Robert M Nerem

Summary

Affiliation: Georgia Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Cell-based therapies: from basic biology to replacement, repair, and regeneration
    Robert M Nerem
    Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
    Biomaterials 28:5074-7. 2007
  2. ncbi request reprint The tissue engineering of blood vessels and the heart
    Robert M Nerem
    Georgia Tech Emory Center for the Engineering of Living Tissues, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA
    Am J Transplant 4:36-42. 2004
  3. pmc Regenerative medicine: the emergence of an industry
    Robert M Nerem
    Parker H Petit Institute for Bioengineering and Bioscience, Georgia Tech Emory Center for Regenerative Medicine, Georgia Institute of Technology, 315 Ferst Drive, NW, Atlanta, GA 30332 0363, USA
    J R Soc Interface 7:S771-5. 2010
  4. ncbi request reprint Role of mechanics in vascular tissue engineering
    Robert M Nerem
    Petit Institute for Bioengineering and Bioscience, 315 Ferst Drive, Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
    Biorheology 40:281-7. 2003
  5. ncbi request reprint Tissue engineering of the vascular system
    R M Nerem
    Georgia Tech Emory Center for the Engineering of Living Tissues, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta 30332 0363, USA
    Vox Sang 87:158-60. 2004
  6. ncbi request reprint Vascular tissue engineering
    R M Nerem
    Georgia Tech Emory Center for the Engineering of Living Tissues, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332 0363, USA
    Annu Rev Biomed Eng 3:225-43. 2001
  7. ncbi request reprint Tissue engineering a blood vessel substitute: the role of biomechanics
    R M Nerem
    Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta 30332 0363, USA
    Yonsei Med J 41:735-9. 2000
  8. ncbi request reprint Incorporation of intact elastin scaffolds in tissue-engineered collagen-based vascular grafts
    Joseph D Berglund
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Tissue Eng 10:1526-35. 2004
  9. doi request reprint Strain magnitude-dependent calcific marker expression in valvular and vascular cells
    Zannatul Ferdous
    Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA
    Cells Tissues Organs 197:372-83. 2013
  10. pmc Fluid shear stress alters the hemostatic properties of endothelial outgrowth cells
    Ann E Ensley
    Parker H Petit Institute for Bioengineering and Bioscience and Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
    Tissue Eng Part A 18:127-36. 2012

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Cell-based therapies: from basic biology to replacement, repair, and regeneration
    Robert M Nerem
    Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
    Biomaterials 28:5074-7. 2007
    ..Long-term clinical therapies and treatments must move beyond the replacement of tissues and organs to the harnessing of the intrinsic repair and regenerative potential of the human body...
  2. ncbi request reprint The tissue engineering of blood vessels and the heart
    Robert M Nerem
    Georgia Tech Emory Center for the Engineering of Living Tissues, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA
    Am J Transplant 4:36-42. 2004
    ..Even though the progress has been considerable and there are even some approaches that have entered clinical trials, we are still a ways off from having FDA-approved replacements and/or repair strategies...
  3. pmc Regenerative medicine: the emergence of an industry
    Robert M Nerem
    Parker H Petit Institute for Bioengineering and Bioscience, Georgia Tech Emory Center for Regenerative Medicine, Georgia Institute of Technology, 315 Ferst Drive, NW, Atlanta, GA 30332 0363, USA
    J R Soc Interface 7:S771-5. 2010
    ..Thus, there is the indication that this industry, and the related technology, may still achieve its potential and address the needs of millions of patients worldwide, in particular those with needs that currently are unmet...
  4. ncbi request reprint Role of mechanics in vascular tissue engineering
    Robert M Nerem
    Petit Institute for Bioengineering and Bioscience, 315 Ferst Drive, Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
    Biorheology 40:281-7. 2003
    ..Thus, the proper incorporation of biomechanics into the design of a vascular substitute is critical to achieving success...
  5. ncbi request reprint Tissue engineering of the vascular system
    R M Nerem
    Georgia Tech Emory Center for the Engineering of Living Tissues, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta 30332 0363, USA
    Vox Sang 87:158-60. 2004
  6. ncbi request reprint Vascular tissue engineering
    R M Nerem
    Georgia Tech Emory Center for the Engineering of Living Tissues, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332 0363, USA
    Annu Rev Biomed Eng 3:225-43. 2001
    ..Specific examples are discussed to illustrate both the benefits and shortcomings of each methodology, as well as to underline common themes. Finally, a brief perspective on challenges for the future is presented...
