Robert Guldberg

Summary

Affiliation: Georgia Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Microcomputed tomography imaging of skeletal development and growth
    Robert E Guldberg
    Schools of Mechanical and Biomedical Engineering and the Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332 0405, USA
    Birth Defects Res C Embryo Today 72:250-9. 2004
  2. ncbi request reprint Functional integration of tissue-engineered bone constructs
    R E Guldberg
    Institute for Bioengineering and Bioscience, School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0405, USA
    J Musculoskelet Neuronal Interact 4:399-400. 2004
  3. ncbi request reprint Consideration of mechanical factors
    Robert E Guldberg
    Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332, USA
    Ann N Y Acad Sci 961:312-4. 2002
  4. ncbi request reprint Biologic augmentation of polymer scaffolds for bone repair
    R E Guldberg
    Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Musculoskelet Neuronal Interact 7:333-4. 2007
  5. doi request reprint Spatiotemporal delivery strategies for promoting musculoskeletal tissue regeneration
    Robert E Guldberg
    Parker H Petit Institute for Bioengineering and Bioscience, GeorgiaInstitute of Technology, Atlanta, GA 30332, USA
    J Bone Miner Res 24:1507-11. 2009
  6. ncbi request reprint Analyzing bone, blood vessels, and biomaterials with microcomputed tomography
    R E Guldberg
    Woodruff School of Mechanical Engineering, Coulter School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0405, USA
    IEEE Eng Med Biol Mag 22:77-83. 2003
  7. ncbi request reprint Mechanical properties of a novel PVA hydrogel in shear and unconfined compression
    J A Stammen
    Georgia Institute of Technology, Atlanta 30332, USA
    Biomaterials 22:799-806. 2001
  8. ncbi request reprint A microstructural finite element simulation of mechanically induced bone formation
    J T Koontz
    Orthopedic Bioengineering Laboratory, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta 30332, USA
    J Biomech Eng 123:607-12. 2001
  9. pmc T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling
    Masakazu Terauchi
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Cell Metab 10:229-40. 2009
  10. ncbi request reprint Quantitative microcomputed tomography analysis of mineralization within three-dimensional scaffolds in vitro
    Sarah Cartmell
    School of Mechanical Engineering, IBB Building, 315 Ferst Drive, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Biomed Mater Res A 69:97-104. 2004

Research Grants

  1. Microdamage Initiation and Progression in Trabecular Bone
    Robert E Guldberg; Fiscal Year: 2010
  2. Microdamage Initiation and Progression in Trabecular Bone
    Robert Guldberg; Fiscal Year: 2007
  3. Vascularization and Bone Repair
    Robert Guldberg; Fiscal Year: 2007
  4. Student Travel Support for Regenerate 2005
    Robert Guldberg; Fiscal Year: 2005
  5. Engineered Delivery of Adult Versus Fetal Stem Cells for Bone Regeneration
    Robert E Guldberg; Fiscal Year: 2010

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Microcomputed tomography imaging of skeletal development and growth
    Robert E Guldberg
    Schools of Mechanical and Biomedical Engineering and the Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332 0405, USA
    Birth Defects Res C Embryo Today 72:250-9. 2004
    ..This review focuses on the use of micro-CT imaging and analysis to better understand normal and abnormal skeletal development and growth...
  2. ncbi request reprint Functional integration of tissue-engineered bone constructs
    R E Guldberg
    Institute for Bioengineering and Bioscience, School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0405, USA
    J Musculoskelet Neuronal Interact 4:399-400. 2004
  3. ncbi request reprint Consideration of mechanical factors
    Robert E Guldberg
    Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332, USA
    Ann N Y Acad Sci 961:312-4. 2002
  4. ncbi request reprint Biologic augmentation of polymer scaffolds for bone repair
    R E Guldberg
    Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Musculoskelet Neuronal Interact 7:333-4. 2007
  5. doi request reprint Spatiotemporal delivery strategies for promoting musculoskeletal tissue regeneration
    Robert E Guldberg
    Parker H Petit Institute for Bioengineering and Bioscience, GeorgiaInstitute of Technology, Atlanta, GA 30332, USA
    J Bone Miner Res 24:1507-11. 2009
    ..The purpose of this perspective article is to review promising spatiotemporal delivery strategies designed to promote functional tissue regeneration with an emphasis on vascularized bone repair...
