M R Prausnitz

Summary

Affiliation: Georgia Institute of Technology
Country: USA

Publications

  1. pmc Tissue electroporation: quantification and analysis of heterogeneous transport in multicellular environments
    Paul J Canatella
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    Biophys J 86:3260-8. 2004
  2. ncbi request reprint Precise microinjection into skin using hollow microneedles
    Ping M Wang
    School of Chemical and Biomolecular Engineering, Atlanta, Georgia, USA
    J Invest Dermatol 126:1080-7. 2006
  3. pmc Influence of the cell wall on intracellular delivery to algal cells by electroporation and sonication
    Harold R Azencott
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    Ultrasound Med Biol 33:1805-17. 2007
  4. ncbi request reprint Permeability of cornea, sclera, and conjunctiva: a literature analysis for drug delivery to the eye
    M R Prausnitz
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332 0100, USA
    J Pharm Sci 87:1479-88. 1998
  5. ncbi request reprint Microneedles for transdermal drug delivery
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Adv Drug Deliv Rev 56:581-7. 2004
  6. ncbi request reprint Overcoming skin's barrier: the search for effective and user-friendly drug delivery
    M R Prausnitz
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332 0100, USA
    Diabetes Technol Ther 3:233-6. 2001
  7. ncbi request reprint Ultrasound-mediated disruption of cell membranes. II. Heterogeneous effects on cells
    H R Guzmán
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332 0100, USA
    J Acoust Soc Am 110:597-606. 2001
  8. ncbi request reprint Sonoluminescence as an indicator of cell membrane disruption by acoustic cavitation
    S A Cochran
    School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0100, USA
    Ultrasound Med Biol 27:841-50. 2001
  9. ncbi request reprint Ultrasound-mediated disruption of cell membranes. I. Quantification of molecular uptake and cell viability
    H R Guzmán
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332 0100, USA
    J Acoust Soc Am 110:588-96. 2001
  10. ncbi request reprint Coating formulations for microneedles
    Harvinder S Gill
    Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332 0535, USA
    Pharm Res 24:1369-80. 2007

Collaborators

  • Jung Hwan Park
  • Sang Moo Kang
  • Henry Edelhauser
  • Ioanna Skountzou
  • ROBERT SAMUEL LANGER
  • Nicholas Hud
  • Ajay K Banga
  • Eva K Lee
  • Alexander K Andrianov
  • Samir Mitragotri
  • Michel Cormier
  • John A Mikszta
  • AURELIE EDWARDS
  • Wensheng Zhang
  • DANIEL PAUL WERMELING
  • Yeu Chun Kim
  • Harvinder S Gill
  • Richard W Compans
  • Fu Shi Quan
  • Wijaya Martanto
  • Jae Min Song
  • Ping M Wang
  • Esi B Ghartey-Tagoe
  • Shawn P Davis
  • Seong O Choi
  • Dae Goon Yoo
  • Jason Jiang
  • Daniel M Hallow
  • Mark G Allen
  • Peter J Ludovice
  • Jason S Moore
  • Héctor R Guzmán
  • Andrew S Neish
  • H R Guzmán
  • Y C Kim
  • Paul J Canatella
  • Ruben O Donis
  • Leonard Y Chu
  • H S Gill
  • Sean P Sullivan
  • J D Hutcheson
  • Kyoung Mi Park
  • Qiyun Zhu
  • Jyoti Gupta
  • Stan L Banks
  • Vladimir Zarnitsyn
  • Jeong W Lee
  • Young Bin Choy
  • Bernard E McCarey
  • Paul Campbell
  • Mangesh C Deshpande
  • Harold R Azencott
  • Anuj D Mahajan
  • Robyn K Schlicher
  • Megan Cornwell
  • Jeremy S Morgan
  • Pavel P Kamaev
  • Devin V McAllister
  • Arlena L Coulberson
  • Daniel X Nguyen
  • Andrew J McNamara
  • S Khan
  • P J Canatella
  • K Keyhani
  • D X Nguyen
  • C Jarrahian
  • D Zehrung
  • S A Cochran
  • R K Schlicher
  • Maria del Pilar Martin
  • Marc Pearton
  • Yong Kyu Yoon
  • Dimitrios G Koutsonanos
  • H K Hicks
  • Aswani Vunnava
  • Aleksandr S Lipatov
  • Jeong Woo Lee
  • J Soderholm
  • M Sallberg
  • C Todd Davis
  • James C Birchall
  • Li Mei Chen
  • Joshua Hutcheson
  • Peter G Barlow
  • D V McAllister
  • Niren Murthy
  • M Jaber Hossain
  • Seth Yellin
  • Yulong Gao
  • Zhiyuan Wen

Detail Information

Publications68

  1. pmc Tissue electroporation: quantification and analysis of heterogeneous transport in multicellular environments
    Paul J Canatella
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    Biophys J 86:3260-8. 2004
    ....
