Y O Chernoff

Summary

Affiliation: Georgia Institute of Technology
Country: USA

Publications

  1. ncbi Evidence for a protein mutator in yeast: role of the Hsp70-related chaperone ssb in formation, stability, and toxicity of the [PSI] prion
    Y O Chernoff
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332 0230, USA
    Mol Cell Biol 19:8103-12. 1999
  2. ncbi Mutation processes at the protein level: is Lamarck back?
    Y O Chernoff
    School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, M C 0363, 315 Ferst Drive, Atlanta, GA 30332 0363, USA
    Mutat Res 488:39-64. 2001
  3. ncbi Mechanism of prion loss after Hsp104 inactivation in yeast
    R D Wegrzyn
    School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332 0363, USA
    Mol Cell Biol 21:4656-69. 2001
  4. ncbi Yeast prion protein derivative defective in aggregate shearing and production of new 'seeds'
    A S Borchsenius
    School of Biology and Institute for Bioengineering and Bioscience, Atlanta, GA 30332-0363, USA
    EMBO J 20:6683-91. 2001
  5. ncbi Genetic study of interactions between the cytoskeletal assembly protein sla1 and prion-forming domain of the release factor Sup35 (eRF3) in Saccharomyces cerevisiae
    P A Bailleul
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332 0230, USA
    Genetics 153:81-94. 1999
  6. ncbi An antiprion effect of the anticytoskeletal drug latrunculin A in yeast
    P A Bailleul Winslett
    School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta 30332 0363, USA
    Gene Expr 9:145-56. 2000
  7. ncbi Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing
    G P Newnam
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332 0230, USA
    Mol Cell Biol 19:1325-33. 1999
  8. ncbi Evolutionary conservation of prion-forming abilities of the yeast Sup35 protein
    Y O Chernoff
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332 0230, USA
    Mol Microbiol 35:865-76. 2000

Collaborators

Detail Information

Publications8

  1. ncbi Evidence for a protein mutator in yeast: role of the Hsp70-related chaperone ssb in formation, stability, and toxicity of the [PSI] prion
    Y O Chernoff
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332 0230, USA
    Mol Cell Biol 19:8103-12. 1999
    ....
  2. ncbi Mutation processes at the protein level: is Lamarck back?
    Y O Chernoff
    School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, M C 0363, 315 Ferst Drive, Atlanta, GA 30332 0363, USA
    Mutat Res 488:39-64. 2001
    ..The prion model also puts in doubt the notion that cloned animals are genetically identical to their genome donors, and suggests that genome sequence would not provide a complete information about the genetic makeup of an organism...
  3. ncbi Mechanism of prion loss after Hsp104 inactivation in yeast
    R D Wegrzyn
    School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332 0363, USA
    Mol Cell Biol 21:4656-69. 2001
    ..Thus, our data confirm that the primary function of Hsp104 in prion propagation is to disassemble prion aggregates and generate the small prion seeds that initiate new rounds of prion propagation (possibly assisted by Hsp70-Ssa)...
  4. ncbi Yeast prion protein derivative defective in aggregate shearing and production of new 'seeds'
    A S Borchsenius
    School of Biology and Institute for Bioengineering and Bioscience, Atlanta, GA 30332-0363, USA
    EMBO J 20:6683-91. 2001
    ..Our results shed light on the mechanisms determining the differences between transmissible prions and non-transmissible protein aggregates...
  5. ncbi Genetic study of interactions between the cytoskeletal assembly protein sla1 and prion-forming domain of the release factor Sup35 (eRF3) in Saccharomyces cerevisiae
    P A Bailleul
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332 0230, USA
    Genetics 153:81-94. 1999
    ..We hypothesize that Sup35N is involved in regulatory interactions with intracellular structural networks, and [PSI] prion may be formed as a by-product of this process...
  6. ncbi An antiprion effect of the anticytoskeletal drug latrunculin A in yeast
    P A Bailleul Winslett
    School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta 30332 0363, USA
    Gene Expr 9:145-56. 2000
    ....
  7. ncbi Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing
    G P Newnam
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332 0230, USA
    Mol Cell Biol 19:1325-33. 1999
    ..Our results suggest it is the interplay between Hsp104 and Hsp70 that allows the maintenance of [PSI] under natural growth conditions...
  8. ncbi Evolutionary conservation of prion-forming abilities of the yeast Sup35 protein
    Y O Chernoff
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332 0230, USA
    Mol Microbiol 35:865-76. 2000
    ..This implies that prion induction by protein overproduction does not require strict correspondence of the 'inducer' and 'inducee' sequences, and can overcome the 'species barrier'...