Research Topics
Genomes and Genes
| Hanjoong JoSummaryAffiliation: Georgia Institute of Technology Country: USA Publications
Research Grants
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Detail Information
Publications
Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cellsAnna Csiszar
Dept of Physiology, New York Medical College, Valhalla, New York 10595, USA
Am J Physiol Heart Circ Physiol 295:H569-77. 2008..The vascular bed-specific endothelial effects of BMP-4 are likely to contribute to its differential pathophysiological role in the systemic and pulmonary circulation...- Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosisDouglas Nam
Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA, USA
Am J Physiol Heart Circ Physiol 297:H1535-43. 2009..It also allows for easy and rapid intimal RNA isolation. This novel model and method could be used for genome-wide studies to determine molecular mechanisms underlying flow-dependent regulation of vascular biology and diseases... 
Role of NADPH oxidases in disturbed flow- and BMP4- induced inflammation and atherosclerosisHanjoong Jo
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, 30322, USA
Antioxid Redox Signal 8:1609-19. 2006..This emerging field of shear stress, BMP4, NADPH oxidases, inflammation, and atherosclerosis is reviewed...- Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinasesYong Chool Boo
Wallace H Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA 30322, USA
Am J Physiol Cell Physiol 285:C499-508. 2003..The functional significance of each phosphorylation site is still unclear. We have attempted to summarize the current status of understanding in shear-dependent eNOS regulation... - Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidaseGeorge P Sorescu
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
Circ Res 95:773-9. 2004..Together, these results suggest that BMP4 produced in ECs by OS stimulates ROS release from the nox1-dependent NADPH oxidase leading to inflammation, a critical early atherogenic step... - Bone morphogenic protein antagonists are coexpressed with bone morphogenic protein 4 in endothelial cells exposed to unstable flow in vitro in mouse aortas and in human coronary arteries: role of bone morphogenic protein antagonists in inflammation and atKyunghwa Chang
Wallace H Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA 30322, USA
Circulation 116:1258-66. 2007..BMP activity is regulated by the level of BMP antagonists. Until now it was not known whether shear also regulates the expression of BMP antagonists and whether they play a role in EC pathophysiology... - Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesionJinah Hwang
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
J Biol Chem 278:47291-8. 2003.... - Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flowLi Li
Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
Arterioscler Thromb Vasc Biol 31:1547-54. 2011..We therefore aimed to determine whether atherosclerosis induced by disturbed flow is due to BH(4) deficiency and NOS uncoupling and whether increasing BH(4) would prevent endothelial dysfunction, plaque inflammation, and atherosclerosis... - Dynamic immune cell accumulation during flow-induced atherogenesis in mouse carotid artery: an expanded flow cytometry methodNoah Alberts-Grill
School of Medicine, Emory University, Woodruff Memorial Bldg, Rm 2005, Atlanta, GA 30322, USA
Arterioscler Thromb Vasc Biol 32:623-32. 2012..However, the detailed changes in the composition and quantity of leukocytes in the arterial wall during atherogenesis are not fully understood in part because of the lack of suitable methods and animal models... - Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxationSumitra Miriyala
Division of Cardiology, Emory University, Emory University, Atlanta, GA 30322, USA
Circulation 113:2818-25. 2006.... - Laminar shear inhibits tubule formation and migration of endothelial cells by an angiopoietin-2 dependent mechanismSarah L Tressel
Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA
Arterioscler Thromb Vasc Biol 27:2150-6. 2007..We hypothesized that LS inhibits EC migration and tubule formation, 2 functions important in angiogenesis, by inhibiting the secretion of proangiogenic factors... - Elevated cyclic stretch induces aortic valve calcification in a bone morphogenic protein-dependent mannerKartik Balachandran
The Wallace H Coulter School of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Dr, Suite 1121, Atlanta, GA 30332 0535, USA
Am J Pathol 177:49-57. 2010..These results underline the potential role of BMPs in valve calcification due to altered stretch... - Expression of CYP1A1 and CYP1B1 in human endothelial cells: regulation by fluid shear stressDaniel E Conway
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology Emory University School of Medicine, 313 Ferst Drive, Suite 2116, Atlanta, GA 30332 0535, USA
Cardiovasc Res 81:669-77. 2009.... - Angiopoietin-2 stimulates blood flow recovery after femoral artery occlusion by inducing inflammation and arteriogenesisSarah L Tressel
Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30322, USA
Arterioscler Thromb Vasc Biol 28:1989-95. 2008..We hypothesized that Ang2 plays an important role in blood flow recovery after arterial occlusion in vivo by regulating angiogenesis and arteriogenesis... - HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cellsWon Jong Rhee
Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
Proc Natl Acad Sci U S A 107:6858-63. 2010..Taken together, these results suggest that HuR plays a critical role in inducing inflammatory response of endothelial cells under mechanical and biochemical stresses... - Early determinants of H2O2-induced endothelial dysfunctionBeth M Boulden
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
Free Radic Biol Med 41:810-7. 2006..Dysfunction required O(2)(*-), ONOO(-), or a functional NADPH oxidase. Repeated activation of the NADPH oxidase by ROS may act as a feed forward system to promote endothelial dysfunction... - GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxideLi Li
Division of Cardiology, Emory University School of Medicine, 1639 Pierce Dr WMBR 319, Atlanta, GA 30322, USA
Circ Res 106:328-36. 2010.... - Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cellsCasey J Holliday
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
Am J Physiol Heart Circ Physiol 301:H856-67. 2011..Using miRWalk and several filtering steps, we identified shear-sensitive mRNAs potentially targeted by shear-sensitive miRNAs. These genes and signaling pathways could act as therapeutic targets of AV disease... 
Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve diseaseKartik Balachandran
The Wallace H Coulter School of Biomedical Engineering, Georgia Inst of Technology, 313 Ferst Dr, Ste 1121, Atlanta, GA 30332 0535, USA
Am J Physiol Heart Circ Physiol 296:H756-64. 2009..This may trigger a cascade of events leading to an accelerated valve degeneration and disease progression...- Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flowChih Wen Ni
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA
Blood 116:e66-73. 2010..Determining the functional importance of these novel mechanosensitive genes may provide important insights into understanding vascular biology and atherosclerosis... - Shear stress and plaque developmentSaurabh S Dhawan
Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA 30322, USA
Expert Rev Cardiovasc Ther 8:545-56. 2010..Clinical and experimental data are emerging that suggest the pathobiology associated with abnormal wall shear stress results in atherosclerotic plaque development and progression... - Laminar shear stress up-regulates peroxiredoxins (PRX) in endothelial cells: PRX 1 as a mechanosensitive antioxidantAmy L Mowbray
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
J Biol Chem 283:1622-7. 2008..However, PRX 5 depletion did not. Together, these results suggest that PRX 1 is a novel mechanosensitive antioxidant, playing an important role in shear-dependent regulation of endothelial biology and atherosclerosis... - Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves--association with low BMP antagonists and SMAD6Randall F Ankeny
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States of America
PLoS ONE 6:e20969. 2011..Here, we tested the hypothesis that side-dependent activation of bone morphogenic protein (BMP) pathway in the endothelium of the ventricularis and fibrosa is associated with human AV calcification... - Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increaseYong Chool Boo
Wallace H Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Emory University School of Medicine, Atlanta, GA 30322, USA
Free Radic Biol Med 35:729-41. 2003..PKA-dependent phosphorylation of eNOS S635 and subsequent basal NO production in a Ca2+-independent manner may play an important role in regulating vascular biology and pathophysiology... - Plasma membrane requirements for 1alpha,25(OH)2D3 dependent PKC signaling in chondrocytes and osteoblastsBarbara D Boyan
Wallace H Coulter Department of Biomedical Engineering at Georgia, Tech and Emory University, Georgia Institute of Technology, Atlanta, 30332 0363, USA
Steroids 71:286-90. 2006..Disruption of lipid rafts using beta-cyclodextrin blocks the activation of PKC by 1alpha,25(OH)(2)D(3) and reduces the ability of 1alpha,25(OH)(2)D(3) to regulate [(35)S]-sulfate incorporation... - Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosisManu O Platt
Wallace H Coulter Dept of Biomedical Engineering at Georgia Tech and Emory Univ, 308D WMB, Atlanta, GA 30322, USA
Am J Physiol Heart Circ Physiol 292:H1479-86. 2007..These findings suggest that cathepsin K is a mechanosensitive, extracellular matrix protease that, in turn, may be involved in arterial wall remodeling and atherosclerosis... - NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin IIHua Cai
Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 277:48311-7. 2002..Because angiotensin II also stimulates O(2)() production from the NAD(P)H oxidase, the H(2)O(2) stimulation of NO(.) may facilitate peroxynitrite formation in response to this octapeptide... - Cyclic pressure and shear stress regulate matrix metalloproteinases and cathepsin activity in porcine aortic valvesManu O Platt
The Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
J Heart Valve Dis 15:622-9. 2006..This observation may have implications for understanding valve biology, as well as for valve tissue engineering... - MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cellsChih Wen Ni
Coulter Department of Biomedical Engineering, Emory University, Atlanta, GA, USA
Am J Physiol Heart Circ Physiol 300:H1762-9. 2011..These OS-sensitive miRNAs may mediate atherosclerosis induced by disturbed flow... - Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences: influence of shear stressJonathan T Butcher
Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA
Arterioscler Thromb Vasc Biol 26:69-77. 2006.... - Endothelial metallothionein expression and intracellular free zinc levels are regulated by shear stressDaniel E Conway
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, Georgia 30332 0535, USA
Am J Physiol Cell Physiol 299:C1461-7. 2010..The sensitivity of intracellular free zinc to differences in shear stress suggests that intracellular zinc levels are important in the regulation of the endothelium and in the progression of vascular disease... - Animal, in vitro, and ex vivo models of flow-dependent atherosclerosis: role of oxidative stressAmir Rezvan
Division of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
Antioxid Redox Signal 15:1433-48. 2011..Here, we review these flow models in the context of the role of oxidative stress in flow-dependent inflammation, a critical proatherogenic step, and atherosclerosis... - Identification of mechanosensitive genes in osteoblasts by comparative microarray studies using the rotating wall vessel and the random positioning machineMamta J Patel
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30322, USA
J Cell Biochem 101:587-99. 2007.... - Differences in valvular and vascular cell responses to strain in osteogenic mediaZannatul Ferdous
Institute of Bioengineering and Biosciences, Georgia Institute of Technology, 315 Ferst Drive, Mail code 0363, Atlanta, GA 30332, USA
Biomaterials 32:2885-93. 2011..Further investigation is necessary for improved understanding and to detect biomarkers for early detection or prevention of these diseases... - Low magnitude and high frequency mechanical loading prevents decreased bone formation responses of 2T3 preosteoblastsMamta J Patel
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30322, USA
J Cell Biochem 106:306-16. 2009..The mechanosensitive genes identified here provide potential targets for pharmaceutical treatments that may be used in combination with low level mechanical loading to better treat osteoporosis or disuse-induced bone loss... - Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetesAlejandra San Martin
Division of Cardiology, Department of Medicine, Emory University, 1639 Pierce Dr, Atlanta, GA 30322, USA
Am J Physiol Heart Circ Physiol 292:H2073-82. 2007..The ability of Tempol to reverse ROS production as well as OPN and BMP-4, but not CTGF, induction suggests that DM-induced vascular inflammation involves both ROS-sensitive and -insensitive pathways... - Bovine caveolin-2 cloning and effects of shear stress on its localization in bovine aortic endothelial cellsNolan Boyd
Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Atlanta, Georgia 30322, USA
Endothelium 11:189-98. 2004..Therefore, the interaction of caveolin-2 with caveolin-1 could play an important role in caveolae biogenesis and shear stimulated mechano-signal transduction... - Systems analysis of the role of bone morphogenic protein 4 in endothelial inflammationWeiwei Yin
Integrative BioSystems Institute, Georgia Institute of Technology, 313 Ferst Drive, Atlanta, GA 30332, USA
Ann Biomed Eng 38:291-307. 2010..In particular, it demonstrates the crucial role of Bone Morphogenic Protein 4 and p47(phox)-dependent NADPH oxidases in endothelial inflammation... - Design of an ex vivo culture system to investigate the effects of shear stress on cardiovascular tissuePhilippe Sucosky
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Parker H Petit Biotechnology Building, Atlanta, GA 30332 0363, USA
J Biomech Eng 130:035001. 2008..Ultimately, this knowledge will permit the production of functional tissue engineered heart valves, and a better understanding of heart valve biology and disease progression... - The effects of combined cyclic stretch and pressure on the aortic valve interstitial cell phenotypePatrick Thayer
W H Coulter School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA
Ann Biomed Eng 39:1654-67. 2011..Our study therefore demonstrates how cyclic stretch and pressure may possibly act together to modulate the AVIC phenotype... 
