Alfred H Merrill Jr

Summary

Affiliation: Georgia Institute of Technology
Country: USA

Publications

  1. ncbi request reprint De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway
    Alfred H Merrill
    School of Biology, Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332 0230, USA
    J Biol Chem 277:25843-6. 2002
  2. ncbi request reprint Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action
    David S Menaldino
    Department of Chemistry, Emory University, Atlanta, GA 30322 0230, USA
    Pharmacol Res 47:373-81. 2003
  3. ncbi request reprint (Glyco)sphingolipidology: an amazing challenge and opportunity for systems biology
    Alfred H Merrill
    School of Biology, Chemistry and Biochemistry, The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Trends Biochem Sci 32:457-68. 2007
  4. doi request reprint Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
    Elad L Laviad
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 283:5677-84. 2008
  5. pmc Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons
    Terina N Martinez
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Rd, Dallas, TX 75390, USA
    Mol Neurodegener 7:45. 2012
  6. pmc An introduction to sphingolipid metabolism and analysis by new technologies
    Yanfeng Chen
    School of Chemistry and Biochemistry, The Wallace H Coulter Department of Biomedical Engineering and the Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Neuromolecular Med 12:306-19. 2010
  7. pmc Elevation of sulfatides in ovarian cancer: an integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry
    Ying Liu
    School of Biology and the Petit Institute for Bioscience and Bioengineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, Georgia 30332 0363, USA
    Mol Cancer 9:186. 2010
  8. pmc Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism
    Shakti Gupta
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    BMC Syst Biol 5:26. 2011
  9. pmc Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and disease
    Alfred H Merrill
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Lipid Res 50:S97-102. 2009
  10. ncbi request reprint Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry
    Alfred H Merrill
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332 0230, USA
    Methods 36:207-24. 2005

Research Grants

  1. STRUCTURE/FUNCTION STUDIES OF LONG-CHAIN BASES
    ALFRED MERRILL; Fiscal Year: 2003
  2. MODULATION BY GROWTH FACTORS AND SIGNAL TRANSDUCTION
    ALFRED MERRILL; Fiscal Year: 2003
  3. Role of Small GTPases in Muscarinic Receptor Trafficking
    ALFRED MERRILL; Fiscal Year: 2005
  4. 2006 Glycolipid & Sphingolipid Gordon Conference
    ALFRED MERRILL; Fiscal Year: 2006
  5. Characterization of mammalian ceramide synthases
    ALFRED MERRILL; Fiscal Year: 2007
  6. 2006 Glycolipid & Sphingolipid Gordon Conference
    ALFRED MERRILL; Fiscal Year: 2007
  7. Characterization of mammalian ceramide synthases
    ALFRED MERRILL; Fiscal Year: 2009
  8. Gordon Conference on Glycolipid & Sphingolipid Biology
    ALFRED MERRILL; Fiscal Year: 2002
  9. STRUCTURE/FUNCTION STUDIES OF LONG-CHAIN BASES
    ALFRED MERRILL; Fiscal Year: 1993
  10. STRUCTURE/FUNCTION STUDIES OF LONG-CHAIN BASES
    ALFRED MERRILL; Fiscal Year: 1999

