Mark R Prausnitz

Summary

Affiliation: Georgia Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Coating formulations for microneedles
    Harvinder S Gill
    Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332 0535, USA
    Pharm Res 24:1369-80. 2007
  2. ncbi request reprint Tapered conical polymer microneedles fabricated using an integrated lens technique for transdermal drug delivery
    Jung Hwan Park
    Department of BioNano Technology, Kyungwon University, Gachon BioNano Research Institute, Gyeonggi do 461 701, Korea
    IEEE Trans Biomed Eng 54:903-13. 2007
  3. ncbi request reprint Current status and future potential of transdermal drug delivery
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Nat Rev Drug Discov 3:115-24. 2004
  4. pmc Intradermal vaccination with influenza virus-like particles by using microneedles induces protection superior to that with intramuscular immunization
    Fu Shi Quan
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 84:7760-9. 2010
  5. ncbi request reprint Synergistic enhancement of skin permeability by N-lauroylsarcosine and ethanol
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Int J Pharm 352:129-38. 2008
  6. pmc Microneedle delivery of H5N1 influenza virus-like particles to the skin induces long-lasting B- and T-cell responses in mice
    Jae Min Song
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Clin Vaccine Immunol 17:1381-9. 2010
  7. pmc Mucoadhesive microdiscs engineered for ophthalmic drug delivery: effect of particle geometry and formulation on preocular residence time
    Young Bin Choy
    School of Chemical and Biomolecular Engineering and Center for Drug Design, Development and Delivery, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    Invest Ophthalmol Vis Sci 49:4808-15. 2008
  8. pmc Dissolving polymer microneedle patches for influenza vaccination
    Sean P Sullivan
    Wallace H Coulter Department of Biomedical Engineering, Emory University, Atlanta, Georgia, USA
    Nat Med 16:915-20. 2010
  9. pmc Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles
    Fu Shi Quan
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Control Release 147:326-32. 2010
  10. pmc Stability of whole inactivated influenza virus vaccine during coating onto metal microneedles
    Hyo Jick Choi
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    J Control Release 166:159-71. 2013

Collaborators

Detail Information

Publications96

  1. ncbi request reprint Coating formulations for microneedles
    Harvinder S Gill
    Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332 0535, USA
    Pharm Res 24:1369-80. 2007
    ....
  2. ncbi request reprint Tapered conical polymer microneedles fabricated using an integrated lens technique for transdermal drug delivery
    Jung Hwan Park
    Department of BioNano Technology, Kyungwon University, Gachon BioNano Research Institute, Gyeonggi do 461 701, Korea
    IEEE Trans Biomed Eng 54:903-13. 2007
    ..quot;Long" polymer microneedles were also demonstrated in human subjects to insert deeply without failure...
  3. ncbi request reprint Current status and future potential of transdermal drug delivery
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Nat Rev Drug Discov 3:115-24. 2004
    ....
  4. pmc Intradermal vaccination with influenza virus-like particles by using microneedles induces protection superior to that with intramuscular immunization
    Fu Shi Quan
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 84:7760-9. 2010
    ....
  5. ncbi request reprint Synergistic enhancement of skin permeability by N-lauroylsarcosine and ethanol
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Int J Pharm 352:129-38. 2008
    ..We conclude that NLS in aqueous ethanol formulations can dramatically increase skin permeability by a mechanism involving synergistic lipid-fluidization activity in the stratum corneum...
  6. pmc Microneedle delivery of H5N1 influenza virus-like particles to the skin induces long-lasting B- and T-cell responses in mice
    Jae Min Song
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Clin Vaccine Immunol 17:1381-9. 2010
    ..Microneedle vaccination in the skin with H5 VLPs represents a promising approach for a self-administered vaccine against viruses with pandemic potential...
