Research Topics
| Nathan J BowenSummaryAffiliation: Georgia Institute of Technology Country: USA Publications
| Collaborators
|
Detail Information
Publications
Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cellsNathan J Bowen
School of Biology, Georgia Institute of Technology, Atlanta, GA, USA
BMC Med Genomics 2:71. 2009....
Emerging roles for PAX8 in ovarian cancer and endosalpingeal developmentNathan J Bowen
School of Biology, Georgia Institute of Technology, and Ovarian Cancer Institute, Atlanta, GA 30332, USA
Gynecol Oncol 104:331-7. 2007..Aberrant transcriptional expression of PAX8 has been reported in epithelial ovarian cancer, prompting us to initiate the molecular characterization of this master regulatory gene in ovarian cancer development...
Isolation and characterization of stem-like cells from a human ovarian cancer cell lineLijuan Wang
Ovarian Cancer Institute and School of Biology, Georgia Institute of Technology, 315 Ferst Dr, Atlanta, GA 30332 0363, USA
Mol Cell Biochem 363:257-68. 2012..Collectively, our results indicate that these SDCs will be a useful model for the study of ovarian CICs and for the development of novel CIC-targeted therapies...- Evidence for the complexity of microRNA-mediated regulation in ovarian cancer: a systems approachShubin W Shahab
School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
PLoS ONE 6:e22508. 2011..Our findings underscore the complexities of miRNA-mediated regulation in vivo and the necessity of understanding the basis of these complexities in cancer cells before the therapeutic potential of miRNAs can be fully realized... - Gene transfection enhanced by ultrasound exposure combined with drug treatment guided by gene chip analysisYing Liu
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
Int J Hyperthermia 28:349-61. 2012..We used these findings to select drugs that regulate intracellular processes expected to enhance gene transfection in combination with US... - Prediction of transposable element derived enhancers using chromatin modification profilesAhsan Huda
School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
PLoS ONE 6:e27513. 2011.... - Elevation of sulfatides in ovarian cancer: an integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometryYing Liu
School of Biology and the Petit Institute for Bioscience and Bioengineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, Georgia 30332 0363, USA
Mol Cancer 9:186. 2010.... - p24 proteins, intracellular trafficking, and behavior: Drosophila melanogaster provides insights and opportunitiesGinger E Carney
School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
Biol Cell 96:271-8. 2004..This identification and mutant characterization of a p24 locus in Drosophila will pave the way for a better understanding of cell-type-specific functions and interactions among p24 proteins... - Identification of metabolites with anticancer properties by computational metabolomicsAdrian K Arakaki
Center for the Study of Systems Biology, Georgia Institute of Technology, Atlanta, Georgia, USA
Mol Cancer 7:57. 2008..The fact that metabolites can affect the cancer process on so many levels suggests that the change in concentration of some metabolites that occurs in cancer cells could have an active role in the progress of the disease... - Epigenetic regulation of transposable element derived human gene promotersAhsan Huda
School of Biology, Georgia Institute of Technology, 310 Ferst Drive, Atlanta, GA 30332, USA
Gene 475:39-48. 2011.... - Homogeneous and organized differentiation within embryoid bodies induced by microsphere-mediated delivery of small moleculesRichard L Carpenedo
The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology Emory University, Atlanta, GA 30332 0535, USA
Biomaterials 30:2507-15. 2009.... - LTR retrotransposons and the evolution of dosage compensation in DrosophilaLilya V Matyunina
School of Biology and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
BMC Mol Biol 9:55. 2008..While epigenetic mechanisms are hypothesized to have evolved originally to silence transposable elements, a connection between transposable elements and the evolution of dosage compensation has yet to be demonstrated... - A c-Myc regulatory subnetwork from human transposable element sequencesJianrong Wang
School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
Mol Biosyst 5:1831-9. 2009..These data point to a substantial contribution of TEs to the regulation of human genes by c-Myc. Genes that are regulated by TE-derived c-Myc binding sites appear to form a distinct c-Myc regulatory subnetwork... - Identification, characterization and comparative genomics of chimpanzee endogenous retrovirusesNalini Polavarapu
School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332-0230, USA
Genome Biol 7:R51. 2006.... - Mi-2/NuRD: multiple complexes for many purposesNathan J Bowen
Department of Genetics, University of Georgia, Athens, GA, USA
Biochim Biophys Acta 1677:52-7. 2004..We summarize evidence supporting the view that the alternative subunits of the complex that have arisen during vertebrate evolution endow unique functional properties... - Identification of candidate methylation-responsive genes in ovarian cancerLaura Menendez
Department of Genetics, University of Georgia, Athens, GA 30605, USA
Mol Cancer 6:10. 2007..Genes associated with CpG islands (CGIs) are especially prone to methylation, but not all CGI-associated genes display changes in methylation patterns in cancers... - Retrotransposons and their recognition of pol II promoters: a comprehensive survey of the transposable elements from the complete genome sequence of Schizosaccharomyces pombeNathan J Bowen
Section on Eukaryotic Transposable Elements, Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development (NICHD, National Institutes of Health (NIH, Bethesda, Maryland 20892, USA
Genome Res 13:1984-97. 2003..Finally we describe a novel repetitive sequence, wtf, which was also preferentially located on chromosome III, and was often located near solo LTRs of Tf elements... - Newly identified families of human endogenous retrovirusesNalini Polavarapu
J Virol 80:4640-2. 2006 - Multiple ribonuclease H-encoding genes in the Caenorhabditis elegans genome contrasts with the two typical ribonuclease H-encoding genes in the human genomeArulvathani Arudchandran
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Biol Evol 19:1910-9. 2002..elegans are quite unrelated to cellular RNases H1, but numerous RNase H domains of human endogenous retroviruses are more closely related to cellular RNases H...