  6. ncbi request reprint Analyzing bone, blood vessels, and biomaterials with microcomputed tomography
    R E Guldberg
    Woodruff School of Mechanical Engineering, Coulter School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0405, USA
    IEEE Eng Med Biol Mag 22:77-83. 2003
  7. ncbi request reprint Mechanical properties of a novel PVA hydrogel in shear and unconfined compression
    J A Stammen
    Georgia Institute of Technology, Atlanta 30332, USA
    Biomaterials 22:799-806. 2001
    ..Compressive failure of the hydrogels was found to occur between 45 and 60% strain, depending on water content...
  8. ncbi request reprint A microstructural finite element simulation of mechanically induced bone formation
    J T Koontz
    Orthopedic Bioengineering Laboratory, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta 30332, USA
    J Biomech Eng 123:607-12. 2001
    ..This simulation approach coupled with an experimental model that delivers controlled in vivo mechanical stimuli can be utilized to study the relationship between physical factors and microstructural adaptation during bone repair...
  9. pmc T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling
    Masakazu Terauchi
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Cell Metab 10:229-40. 2009
    ....
  10. ncbi request reprint Quantitative microcomputed tomography analysis of mineralization within three-dimensional scaffolds in vitro
    Sarah Cartmell
    School of Mechanical Engineering, IBB Building, 315 Ferst Drive, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Biomed Mater Res A 69:97-104. 2004
    ..PLDL scaffolds with an oriented microarchitecture were shown to support cell attachment, differentiation, and cell-mediated mineralization comparable to natural DTBM scaffolds...
  11. ncbi request reprint 3-D computational modeling of media flow through scaffolds in a perfusion bioreactor
    Blaise Porter
    Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA 30332, USA
    J Biomech 38:543-9. 2005
    ....
  12. ncbi request reprint Variations in matrix composition and GAG fine structure among scaffolds for cartilage tissue engineering
    J K Mouw
    George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0405, USA
    Osteoarthritis Cartilage 13:828-36. 2005
    ..To compare matrix composition and glycosaminoglycan (GAG) fine structure among five scaffolds commonly used for in vitro chondrocyte culture and cartilage tissue engineering...
  13. pmc Quantitative assessment of articular cartilage morphology via EPIC-microCT
    L Xie
    George W Woodruff School of Mechanical Engineering, 315 Ferst Drive, Georgia Institute of Technology, Atlanta, GA 30332 0405, United States
    Osteoarthritis Cartilage 17:313-20. 2009
    ..The objective of the present study was to validate the ability of Equilibrium Partitioning of an Ionic Contrast agent via microcomputed tomography (EPIC-microCT) to nondestructively assess cartilage morphology in the rat model...
  14. pmc Nondestructive assessment of sGAG content and distribution in normal and degraded rat articular cartilage via EPIC-microCT
    L Xie
    George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0405, USA
    Osteoarthritis Cartilage 18:65-72. 2010
    ....
  15. ncbi request reprint Inducible regulation of Runx2-stimulated osteogenesis
    C A Gersbach
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Drive, Atlanta, GA 30332, USA
    Gene Ther 13:873-82. 2006
    ..This system is significant to developing controlled and effective orthopedic gene therapy strategies and studying the regulation of osteoblastic differentiation...
  16. pmc Sustained VEGF delivery via PLGA nanoparticles promotes vascular growth
    Justin S Golub
    Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr, Atlanta, GA 30332, USA
    Am J Physiol Heart Circ Physiol 298:H1959-65. 2010
    ..In conclusion, sustained VEGF delivery via PLGA NPs shows promise for encouraging blood vessel growth in tissue engineering and cardiovascular medicine applications...
  17. ncbi request reprint Combination of platelet-rich plasma with polycaprolactone-tricalcium phosphate scaffolds for segmental bone defect repair
    Bina Rai
    Department of Oral and Maxillofacial Surgery, National University of Singapore, Singapore
    J Biomed Mater Res A 81:888-99. 2007
    ....
  18. pmc Engineering graded tissue interfaces
    Jennifer E Phillips
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
    Proc Natl Acad Sci U S A 105:12170-5. 2008
    ..Development of this facile and robust strategy is significant toward the regeneration of continuous interfacial zones that mimic the cellular and microstructural characteristics of native tissue...