  7. pmc Mucoadhesive microdiscs engineered for ophthalmic drug delivery: effect of particle geometry and formulation on preocular residence time
    Young Bin Choy
    School of Chemical and Biomolecular Engineering and Center for Drug Design, Development and Delivery, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    Invest Ophthalmol Vis Sci 49:4808-15. 2008
    ..To test the hypothesis that mucoadhesive microdiscs formulated in a rapidly dissolving tablet can increase preocular residence time...
  8. pmc Dissolving polymer microneedle patches for influenza vaccination
    Sean P Sullivan
    Wallace H Coulter Department of Biomedical Engineering, Emory University, Atlanta, Georgia, USA
    Nat Med 16:915-20. 2010
    ..These results suggest that dissolving microneedle patches can provide a new technology for simpler and safer vaccination with improved immunogenicity that could facilitate increased vaccination coverage...
  9. pmc Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles
    Fu Shi Quan
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Control Release 147:326-32. 2010
    ..Therefore, this study demonstrates that microneedle vaccination in the skin confers more effective protective immunity at a lower dose, thus providing vaccine dose-sparing effects...
  10. pmc Stability of whole inactivated influenza virus vaccine during coating onto metal microneedles
    Hyo Jick Choi
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    J Control Release 166:159-71. 2013
    ..We conclude that trehalose and a viscosity enhancer are beneficial coating excipients, but the inclusion of surfactant is detrimental to vaccine stability...
  11. pmc Coated microneedles for transdermal delivery
    Harvinder S Gill
    Wallace H Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University, Atlanta, GA 30332 0100, USA
    J Control Release 117:227-37. 2007
    ..In conclusion, this study presents a simple, versatile, and controllable method to coat microneedles with proteins, DNA, viruses and microparticles for rapid delivery into the skin...
  12. pmc Local response to microneedle-based influenza immunization in the skin
    Maria del Pilar Martin
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA
    MBio 3:e00012-12. 2012
    ..We also observed prolonged antigen deposition, and migration of matured dendritic cells bearing influenza virus antigen from the skin...
  13. pmc Stability kinetics of influenza vaccine coated onto microneedles during drying and storage
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Pharm Res 28:135-44. 2011
    ..This study sought to determine the effects of microneedle coating formulation, drying time and storage time on antigen stability and in vivo immunogenicity of influenza microneedle vaccines...
  14. pmc Improved protection against avian influenza H5N1 virus by a single vaccination with virus-like particles in skin using microneedles
    Jae Min Song
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA
    Antiviral Res 88:244-7. 2010
    ..Thus, this study provides evidence that skin delivery of H5 VLP vaccines using microneedles designed for self-administration induces improved protection compared to conventional intramuscular immunization...
  15. ncbi request reprint Polymer microneedles for controlled-release drug delivery
    Jung Hwan Park
    Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Pharm Res 23:1008-19. 2006
    ....
  16. pmc Intrascleral drug delivery to the eye using hollow microneedles
    Jason Jiang
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Pharm Res 26:395-403. 2009
    ..This study tested the hypothesis that hollow microneedles can infuse solutions containing soluble molecules, nanoparticles, and microparticles into sclera in a minimally invasive manner...
  17. pmc Intracellular protein delivery and gene transfection by electroporation using a microneedle electrode array
    Seong O Choi
    School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Small 8:1081-91. 2012
    ....
  18. ncbi request reprint Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery
    Jung Hwan Park
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Control Release 104:51-66. 2005
    ..Altogether, these results indicate that biodegradable polymer microneedles can be fabricated with an appropriate geometry and sufficient strength to insert into skin, and thereby dramatically increase transdermal transport of molecules...
  19. pmc Improved influenza vaccination in the skin using vaccine coated microneedles
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Vaccine 27:6932-8. 2009
    ..These findings suggest that vaccination in the skin using a microneedle patch can improve protective immunity, and simplify delivery of influenza and possibly other vaccines...
  20. pmc Targeted administration into the suprachoroidal space using a microneedle for drug delivery to the posterior segment of the eye
    Samirkumar R Patel
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
    Invest Ophthalmol Vis Sci 53:4433-41. 2012
    ..This study seeks to determine the intraocular pharmacokinetics of molecules and particles injected into the suprachoroidal space of the rabbit eye in vivo using a hollow microneedle...
