52-4. 1998
  3. ncbi request reprint GDKV-induced antiphospholipid antibodies enhance thrombosis and activate endothelial cells in vivo and in vitro
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 163:2922-7. 1999
  4. ncbi request reprint New developments in viral peptides and APL induction
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    J Autoimmun 15:227-30. 2000
  5. ncbi request reprint Mechanisms of pregnancy loss in antiphospholipid syndrome
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
    Clin Obstet Gynecol 44:11-9. 2001
  6. ncbi request reprint Origin of antiphospholipid antibodies
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia, USA
    Rheum Dis Clin North Am 27:551-63. 2001
  7. ncbi request reprint Viral origin of antiphospholipid antibodies: endothelial cell activation and thrombus enhancement by CMV peptide-induced APL antibodies
    Azzudin E Gharavi
    Dept of Medicine, Morehouse School of Medicine, University of Atlanta, Atlanta Georgia 30310 1495, USA
    Immunobiology 207:37-42. 2003
  8. ncbi request reprint Antiphospholipid antibodies induced in mice by immunization with a cytomegalovirus-derived peptide cause thrombosis and activation of endothelial cells in vivo
    Azzudin E Gharavi
    Department of Medicine, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Arthritis Rheum 46:545-52. 2002
  9. ncbi request reprint Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies
    Ricardo G Espinola
    Department of Microbiology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Thromb Haemost 87:518-22. 2002
  10. ncbi request reprint Origin and pathogenesis of antiphospholipid antibodies
    C M Celli
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 31:723-32. 1998

Collaborators

Detail Information

Publications13

  1. ncbi request reprint The molecular basis of antiphospholipid syndrome
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Lupus 12:579-83. 2003
    ..In people who are susceptible to APS, tolerance to self-beta2GPI and phospholipids is likely to be broken by foreign bacterial or viral proteins that contain such beta2GPI-like epitopes...
  2. ncbi request reprint Origin of antiphospholipid antibodies: induction of aPL by viral peptides
    A E Gharavi
    Morehouse School of Medicine, Department of Medicine, Atlanta, GA 30310 1495, USA
    Lupus 7:S52-4. 1998
    ..We also induced aPL and anti-beta2-GPI in mice by immunization with PL-binding viral peptides and hypothesized that in APS patients, aPL may be induced by beta2GPI-like-PL-binding products of common human bacteria and viruses...
  3. ncbi request reprint GDKV-induced antiphospholipid antibodies enhance thrombosis and activate endothelial cells in vivo and in vitro
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 163:2922-7. 1999
    ..These data indicate that aPL induced by immunization with the phospholipid binding site of beta2GPI are thrombogenic and activate endothelial cells...
  4. ncbi request reprint New developments in viral peptides and APL induction
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    J Autoimmun 15:227-30. 2000
    ..We hypothesize that in APS patients aPL is induced by beta(2)-GPL-like PL-binding products of human common bacteria or viruses...
  5. ncbi request reprint Mechanisms of pregnancy loss in antiphospholipid syndrome
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
    Clin Obstet Gynecol 44:11-9. 2001
    ....
  6. ncbi request reprint Origin of antiphospholipid antibodies
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia, USA
    Rheum Dis Clin North Am 27:551-63. 2001
    ..Identification of those bacterial or viral agents may help to find strategies for the prevention of production of "pathogenic" aPL. Alternatively, free peptides may be used to induce tolerance against aPL production...
  7. ncbi request reprint Viral origin of antiphospholipid antibodies: endothelial cell activation and thrombus enhancement by CMV peptide-induced APL antibodies
    Azzudin E Gharavi
    Dept of Medicine, Morehouse School of Medicine, University of Atlanta, Atlanta Georgia 30310 1495, USA
    Immunobiology 207:37-42. 2003
    ..Alternatively, free peptides may be used to induce tolerance against aPL production...
  8. ncbi request reprint Antiphospholipid antibodies induced in mice by immunization with a cytomegalovirus-derived peptide cause thrombosis and activation of endothelial cells in vivo
    Azzudin E Gharavi
    Department of Medicine, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Arthritis Rheum 46:545-52. 2002
    ..To characterize the binding and functional properties of antiphospholipid antibodies (aPL) induced by immunization with a viral peptide and to determine whether aPL are pathogenic in vivo...
  9. ncbi request reprint Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies
    Ricardo G Espinola
    Department of Microbiology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Thromb Haemost 87:518-22. 2002
    ..0125 mM). This suggests at least one possible mechanism by which HQ may prevent thrombosis. This may have important implications in treatment of thrombosis in APS patients...
  10. ncbi request reprint Origin and pathogenesis of antiphospholipid antibodies
    C M Celli
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 31:723-32. 1998
    ..Within this context, we discuss the most probable pathogenic mechanisms induced by these antibodies...
  11. ncbi request reprint Catastrophic antiphospholipid syndrome associated with typhoid fever: comment on the article by Hayem et al
    Imad Uthman
    Arthritis Rheum 46:850. 2002
  12. ncbi request reprint Antiphospholipid syndrome: diagnosis, pathogenesis, and management
    E Nigel Harris
    J Med Assoc Ga 91:31-4. 2002
  13. ncbi request reprint Viral infections and antiphospholipid antibodies
    Imad W Uthman
    Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
    Semin Arthritis Rheum 31:256-63. 2002
    ..To study the relationship between viral infections and the induction of antiphospholipid (aPL) antibodies...