  19. ncbi request reprint In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts
    Charles A Gersbach
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA
    J Cell Biochem 100:1324-36. 2007
    ..This study is significant in evaluating proposed therapeutic systems and defining a successful strategy for integrating gene medicine and orthopedic regeneration...
  20. ncbi request reprint Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice
    Craig L Duvall
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
    J Bone Miner Res 22:286-97. 2007
    ..Results showed that OPN plays an important role in regulation of angiogenesis, callus formation, and mechanical strength in early stages of healing and facilitates late stage bone remodeling and ECM organization...
  21. ncbi request reprint Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defects
    Megan E Oest
    Orthopaedic Research Laboratory, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, IBB Room 2311, 315 Ferst Drive NW, Atlanta, Georgia 30332, USA
    J Orthop Res 25:941-50. 2007
    ..However, functional integration of the constructs appeared limited by continued presence of slow-degrading scaffolds and suboptimal dose or delivery of osteoinductive signals...
  22. ncbi request reprint Dermal fibroblasts genetically modified to express Runx2/Cbfa1 as a mineralizing cell source for bone tissue engineering
    Jennifer E Phillips
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
    Tissue Eng 13:2029-40. 2007
    ....
  23. ncbi request reprint Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering
    Chao Xie
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Tissue Eng 13:435-45. 2007
    ..Taken together, we propose a novel strategy to combine structural bone allograft with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering...
  24. pmc The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development
    Ying Wang
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Clin Invest 117:1616-26. 2007
    ..These studies suggest that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone...
  25. ncbi request reprint Essential role of extracellular SOD in reparative neovascularization induced by hindlimb ischemia
    Ha Won Kim
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Circ Res 101:409-19. 2007
    ....
  26. pmc 3D imaging of tissue integration with porous biomaterials
    Robert E Guldberg
    Institute for Bioengineering and Bioscience, George W Woodruff School of Mechanical Engineering, 315 Ferst Drive, Georgia Institute of Technology, Atlanta, GA 30332 0405, USA
    Biomaterials 29:3757-61. 2008
    ..This paper will specifically illustrate the use of microcomputed tomography (micro-CT) imaging with and without contrast agents to nondestructively quantify the formation of bone, cartilage, and vasculature within porous biomaterials...
  27. ncbi request reprint Noninvasive image analysis of 3D construct mineralization in a perfusion bioreactor
    Blaise D Porter
    Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Biomaterials 28:2525-33. 2007
    ....
  28. ncbi request reprint Regulation of growth plate chondrocytes by 1,25-dihydroxyvitamin D3 requires caveolae and caveolin-1
    Barbara D Boyan
    Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0363, USA
    J Bone Miner Res 21:1637-47. 2006
    ..We found that caveolae are required for rapid 1alpha,25(OH)(2)D(3)-dependent PKC signaling, and caveolin-1 must be present based on studies using chondrocytes from Cav-1(-/-) mice...
  29. ncbi request reprint Mineralization capacity of Runx2/Cbfa1-genetically engineered fibroblasts is scaffold dependent
    Jennifer E Phillips
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
    Biomaterials 27:5535-45. 2006
    ..These results highlight the important effect of scaffold properties on the capacity of Runx2-expressing primary dermal fibroblasts to differentiate into a mineralizing osteoblastic phenotype for bone tissue engineering applications...
  30. ncbi request reprint Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro
    Charles A Gersbach
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA
    Biotechnol Bioeng 88:369-78. 2004
    ....
  31. ncbi request reprint Effects of Runx2 genetic engineering and in vitro maturation of tissue-engineered constructs on the repair of critical size bone defects
    Benjamin A Byers
    Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Biomed Mater Res A 76:646-55. 2006
    ..These results demonstrate interplay between Runx2 genetically-modified cells and in vitro construct maturation in bone healing responses...
  32. ncbi request reprint Addressing cell-sourcing limitations with gene therapy
    Andres J Garcia
    Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive, Room 2314, Institute for Bioengineering and Bioscience, Atlanta, GA 30332 0363, USA
    IEEE Eng Med Biol Mag 22:65-70. 2003
  33. ncbi request reprint Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitro
    Sarah H Cartmell
    School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Tissue Eng 9:1197-203. 2003
    ..These data suggest that medium perfusion may benefit the development of 3-D tissues in vitro by enhancing transport of nutrients and waste within the constructs and providing flow-mediated mechanical stimuli...