  21. pmc Stability of influenza vaccine coated onto microneedles
    Hyo Jick Choi
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Biomaterials 33:3756-69. 2012
    ..This work shows that crystallization and phase separation of the dried coating matrix are important factors affecting long-term stability of influenza vaccine-coated microneedles...
  22. pmc Enhanced memory responses to seasonal H1N1 influenza vaccination of the skin with the use of vaccine-coated microneedles
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Emory University School of Medicine, Atlanta, Georgia 30332, USA
    J Infect Dis 201:190-8. 2010
    ..Morbidity and mortality due to influenza could be reduced by improved vaccination...
  23. pmc An electrically active microneedle array for electroporation
    Seong O Choi
    School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Biomed Microdevices 12:263-73. 2010
    ..This study demonstrates the mechanical and electrical functionalities of the first MEMS-fabricated microneedle array for electroporation, designed for DNA vaccine delivery...
  24. pmc Suprachoroidal drug delivery to the back of the eye using hollow microneedles
    Samirkumar R Patel
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, Georgia 30332 0100, USA
    Pharm Res 28:166-76. 2011
    ..In this work, we tested the hypothesis that microneedles provide a minimally invasive method to inject particles into the suprachoroidal space for drug delivery to the back of the eye...
  25. pmc Microsecond thermal ablation of skin for transdermal drug delivery
    Jeong Woo Lee
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Control Release 154:58-68. 2011
    ..We conclude that microsecond thermal ablation of skin can selectively remove stratum corneum and thereby dramatically increase skin permeability for transdermal drug delivery...
  26. pmc Serological memory and long-term protection to novel H1N1 influenza virus after skin vaccination
    Dimitrios G Koutsonanos
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Infect Dis 204:582-91. 2011
    ..Here, we investigate induction of long-lived immunity against the 2009 H1N1 virus after skin vaccination...
  27. ncbi request reprint Measurement and correlation of acoustic cavitation with cellular bioeffects
    Daniel M Hallow
    School of Chemical and Biomolecular Engineering, Georgia Insitute of Technology, Atlanta, GA 30332 0100, USA
    Ultrasound Med Biol 32:1111-22. 2006
    ..These results demonstrate that broadband noise correlates with bioeffects over a broad range of experimental conditions, which suggests a noninvasive feedback method to control ultrasound's bioeffects in real time...
  28. pmc Hollow microneedles for intradermal injection fabricated by sacrificial micromolding and selective electrodeposition
    James J Norman
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Biomed Microdevices 15:203-10. 2013
    ..The injections targeted 90 % of the material within the skin with minimal leakage onto the skin surface. We conclude that hollow microneedles made by this simple microfabrication method can achieve targeted intradermal injection...
  29. pmc DNA vaccination in the skin using microneedles improves protection against influenza
    Jae Min Song
    Center for Inflammation, Immunity and Infection, and Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA
    Mol Ther 20:1472-80. 2012
    ..This study demonstrates that DNA vaccination in the skin using microneedles induces higher humoral and cellular immune responses as well as improves protective immunity compared to conventional i.m. injection of HA DNA vaccine...
  30. pmc Delivery of salmon calcitonin using a microneedle patch
    Cetin Tas
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Int J Pharm 423:257-63. 2012
    ..These results suggest that with further optimization of coating formulations, microneedles may enable administration of sCT and other peptides without the need for hypodermic injections...
  31. pmc Rapid local anesthesia in humans using minimally invasive microneedles
    Jyoti Gupta
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Clin J Pain 28:129-35. 2012
    ....
  32. pmc Shear-induced intracellular loading of cells with molecules by controlled microfluidics
    Daniel M Hallow
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, Georgia 30332, USA
    Biotechnol Bioeng 99:846-54. 2008
    ..Such a device could benefit biological research and the biotechnology industry...