  2. ncbi request reprint Precise microinjection into skin using hollow microneedles
    Ping M Wang
    School of Chemical and Biomolecular Engineering, Atlanta, Georgia, USA
    J Invest Dermatol 126:1080-7. 2006
    ....
  3. pmc Influence of the cell wall on intracellular delivery to algal cells by electroporation and sonication
    Harold R Azencott
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    Ultrasound Med Biol 33:1805-17. 2007
    ....
  4. ncbi request reprint Permeability of cornea, sclera, and conjunctiva: a literature analysis for drug delivery to the eye
    M R Prausnitz
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332 0100, USA
    J Pharm Sci 87:1479-88. 1998
    ..This study provides an extensive database of ocular tissue permeabilities, which should be useful for future development and validation of models to predict rates of drug delivery to the eye...
  5. ncbi request reprint Microneedles for transdermal drug delivery
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Adv Drug Deliv Rev 56:581-7. 2004
    ..Together, these results suggest that microneedles represent a promising technology to deliver therapeutic compounds into the skin for a range of possible applications...
  6. ncbi request reprint Overcoming skin's barrier: the search for effective and user-friendly drug delivery
    M R Prausnitz
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332 0100, USA
    Diabetes Technol Ther 3:233-6. 2001
    ..Chemical enhancers, iontophoresis, electroporation, and ultrasound increase skin permeability by making submicron alterations in skin microstructure for continuous delivery over time...
  7. ncbi request reprint Ultrasound-mediated disruption of cell membranes. II. Heterogeneous effects on cells
    H R Guzmán
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332 0100, USA
    J Acoust Soc Am 110:597-606. 2001
    ..The distribution of cells among the three subpopulations correlated with acoustic energy exposure, which suggests that energy exposure may govern the ability of ultrasound to induce bioeffects by a nonthermal mechanism...
  8. ncbi request reprint Sonoluminescence as an indicator of cell membrane disruption by acoustic cavitation
    S A Cochran
    School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0100, USA
    Ultrasound Med Biol 27:841-50. 2001
    ..These results support a cavitation-based mechanism for these bioeffects and suggest a means to control US effects on cells using sonoluminescence-based feedback...
  9. ncbi request reprint Ultrasound-mediated disruption of cell membranes. I. Quantification of molecular uptake and cell viability
    H R Guzmán
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332 0100, USA
    J Acoust Soc Am 110:588-96. 2001
    ..This suggests that acoustic energy exposure may be predictive of ultrasound's nonthermal bioeffects...
  10. ncbi request reprint Coating formulations for microneedles
    Harvinder S Gill
    Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332 0535, USA
    Pharm Res 24:1369-80. 2007
    ....
  11. pmc Coated microneedles for transdermal delivery
    Harvinder S Gill
    Wallace H Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University, Atlanta, GA 30332 0100, USA
    J Control Release 117:227-37. 2007
    ..In conclusion, this study presents a simple, versatile, and controllable method to coat microneedles with proteins, DNA, viruses and microparticles for rapid delivery into the skin...
  12. ncbi request reprint Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force
    Shawn P Davis
    School of Chemical and Biomolecular Engineering, 311 Ferst Drive, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    J Biomech 37:1155-63. 2004
    ..Together, these results provide the ability to predict insertion and fracture forces, which facilitates rational design of microneedles with robust mechanical properties...
  13. ncbi request reprint Transdermal delivery of insulin using microneedles in vivo
    Wijaya Martanto
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Pharm Res 21:947-52. 2004
    ..The purpose of this study was to design and fabricate arrays of solid microneedles and insert them into the skin of diabetic hairless rats for transdermal delivery of insulin to lower blood glucose level...
  14. ncbi request reprint Polymer microneedles for controlled-release drug delivery
    Jung Hwan Park
    Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Pharm Res 23:1008-19. 2006
    ....