  7. ncbi request reprint Tissue engineering a blood vessel substitute: the role of biomechanics
    R M Nerem
    Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta 30332 0363, USA
    Yonsei Med J 41:735-9. 2000
    ..Only if an engineered blood vessel substitute possesses all of these functional characteristics, can one say that the functionality exhibited by a native vessel is being mimicked...
  8. ncbi request reprint Incorporation of intact elastin scaffolds in tissue-engineered collagen-based vascular grafts
    Joseph D Berglund
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Tissue Eng 10:1526-35. 2004
    ..Future challenges include stimulating appropriate reorganization or synthesis of the collagen matrix to provide the necessary strength and viscoelastic properties for implantation...
  9. doi request reprint Strain magnitude-dependent calcific marker expression in valvular and vascular cells
    Zannatul Ferdous
    Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA
    Cells Tissues Organs 197:372-83. 2013
    ..Our results suggest that cellular differences exist between vascular and valvular cells in their response to altered levels of cyclic strain during calcification...
  10. pmc Fluid shear stress alters the hemostatic properties of endothelial outgrowth cells
    Ann E Ensley
    Parker H Petit Institute for Bioengineering and Bioscience and Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
    Tissue Eng Part A 18:127-36. 2012
    ..Accordingly, manipulation of EOC phenotype by mechanical forces may be important for the development of thrombo-resistant surfaces on engineered vascular implants...
  11. ncbi request reprint Phenotype modulation in vascular tissue engineering using biochemical and mechanical stimulation
    Jan P Stegemann
    Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
    Ann Biomed Eng 31:391-402. 2003
    ....
  12. doi request reprint Human mesenchymal stem cells form multicellular structures in response to applied cyclic strain
    Adele M Doyle
    Parker H Petit Institute for Biomedical Engineering and Biosciences, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332 0363, USA
    Ann Biomed Eng 37:783-93. 2009
    ..This system can thus be used to study the mechanoresponse over hours to days of MSCs exposed to applied cyclic strain in the context of cell-cell and cell-matrix interactions...
  13. ncbi request reprint Embryonic stem cell-derived endothelial cells may lack complete functional maturation in vitro
    Kara E McCloskey
    The Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA
    J Vasc Res 43:411-21. 2006
    ..These results indicate that ESC-derived EC share some key characteristics of 'mature' EC, while retaining markers of alternate phenotypes including immature endothelium...
  14. ncbi request reprint Use of embryonic stem cell-derived endothelial cells as a cell source to generate vessel structures in vitro
    Kara E McCloskey
    The Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Tissue Eng 11:497-505. 2005
    ....
  15. ncbi request reprint Mechanical, biochemical, and extracellular matrix effects on vascular smooth muscle cell phenotype
    Jan P Stegemann
    Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Appl Physiol 98:2321-7. 2005
    ..Future improvements in creating more complex in vitro culture environments will lead to a better understanding of VSMC biology, new treatments for vascular disease, as well as improved blood vessel substitutes...
  16. ncbi request reprint Valvular endothelial cells regulate the phenotype of interstitial cells in co-culture: effects of steady shear stress
    Jonathan T Butcher
    Petit Institute for Bioengineering and Bioscience, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, 30332, USA
    Tissue Eng 12:905-15. 2006
    ..Additionally, we show that tissue-engineered models can be used to discover and understand complex biomechanical relationships between cells that interact in vivo...
  17. ncbi request reprint Viscoelastic testing methodologies for tissue engineered blood vessels
    Joseph D Berglund
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Biomech Eng 127:1176-84. 2005
    ..These findings emphasize the importance of viscoelastic characterization when evaluating the mechanical performance of TEBVs. Limits of testing methods and modeling systems are presented and discussed...