Collaborators

Detail Information

Publications51

  1. ncbi request reprint De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway
    Alfred H Merrill
    School of Biology, Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332 0230, USA
    J Biol Chem 277:25843-6. 2002
  2. ncbi request reprint Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action
    David S Menaldino
    Department of Chemistry, Emory University, Atlanta, GA 30322 0230, USA
    Pharmacol Res 47:373-81. 2003
    ..Through studying such compounds, there is now a greater understanding of the metabolism and mechanism(s) of action of naturally occurring sphingoid bases as well as of these analogs...
  3. ncbi request reprint (Glyco)sphingolipidology: an amazing challenge and opportunity for systems biology
    Alfred H Merrill
    School of Biology, Chemistry and Biochemistry, The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Trends Biochem Sci 32:457-68. 2007
    ..Dealing with such large data sets poses special challenges for systems biology, but the intrinsic and elegant interrelationships among these compounds might provide a key to dealing with the complexity of the sphingolipidome...
  4. doi request reprint Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
    Elad L Laviad
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 283:5677-84. 2008
    ....
  5. pmc Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons
    Terina N Martinez
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Rd, Dallas, TX 75390, USA
    Mol Neurodegener 7:45. 2012
    ..Here we investigated the contribution of ceramide sphingolipid signaling in TNF-dependent toxicity...
  6. pmc An introduction to sphingolipid metabolism and analysis by new technologies
    Yanfeng Chen
    School of Chemistry and Biochemistry, The Wallace H Coulter Department of Biomedical Engineering and the Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Neuromolecular Med 12:306-19. 2010
    ..This review summarizes the basic metabolism of SP and state-of-art mass spectrometric techniques that are producing insights into SP structure, metabolism, functions, and some of the dysfunctions of relevance to neuromedicine...
  7. pmc Elevation of sulfatides in ovarian cancer: an integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry
    Ying Liu
    School of Biology and the Petit Institute for Bioscience and Bioengineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, Georgia 30332 0363, USA
    Mol Cancer 9:186. 2010
    ....
  8. pmc Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism
    Shakti Gupta
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    BMC Syst Biol 5:26. 2011
    ....
  9. pmc Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and disease
    Alfred H Merrill
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Lipid Res 50:S97-102. 2009
    ....
  10. ncbi request reprint Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry
    Alfred H Merrill
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332 0230, USA
    Methods 36:207-24. 2005
    ..Also discussed are some of the issues remaining to be resolved in the analysis of the full sphingolipidome...
  11. pmc Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers
    Rebecca L Shaner
    Schools of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332 0230, USA
    J Lipid Res 50:1692-707. 2009
    ..The application of these methods is illustrated with RAW264.7 cells, a mouse macrophage cell line. These methods should be useful for a wide range of focused (sphingo)lipidomic investigations...
  12. doi request reprint An interactive visualization tool and data model for experimental design in systems biology
    Shray Kapoor
    College of Computing, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:2423-6. 2008
    ..We aim to build a comprehensive and interactive communication platform to improve experimental design for scientists globally in high-throughput lipid systems biology research...
  13. ncbi request reprint Computational modeling of a metabolic pathway in ceramide de novo synthesis
    Shobhika Dhingra
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:1405-8. 2007
    ..Our future work includes more experimental validation of the model, dynamic rate constants assessment, and expansion of the model to include additional enzymes in the ceramide de novo synthesis pathway...
  14. pmc Adaptive control model reveals systematic feedback and key molecules in metabolic pathway regulation
    Chang F Quo
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
    J Comput Biol 18:169-82. 2011
    ..This new modeling approach and the implementation routines designed for this case study may be extended to other systems. Supplementary Material is available at www.liebertonline.com/cmb ...
  15. ncbi request reprint Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy
    Wenjing Zheng
    School of Biology, Chemistry and Biochemistry, Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332 0230, USA
    Biochim Biophys Acta 1758:1864-84. 2006
    ....
  16. pmc Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols
    Sarah T Pruett
    Department of Chemistry, Emory University, Atlanta, GA 30322, USA
    J Lipid Res 49:1621-39. 2008
    ..This thematic review gives an overview of the biodiversity of the backbones of sphingolipids and the broader field of naturally occurring and synthetic sphingoid base-like compounds...
  17. ncbi request reprint Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis
    Kena Desai
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332 0230, USA
    Biochim Biophys Acta 1585:188-92. 2002
    ..These findings underscore the complexity of sphingolipid metabolism and the difficulty of identifying the pertinent mediators unless a full profile of the potentially bioactive species is evaluated...
  18. ncbi request reprint Structure-specific, quantitative methods for analysis of sphingolipids by liquid chromatography-tandem mass spectrometry: "inside-out" sphingolipidomics
    M Cameron Sullards
    School of Biology, and the Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA
    Methods Enzymol 432:83-115. 2007
    ....
  19. pmc Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies
    Hyejung Park
    School of Biology and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Lipid Res 51:480-9. 2010
    ....
  20. doi request reprint Imaging MALDI mass spectrometry using an oscillating capillary nebulizer matrix coating system and its application to analysis of lipids in brain from a mouse model of Tay-Sachs/Sandhoff disease
    Yanfeng Chen
    School of Chemistry and Biochemistry, The Parker H Petit Institute for Bioengineering and Bioscience, 315 Ferst Drive, Georgia Institute of Technology, Atlanta, Georgia 30332 0363, USA
    Anal Chem 80:2780-8. 2008
    ..These results illustrate the usefulness of tissue-imaging MALDI-MS with matrix deposition by OCN for histologic comparison of lipids in tissues such as brains from this mouse model of Tay-Sachs and Sandhoff disease...
  21. pmc Steroidogenic factor-1 is a sphingolipid binding protein
    Aarti N Urs
    School of Biology and the Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 310 Ferst Drive, Atlanta, GA 30332 0230, United States
    Mol Cell Endocrinol 265:174-8. 2007
    ..Finally, these findings highlight a central role for bioactive lipids as mediators of trophic hormone-stimulated steroid hormone biosynthesis...
  22. pmc Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17
    Donghui Li
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332 0230, USA
    Mol Cell Biol 27:6669-85. 2007
    ..We conclude that ACTH/cAMP stimulates PA production in the nucleus of H295R cells and that this increase in PA concentrations facilitates CYP17 induction...
  23. ncbi request reprint ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism
    Tuba Ozbay
    School of Biology, Parker H Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia, USA
    Endocr Res 30:787-94. 2004
    ..Finally, these findings suggest that sphingolipids may serve as signaling mediators in ACTH-stimulated cortisol biosynthesis...
  24. ncbi request reprint Synthesis of 1-deoxysphingosine derivatives with conformationally restricted pyrrolidinediol head groups
    Ann M Dougherty
    Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA
    Org Lett 8:649-52. 2006
    ..The synthetic chemistry for pyrrolidine ring closure at C3-C4 features ring-closing metathesis followed by hydroboration-oxidation...
  25. doi request reprint Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer
    Holly Symolon
    School of Biology, 310 Ferst Drive, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Mol Cancer Ther 10:648-57. 2011
    ..Thus, Enigmol represents a novel category of sphingoid base analogue that is orally bioavailable and has the potential to be effective against multiple types of cancer...
  26. ncbi request reprint Safingol toxicology after oral administration to TRAMP mice: demonstration of safingol uptake and metabolism by N-acylation and N-methylation
    Pablo R Morales
    Division of Animal Resources, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Drug Chem Toxicol 30:197-216. 2007
    ..Safingol and its N-methyl metabolites were cytotoxic to both a human prostate cell line (DU145) and mouse BALB 3T3 cells; therefore, the host and potential antitumor toxicity may be due to multiple molecular species of safingol...
  27. ncbi request reprint Dietary soy sphingolipids suppress tumorigenesis and gene expression in 1,2-dimethylhydrazine-treated CF1 mice and ApcMin/+ mice
    Holly Symolon
    Program in Nutrition and Health Science, Emory University, Atlanta, GA 30322, USA
    J Nutr 134:1157-61. 2004
    ..Because soy contains relatively high amounts of GlcCer, sphingolipids may partially account for the anticancer benefits attributed to soy-based foods...
  28. pmc Imaging MALDI mass spectrometry of sphingolipids using an oscillating capillary nebulizer matrix application system
    Yanfeng Chen
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA
    Methods Mol Biol 656:131-46. 2010
    ..In addition, the observation of numerous lipid subclasses with distinct localizations in the brain slices demonstrates that imaging MALDI-MS could be effectively used for "lipidomic" studies...
  29. pmc Serine palmitoyltransferase subunit 1 is present in the endoplasmic reticulum, nucleus and focal adhesions, and functions in cell morphology
    Jia Wei
    Petit Institute for Bioengineering and Bioscience, Atlanta, GA 30332, USA
    Biochim Biophys Acta 1791:746-56. 2009
    ..Thus, in addition to its "traditional" localization in the ER for de novo sphingolipid biosynthesis, SPT1 is present in other cellular compartments, including focal adhesions where it is associated with cell morphology...
  30. pmc Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy
    Kacee Sims
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Biol Chem 285:38568-79. 2010
    ....
  31. pmc Quantitation of fatty acyl-coenzyme As in mammalian cells by liquid chromatography-electrospray ionization tandem mass spectrometry
    Christopher A Haynes
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332 0230, USA
    J Lipid Res 49:1113-25. 2008
    ..This simple and robust method should facilitate the inclusion of this family of compounds in "lipidomics" and "metabolomics" studies...
  32. doi request reprint N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing
    Hongtao Wang
    Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Mol Cancer Ther 7:2967-76. 2008
    ..These studies suggest that enhanced clinical efficacy of 4-HPR may be realized through regimens containing agents that modulate sphingoid base metabolism...
  33. ncbi request reprint Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors
    Christian Riebeling
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 278:43452-9. 2003
    ..and Futerman, A. H. (2002) FEBS Lett. 528, 3-4) that Lag1p family members regulate (dihydro)ceramide synthases responsible for production of sphingolipids containing different fatty acids...
  34. ncbi request reprint Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis
    Ulrike Reiss
