Research Topics
Genomes and Genes
| Robert GuldbergSummaryAffiliation: Georgia Institute of Technology Country: USA Publications
Research Grants
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Detail Information
Publications
Microcomputed tomography imaging of skeletal development and growthRobert E Guldberg
Schools of Mechanical and Biomedical Engineering and the Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332 0405, USA
Birth Defects Res C Embryo Today 72:250-9. 2004..This review focuses on the use of micro-CT imaging and analysis to better understand normal and abnormal skeletal development and growth...- Functional integration of tissue-engineered bone constructsR E Guldberg
Institute for Bioengineering and Bioscience, School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0405, USA
J Musculoskelet Neuronal Interact 4:399-400. 2004 - Consideration of mechanical factorsRobert E Guldberg
Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332, USA
Ann N Y Acad Sci 961:312-4. 2002 - Biologic augmentation of polymer scaffolds for bone repairR E Guldberg
Georgia Institute of Technology, Atlanta, GA 30332, USA
J Musculoskelet Neuronal Interact 7:333-4. 2007 - Spatiotemporal delivery strategies for promoting musculoskeletal tissue regenerationRobert E Guldberg
Parker H Petit Institute for Bioengineering and Bioscience, GeorgiaInstitute of Technology, Atlanta, GA 30332, USA
J Bone Miner Res 24:1507-11. 2009..The purpose of this perspective article is to review promising spatiotemporal delivery strategies designed to promote functional tissue regeneration with an emphasis on vascularized bone repair... - Analyzing bone, blood vessels, and biomaterials with microcomputed tomographyR E Guldberg
Woodruff School of Mechanical Engineering, Coulter School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0405, USA
IEEE Eng Med Biol Mag 22:77-83. 2003 - Mechanical properties of a novel PVA hydrogel in shear and unconfined compressionJ A Stammen
Georgia Institute of Technology, Atlanta 30332, USA
Biomaterials 22:799-806. 2001..Compressive failure of the hydrogels was found to occur between 45 and 60% strain, depending on water content... - A microstructural finite element simulation of mechanically induced bone formationJ T Koontz
Orthopedic Bioengineering Laboratory, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta 30332, USA
J Biomech Eng 123:607-12. 2001..This simulation approach coupled with an experimental model that delivers controlled in vivo mechanical stimuli can be utilized to study the relationship between physical factors and microstructural adaptation during bone repair... - T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signalingMasakazu Terauchi
Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
Cell Metab 10:229-40. 2009.... - Quantitative microcomputed tomography analysis of mineralization within three-dimensional scaffolds in vitroSarah Cartmell
School of Mechanical Engineering, IBB Building, 315 Ferst Drive, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
J Biomed Mater Res A 69:97-104. 2004..PLDL scaffolds with an oriented microarchitecture were shown to support cell attachment, differentiation, and cell-mediated mineralization comparable to natural DTBM scaffolds... - 3-D computational modeling of media flow through scaffolds in a perfusion bioreactorBlaise Porter
Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Dr. NW, Atlanta, GA 30332, USA
J Biomech 38:543-9. 2005.... - Variations in matrix composition and GAG fine structure among scaffolds for cartilage tissue engineeringJ K Mouw
George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0405, USA
Osteoarthritis Cartilage 13:828-36. 2005.... - Quantitative assessment of articular cartilage morphology via EPIC-microCTL Xie
George W Woodruff School of Mechanical Engineering, 315 Ferst Drive, Georgia Institute of Technology, Atlanta, GA 30332 0405, United States
Osteoarthritis Cartilage 17:313-20. 2009..The objective of the present study was to validate the ability of Equilibrium Partitioning of an Ionic Contrast agent via microcomputed tomography (EPIC-microCT) to nondestructively assess cartilage morphology in the rat model... - Nondestructive assessment of sGAG content and distribution in normal and degraded rat articular cartilage via EPIC-microCTL Xie
George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0405, USA
Osteoarthritis Cartilage 18:65-72. 2010.... - Inducible regulation of Runx2-stimulated osteogenesisC A Gersbach
Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Drive, Atlanta, GA 30332, USA
Gene Ther 13:873-82. 2006..This system is significant to developing controlled and effective orthopedic gene therapy strategies and studying the regulation of osteoblastic differentiation... - Sustained VEGF delivery via PLGA nanoparticles promotes vascular growthJustin S Golub
Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr, Atlanta, GA 30332, USA
Am J Physiol Heart Circ Physiol 298:H1959-65. 2010..In conclusion, sustained VEGF delivery via PLGA NPs shows promise for encouraging blood vessel growth in tissue engineering and cardiovascular medicine applications... - Combination of platelet-rich plasma with polycaprolactone-tricalcium phosphate scaffolds for segmental bone defect repairBina Rai
Department of Oral and Maxillofacial Surgery, National University of Singapore, Singapore
J Biomed Mater Res A 81:888-99. 2007.... - Engineering graded tissue interfacesJennifer E Phillips
Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
Proc Natl Acad Sci U S A 105:12170-5. 2008..Development of this facile and robust strategy is significant toward the regeneration of continuous interfacial zones that mimic the cellular and microstructural characteristics of native tissue... - In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblastsCharles A Gersbach
Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA
J Cell Biochem 100:1324-36. 2007..This study is significant in evaluating proposed therapeutic systems and defining a successful strategy for integrating gene medicine and orthopedic regeneration... - Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient miceCraig L Duvall
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
J Bone Miner Res 22:286-97. 2007..Results showed that OPN plays an important role in regulation of angiogenesis, callus formation, and mechanical strength in early stages of healing and facilitates late stage bone remodeling and ECM organization... - Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defectsMegan E Oest
Orthopaedic Research Laboratory, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, IBB Room 2311, 315 Ferst Drive NW, Atlanta, Georgia 30332, USA
J Orthop Res 25:941-50. 2007..However, functional integration of the constructs appeared limited by continued presence of slow-degrading scaffolds and suboptimal dose or delivery of osteoinductive signals... - Dermal fibroblasts genetically modified to express Runx2/Cbfa1 as a mineralizing cell source for bone tissue engineeringJennifer E Phillips
Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
Tissue Eng 13:2029-40. 2007.... - Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineeringChao Xie
Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
Tissue Eng 13:435-45. 2007..Taken together, we propose a novel strategy to combine structural bone allograft with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering... - The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal developmentYing Wang
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
J Clin Invest 117:1616-26. 2007..These studies suggest that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone... - Essential role of extracellular SOD in reparative neovascularization induced by hindlimb ischemiaHa Won Kim
Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Circ Res 101:409-19. 2007.... - 3D imaging of tissue integration with porous biomaterialsRobert E Guldberg
Institute for Bioengineering and Bioscience, George W Woodruff School of Mechanical Engineering, 315 Ferst Drive, Georgia Institute of Technology, Atlanta, GA 30332 0405, USA
Biomaterials 29:3757-61. 2008..This paper will specifically illustrate the use of microcomputed tomography (micro-CT) imaging with and without contrast agents to nondestructively quantify the formation of bone, cartilage, and vasculature within porous biomaterials... - Noninvasive image analysis of 3D construct mineralization in a perfusion bioreactorBlaise D Porter
Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
Biomaterials 28:2525-33. 2007.... - Regulation of growth plate chondrocytes by 1,25-dihydroxyvitamin D3 requires caveolae and caveolin-1Barbara D Boyan
Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0363, USA
J Bone Miner Res 21:1637-47. 2006..We found that caveolae are required for rapid 1alpha,25(OH)(2)D(3)-dependent PKC signaling, and caveolin-1 must be present based on studies using chondrocytes from Cav-1(-/-) mice... - Mineralization capacity of Runx2/Cbfa1-genetically engineered fibroblasts is scaffold dependentJennifer E Phillips
Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
Biomaterials 27:5535-45. 2006..These results highlight the important effect of scaffold properties on the capacity of Runx2-expressing primary dermal fibroblasts to differentiate into a mineralizing osteoblastic phenotype for bone tissue engineering applications... - Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitroCharles A Gersbach
Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA
Biotechnol Bioeng 88:369-78. 2004.... - Effects of Runx2 genetic engineering and in vitro maturation of tissue-engineered constructs on the repair of critical size bone defectsBenjamin A Byers
Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
J Biomed Mater Res A 76:646-55. 2006..These results demonstrate interplay between Runx2 genetically-modified cells and in vitro construct maturation in bone healing responses... - Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitroSarah H Cartmell
School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
Tissue Eng 9:1197-203. 2003..These data suggest that medium perfusion may benefit the development of 3-D tissues in vitro by enhancing transport of nutrients and waste within the constructs and providing flow-mediated mechanical stimuli... - Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineeringXinping Zhang
Department of Orthopaedics, University of Rochester Medical Center, New York, USA
J Bone Miner Res 20:2124-37. 2005.... - Bone formation on tissue-engineered cartilage constructs in vivo: effects of chondrocyte viability and mechanical loadingNatasha D Case
Schools of Mechanical and Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0405, USA
Tissue Eng 9:587-96. 2003.... - Microarchitectural and mechanical characterization of oriented porous polymer scaffoldsAngela S P Lin
Orthopaedic Bioengineering Laboratory, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive, NW IBB Building, Room 2311, Atlanta, GA 30332-0405, USA
Biomaterials 24:481-9. 2003.... - Synergy between genetic and tissue engineering: Runx2 overexpression and in vitro construct development enhance in vivo mineralizationBenjamin A Byers
Woodruff School of Mechanical Engineering; and Petit Institute for Bioengineering and Bioscience and Georgia Tech/Emory Center for the Engineering of Living Tissues, Georgia Institute of Technology, Atlanta, Georgia, USA
Tissue Eng 10:1757-66. 2004..This work provides a novel integrated genetic and tissue-engineering strategy to create mineralized templates for generating robust bone-grafting material... - Trabecular bone microdamage and microstructural stresses under uniaxial compressionSrinidhi Nagaraja
School of Mechanical Engineering, Orthopaedic Bioengineering Laboratory, Georgia Institute of Technology, Atlanta, GA 30332-0405, USA
J Biomech 38:707-16. 2005..46-0.63% in compression and 0.18-0.24% in tension. These data provide an important step towards understanding factors contributing to microdamage initiation and establishing local failure criteria for normal and diseased trabecular bone... - The role of osteopontin in recovery from hind limb ischemiaCraig L Duvall
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, USA
Arterioscler Thromb Vasc Biol 28:290-5. 2008..In this study, we hypothesized that OPN plays a critical role in recovery from limb ischemia... - Voluntary run training but not estradiol deficiency alters the tibial bone-soleus muscle functional relationship in miceGordon L Warren
Division of Physical Therapy, Georgia State University, Atlanta, GA 30302 4019, USA
Am J Physiol Regul Integr Comp Physiol 293:R2015-26. 2007..Thus a mismatch of bone-muscle function occurred in mice that voluntarily ran on wheels, irrespective of estrogen status... - Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injuryCraig L Duvall
Wallace H Couler Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
Am J Physiol Heart Circ Physiol 287:H302-10. 2004..Whereas these initial efforts focused on the mouse hindlimb ischemia model, the developed techniques may be applied to a variety of model systems to investigate mechanisms of angiogenesis and arteriogenesis... - Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivoMei Y Speer
Bioengineering Department, University of Washington, Seattle 98195, USA
J Exp Med 196:1047-55. 2002..These studies are the first to demonstrate a role for OPN as an inducible inhibitor of ectopic calcification in vivo... - In vivo remodeling: breakout session summaryStephen F Badylak
Purdue University, 1296 Potter Building, Room 204, West Lafayette, IN 47907, USA
Ann N Y Acad Sci 961:319-22. 2002 - Chondrogenic differentiation of amniotic fluid-derived stem cellsYash M Kolambkar
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
J Mol Histol 38:405-13. 2007..Even so, this study demonstrates that AFS cells have the potential to differentiate along the chondrogenic lineage, thus establishing the feasibility of using these cells for cartilage repair applications... - Cyclic mechanical compression increases mineralization of cell-seeded polymer scaffolds in vivoAngel O Duty
Biomedical Engineering Department, Georgia Institute of Technology, IBB Room 2414, 315 Ferst Drive NW, Atlanta, GA 30332, USA