  33. pmc Optimization of microdermabrasion for controlled removal of stratum corneum
    Samantha N Andrews
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Int J Pharm 407:95-104. 2011
    ....
  34. pmc Microneedle vaccination with stabilized recombinant influenza virus hemagglutinin induces improved protective immunity
    William C Weldon
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    Clin Vaccine Immunol 18:647-54. 2011
    ..Our data therefore demonstrate the improved efficacy of a skin-based recombinant subunit influenza vaccine and emphasize the advantage of this route of vaccination for a protein subunit vaccine...
  35. ncbi request reprint Transdermal delivery of insulin using microneedles in vivo
    Wijaya Martanto
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Pharm Res 21:947-52. 2004
    ..The purpose of this study was to design and fabricate arrays of solid microneedles and insert them into the skin of diabetic hairless rats for transdermal delivery of insulin to lower blood glucose level...
  36. pmc Transdermal insulin delivery using microdermabrasion
    Samantha Andrews
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Pharm Res 28:2110-8. 2011
    ..Transdermal insulin delivery is an attractive needle-free alternative to subcutaneous injection conventionally used to treat diabetes. However, skin's barrier properties prevent insulin permeation at useful levels...
  37. pmc Infusion pressure and pain during microneedle injection into skin of human subjects
    Jyoti Gupta
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Biomaterials 32:6823-31. 2011
    ..We conclude that microneedles offer a simple method to infuse fluid into the skin that can be carried out with little to no pain...
  38. pmc Synergistic effect of ultrasound and PEI on DNA transfection in vitro
    Mangesh C Deshpande
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    J Control Release 118:126-35. 2007
    ..Electrophoresis assay showed no damage to DNA or PEI-DNA complexes after sonication. Overall, these results suggest that the combination of ultrasound and PEI can have a synergistic effect to increase DNA transfection...
  39. pmc Transdermal delivery of molecules is limited by full epidermis, not just stratum corneum
    Samantha N Andrews
    Wallace Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA
    Pharm Res 30:1099-109. 2013
    ..Here, we assess the hypothesis that viable epidermis offers a significant permeability barrier that becomes rate limiting upon sufficient permeabilization of stratum corneum...
  40. pmc Delivery of subunit influenza vaccine to skin with microneedles improves immunogenicity and long-lived protection
    Dimitrios G Koutsonanos
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA, USA
    Sci Rep 2:357. 2012
    ..These results demonstrate the promising potential of microneedle delivery of licensed influenza subunit vaccines, that could be beneficial in increasing vaccine coverage and protection and reducing influenza-related mortality worldwide...
  41. doi request reprint Gene transfection enhanced by ultrasound exposure combined with drug treatment guided by gene chip analysis
    Ying Liu
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Int J Hyperthermia 28:349-61. 2012
    ..We used these findings to select drugs that regulate intracellular processes expected to enhance gene transfection in combination with US...
  42. ncbi request reprint Quantification of optison bubble size and lifetime during sonication dominant role of secondary cavitation bubbles causing acoustic bioeffects
    Pavel P Kamaev
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, Georgia 30332 0100, USA
    J Acoust Soc Am 115:1818-25. 2004
    ..Because Optison solutions presonicated to destroy all detectable bubbles also caused significant bioeffects, the indirect mechanism involving secondary cavitation bubbles is more likely...
  43. pmc Minimally invasive insulin delivery in subjects with type 1 diabetes using hollow microneedles
    Jyoti Gupta
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    Diabetes Technol Ther 11:329-37. 2009
    ..This study tested the hypothesis that hollow microneedles can deliver insulin to modulate blood glucose levels in subjects with type 1 diabetes in a minimally invasive manner...
  44. ncbi request reprint Physical parameters influencing optimization of ultrasound-mediated DNA transfection
    Vladimir G Zarnitsyn
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    Ultrasound Med Biol 30:527-38. 2004
    ....