  15. ncbi request reprint Current status and future potential of transdermal drug delivery
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Nat Rev Drug Discov 3:115-24. 2004
    ....
  16. pmc Dissolving polymer microneedle patches for influenza vaccination
    Sean P Sullivan
    Wallace H Coulter Department of Biomedical Engineering, Emory University, Atlanta, Georgia, USA
    Nat Med 16:915-20. 2010
    ..These results suggest that dissolving microneedle patches can provide a new technology for simpler and safer vaccination with improved immunogenicity that could facilitate increased vaccination coverage...
  17. pmc Transdermal drug delivery
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Dr, Atlanta, Georgia 30332 0100, USA
    Nat Biotechnol 26:1261-8. 2008
    ..Using these novel second- and third-generation enhancement strategies, transdermal delivery is poised to significantly increase its impact on medicine...
  18. pmc Microneedle-based vaccines
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Curr Top Microbiol Immunol 333:369-93. 2009
    ....
  19. ncbi request reprint Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery
    Jung Hwan Park
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Control Release 104:51-66. 2005
    ..Altogether, these results indicate that biodegradable polymer microneedles can be fabricated with an appropriate geometry and sufficient strength to insert into skin, and thereby dramatically increase transdermal transport of molecules...
  20. pmc Microneedle delivery of H5N1 influenza virus-like particles to the skin induces long-lasting B- and T-cell responses in mice
    Jae Min Song
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Clin Vaccine Immunol 17:1381-9. 2010
    ..Microneedle vaccination in the skin with H5 VLPs represents a promising approach for a self-administered vaccine against viruses with pandemic potential...
  21. pmc Improved protection against avian influenza H5N1 virus by a single vaccination with virus-like particles in skin using microneedles
    Jae Min Song
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA
    Antiviral Res 88:244-7. 2010
    ..Thus, this study provides evidence that skin delivery of H5 VLP vaccines using microneedles designed for self-administration induces improved protection compared to conventional intramuscular immunization...
  22. ncbi request reprint Prediction of ultrasound-mediated disruption of cell membranes using machine learning techniques and statistical analysis of acoustic spectra
    Eva K Lee
    Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA
    IEEE Trans Biomed Eng 51:82-9. 2004
    ..These rules and the methods used to derive them could be used for real-time feedback about ultrasound's biological effects...
  23. ncbi request reprint Microfabricated microneedles for gene and drug delivery
    D V McAllister
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Annu Rev Biomed Eng 2:289-313. 2000
    ..These needles have been shown to be robust enough to penetrate skin and dramatically increase skin permeability to macromolecules...
  24. pmc Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine
    H S Gill
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    Gene Ther 17:811-4. 2010
    ..Thus, microneedles may offer a promising technology for DNA vaccination...
  25. pmc Delivery systems for intradermal vaccination
    Y C Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Curr Top Microbiol Immunol 351:77-112. 2012
    ..The prospects for bringing ID vaccination into more widespread clinical practice are encouraging, given the large number of technologies for ID delivery under development...
  26. pmc Improved influenza vaccination in the skin using vaccine coated microneedles
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Vaccine 27:6932-8. 2009
    ..These findings suggest that vaccination in the skin using a microneedle patch can improve protective immunity, and simplify delivery of influenza and possibly other vaccines...
  27. ncbi request reprint Synergistic enhancement of skin permeability by N-lauroylsarcosine and ethanol
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Int J Pharm 352:129-38. 2008
    ..We conclude that NLS in aqueous ethanol formulations can dramatically increase skin permeability by a mechanism involving synergistic lipid-fluidization activity in the stratum corneum...
  28. pmc Biochemical enhancement of transdermal delivery with magainin peptide: modification of electrostatic interactions by changing pH
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Int J Pharm 362:20-8. 2008
    ..We conclude that magainin increases transdermal delivery by a mechanism involving electrostatic interaction between magainin peptides and drugs...
  29. pmc Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Control Release 142:187-95. 2010
    ..Overall, these results show that antigen activity loss during microneedle coating can be largely prevented through optimized formulation and that stabilized microneedle patches can be used for effective vaccination...
  30. pmc Saving cells from ultrasound-induced apoptosis: quantification of cell death and uptake following sonication and effects of targeted calcium chelation
    J D Hutcheson
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Ultrasound Med Biol 36:1008-21. 2010
    ..We conclude that cells can be saved from ultrasound-induced death by appropriate selection of ultrasound conditions and Ca(2+) chelation after sonication...
