T D Geracioti
- CSF norepinephrine concentrations in posttraumatic stress disorderT D Geracioti
Mental Health Service, Veterans Affairs Medical Center, 3200 Vine St, Cincinnati, OH 45220, USA
Am J Psychiatry 158:1227-30. 2001..The goal of this study was to determine serial CSF norepinephrine levels in patients with PTSD...
- Intra- and inter-individual correlations between cholecystokinin and corticotropin-releasing hormone concentrations in human cerebrospinal fluidT D Geracioti
Psychiatry Service, Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
Depress Anxiety 10:77-80. 1999....
- Elevated cerebrospinal fluid substance p concentrations in posttraumatic stress disorder and major depressionThomas D Geracioti
Research Service, VA Medical Center, 3200 Vine St, Box 151, Cincinnati, OH 45220, USA
Am J Psychiatry 163:637-43. 2006..The authors also sought to determine if CNS substance P concentrations change on provocation of symptoms in PTSD patients...
- Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorderD G Baker
Psychiatry Service, Cincinnati VA Medical Center, OH, USA
Am J Psychiatry 156:585-8. 1999..They also sought to assess the relationship among PTSD symptoms, adrenocortical activity, and CSF CRH levels...
- Cerebrospinal fluid and plasma beta-endorphin in combat veterans with post-traumatic stress disorderD G Baker
Psychiatry Service, Cincinnati Veterans Affairs Medical Center, OH 15220, USA
Psychoneuroendocrinology 22:517-29. 1997..Poor correlation between CSF and plasma ir beta END limits use of plasma measures to assess CNS opioid activity...
- Stress hormone dysregulation at rest and after serotonergic stimulation among alcohol-dependent men with extended abstinence and controlsR M Anthenelli
Department of Psychiatry, University of Cincinnati College of Medicine, and Substance Dependence Program, Cincinnati Veterans Affairs Medical Center, OH 45220, USA
Alcohol Clin Exp Res 25:692-703. 2001..3 months) and controls to determine the relative contributions of alcoholism, cigarette smoking, and ASPD on baseline and provoked plasma cortisol and adrenocorticotropin hormone (ACTH) concentrations...
- Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorderD G Baker
Psychiatry Service, Cincinnati Veterans Affairs Medical Center and the Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45220, USA
Neuroimmunomodulation 9:209-17. 2001..The purpose of this study was to assess the relation of IL-6 levels and hypothalamic-pituitary-adrenal and noradrenergic activity in patients with well-characterized PTSD...
- Cerebrospinal fluid and plasma testosterone levels in post-traumatic stress disorder and tobacco dependenceJ J Mulchahey
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Psychoneuroendocrinology 26:273-85. 2001..The goal of this study was to screen for potential abnormalities in CNS testosterone levels in patients with post-traumatic stress disorder (PTSD) and/or tobacco dependence...
- Intra- and inter-individual relationships between central and peripheral serotonergic activity in humans: a serial cerebrospinal fluid sampling studyJ R Strawn
Department of Psychiatry, Cincinnati VAMC and University of Cincinnati College of Medicine, Cincinnati, OH, USA
Life Sci 71:1219-25. 2002..However, plasma 5-HIAA concentrations provide no significant information about absolute levels of the serotonin metabolite in the CSF...
- Pituitary-thyroid state correlates with central dopaminergic and serotonergic activity in healthy humansJ R Strawn
Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA
Neuropsychobiology 49:84-7. 2004..These results indicate that CNS monoamine-thyroid interactions are of physiological significance in the normal, euthyroid human...
- The effect of feeding on cerebrospinal fluid corticotropin-releasing hormone levels in humansJ W Kasckow
Cincinnati VAMC, Psychiatry Service, 3200 Vine St, Cincinnati, OH 45220, USA
Brain Res 904:218-24. 2001..Alternatively, our findings could also reflect changes in CRH levels associated with feeding in multiple brain areas and in the spinal cord with the net effect being in the negative direction...