    Children s Hospital Oakland Research Institute, Oakland, California 94609 1673, USA
    J Biol Chem 279:1281-90. 2004
    ....
  35. pmc Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy
    Todd E Fox
    Department of Pharmacology H078, Penn State College of Medicine, Hershey, PA 17033, USA
    Diabetes 55:3573-80. 2006
    ..Thus, dysfunctional glycosphingolipid metabolism may contribute to metabolic stress in diabetes, and therapeutic strategies to restore normal sphingolipid metabolism may be a viable approach for treatment of diabetic retinopathy...
  36. ncbi request reprint Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites
    Michaela Seiferlein
    Institute for Food Chemistry, University of Munster, Munster, Germany
    Mol Nutr Food Res 51:1120-30. 2007
    ..The contribution of acylated HFB1 and HFB2 metabolites to fumonisin toxicity in vivo warrants further investigation...
  37. ncbi request reprint SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism
    Michael Maceyka
    Department of Biochemistry, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    J Biol Chem 280:37118-29. 2005
    ..Our results demonstrate that SphK1 and SphK2 have opposing roles in the regulation of ceramide biosynthesis and suggest that the location of sphingosine 1-phosphate production dictates its functions...
  38. ncbi request reprint Sphingolipid metabolism and signaling minireview series
    William L Smith
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 277:25841-2. 2002
  39. ncbi request reprint Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells
    Krishnan Venkataraman
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 277:35642-9. 2002
    ....
  40. pmc Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide
    Paola Giussani
    Department of Biochemistry, Virginia Commonwealth University School of Medicine, 1101 E Marshall Street, Room 2 011 Sanger Hall, Richmond, VA 23298 0614, USA
    Mol Cell Biol 26:5055-69. 2006
    ..Our results suggest that SPP-1 regulates ceramide levels in the ER and thus influences the anterograde membrane transport of both ceramide and proteins from the ER to the Golgi apparatus...
  41. ncbi request reprint Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus
    Mihaela Dragusin
    Kekulé Institute for Organic Chemistry and Biochemistry, University Bonn, Germany
    FASEB J 20:1930-2. 2006
    ..Thus, the sustained elevated concentration of the two bioactive sphingolipids in this tissue could at least in part explain postoperative intestinal dysmotility...
  42. ncbi request reprint The cell surface glycosphingolipids SSEA-3 and SSEA-4 are not essential for human ESC pluripotency
    Sandii N Brimble
    Novocell, Athens, Georgia, USA
    Stem Cells 25:54-62. 2007
    ....
  43. pmc LMSD: LIPID MAPS structure database
    Manish Sud
    LIPID MAPS Bioinformatics Core, San Diego Supercomputer Center San Diego, La Jolla, CA 92093, USA
    Nucleic Acids Res 35:D527-32. 2007
    ..Search results, in addition to structure and annotations, also include relevant links to external databases. The LMSD is publicly available at www.lipidmaps.org/data/structure/...
  44. ncbi request reprint Aging up-regulates expression of inflammatory mediators in mouse adipose tissue
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer Unites States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Immunol 179:4829-39. 2007
    ....
  45. ncbi request reprint Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis
    Nadia F Lamour
    Department of Biochemistry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Lipid Res 48:1293-304. 2007
    ..In conclusion, these results demonstrate that CERK localizes to areas of eicosanoid synthesis and uses a ceramide "pool" transported in an active manner via CERT...
  46. pmc Ceramide transfer protein function is essential for normal oxidative stress response and lifespan
    Raghavendra Pralhada Rao
    Laboratory of Cell and Developmental Signaling, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 104:11364-9. 2007
    ....
  47. ncbi request reprint Activity of partially inhibited serine palmitoyltransferase is sufficient for normal sphingolipid metabolism and viability of HSN1 patient cells
    Vadim N Dedov
    Neurobiology Laboratory, ANZAC Research Institute, Concord Repatriation General Hospital, Hospital Road, Concord, NSW 2139, Australia
    Biochim Biophys Acta 1688:168-75. 2004
    ....
  48. ncbi request reprint Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize
    Walter F O Marasas
    Medical Research Council, PROMEC Unit, Tygerberg 7505, South Africa
    J Nutr 134:711-6. 2004
    ..Hence, we propose that fumonisins are potential risk factors for NTD, craniofacial anomalies, and other birth defects arising from neural crest cells because of their apparent interference with folate utilization...
  49. ncbi request reprint Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity
    Martha M Monick
    Division of Pulmonary, Critical Care, and Occupational Medicine, Roy J and Lucille A Carver College of Medicine, Eckstein Medical Research Building Room 100, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 173:123-35. 2004
    ..These studies suggest an important role for sphingolipids in prolonging survival of human alveolar macrophages via distinct survival pathways...
  50. pmc Human cytomegalovirus regulates bioactive sphingolipids
    Nicholas J Machesky
    Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 283:26148-60. 2008
    ..Together, these findings demonstrate that host cell sphingolipids are dynamically regulated upon infection with a herpes virus in a manner that impacts virus replication...
  51. ncbi request reprint A comprehensive classification system for lipids
    Eoin Fahy
    San Diego Supercomputer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0505, USA
    J Lipid Res 46:839-61. 2005
    ..This structured vocabulary will facilitate the systematization of lipid biology and enable the cataloging of lipids and their properties in a way that is compatible with other macromolecular databases...