  31. pmc Dissolving microneedles for transdermal drug delivery
    Jeong W Lee
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332, USA
    Biomaterials 29:2113-24. 2008
    ..We conclude that dissolving microneedles can be designed to gently encapsulate molecules, insert into skin, and enable bolus or sustained release delivery...
  32. pmc An electrically active microneedle array for electroporation
    Seong O Choi
    School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Biomed Microdevices 12:263-73. 2010
    ..This study demonstrates the mechanical and electrical functionalities of the first MEMS-fabricated microneedle array for electroporation, designed for DNA vaccine delivery...
  33. pmc Recovery of skin barrier properties after sonication in human subjects
    Jyoti Gupta
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA
    Ultrasound Med Biol 35:1405-8. 2009
    ..Therefore, sonication can increase skin permeability for prolonged periods of time, especially under the effect of occlusion, and has potential to facilitate continuous transdermal drug delivery and diagnostic metabolite extraction...
  34. ncbi request reprint Mechanism of intracellular delivery by acoustic cavitation
    Robyn K Schlicher
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    Ultrasound Med Biol 32:915-24. 2006
    ..In this way, noninvasively focused ultrasound could deliver drugs and genes to targeted tissues, thereby minimizing side effects, lowering drug dosages, and improving efficacy...
  35. pmc Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies
    Devin V McAllister
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta 30332, USA
    Proc Natl Acad Sci U S A 100:13755-60. 2003
    ..Hollow microneedles permitted flow of microliter quantities into skin in vivo, including microinjection of insulin to reduce blood glucose levels in diabetic rats...
  36. ncbi request reprint Mechanism of fluid infusion during microneedle insertion and retraction
    Wijaya Martanto
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    J Control Release 112:357-61. 2006
    ..Altogether, these results suggest that microneedle insertion to penetrate into the skin followed by microneedle retraction to relieve skin compaction is an effective approach to infuse fluid into the skin in a minimally invasive manner...
  37. ncbi request reprint Microinfusion using hollow microneedles
    Wijaya Martanto
    School of Chemical and Biomolecular Engineering and Center for Drug Design, Development and Delivery, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Pharm Res 23:104-13. 2006
    ..The aim of the study is to determine the effect of experimental parameters on microinfusion through hollow microneedles into skin to optimize drug delivery protocols and identify rate-limiting barriers to flow...
  38. ncbi request reprint Electroporation-mediated delivery of molecules to model intestinal epithelia
    Esi B Ghartey-Tagoe
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Int J Pharm 270:127-38. 2004
    ..These findings suggest that electroporation may be useful for intracellular delivery into monolayers to study epithelial biology and, possibly, for drug delivery to intestinal epithelium...
  39. ncbi request reprint Prediction and optimization of gene transfection and drug delivery by electroporation
    P J Canatella
    School of Chemical Engineering, Georgia Institute of Technology, 778 Atlantic Drive, Atlanta, GA 30332-0100, USA
    Gene Ther 8:1464-9. 2001
    ..For gene therapy applications, this approach should facilitate rational design of electroporation protocols...
  40. ncbi request reprint Intracellular drug delivery using low-frequency ultrasound: quantification of molecular uptake and cell viability
    K Keyhani
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332-0100, USA
    Pharm Res 18:1514-20. 2001
    ..CONCLUSIONS: Large numbers of molecules can be delivered intracellularly using low-frequency ultrasound. Both uptake and viability correlate with acoustic energy, which is useful for design and control of ultrasound protocols...
  41. pmc Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge
    Qiyun Zhu
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 106:7968-73. 2009
    ..These results show that MNs are highly effective as a simple method of vaccine delivery to elicit protective immune responses against virus infection...
  42. ncbi request reprint Increased permeability of intestinal epithelial monolayers mediated by electroporation
    Esi B Ghartey-Tagoe
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech, Atlanta, GA 30332, USA
    J Control Release 103:177-90. 2005
    ..These findings could form the basis for the development of electroporation as a clinical tool to increase intestinal permeability and, thereby, increase the absorption of poorly absorbed drugs...