- Corticotropin-releasing hormone in depression and post-traumatic stress disorderJ W Kasckow
Cincinnati VAMC, Psychiatry Service, 3200 Vine Street, Cincinnati, OH 45220, USA
Peptides 22:845-51. 2001..Furthermore, the neuroendocrinology of PTSD appears to be unique, in that patients have hyperactive central CRH systems with underactivity of the pituitary-adrenal axis...
- Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorderJ R Strawn
Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0559, USA
Depress Anxiety 25:260-71. 2008..The utility of these anti-adrenergics in the clinical treatment of PTSD remains to be determined, though it is possible that they may prove to have primary roles in a disorder that is only modestly responsive to antidepressant treatment...
- Regulation of corticotropin-releasing factor messenger RNA by nicotine in an immortalized amygdalar cell lineJ W Kasckow
Cincinnati VAMC, Psychiatry Service, OH 45220, USA
Life Sci 65:2709-14. 1999..This cell line thus confirms that nicotinic agonists stimulate amygdalar CRF and appears to be a useful model for studying molecular factors important in this interaction...
- Regulation of corticotropin-releasing hormone in vitroM Pisarska
Cincinnati VAMC, Psychiatry Service, 3200 Vine Street, Cincinnati, OH 45220, USA
Peptides 22:705-12. 2001..These mechanistic studies have focused on PKA- and glucocorticoid-mediated changes in CRH expression. Clearly much more investigative work in better understanding CRH regulation in vitro is needed...
- Childhood trauma and personality disorder: positive correlation with adult CSF corticotropin-releasing factor concentrationsRoyce Lee
Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
Am J Psychiatry 162:995-7. 2005....
- Higher levels of basal serial CSF cortisol in combat veterans with posttraumatic stress disorderDewleen G Baker
Psychiatry Service, San Diego VA Healthcare System, CA, USA
Am J Psychiatry 162:992-4. 2005..The authors' goal was to measure CSF cortisol concentrations, which more accurately reflect brain glucocorticoid exposure, in subjects with or without PTSD...
- Blood pressure and cerebrospinal fluid norepinephrine in combat-related posttraumatic stress disorderJeffrey R Strawn
Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
Psychosom Med 66:757-9. 2004..Central nervous system norepinephrine (NE) is normally involved in blood pressure regulation, but it is pathophysiologically elevated in posttraumatic stress disorder (PTSD)...
- Antithyroid antibody-linked symptoms in borderline personality disorderThomas D Geracioti
Clinical Neuroendocrinology, National Institute of Mental Health, Bethesda, MD, USA
Endocrine 21:153-8. 2003..It will be of interest to determine the prevalence, pathophysiologic mechanisms, and treatment implications of this putative autoimmune- BPD link...
- Effects of trauma-related audiovisual stimulation on cerebrospinal fluid norepinephrine and corticotropin-releasing hormone concentrations in post-traumatic stress disorderThomas D Geracioti
Veterans Affairs Medical Center, Research Service, Cincinnati, OH, USA
Psychoneuroendocrinology 33:416-24. 2008....
- Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholiaPhilip W Gold
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
Proc Natl Acad Sci U S A 102:8303-8. 2005..Even mildly-to-moderately depressed melancholic patients had clinically relevant increases in the arterial NE-appearance rate. These findings will not apply to all clinical subtypes of major depression...
- DHEA supplementation of systemic glucocorticoids for treatment of poison ivy dermatitisThomas D Geracioti
Int J Dermatol 44:974-6. 2005
- Effects of the vanilloid agonist olvanil and antagonist capsazepine on rat behaviorsJohn W Kasckow
Psychiatry Service 116A, Cincinnati VAMC, and Department of Psychiatry, School of Medicine, University of Cincinnati, OH 45267 0559, USA
Prog Neuropsychopharmacol Biol Psychiatry 28:291-5. 2004..The results suggest that the vanilloid agonists and antagonists may impact on behaviors involving anxiety and affect. However, it cannot be ruled that the findings could be due to nonspecific motor effect...