An ex vivo study of the biological properties of porcine aortic valves in response to circumferential cyclic stretchKartik Balachandran
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
Ann Biomed Eng 34:1655-65. 2006..Most interestingly, the contractile and fibrotic phenotypic expression of valve interstitial cells was enhanced. These results show that circumferential cyclic stretch is a possible mediator for AVL remodeling activity...- Laminar shear stress inhibits cathepsin L activity in endothelial cellsManu O Platt
Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, 308D WMB, Atlanta, GA 30322, USA
Arterioscler Thromb Vasc Biol 26:1784-90. 2006..CONCLUSIONS: These results suggest that cathepsin L is a shear-sensitive matrix protease and that it may play an important role in flow-mediated vascular remodeling and atherogenic responses... - Embryonic stem cell-derived endothelial cells may lack complete functional maturation in vitroKara E McCloskey
The Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA
J Vasc Res 43:411-21. 2006..These results indicate that ESC-derived EC share some key characteristics of 'mature' EC, while retaining markers of alternate phenotypes including immature endothelium... - Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory responseGeorge P Sorescu
Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Atlanta, Georgia 30322, USA
J Biol Chem 278:31128-35. 2003..We suggest that BMP4 is a mechanosensitive, inflammatory factor playing a critical role in early steps of atherogenesis in the lesion-prone areas... - Optimization of isolation and functional characterization of primary murine aortic endothelial cellsRichard Magid
Wallace Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University School of Medicine, Atlanta, GA 30322, USA
Endothelium 10:103-9. 2003.... - Disturbed flow: p53 SUMOylation in the turnover of endothelial cellsWakako Takabe
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30322, USA
J Cell Biol 193:805-7. 2011..This leads to p53 SUMOylation and its export to the cytosol, where it binds to the antiapoptotic protein Bcl-2 to induce apoptosis... - Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signalingDong Ju Son
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA, USA
Biochem Biophys Res Commun 427:349-54. 2012..In conclusion, our findings demonstrate a novel, therapeutic mechanism by which PL suppresses atherosclerosis plaque formation in vivo... - Regulation of growth plate chondrocytes by 1,25-dihydroxyvitamin D3 requires caveolae and caveolin-1Barbara D Boyan
Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0363, USA
J Bone Miner Res 21:1637-47. 2006..We found that caveolae are required for rapid 1alpha,25(OH)(2)D(3)-dependent PKC signaling, and caveolin-1 must be present based on studies using chondrocytes from Cav-1(-/-) mice... - Mechanical inhibition of RANKL expression is regulated by H-Ras-GTPaseJanet Rubin
Department of Medicine, Emory University School of Medicine and Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA
J Biol Chem 281:1412-8. 2006..By partitioning signals this way, cells may be able to generate different downstream responses through seemingly similar signaling cascades... - Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin IIUlf Landmesser
Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA
Hypertension 40:511-5. 2002..These results suggest a pivotal role of the NAD(P)H oxidase and its subunit p47(phox) in the vascular oxidant stress and the blood pressure response to angiotensin II in vivo... - Target accessibility and signal specificity in live-cell detection of BMP-4 mRNA using molecular beaconsWon Jong Rhee
Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
Nucleic Acids Res 36:e30. 2008..Possible beacon design rules are identified and approaches for enhancing target accessibility are discussed. This has significant implications to MB design for live cell mRNA detection... - IkappaBalpha-dependent regulation of low-shear flow-induced NF-kappa B activity: role of nitric oxideSumathy Mohan
Department of Pathology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
Am J Physiol Cell Physiol 284:C1039-47. 2003.... - Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cellsNolan L Boyd
GA Inst Tech and Emory U, Atlanta
Am J Physiol Heart Circ Physiol 285:H1113-22. 2003..These results suggest that chronic shear stimulates caveolae formation by translocating caveolin-1 from the Golgi to the luminal plasma membrane and alters cell signaling responses... - Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanismYong Chool Boo
GA Inst Tech, Atlanta
Am J Physiol Heart Circ Physiol 283:H1819-28. 2002..Phosphorylation of Ser(635) may play an important role in chronic regulation of eNOS in response to mechanical and humoral stimuli... - Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stressJ Scott McNally
GA Inst Technol and Emory U, Atlanta