  18. ncbi request reprint Equibiaxial strain stimulates fibroblastic phenotype shift in smooth muscle cells in an engineered tissue model of the aortic wall
    Jonathan T Butcher
    Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA
    Biomaterials 27:5252-8. 2006
    ..We conclude that this system is effective in stimulating cells with cyclic equibiaxial strain in 3D cultures, and can be applied to a variety of biomaterial and tissue engineering applications...
  19. ncbi request reprint In vitro derivation and expansion of endothelial cells from embryonic stem cells
    Kara E McCloskey
    School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, USA
    Methods Mol Biol 330:287-301. 2006
    ..Using this in vitro derivation procedure, millions of cells at various stages of differentiation may be obtained and expanded up to 25 population doublings...
  20. ncbi request reprint Properties of engineered vascular constructs made from collagen, fibrin, and collagen-fibrin mixtures
    Christopher L Cummings
    Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Biomaterials 25:3699-706. 2004
    ..These results demonstrate that the properties of engineered vascular tissues can be modulated by the combination of selected extracellular matrix components, and the application of mechanical stimulation...
  21. ncbi request reprint Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences: influence of shear stress
    Jonathan T Butcher
    Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA
    Arterioscler Thromb Vasc Biol 26:69-77. 2006
    ..The similarities between valvular and vascular lesions suggest pathological initiation mediated through endothelium, but the role of hemodynamics in valvular endothelial biology is poorly understood...
  22. pmc Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells
    Casey J Holliday
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
    Am J Physiol Heart Circ Physiol 301:H856-67. 2011
    ..Using miRWalk and several filtering steps, we identified shear-sensitive mRNAs potentially targeted by shear-sensitive miRNAs. These genes and signaling pathways could act as therapeutic targets of AV disease...
  23. ncbi request reprint Porcine aortic valve interstitial cells in three-dimensional culture: comparison of phenotype with aortic smooth muscle cells
    Jonathan T Butcher
    Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332, USA
    J Heart Valve Dis 13:478-85; discussion 485-6. 2004
    ..The study aim was to compare the phenotype of porcine aortic valve interstitial cells (PAVICs) and porcine aortic smooth muscle cells (PASMCs) in two-dimensional cultures and within three-dimensional (3D) collagen gels...
  24. pmc Tissue engineering of a collagen-based vascular media: Demonstration of functionality
    Stacey C Schutte
    Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA
    Organogenesis 6:204-11. 2010
    ..This highlights the need for functional testing of engineered tissue and the importance of cell-matrix interactions in vasoactivity...
  25. ncbi request reprint Altered response of vascular smooth muscle cells to exogenous biochemical stimulation in two- and three-dimensional culture
    Jan P Stegemann
    Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
    Exp Cell Res 283:146-55. 2003
    ..These findings have implications for the study of vascular biology in vitro, as well as for the development of engineered vascular tissues...
  26. ncbi request reprint Genetic modification of smooth muscle cells to control phenotype and function in vascular tissue engineering
    Jan P Stegemann
    Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332 0363, USA
    Tissue Eng 10:189-99. 2004
    ....
  27. ncbi request reprint Endothelial connexin 37, connexin 40, and connexin 43 respond uniquely to substrate and shear stress
    Tiffany L Johnson
    Georgia Tech Emory Center for the Engineering of Living Tissues, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA
    Endothelium 14:215-26. 2007
    ..Individual isotypes show differential responses and RNAi knockdown provides new insight into connexin function and potential roles in the vasculature...
  28. ncbi request reprint Purified and proliferating endothelial cells derived and expanded in vitro from embryonic stem cells
    Kara E McCloskey
    Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Endothelium 10:329-36. 2003
    ..Our findings indicate that it is possible to obtain proliferating populations of homogeneous endothelial cells from mouse ES cells without genetically manipulating the ES cells or coculturing with feeder cells...
  29. pmc Dynamic shear stress regulation of inflammatory and thrombotic pathways in baboon endothelial outgrowth cells
    Randall F Ankeny
    Parker H Petit Institute for Bioengineering and Bioscience and Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Tissue Eng Part A 19:1573-82. 2013
    ..Further, these results suggest SS hemodynamic preconditioning may be optimal in increasing the efficacy of a vascular implant or in tissue-engineered applications that have incorporated EOCs...