  45. pmc Biochemical enhancement of transdermal delivery with magainin peptide: modification of electrostatic interactions by changing pH
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Int J Pharm 362:20-8. 2008
    ..We conclude that magainin increases transdermal delivery by a mechanism involving electrostatic interaction between magainin peptides and drugs...
  46. pmc Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Control Release 142:187-95. 2010
    ..Overall, these results show that antigen activity loss during microneedle coating can be largely prevented through optimized formulation and that stabilized microneedle patches can be used for effective vaccination...
  47. pmc Dissolving microneedles for transdermal drug delivery
    Jeong W Lee
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332, USA
    Biomaterials 29:2113-24. 2008
    ..We conclude that dissolving microneedles can be designed to gently encapsulate molecules, insert into skin, and enable bolus or sustained release delivery...
  48. pmc Formulation of microneedles coated with influenza virus-like particle vaccine
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Dr, Atlanta, Georgia 30332, USA
    AAPS PharmSciTech 11:1193-201. 2010
    ..In summary, this study provides detailed analysis to guide formulation of microneedle patches coated with influenza VLP vaccine and demonstrates effective vaccination in vivo using this system...
  49. ncbi request reprint Ultrasound-enhanced chemotherapy and gene delivery for glioma cells
    Vladimir G Zarnitsyn
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332 0100, USA
    Technol Cancer Res Treat 6:433-42. 2007
    ..Altogether, these findings suggest that ultrasound may be useful to increase the efficacy of chemotherapy and gene therapy of glioma cells...
  50. ncbi request reprint Polymer particle-based micromolding to fabricate novel microstructures
    Jung Hwan Park
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Biomed Microdevices 9:223-34. 2007
    ..We conclude that polymer particle-based micromolding can encapsulate compounds within microstructures composed of multiple materials, having complex geometries, and made using mild processing conditions...
  51. ncbi request reprint Increased permeability of intestinal epithelial monolayers mediated by electroporation
    Esi B Ghartey-Tagoe
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech, Atlanta, GA 30332, USA
    J Control Release 103:177-90. 2005
    ..These findings could form the basis for the development of electroporation as a clinical tool to increase intestinal permeability and, thereby, increase the absorption of poorly absorbed drugs...
  52. pmc Can ultrasound enable efficient intracellular uptake of molecules? A retrospective literature review and analysis
    Ying Liu
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Ultrasound Med Biol 38:876-88. 2012
    ....
  53. pmc Kinetics of skin resealing after insertion of microneedles in human subjects
    Jyoti Gupta
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Control Release 154:148-55. 2011
    ....
  54. ncbi request reprint Coated microneedles for drug delivery to the eye
    Jason Jiang
    Emory Eye Center, Emory University, Atlanta, Georgia 30322, USA
    Invest Ophthalmol Vis Sci 48:4038-43. 2007
    ..To test the hypothesis that coated microneedles can deliver drugs into the eye via intrascleral and intracorneal routes in a minimally invasive manner...
  55. pmc Changes in cell morphology due to plasma membrane wounding by acoustic cavitation
    Robyn K Schlicher
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Atlanta, GA, USA
    Ultrasound Med Biol 36:677-92. 2010
    ....
  56. doi request reprint Fabrication of dissolving polymer microneedles for controlled drug encapsulation and delivery: Bubble and pedestal microneedle designs
    Leonard Y Chu
    Wallace Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Pharm Sci 99:4228-38. 2010
    ..018 to 0.053 microL per needle. Altogether, these novel microneedle designs provide a new set of tools to fabricate dissolving polymer microneedles with improved control over drug encapsulation, loading, and delivery...
  57. ncbi request reprint Hollow metal microneedles for insulin delivery to diabetic rats
    Shawn P Davis
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    IEEE Trans Biomed Eng 52:909-15. 2005
    ..Direct measurement of plasma insulin levels showed a peak value of 0.43 ng/ml. Together, these data suggest that microneedles can be fabricated and used for in vivo insulin delivery...