Am J Physiol Heart Circ Physiol 285:H2290-7. 2003..These data suggest that the NAD(P)H oxidase maintains endothelial cell XO levels and that XO is responsible for increased reactive oxygen species production in response to oscillatory shear stress... - Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase AYong Chool Boo
GA Inst Technol, Atlanta
J Biol Chem 277:3388-96. 2002..A coordinated interaction between Akt and PKA may be an important mechanism by which eNOS activity is regulated in response to physiological stimuli such as shear stress... - Caveolin-1 is transiently dephosphorylated by shear stress-activated protein tyrosine phosphatase muJaeyoung Shin
Department of Molecular Biology and Institute of Nanosensor and Biotechnology, Dankook University, San 8, Hannam Dong, Yongsan Ku, Seoul 140 714, Republic of Korea
Biochem Biophys Res Commun 339:737-41. 2006..We also observed that protein tyrosine phosphatase mu was transiently activated by shear stress, suggesting its role in the dephosphorylation of caveolin-1... - High glucose induced NF-kappaB DNA-binding activity in HAEC is maintained under low shear stress but inhibited under high shear stress: role of nitric oxideSumathy Mohan
Department of Pathology, The University of Texas Health Science Center, San Antonio, TX 78229, USA
Atherosclerosis 171:225-34. 2003..These observations explain, in part, the mechanism by means of which hyperglycemia accelerates the focal development of atherosclerotic lesions in low shear (lesion prone) areas of the arterial tree... - Activation of c-Jun N-terminal kinase and apoptosis in endothelial cells mediated by endogenous generation of hydrogen peroxideAnup Ramachandran
GA Inst Technol, Atlanta
Biol Chem 383:693-701. 2002..However, a detailed analysis reveals important differences in both the duration and profile for activation of these signaling pathways... - Emerging role of IGF-1R in stretch-induced neointimal hyperplasia in venous graftsHannah Song
Arterioscler Thromb Vasc Biol 27:1679-81. 2007 - Caveolin-1 knockout mice have increased bone size and stiffnessJanet Rubin
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Bone Miner Res 22:1408-18. 2007..Cell studies showed that cav-1 deficiency leads to increased osteoblast differentiation. These results suggest that cav-1 helps to maintain osteoblast progenitors in a less differentiated state... - Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthasePhilip M Bauer
Department of Pharmacology and Vascular Cell Signaling and Therapeutics Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
J Biol Chem 278:14841-9. 2003..Ser-617 may not be important for directly regulating NO release but is important as a modulator of phosphorylation at other sites and protein-protein interactions... - Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathwayAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Arterioscler Thromb Vasc Biol 27:776-82. 2007..Recent studies suggested that atheroprotective levels of shear stress control endothelial BMP-4 expression; however, the underlying mechanisms remained unknown... - Ascorbic acid synthesis due to L-gulono-1,4-lactone oxidase expression enhances NO production in endothelial cellsHyo Jung Kim
Department of Molecular Medicine, Kyungpook National University School of Medicine, Junggu, Daegu, Republic of Korea
Biochem Biophys Res Commun 345:1657-62. 2006..The present study strongly suggests that intracellular AA plays critical roles in vascular physiology through enhancing endothelial NO production... - NFKB1 promoter variation implicates shear-induced NOS3 gene expression and endothelial function in prehypertensives and stage I hypertensivesJoon Young Park
Department of Kinesiology, College of Health Professions, Temple University, Philadelphia, Pennsylvania 19122, USA
Am J Physiol Heart Circ Physiol 293:H2320-7. 2007..We conclude that the (-94)NFKB1 I/D promoter variation contributes to the modulation of vascular function and adaptability to exercise-induced flow shear stress, most likely due to differences in NFKB1 gene transactivity...
Research Grants
- How does blood flow regulate endothelial function?Hanjoong Jo; Fiscal Year: 2003..Aim I. Define the role of caveolin in shear- dependent activation of ERK. Aim II. Determine the role of caveolae in shear-dependent activation of ERK. ..
- Shear Stress, BMP and Aortic Valve InflammationHanjoong Jo; Fiscal Year: 2007..Identification of BMP4 as the mechanosensitive, pro-inflammatory cytokine leading to AV inflammation and calcification may provide a potential non-surgical therapeutic avenue to treat and prevent AV diseases. ..
- Reactive nitrogen species in shear-dependent signalingHanjoong Jo; Fiscal Year: 2005..Aim 2: Determine the effect of laminar shear on RNS productions. Aim 4: Define the role of NO and RNS in laminar shear-dependent, anti-atherogenic responses of endothelial cells. ..
- Shear Stress, BMP and Aortic Valve InflammationHanjoong Jo; Fiscal Year: 2010..Identification of BMP4 as the mechanosensitive, pro-inflammatory cytokine leading to AV inflammation and calcification may provide a potential non-surgical therapeutic avenue to treat and prevent AV diseases. ..