  34. ncbi request reprint Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering
    Xinping Zhang
    Department of Orthopaedics, University of Rochester Medical Center, New York, USA
    J Bone Miner Res 20:2124-37. 2005
    ....
  35. ncbi request reprint Bone formation on tissue-engineered cartilage constructs in vivo: effects of chondrocyte viability and mechanical loading
    Natasha D Case
    Schools of Mechanical and Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0405, USA
    Tissue Eng 9:587-96. 2003
    ....
  36. ncbi request reprint Microarchitectural and mechanical characterization of oriented porous polymer scaffolds
    Angela S P Lin
    Orthopaedic Bioengineering Laboratory, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive, NW IBB Building, Room 2311, Atlanta, GA 30332 0405, USA
    Biomaterials 24:481-9. 2003
    ....
  37. ncbi request reprint Synergy between genetic and tissue engineering: Runx2 overexpression and in vitro construct development enhance in vivo mineralization
    Benjamin A Byers
    Woodruff School of Mechanical Engineering and Petit Institute for Bioengineering and Bioscience and Georgia Tech Emory Center for the Engineering of Living Tissues, Georgia Institute of Technology, Atlanta, Georgia, USA
    Tissue Eng 10:1757-66. 2004
    ..This work provides a novel integrated genetic and tissue-engineering strategy to create mineralized templates for generating robust bone-grafting material...
  38. ncbi request reprint Trabecular bone microdamage and microstructural stresses under uniaxial compression
    Srinidhi Nagaraja
    School of Mechanical Engineering, Orthopaedic Bioengineering Laboratory, Georgia Institute of Technology, Atlanta, GA 30332 0405, USA
    J Biomech 38:707-16. 2005
    ..46-0.63% in compression and 0.18-0.24% in tension. These data provide an important step towards understanding factors contributing to microdamage initiation and establishing local failure criteria for normal and diseased trabecular bone...
  39. ncbi request reprint The role of osteopontin in recovery from hind limb ischemia
    Craig L Duvall
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, USA
    Arterioscler Thromb Vasc Biol 28:290-5. 2008
    ..In this study, we hypothesized that OPN plays a critical role in recovery from limb ischemia...
  40. ncbi request reprint Voluntary run training but not estradiol deficiency alters the tibial bone-soleus muscle functional relationship in mice
    Gordon L Warren
    Division of Physical Therapy, Georgia State University, Atlanta, GA 30302 4019, USA
    Am J Physiol Regul Integr Comp Physiol 293:R2015-26. 2007
    ..Thus a mismatch of bone-muscle function occurred in mice that voluntarily ran on wheels, irrespective of estrogen status...
  41. ncbi request reprint Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury
    Craig L Duvall
    Wallace H Couler Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Am J Physiol Heart Circ Physiol 287:H302-10. 2004
    ..Whereas these initial efforts focused on the mouse hindlimb ischemia model, the developed techniques may be applied to a variety of model systems to investigate mechanisms of angiogenesis and arteriogenesis...
  42. pmc Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo
    Mei Y Speer
    Bioengineering Department, University of Washington, Seattle 98195, USA
    J Exp Med 196:1047-55. 2002
    ..These studies are the first to demonstrate a role for OPN as an inducible inhibitor of ectopic calcification in vivo...
  43. ncbi request reprint In vivo remodeling: breakout session summary
    Stephen F Badylak
    Purdue University, 1296 Potter Building, Room 204, West Lafayette, IN 47907, USA
    Ann N Y Acad Sci 961:319-22. 2002
  44. ncbi request reprint Chondrogenic differentiation of amniotic fluid-derived stem cells
    Yash M Kolambkar
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Mol Histol 38:405-13. 2007
    ..Even so, this study demonstrates that AFS cells have the potential to differentiate along the chondrogenic lineage, thus establishing the feasibility of using these cells for cartilage repair applications...
  45. ncbi request reprint Cyclic mechanical compression increases mineralization of cell-seeded polymer scaffolds in vivo
    Angel O Duty
    Biomedical Engineering Department, Georgia Institute of Technology, IBB Room 2414, 315 Ferst Drive NW, Atlanta, GA 30332, USA
    J Biomech Eng 129:531-9. 2007
    ....