  43. ncbi request reprint Equilibrium loading of cells with macromolecules by ultrasound: effects of molecular size and acoustic energy
    Héctor R Guzmán
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    J Pharm Sci 91:1693-701. 2002
    ..The results demonstrate that ultrasound provides a means to load viable cells with large numbers of macromolecules, which may be of use for laboratory and possible clinical drug delivery applications...
  44. pmc Enhanced memory responses to seasonal H1N1 influenza vaccination of the skin with the use of vaccine-coated microneedles
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Emory University School of Medicine, Atlanta, Georgia 30332, USA
    J Infect Dis 201:190-8. 2010
    ..Morbidity and mortality due to influenza could be reduced by improved vaccination...
  45. pmc Intradermal vaccination with influenza virus-like particles by using microneedles induces protection superior to that with intramuscular immunization
    Fu Shi Quan
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 84:7760-9. 2010
    ....
  46. ncbi request reprint Gene packaging with lipids, peptides and viruses inhibits transfection by electroporation in vitro
    Arlena L Coulberson
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332 0100, USA
    J Control Release 86:361-70. 2003
    ..The combination of retroviral vectors and electroporation transfected fewer cells than retrovirus alone. We conclude that the combination of electroporation with chemical or viral vectors does not improve gene transfection in vitro...
  47. doi request reprint Fabrication of dissolving polymer microneedles for controlled drug encapsulation and delivery: Bubble and pedestal microneedle designs
    Leonard Y Chu
    Wallace Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Pharm Sci 99:4228-38. 2010
    ..018 to 0.053 microL per needle. Altogether, these novel microneedle designs provide a new set of tools to fabricate dissolving polymer microneedles with improved control over drug encapsulation, loading, and delivery...
  48. pmc Intrascleral drug delivery to the eye using hollow microneedles
    Jason Jiang
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Pharm Res 26:395-403. 2009
    ..This study tested the hypothesis that hollow microneedles can infuse solutions containing soluble molecules, nanoparticles, and microparticles into sclera in a minimally invasive manner...
  49. pmc Ultrasonically targeted delivery into endothelial and smooth muscle cells in ex vivo arteries
    Daniel M Hallow
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    J Control Release 118:285-93. 2007
    ..We conclude that significant intracellular uptake of molecules can be targeted into ECs and SMCs by ultrasound-enhanced delivery suggesting possible applications for treatment of cardiovascular diseases and dysfunctions...
  50. ncbi request reprint Coated microneedles for drug delivery to the eye
    Jason Jiang
    Emory Eye Center, Emory University, Atlanta, Georgia 30322, USA
    Invest Ophthalmol Vis Sci 48:4038-43. 2007
    ..To test the hypothesis that coated microneedles can deliver drugs into the eye via intrascleral and intracorneal routes in a minimally invasive manner...
  51. ncbi request reprint Hollow metal microneedles for insulin delivery to diabetic rats
    Shawn P Davis
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    IEEE Trans Biomed Eng 52:909-15. 2005
    ..Direct measurement of plasma insulin levels showed a peak value of 0.43 ng/ml. Together, these data suggest that microneedles can be fabricated and used for in vivo insulin delivery...
  52. ncbi request reprint Plasmid DNA and siRNA transfection of intestinal epithelial monolayers by electroporation
    Esi B Ghartey-Tagoe
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Int J Pharm 315:122-33. 2006
    ....
  53. ncbi request reprint Bioeffects caused by changes in acoustic cavitation bubble density and cell concentration: a unified explanation based on cell-to-bubble ratio and blast radius
    Héctor R Guzmán
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Ultrasound Med Biol 29:1211-22. 2003
    ..Combined, these results suggest that extensive molecular uptake into cells at high viability occurs for low-energy exposure US applied at a high cell-to-bubble ratio...
  54. pmc Transdermal delivery enhanced by magainin pore-forming peptide
    Yeu Chun Kim
    Center for Drug Design, Development and Delivery and the Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, United States
    J Control Release 122:375-83. 2007
    ..This study also presents the novel concept of using a first chemical enhancer to increase penetration of a second chemical enhancer into the skin to synergistically increase skin permeability to a model drug...
  55. ncbi request reprint Quantification of optison bubble size and lifetime during sonication dominant role of secondary cavitation bubbles causing acoustic bioeffects
    Pavel P Kamaev
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, Georgia 30332 0100, USA
    J Acoust Soc Am 115:1818-25. 2004
    ..Because Optison solutions presonicated to destroy all detectable bubbles also caused significant bioeffects, the indirect mechanism involving secondary cavitation bubbles is more likely...