Research Grants28

  1. STRUCTURE/FUNCTION STUDIES OF LONG-CHAIN BASES
    ALFRED MERRILL; Fiscal Year: 2003
    ....
  2. MODULATION BY GROWTH FACTORS AND SIGNAL TRANSDUCTION
    ALFRED MERRILL; Fiscal Year: 2003
    ..abstract_text> ..
  3. Role of Small GTPases in Muscarinic Receptor Trafficking
    ALFRED MERRILL; Fiscal Year: 2005
    ..abstract_text> ..
  4. 2006 Glycolipid & Sphingolipid Gordon Conference
    ALFRED MERRILL; Fiscal Year: 2006
    ....
  5. Characterization of mammalian ceramide synthases
    ALFRED MERRILL; Fiscal Year: 2007
    ....
  6. 2006 Glycolipid & Sphingolipid Gordon Conference
    ALFRED MERRILL; Fiscal Year: 2007
    ..abstract_text> ..
  7. Characterization of mammalian ceramide synthases
    ALFRED MERRILL; Fiscal Year: 2009
    ....
  8. Gordon Conference on Glycolipid & Sphingolipid Biology
    ALFRED MERRILL; Fiscal Year: 2002
    ....
  9. STRUCTURE/FUNCTION STUDIES OF LONG-CHAIN BASES
    ALFRED MERRILL; Fiscal Year: 1993
    ..These investigations will provide fundamental information about the biochemistry and cell biology of sphingosine, and could provide valuable tools and insight into long-chain bases as modulators of cell behavior...
  10. STRUCTURE/FUNCTION STUDIES OF LONG-CHAIN BASES
    ALFRED MERRILL; Fiscal Year: 1999
    ..These investigations will provide fundamental information about the biochemistry and cell biology of sphingosine, and could provide valuable tools and insight into long-chain bases as modulators of cell behavior. ..
  11. Characterization of mammalian ceramide synthases
    ALFRED HARRISON MERRILL; Fiscal Year: 2010
    ....