J Biomech Eng 129:531-9. 2007.... - Integrated approach to designing growth factor delivery systemsRuth R Chen
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
FASEB J 21:3896-903. 2007..This system significantly enhanced blood vessel formation, and perfusion and recovery from severe ischemia. This general approach may be broadly applicable to growth factor therapies... - Alteration of femoral bone morphology and density in COX-2-/- miceGalen Robertson
Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
Bone 39:767-72. 2006..In conclusion, our study suggests that genetic ablation of COX-2 may have a sex-related effect on cortical bone homeostasis and COX-2 plays a role in maintaining normal bone micro-architecture and density in mice... - Fluid flow increases type II collagen deposition and tensile mechanical properties in bioreactor-grown tissue-engineered cartilageChristopher V Gemmiti
Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
Tissue Eng 12:469-79. 2006.... - Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomographyAshley W Palmer
George W. Woodruff School of Mechanical Engineering and Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
Proc Natl Acad Sci U S A 103:19255-60. 2006..Equilibrium partitioning of an ionic contrast agent via microcomputed tomography thus provides a powerful approach to quantitatively assess 3D cartilage composition and morphology for studies of cartilage degradation and repair... - Age-related changes in trabecular bone microdamage initiationSrinidhi Nagaraja
Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
Bone 40:973-80. 2007..The combined experimental, computational, and histochemical approaches used in this study provide an improved understanding of microdamage initiation and bone quality... - Hydrogel effects on bone marrow stromal cell response to chondrogenic growth factorsRhima M Coleman
Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
Biomaterials 28:2077-86. 2007..These results indicate that the response of BMSCs to a chondrogenic growth factor regimen is scaffold dependent... - Quantitative volumetric analysis of cardiac morphogenesis assessed through micro-computed tomographyJonathan T Butcher
Cardiovascular Developmental Biology Center, Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA
Dev Dyn 236:802-9. 2007..These results demonstrate that Micro-CT can be used to image and quantify cardiovascular structures during development... - Host immune competence and local ischemia affects the functionality of engineered vasculatureRuth R Chen
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
Microcirculation 14:77-88. 2007..The authors examined the effects of host immune competence and local ischemia on the functionality of new vessel networks formed with this approach... - Biological effects of rAAV-caAlk2 coating on structural allograft healingMette Koefoed
The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Mol Ther 12:212-8. 2005..These results indicate that cell-free, rAAV-coated allografts have the potential to revitalize in vivo following transplantation... - Recent advances in gene delivery for structural bone allograftsHani A Awad
Department of Biomedical Engineering, The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14620, USA
Tissue Eng 13:1973-85. 2007..Therefore, innovations in gene delivery offer promising therapeutic approaches for tissue engineering of structural bone substitutes that can potentially have clinical applications in challenging indications... - Estrogen prevents bone loss through transforming growth factor beta signaling in T cellsYuhao Gao
Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 101:16618-23. 2004.... - A perspective: engineering periosteum for structural bone graft healingXinping Zhang
The Center for Musculoskeletal Research, University of Rochester Medical Center, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
Clin Orthop Relat Res 466:1777-87. 2008....
Research Grants
- Microdamage Initiation and Progression in Trabecular BoneRobert E Guldberg; Fiscal Year: 2010....
- Microdamage Initiation and Progression in Trabecular BoneRobert Guldberg; Fiscal Year: 2007....
- Vascularization and Bone RepairRobert Guldberg; Fiscal Year: 2007..Furthermore, the developed methodologies will have broad applicability to other research areas, including for example studies on fracture healing, skeletal development, vascular injury, and tumorigenesis. ..
- Student Travel Support for Regenerate 2005Robert Guldberg; Fiscal Year: 2005..The second forum will be a Stem Cell Workshop focused on advances in stem cell research. ..
- Engineered Delivery of Adult Versus Fetal Stem Cells for Bone RegenerationRobert E Guldberg; Fiscal Year: 2010....