  58. pmc Separable arrowhead microneedles
    Leonard Y Chu
    Wallace Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Control Release 149:242-9. 2011
    ..Thus, drug and vaccine delivery using arrowhead microneedles are designed to offer a quick, convenient, safe and potentially self-administered method of drug delivery as an alternative to hypodermic needles...
  59. ncbi request reprint Mechanism of intracellular delivery by acoustic cavitation
    Robyn K Schlicher
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    Ultrasound Med Biol 32:915-24. 2006
    ..In this way, noninvasively focused ultrasound could deliver drugs and genes to targeted tissues, thereby minimizing side effects, lowering drug dosages, and improving efficacy...
  60. pmc Influence of the cell wall on intracellular delivery to algal cells by electroporation and sonication
    Harold R Azencott
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    Ultrasound Med Biol 33:1805-17. 2007
    ....
  61. ncbi request reprint Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force
    Shawn P Davis
    School of Chemical and Biomolecular Engineering, 311 Ferst Drive, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    J Biomech 37:1155-63. 2004
    ..Together, these results provide the ability to predict insertion and fracture forces, which facilitates rational design of microneedles with robust mechanical properties...
  62. pmc Modeling transmembrane transport through cell membrane wounds created by acoustic cavitation
    Vladimir Zarnitsyn
    School of Chemical and Biomolecular Engineering, and Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
    Biophys J 95:4124-38. 2008
    ..Overall, this study developed a theoretical framework for analysis of transmembrane transport through cell membrane wounds and thereby provided quantitative estimates of their size and lifetime...
  63. pmc Improving patient acceptance of insulin therapy by improving needle design
    James J Norman
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Diabetes Sci Technol 6:336-8. 2012
    ..While 5-bevel needles may increase patient acceptance, more dramatic changes of needle design, such as microneedles, could enable still greater patient acceptance through reduced pain as well as improved insulin pharmacokinetics...
  64. ncbi request reprint Mechanism of fluid infusion during microneedle insertion and retraction
    Wijaya Martanto
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    J Control Release 112:357-61. 2006
    ..Altogether, these results suggest that microneedle insertion to penetrate into the skin followed by microneedle retraction to relieve skin compaction is an effective approach to infuse fluid into the skin in a minimally invasive manner...
  65. pmc Ultrasound-enhanced drug transport and distribution in the brain
    Ying Liu
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    AAPS PharmSciTech 11:1005-17. 2010
    ..Altogether, these studies demonstrate that ultrasound can increase drug permeation in the brain in vitro and in vivo under conditions that did not cause detectable damage...
  66. ncbi request reprint Precise microinjection into skin using hollow microneedles
    Ping M Wang
    School of Chemical and Biomolecular Engineering, Atlanta, Georgia, USA
    J Invest Dermatol 126:1080-7. 2006
    ....
  67. ncbi request reprint Microneedles for transdermal drug delivery
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Adv Drug Deliv Rev 56:581-7. 2004
    ..Together, these results suggest that microneedles represent a promising technology to deliver therapeutic compounds into the skin for a range of possible applications...
  68. ncbi request reprint Plasmid DNA and siRNA transfection of intestinal epithelial monolayers by electroporation
    Esi B Ghartey-Tagoe
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Int J Pharm 315:122-33. 2006
    ....
  69. pmc Bacillus Calmette-Guérin vaccination using a microneedle patch
    Yasuhiro Hiraishi
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, N W, Atlanta, GA 30332, USA
    Vaccine 29:2626-36. 2011
    ....
  70. pmc Ultrasonically targeted delivery into endothelial and smooth muscle cells in ex vivo arteries
    Daniel M Hallow
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    J Control Release 118:285-93. 2007
    ..We conclude that significant intracellular uptake of molecules can be targeted into ECs and SMCs by ultrasound-enhanced delivery suggesting possible applications for treatment of cardiovascular diseases and dysfunctions...
  71. doi request reprint Dissolving microneedle patch for transdermal delivery of human growth hormone
    Jeong Woo Lee
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Small 7:531-9. 2011
    ..This study suggests that a dissolving microneedle patch can deliver hGH and other biopharmaceuticals in a manner suitable for self-administration without sharp biohazardous waste...