  30. doi request reprint Vessel wall-embedded dendritic cells induce T-cell autoreactivity and initiate vascular inflammation
    Ji W Han
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 102:546-53. 2008
    ..DCs are superior in sensing pathogen-derived motifs and are highly efficient in breaking T-cell tolerance, guiding T cells toward proinflammatory and tissue-invasive behavior...
  31. ncbi request reprint Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments
    Jonathan T Butcher
    Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Arterioscler Thromb Vasc Biol 24:1429-34. 2004
    ....
  32. ncbi request reprint A biological hybrid model for collagen-based tissue engineered vascular constructs
    Joseph D Berglund
    School of Chemical Engineering, Georgia Institute of Technology, 30332, Atlanta, GA, USA
    Biomaterials 24:1241-54. 2003
    ..Construct compaction, cell viability, and histological examination demonstrated that the function of most cells remained unimpaired with the incorporation of the biological support sleeve...
  33. ncbi request reprint Mechanical strain-stimulated remodeling of tissue-engineered blood vessel constructs
    Dror Seliktar
    Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA
    Tissue Eng 9:657-66. 2003
    ..Taken together, these results illustrate the importance of mechanical stimulus as a major regulatory component of tissue-engineered blood vessel remodeling...
  34. ncbi request reprint Human platelet lysate stimulates high-passage and senescent human multipotent mesenchymal stromal cell growth and rejuvenation in vitro
    Sarah Griffiths
    The Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA
    Cytotherapy 15:1469-83. 2013
    ..Recently, pooled human platelet lysate (hPL) has been used as a culture supplement to promote MSC growth; however, the effects of hPL on MSCs after fetal bovine serum (FBS) exposure remain unknown...
  35. doi request reprint Cyclic strain improves strength and function of a collagen-based tissue-engineered vascular media
    Stacey C Schutte
    Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Tissue Eng Part A 16:3149-57. 2010
    ..Mechanical stimulation promoted a more contractile phenotype and led to a greater contractile response to the vasoconstrictor endothelin-1...
  36. ncbi request reprint Poly(glycerol sebacate) supports the proliferation and phenotypic protein expression of primary baboon vascular cells
    Jin Gao
    Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Biomed Mater Res A 83:1070-5. 2007
    ..These results suggest that PGS is an appropriate scaffold material for blood vessel tissue engineering...
  37. pmc Differences in valvular and vascular cell responses to strain in osteogenic media
    Zannatul Ferdous
    Institute of Bioengineering and Biosciences, Georgia Institute of Technology, 315 Ferst Drive, Mail code 0363, Atlanta, GA 30332, USA
    Biomaterials 32:2885-93. 2011
    ..Further investigation is necessary for improved understanding and to detect biomarkers for early detection or prevention of these diseases...
  38. ncbi request reprint Fluid-induced shear stress stimulates chondrocyte proliferation partially mediated via TGF-beta1
    Prasanna Malaviya
    Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA
    Tissue Eng 8:581-90. 2002
    ..These results show that fluid shear stress upregulates chondrocyte proliferation and that this effect is partially mediated by TGF-beta1...
  39. ncbi request reprint The role of matrix metalloproteinase-2 in the remodeling of cell-seeded vascular constructs subjected to cyclic strain
    D Seliktar
    Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, USA
    Ann Biomed Eng 29:923-34. 2001
    ..Our observations suggest that a better understanding of the complex relation between mechanical stimulation and construct remodeling is key for the proper design of tissue-engineered blood vessel substitutes...
  40. ncbi request reprint Dynamic mechanical conditioning of collagen-gel blood vessel constructs induces remodeling in vitro
    D Seliktar
    Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta 30332 0363, USA
    Ann Biomed Eng 28:351-62. 2000
    ..This concept, in conjunction with a proper biochemical environment, could present a better model for engineering vascular constructs...
  41. pmc Fluid shear stress pre-conditioning promotes endothelial morphogenesis of embryonic stem cells within embryoid bodies
    Barbara A Nsiah
    1 George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia
    Tissue Eng Part A 20:954-65. 2014
    ..Together, these studies highlight a novel approach to promote in vitro morphogenesis of developmental vasculogenic models and potentially promote pre-vascularization of tissue-engineered constructs derived from pluripotent stem cells. ..
