Manu O Platt

Summary

Affiliation: Georgia Institute of Technology
Country: USA

Publications

  1. doi request reprint Endothelial cells and cathepsins: Biochemical and biomechanical regulation
    Manu O Platt
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 950 Atlantic Drive, Suite 3015, Atlanta, GA 30332, USA Electronic address
    Biochimie 122:314-23. 2016
  2. doi request reprint Low-Cost Method to Monitor Patient Adherence to HIV Antiretroviral Therapy Using Multiplex Cathepsin Zymography
    Manu O Platt
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Drive, IBB 1308, Atlanta, GA, 30332, USA
    Mol Biotechnol 58:56-64. 2016
  3. pmc Sickle cell disease activates peripheral blood mononuclear cells to induce cathepsins k and v activity in endothelial cells
    Philip M Keegan
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
    Anemia 2012:201781. 2012
  4. pmc Patient specific proteolytic activity of monocyte-derived macrophages and osteoclasts predicted with temporal kinase activation states during differentiation
    Keon Young Park
    Department of Biomedical Engineering and Parker H Petit Institute of Bioengineering and Biosciences, Georgia Institute of Technology and Emory University, 315 Ferst Drive, Atlanta, GA 30332, USA
    Integr Biol (Camb) 4:1459-69. 2012
  5. ncbi request reprint T-cell phosphokinome as a fingerprint of effective graft versus leukemia
    Manu O Platt
    Wallace H Coulter Department of Biomedical Engineering and Institute for Bioengineering and Biosciences, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
    Front Biosci (Elite Ed) 4:721-33. 2012
  6. pmc Multiplex zymography captures stage-specific activity profiles of cathepsins K, L, and S in human breast, lung, and cervical cancer
    Binbin Chen
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, GA 30332, Atlanta, USA
    J Transl Med 9:109. 2011
  7. doi request reprint Sickle cell biomechanics
    Gilda A Barabino
    The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA
    Annu Rev Biomed Eng 12:345-67. 2010
  8. doi request reprint Efavirenz treatment causes arterial stiffening in apolipoprotein E-null mice
    Alexander W Caulk
    The George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive, IBB 2305, Atlanta, GA 30332, USA
    J Biomech 48:2176-80. 2015
  9. pmc Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues
    Catera L Wilder
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, 30332, USA
    Arch Biochem Biophys 516:52-7. 2011
  10. ncbi request reprint Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis
    Manu O Platt
    Wallace H Coulter Dept of Biomedical Engineering at Georgia Tech and Emory Univ, 308D WMB, Atlanta, GA 30322, USA
    Am J Physiol Heart Circ Physiol 292:H1479-86. 2007

Collaborators

  • Gilda A Barabino
  • Philip M Keegan
  • Keon Young Park
  • Alexander W Caulk
  • Binbin Chen
  • Catera L Wilder
  • Rudolph L Gleason
  • Jose Soler
  • Weiwei A Li
  • Sindhuja Surapaneni

Detail Information

Publications10

  1. doi request reprint Endothelial cells and cathepsins: Biochemical and biomechanical regulation
    Manu O Platt
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 950 Atlantic Drive, Suite 3015, Atlanta, GA 30332, USA Electronic address
    Biochimie 122:314-23. 2016
    ....
  2. doi request reprint Low-Cost Method to Monitor Patient Adherence to HIV Antiretroviral Therapy Using Multiplex Cathepsin Zymography
    Manu O Platt
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Drive, IBB 1308, Atlanta, GA, 30332, USA
    Mol Biotechnol 58:56-64. 2016
    ..Low cost of this electrophoresis-based assay makes it a prime candidate for implementation in resource-limited settings. ..
  3. pmc Sickle cell disease activates peripheral blood mononuclear cells to induce cathepsins k and v activity in endothelial cells
    Philip M Keegan
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
    Anemia 2012:201781. 2012
    ....
  4. pmc Patient specific proteolytic activity of monocyte-derived macrophages and osteoclasts predicted with temporal kinase activation states during differentiation
    Keon Young Park
    Department of Biomedical Engineering and Parker H Petit Institute of Bioengineering and Biosciences, Georgia Institute of Technology and Emory University, 315 Ferst Drive, Atlanta, GA 30332, USA
    Integr Biol (Camb) 4:1459-69. 2012
    ..Such analyses may provide beneficial tools for personalized kinase and protease inhibitor therapies for tissue destructive diseases...
  5. ncbi request reprint T-cell phosphokinome as a fingerprint of effective graft versus leukemia
    Manu O Platt
    Wallace H Coulter Department of Biomedical Engineering and Institute for Bioengineering and Biosciences, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
    Front Biosci (Elite Ed) 4:721-33. 2012
    ..Higher throughput methods to characterize these signals and different model systems will be discussed, along with benefits and challenges of using the T cell phosphokinome as a fingerprint to predict GvHD and GvL...
  6. pmc Multiplex zymography captures stage-specific activity profiles of cathepsins K, L, and S in human breast, lung, and cervical cancer
    Binbin Chen
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, GA 30332, Atlanta, USA
    J Transl Med 9:109. 2011
    ..Here, we have developed multiplex cathepsin zymography to profile cathepsins K, L, and S activity in 10 μg human breast, lung, and cervical tumors by exploiting unique electrophoretic mobility and renaturation properties...
  7. doi request reprint Sickle cell biomechanics
    Gilda A Barabino
    The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA
    Annu Rev Biomed Eng 12:345-67. 2010
    ..This review discusses the characterization of the biomechanical properties of sickle RBCs and sickle blood as well as their implications toward a better understanding of the pathophysiology of the disease...
  8. doi request reprint Efavirenz treatment causes arterial stiffening in apolipoprotein E-null mice
    Alexander W Caulk
    The George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive, IBB 2305, Atlanta, GA 30332, USA
    J Biomech 48:2176-80. 2015
    ..Taken together, these data suggest that EFV leads to arterial stiffening but, for the dose and duration tested, did not lead to elevated plaque progression in ApoE(-/-) mice...
  9. pmc Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues
    Catera L Wilder
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, 30332, USA
    Arch Biochem Biophys 516:52-7. 2011
    ....
  10. ncbi request reprint Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis
    Manu O Platt
    Wallace H Coulter Dept of Biomedical Engineering at Georgia Tech and Emory Univ, 308D WMB, Atlanta, GA 30322, USA
    Am J Physiol Heart Circ Physiol 292:H1479-86. 2007
    ..These findings suggest that cathepsin K is a mechanosensitive, extracellular matrix protease that, in turn, may be involved in arterial wall remodeling and atherosclerosis...