  56. pmc Synergistic effect of ultrasound and PEI on DNA transfection in vitro
    Mangesh C Deshpande
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    J Control Release 118:126-35. 2007
    ..Electrophoresis assay showed no damage to DNA or PEI-DNA complexes after sonication. Overall, these results suggest that the combination of ultrasound and PEI can have a synergistic effect to increase DNA transfection...
  57. ncbi request reprint Measurement and correlation of acoustic cavitation with cellular bioeffects
    Daniel M Hallow
    School of Chemical and Biomolecular Engineering, Georgia Insitute of Technology, Atlanta, GA 30332 0100, USA
    Ultrasound Med Biol 32:1111-22. 2006
    ..These results demonstrate that broadband noise correlates with bioeffects over a broad range of experimental conditions, which suggests a noninvasive feedback method to control ultrasound's bioeffects in real time...
  58. pmc Selective removal of stratum corneum by microdermabrasion to increase skin permeability
    Harvinder S Gill
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Eur J Pharm Sci 38:95-103. 2009
    ..In conclusion, microdermabrasion can selectively remove full-thickness stratum corneum with little damage to deeper tissues and thereby increase skin permeability...
  59. pmc Mucoadhesive microdiscs engineered for ophthalmic drug delivery: effect of particle geometry and formulation on preocular residence time
    Young Bin Choy
    School of Chemical and Biomolecular Engineering and Center for Drug Design, Development and Delivery, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    Invest Ophthalmol Vis Sci 49:4808-15. 2008
    ..To test the hypothesis that mucoadhesive microdiscs formulated in a rapidly dissolving tablet can increase preocular residence time...
  60. pmc Effect of microneedle design on pain in human volunteers
    Harvinder S Gill
    Center for Drug Design, Development and Delivery, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Clin J Pain 24:585-94. 2008
    ....
  61. ncbi request reprint Minimally invasive extraction of dermal interstitial fluid for glucose monitoring using microneedles
    Ping M Wang
    School of Chemical and Biomolecular Engineering and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
    Diabetes Technol Ther 7:131-41. 2005
    ....
  62. ncbi request reprint Tapered conical polymer microneedles fabricated using an integrated lens technique for transdermal drug delivery
    Jung Hwan Park
    Department of BioNano Technology, Kyungwon University, Gachon BioNano Research Institute, Gyeonggi do 461 701, Korea
    IEEE Trans Biomed Eng 54:903-13. 2007
    ..quot;Long" polymer microneedles were also demonstrated in human subjects to insert deeply without failure...
  63. pmc Microneedles permit transdermal delivery of a skin-impermeant medication to humans
    Daniel P Wermeling
    Department of Pharmacy Practice, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 105:2058-63. 2008
    ..These findings set the stage for future human studies of skin-impermeant medications and biopharmaceuticals for clinical applications...
  64. ncbi request reprint Model of transient drug diffusion across cornea
    Wensheng Zhang
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    J Control Release 99:241-58. 2004
    ..Because of its mechanistic basis, this model will be useful to predict drug transport kinetics and bioavailability for new compounds and in diseased eyes...
  65. pmc The effect of heat on skin permeability
    Jung Hwan Park
    Department of BioNano Technology and Gachon BioNano Research Institute, Kyungwon University, Seongnam, Geonggi do 461 701, Republic of Korea
    Int J Pharm 359:94-103. 2008
    ..We conclude that heating the skin with short, high temperature pulses can increase skin permeability by orders of magnitude due to structural disruption and removal of stratum corneum...
  66. pmc Flux across [corrected] microneedle-treated skin is increased by increasing charge of naltrexone and naltrexol in vitro
    Stan L Banks
    Department of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, Lexington, Kentucky 40536 0082, USA
    Pharm Res 25:1677-85. 2008
    ..In a second set of experiments, permeability of the major active metabolite 6-beta-naltrexol base (NTXOL) in the primarily unionized (unprotonated) form at pH 8.5 was compared to the ionized form (pH 4.5)...
  67. pmc Future directions for therapeutic ultrasound
    Paul Campbell
    Ultrasound Med Biol 33:657. 2007
  68. ncbi request reprint A peptide chaperone for transdermal drug delivery
    Mark R Prausnitz
    Nat Biotechnol 24:416-7. 2006