  72. pmc Tissue electroporation: quantification and analysis of heterogeneous transport in multicellular environments
    Paul J Canatella
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    Biophys J 86:3260-8. 2004
    ....
  73. pmc Transdermal drug delivery
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Dr, Atlanta, Georgia 30332 0100, USA
    Nat Biotechnol 26:1261-8. 2008
    ..Using these novel second- and third-generation enhancement strategies, transdermal delivery is poised to significantly increase its impact on medicine...
  74. ncbi request reprint Microinfusion using hollow microneedles
    Wijaya Martanto
    School of Chemical and Biomolecular Engineering and Center for Drug Design, Development and Delivery, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Pharm Res 23:104-13. 2006
    ..The aim of the study is to determine the effect of experimental parameters on microinfusion through hollow microneedles into skin to optimize drug delivery protocols and identify rate-limiting barriers to flow...
  75. pmc Recovery of skin barrier properties after sonication in human subjects
    Jyoti Gupta
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA
    Ultrasound Med Biol 35:1405-8. 2009
    ..Therefore, sonication can increase skin permeability for prolonged periods of time, especially under the effect of occlusion, and has potential to facilitate continuous transdermal drug delivery and diagnostic metabolite extraction...
  76. pmc Delivery of molecules into cells using carbon nanoparticles activated by femtosecond laser pulses
    Prerona Chakravarty
    Institute for Bioengineering and Biosciences, Center for Drug Design, Development and Delivery, and Laser Dynamics Laboratory, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Nat Nanotechnol 5:607-11. 2010
    ..Our initial results suggest that interaction between the laser energy and carbon black nanoparticles may generate photoacoustic forces by chemical reaction to create transient holes in the membrane for intracellular delivery...
  77. ncbi request reprint Transdermal delivery enhanced by antimicrobial peptides
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    J Biomed Nanotechnol 6:612-20. 2010
    ..We conclude that over the range of conditions studied here, most antimicrobial peptides did not enhance skin permeability and that magainin peptide provided the optimal structure...
  78. ncbi request reprint Assessment of trueness of a glucose monitor using interstitial fluid and whole blood as specimen matrix
    Hubert W Vesper
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Georgia Institute of Technology, Atlanta, Georgia 30341, USA
    Diabetes Technol Ther 8:76-80. 2006
    ..The aim of this study was to assess the trueness of this glucose monitor using split-sample comparison with whole blood. We used ISF as specimen and our gas chromatography/mass spectrometry (GC/MS) method as reference...
  79. pmc Microneedle-based vaccines
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Curr Top Microbiol Immunol 333:369-93. 2009
    ....
  80. ncbi request reprint Prediction of ultrasound-mediated disruption of cell membranes using machine learning techniques and statistical analysis of acoustic spectra
    Eva K Lee
    Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA
    IEEE Trans Biomed Eng 51:82-9. 2004
    ..These rules and the methods used to derive them could be used for real-time feedback about ultrasound's biological effects...
  81. pmc Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies
    Devin V McAllister
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta 30332, USA
    Proc Natl Acad Sci U S A 100:13755-60. 2003
    ..Hollow microneedles permitted flow of microliter quantities into skin in vivo, including microinjection of insulin to reduce blood glucose levels in diabetic rats...
  82. ncbi request reprint Electroporation-mediated delivery of molecules to model intestinal epithelia
    Esi B Ghartey-Tagoe
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Int J Pharm 270:127-38. 2004
    ..These findings suggest that electroporation may be useful for intracellular delivery into monolayers to study epithelial biology and, possibly, for drug delivery to intestinal epithelium...
  83. pmc Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge
    Qiyun Zhu
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 106:7968-73. 2009
    ..These results show that MNs are highly effective as a simple method of vaccine delivery to elicit protective immune responses against virus infection...