  42. ncbi request reprint Maintenance of a functional endothelial cell monolayer on a fibroblast/polymer substrate under physiologically relevant shear stress conditions
    Linda G Braddon
    Georgia Institute of Technology, Atlanta, Georgia, USA
    Tissue Eng 8:695-708. 2002
    ..These results demonstrate that a fibroblast/polymer scaffold can serve as a suitable substrate for ECs and that such a monolayer demonstrates the normal EC responsiveness to flow...
  43. ncbi request reprint Tissue engineering: the hope, the hype, and the future
    Robert M Nerem
    Georgia Tech Emory Center for the Engineering of Living Tissues, Georgia Institute of Technology, Atlanta, Georgia, USA
    Tissue Eng 12:1143-50. 2006
  44. ncbi request reprint Bioengineered tissues: the science, the technology, and the industry
    T Ahsan
    Georgia Tech Emory Center for the Engineering of Living Tissues, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
    Orthod Craniofac Res 8:134-40. 2005
    ..The goal is the repair, replacement, and/or the regeneration of tissues and organs. The objective of this paper is to identify and discuss the major issues that have become apparent...
  45. ncbi request reprint The response of endothelial cells to fluid shear stress using a co-culture model of the arterial wall
    B Imberti
    Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
    Endothelium 9:11-23. 2002
    ..These results suggest that EC response to fluid shear stress in a collagen co-culture model is influenced by the underlying substrate, and one that in this study is modified by strain preconditioning...
  46. ncbi request reprint Mechanical compression alters gene expression and extracellular matrix synthesis by chondrocytes cultured in collagen I gels
    Christopher J Hunter
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta 30332 0535, USA
    Biomaterials 23:1249-59. 2002
    ..This suggests that mechanical stimuli may be useful in modulating chondrocyte metabolism in tissue engineering systems using fibrillar protein scaffolds...
  47. ncbi request reprint Tissue engineering: confronting the transplantation crisis
    Robert M Nerem
    Georgia Tech Emory Center For the Engineering of Living Tissue, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332 0363, USA
    Adv Exp Med Biol 534:1-9. 2003
  48. ncbi request reprint Uniaxial strain upregulates matrix-degrading enzymes produced by human vascular smooth muscle cells
    Kazuhiko Asanuma
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30332, USA
    Am J Physiol Heart Circ Physiol 284:H1778-84. 2003
    ..We suggest that local increases in stationary mechanical strain resulting from stenting, hypertension, or atherosclerosis may lead to enhanced matrix degradation by SMC...
  49. ncbi request reprint Modeling of cryopreservation of engineered tissues with one-dimensional geometry
    Z F Cui
    Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, USA
    Biotechnol Prog 18:354-61. 2002
    ..The outcome of such a model study can be used to evaluate the construct design on its survivability during cryopreservation and to select a cryopreservation protocol to achieve maximum cell survival...
  50. ncbi request reprint Tissue engineering: confronting the transplantation crisis
    R M Nerem
    Georgia Tech Emory Center for the Engineering of Living Tissues, Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta 30332 0363, USA
    Proc Inst Mech Eng H 214:95-9. 2000
    ..With the development of these core technologies, tissue engineering will evolve from an art form to a technology based on science and engineering...
  51. ncbi request reprint Editorial: advancing tissue engineering and regenerative medicine
    Kiki B Hellman
    Tissue Eng 13:2823-4. 2007
  52. ncbi request reprint Potential of baboon endothelial progenitor cells for tissue engineered vascular grafts
    Monica T Hinds
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biomed Mater Res A 86:804-12. 2008
    ..Thus while the lack of eNOS expression is worthy of investigation, EPCs are an attractive cell source for tissue engineered vascular grafts and the baboon model has great potential for continuing evaluations of these cells...
  53. pmc Valvular endothelial cells and the mechanoregulation of valvular pathology
    Jonathan T Butcher
    Department of Biomedical Engineering, 270 Olin Hall, Cornell University, Ithaca, NY 14850, USA
    Philos Trans R Soc Lond B Biol Sci 362:1445-57. 2007
    ..Further understanding of these mechanisms may help lead to earlier diagnostic tools and therapeutic strategies...