  46. ncbi request reprint Integrated approach to designing growth factor delivery systems
    Ruth R Chen
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
    FASEB J 21:3896-903. 2007
    ..This system significantly enhanced blood vessel formation, and perfusion and recovery from severe ischemia. This general approach may be broadly applicable to growth factor therapies...
  47. pmc Alteration of femoral bone morphology and density in COX-2-/- mice
    Galen Robertson
    Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Bone 39:767-72. 2006
    ..In conclusion, our study suggests that genetic ablation of COX-2 may have a sex-related effect on cortical bone homeostasis and COX-2 plays a role in maintaining normal bone micro-architecture and density in mice...
  48. ncbi request reprint Fluid flow increases type II collagen deposition and tensile mechanical properties in bioreactor-grown tissue-engineered cartilage
    Christopher V Gemmiti
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Tissue Eng 12:469-79. 2006
    ....
  49. pmc Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography
    Ashley W Palmer
    George W Woodruff School of Mechanical Engineering and Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Proc Natl Acad Sci U S A 103:19255-60. 2006
    ..Equilibrium partitioning of an ionic contrast agent via microcomputed tomography thus provides a powerful approach to quantitatively assess 3D cartilage composition and morphology for studies of cartilage degradation and repair...
  50. ncbi request reprint Age-related changes in trabecular bone microdamage initiation
    Srinidhi Nagaraja
    Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Bone 40:973-80. 2007
    ..The combined experimental, computational, and histochemical approaches used in this study provide an improved understanding of microdamage initiation and bone quality...
  51. ncbi request reprint Hydrogel effects on bone marrow stromal cell response to chondrogenic growth factors
    Rhima M Coleman
    Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Biomaterials 28:2077-86. 2007
    ..These results indicate that the response of BMSCs to a chondrogenic growth factor regimen is scaffold dependent...
  52. ncbi request reprint Quantitative volumetric analysis of cardiac morphogenesis assessed through micro-computed tomography
    Jonathan T Butcher
    Cardiovascular Developmental Biology Center, Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA
    Dev Dyn 236:802-9. 2007
    ..These results demonstrate that Micro-CT can be used to image and quantify cardiovascular structures during development...
  53. ncbi request reprint Host immune competence and local ischemia affects the functionality of engineered vasculature
    Ruth R Chen
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
    Microcirculation 14:77-88. 2007
    ..The authors examined the effects of host immune competence and local ischemia on the functionality of new vessel networks formed with this approach...
  54. ncbi request reprint Biological effects of rAAV-caAlk2 coating on structural allograft healing
    Mette Koefoed
    The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mol Ther 12:212-8. 2005
    ..These results indicate that cell-free, rAAV-coated allografts have the potential to revitalize in vivo following transplantation...
  55. ncbi request reprint Recent advances in gene delivery for structural bone allografts
    Hani A Awad
    Department of Biomedical Engineering, The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14620, USA
    Tissue Eng 13:1973-85. 2007
    ..Therefore, innovations in gene delivery offer promising therapeutic approaches for tissue engineering of structural bone substitutes that can potentially have clinical applications in challenging indications...
  56. pmc Estrogen prevents bone loss through transforming growth factor beta signaling in T cells
    Yuhao Gao
    Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:16618-23. 2004
    ....
  57. pmc A perspective: engineering periosteum for structural bone graft healing
    Xinping Zhang
    The Center for Musculoskeletal Research, University of Rochester Medical Center, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Orthop Relat Res 466:1777-87. 2008
    ....

Research Grants11

  1. Microdamage Initiation and Progression in Trabecular Bone
    Robert E Guldberg; Fiscal Year: 2010
    ....
  2. Microdamage Initiation and Progression in Trabecular Bone
    Robert Guldberg; Fiscal Year: 2007
    ....
  3. Vascularization and Bone Repair
    Robert Guldberg; Fiscal Year: 2007
    ..Furthermore, the developed methodologies will have broad applicability to other research areas, including for example studies on fracture healing, skeletal development, vascular injury, and tumorigenesis. ..
  4. Student Travel Support for Regenerate 2005
    Robert Guldberg; Fiscal Year: 2005
    ..The second forum will be a Stem Cell Workshop focused on advances in stem cell research. ..
  5. Engineered Delivery of Adult Versus Fetal Stem Cells for Bone Regeneration
    Robert E Guldberg; Fiscal Year: 2010
    ....