  84. ncbi request reprint Gene packaging with lipids, peptides and viruses inhibits transfection by electroporation in vitro
    Arlena L Coulberson
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332 0100, USA
    J Control Release 86:361-70. 2003
    ..The combination of retroviral vectors and electroporation transfected fewer cells than retrovirus alone. We conclude that the combination of electroporation with chemical or viral vectors does not improve gene transfection in vitro...
  85. ncbi request reprint Equilibrium loading of cells with macromolecules by ultrasound: effects of molecular size and acoustic energy
    Héctor R Guzmán
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    J Pharm Sci 91:1693-701. 2002
    ..The results demonstrate that ultrasound provides a means to load viable cells with large numbers of macromolecules, which may be of use for laboratory and possible clinical drug delivery applications...
  86. ncbi request reprint Bioeffects caused by changes in acoustic cavitation bubble density and cell concentration: a unified explanation based on cell-to-bubble ratio and blast radius
    Héctor R Guzmán
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Ultrasound Med Biol 29:1211-22. 2003
    ..Combined, these results suggest that extensive molecular uptake into cells at high viability occurs for low-energy exposure US applied at a high cell-to-bubble ratio...
  87. pmc Transdermal delivery enhanced by magainin pore-forming peptide
    Yeu Chun Kim
    Center for Drug Design, Development and Delivery and the Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, United States
    J Control Release 122:375-83. 2007
    ..This study also presents the novel concept of using a first chemical enhancer to increase penetration of a second chemical enhancer into the skin to synergistically increase skin permeability to a model drug...
  88. pmc Effect of microneedle design on pain in human volunteers
    Harvinder S Gill
    Center for Drug Design, Development and Delivery, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Clin J Pain 24:585-94. 2008
    ....
  89. pmc Selective removal of stratum corneum by microdermabrasion to increase skin permeability
    Harvinder S Gill
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Eur J Pharm Sci 38:95-103. 2009
    ..In conclusion, microdermabrasion can selectively remove full-thickness stratum corneum with little damage to deeper tissues and thereby increase skin permeability...
  90. ncbi request reprint Minimally invasive extraction of dermal interstitial fluid for glucose monitoring using microneedles
    Ping M Wang
    School of Chemical and Biomolecular Engineering and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    Diabetes Technol Ther 7:131-41. 2005
    ....
  91. ncbi request reprint Model of transient drug diffusion across cornea
    Wensheng Zhang
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    J Control Release 99:241-58. 2004
    ..Because of its mechanistic basis, this model will be useful to predict drug transport kinetics and bioavailability for new compounds and in diseased eyes...
  92. pmc Microneedles permit transdermal delivery of a skin-impermeant medication to humans
    Daniel P Wermeling
    Department of Pharmacy Practice, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 105:2058-63. 2008
    ..These findings set the stage for future human studies of skin-impermeant medications and biopharmaceuticals for clinical applications...
  93. ncbi request reprint A peptide chaperone for transdermal drug delivery
    Mark R Prausnitz
    Nat Biotechnol 24:416-7. 2006
  94. pmc Flux across [corrected] microneedle-treated skin is increased by increasing charge of naltrexone and naltrexol in vitro
    Stan L Banks
    Department of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, Lexington, Kentucky 40536 0082, USA
    Pharm Res 25:1677-85. 2008
    ..In a second set of experiments, permeability of the major active metabolite 6-beta-naltrexol base (NTXOL) in the primarily unionized (unprotonated) form at pH 8.5 was compared to the ionized form (pH 4.5)...
  95. pmc The effect of heat on skin permeability
    Jung Hwan Park
    Department of BioNano Technology and Gachon BioNano Research Institute, Kyungwon University, Seongnam, Geonggi do 461 701, Republic of Korea
    Int J Pharm 359:94-103. 2008
    ..We conclude that heating the skin with short, high temperature pulses can increase skin permeability by orders of magnitude due to structural disruption and removal of stratum corneum...
  96. pmc Future directions for therapeutic ultrasound
    Paul Campbell
    Ultrasound Med Biol 33:657. 2007