Chunhui Xu

Summary

Affiliation: Geron Corporation
Country: USA

Publications

  1. ncbi Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells
    Chunhui Xu
    Geron Corporation, Menlo Park, Calif 94025, USA
    Circ Res 91:501-8. 2002
  2. ncbi Growth and differentiation of human embryonic stem cells for cardiac cell replacement therapy
    Chunhui Xu
    Geron Corporation, 230 Constitution Drive, Menlo Park, CA 94025, USA
    Curr Stem Cell Res Ther 1:173-87. 2006
  3. ncbi Human embryonic stem cell-derived cardiomyocytes can be maintained in defined medium without serum
    Chunhui Xu
    Geron Corporation, Menlo Park, CA 94025, USA
    Stem Cells Dev 15:931-41. 2006
  4. ncbi Cardiac bodies: a novel culture method for enrichment of cardiomyocytes derived from human embryonic stem cells
    Chunhui Xu
    Geron Corporation, Menlo Park, CA 94025, USA
    Stem Cells Dev 15:631-9. 2006
  5. ncbi Basic fibroblast growth factor supports undifferentiated human embryonic stem cell growth without conditioned medium
    Chunhui Xu
    Geron Corporation, 230 Constitution Drive, Menlo Park, California 94025, USA
    Stem Cells 23:315-23. 2005
  6. ncbi Immortalized fibroblast-like cells derived from human embryonic stem cells support undifferentiated cell growth
    Chunhui Xu
    Geron Corporation, 230 Constitution Drive, Menlo Park, California 94025, USA
    Stem Cells 22:972-80. 2004
  7. pmc Efficient generation and cryopreservation of cardiomyocytes derived from human embryonic stem cells
    Chunhui Xu
    Geron Corporation, Menlo Park, CA 94025, USA
    Regen Med 6:53-66. 2011
  8. ncbi Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation
    Ralph Brandenberger
    Geron Corporation, Menlo Park, California 94025, USA
    Nat Biotechnol 22:707-16. 2004
  9. ncbi Characterization and evaluation of human embryonic stem cells
    Chunhui Xu
    Geron Corporation, Menlo Par, California, USA
    Methods Enzymol 420:18-37. 2006
  10. pmc Formation of human myocardium in the rat heart from human embryonic stem cells
    Michael A Laflamme
    Department of Pathology, University of Washington, Seattle, WA 98109, USA
    Am J Pathol 167:663-71. 2005

Detail Information

Publications12

  1. ncbi Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells
    Chunhui Xu
    Geron Corporation, Menlo Park, Calif 94025, USA
    Circ Res 91:501-8. 2002
    ..The extended replicative capacity of hES cells and the ability to differentiate and enrich for functional human cardiomyocytes warrant further development of these cells for clinical application in heart diseases...
  2. ncbi Growth and differentiation of human embryonic stem cells for cardiac cell replacement therapy
    Chunhui Xu
    Geron Corporation, 230 Constitution Drive, Menlo Park, CA 94025, USA
    Curr Stem Cell Res Ther 1:173-87. 2006
    ..Here we review and discuss current findings on growth and differentiation of hESCs, and on characterization, enrichment and transplantation of hESC-derived cardiomyocytes...
  3. ncbi Human embryonic stem cell-derived cardiomyocytes can be maintained in defined medium without serum
    Chunhui Xu
    Geron Corporation, Menlo Park, CA 94025, USA
    Stem Cells Dev 15:931-41. 2006
    ..Therefore, culturing hES cell-derived cardiomyocytes in serum-free medium as described here should facilitate the use of the cells for in vitro and in vivo applications...
  4. ncbi Cardiac bodies: a novel culture method for enrichment of cardiomyocytes derived from human embryonic stem cells
    Chunhui Xu
    Geron Corporation, Menlo Park, CA 94025, USA
    Stem Cells Dev 15:631-9. 2006
    ..These data suggest that the CB method is a useful approach for the generation of cardiomyocytes at an adequate purity for cardiovascular therapies...
  5. ncbi Basic fibroblast growth factor supports undifferentiated human embryonic stem cell growth without conditioned medium
    Chunhui Xu
    Geron Corporation, 230 Constitution Drive, Menlo Park, California 94025, USA
    Stem Cells 23:315-23. 2005
    ..These data demonstrate that hESCs can be maintained in nonconditioned medium using growth factors...
  6. ncbi Immortalized fibroblast-like cells derived from human embryonic stem cells support undifferentiated cell growth
    Chunhui Xu
    Geron Corporation, 230 Constitution Drive, Menlo Park, California 94025, USA
    Stem Cells 22:972-80. 2004
    ..These results suggest that immortalized cell lines can be generated from hESCs and that cells derived from hESCs can be used to support their own growth, creating a genotypically homogeneous system for the culture of hESCs...
  7. pmc Efficient generation and cryopreservation of cardiomyocytes derived from human embryonic stem cells
    Chunhui Xu
    Geron Corporation, Menlo Park, CA 94025, USA
    Regen Med 6:53-66. 2011
    ..We also aim to examine whether these methods are scalable and whether the differentiated cells can be cryopreserved...
  8. ncbi Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation
    Ralph Brandenberger
    Geron Corporation, Menlo Park, California 94025, USA
    Nat Biotechnol 22:707-16. 2004
    ..The genomic data presented here may facilitate the derivation of clinically useful cell types from hES cells...
  9. ncbi Characterization and evaluation of human embryonic stem cells
    Chunhui Xu
    Geron Corporation, Menlo Par, California, USA
    Methods Enzymol 420:18-37. 2006
    ..This chapter will summarize the current development in culture conditions and provide technical details for the evaluation and characterization of hESCs...
  10. pmc Formation of human myocardium in the rat heart from human embryonic stem cells
    Michael A Laflamme
    Department of Pathology, University of Washington, Seattle, WA 98109, USA
    Am J Pathol 167:663-71. 2005
    ..Thus, hESCs can form human myocardium in the rat heart, permitting studies of human myocardial development and physiology and supporting the feasibility of their use in myocardial repair...
  11. ncbi Allopurinol/uricase and ibuprofen enhance engraftment of cardiomyocyte-enriched human embryonic stem cells and improve cardiac function following myocardial injury
    Theo Kofidis
    Cardiothoracic Surgery Falk Research Center, Stanford University Medical School, Stanford, CA, USA
    Eur J Cardiothorac Surg 29:50-5. 2006
    ....
  12. ncbi Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
    Michael A Laflamme
    Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 815 Mercer Street, Seattle, WA 98109, USA
    Nat Biotechnol 25:1015-24. 2007
    ..The ability of hES cell-derived cardiomyocytes to partially remuscularize myocardial infarcts and attenuate heart failure encourages their study under conditions that closely match human disease...