Nathan J Bowen

Summary

Affiliation: Georgia Institute of Technology
Country: USA

Publications

  1. pmc Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells
    Nathan J Bowen
    School of Biology, Georgia Institute of Technology, Atlanta, GA, USA
    BMC Med Genomics 2:71. 2009
  2. ncbi request reprint Emerging roles for PAX8 in ovarian cancer and endosalpingeal development
    Nathan J Bowen
    School of Biology, Georgia Institute of Technology, and Ovarian Cancer Institute, Atlanta, GA 30332, USA
    Gynecol Oncol 104:331-7. 2007
  3. doi request reprint Isolation and characterization of stem-like cells from a human ovarian cancer cell line
    Lijuan Wang
    Ovarian Cancer Institute and School of Biology, Georgia Institute of Technology, 315 Ferst Dr, Atlanta, GA 30332 0363, USA
    Mol Cell Biochem 363:257-68. 2012
  4. pmc Evidence for the complexity of microRNA-mediated regulation in ovarian cancer: a systems approach
    Shubin W Shahab
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
    PLoS ONE 6:e22508. 2011
  5. doi request reprint Gene transfection enhanced by ultrasound exposure combined with drug treatment guided by gene chip analysis
    Ying Liu
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Int J Hyperthermia 28:349-61. 2012
  6. pmc Prediction of transposable element derived enhancers using chromatin modification profiles
    Ahsan Huda
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
    PLoS ONE 6:e27513. 2011
  7. pmc Elevation of sulfatides in ovarian cancer: an integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry
    Ying Liu
    School of Biology and the Petit Institute for Bioscience and Bioengineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, Georgia 30332 0363, USA
    Mol Cancer 9:186. 2010
  8. ncbi request reprint p24 proteins, intracellular trafficking, and behavior: Drosophila melanogaster provides insights and opportunities
    Ginger E Carney
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Biol Cell 96:271-8. 2004
  9. pmc Identification of metabolites with anticancer properties by computational metabolomics
    Adrian K Arakaki
    Center for the Study of Systems Biology, Georgia Institute of Technology, Atlanta, Georgia, USA
    Mol Cancer 7:57. 2008
  10. doi request reprint Epigenetic regulation of transposable element derived human gene promoters
    Ahsan Huda
    School of Biology, Georgia Institute of Technology, 310 Ferst Drive, Atlanta, GA 30332, USA
    Gene 475:39-48. 2011

Collaborators

Detail Information

Publications19

  1. pmc Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells
    Nathan J Bowen
    School of Biology, Georgia Institute of Technology, Atlanta, GA, USA
    BMC Med Genomics 2:71. 2009
    ....
  2. ncbi request reprint Emerging roles for PAX8 in ovarian cancer and endosalpingeal development
    Nathan J Bowen
    School of Biology, Georgia Institute of Technology, and Ovarian Cancer Institute, Atlanta, GA 30332, USA
    Gynecol Oncol 104:331-7. 2007
    ..Aberrant transcriptional expression of PAX8 has been reported in epithelial ovarian cancer, prompting us to initiate the molecular characterization of this master regulatory gene in ovarian cancer development...
  3. doi request reprint Isolation and characterization of stem-like cells from a human ovarian cancer cell line
    Lijuan Wang
    Ovarian Cancer Institute and School of Biology, Georgia Institute of Technology, 315 Ferst Dr, Atlanta, GA 30332 0363, USA
    Mol Cell Biochem 363:257-68. 2012
    ..Collectively, our results indicate that these SDCs will be a useful model for the study of ovarian CICs and for the development of novel CIC-targeted therapies...
  4. pmc Evidence for the complexity of microRNA-mediated regulation in ovarian cancer: a systems approach
    Shubin W Shahab
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
    PLoS ONE 6:e22508. 2011
    ..Our findings underscore the complexities of miRNA-mediated regulation in vivo and the necessity of understanding the basis of these complexities in cancer cells before the therapeutic potential of miRNAs can be fully realized...
  5. doi request reprint Gene transfection enhanced by ultrasound exposure combined with drug treatment guided by gene chip analysis
    Ying Liu
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Int J Hyperthermia 28:349-61. 2012
    ..We used these findings to select drugs that regulate intracellular processes expected to enhance gene transfection in combination with US...
  6. pmc Prediction of transposable element derived enhancers using chromatin modification profiles
    Ahsan Huda
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
    PLoS ONE 6:e27513. 2011
    ....
  7. pmc Elevation of sulfatides in ovarian cancer: an integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry
    Ying Liu
    School of Biology and the Petit Institute for Bioscience and Bioengineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, Georgia 30332 0363, USA
    Mol Cancer 9:186. 2010
    ....
  8. ncbi request reprint p24 proteins, intracellular trafficking, and behavior: Drosophila melanogaster provides insights and opportunities
    Ginger E Carney
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Biol Cell 96:271-8. 2004
    ..This identification and mutant characterization of a p24 locus in Drosophila will pave the way for a better understanding of cell-type-specific functions and interactions among p24 proteins...
  9. pmc Identification of metabolites with anticancer properties by computational metabolomics
    Adrian K Arakaki
    Center for the Study of Systems Biology, Georgia Institute of Technology, Atlanta, Georgia, USA
    Mol Cancer 7:57. 2008
    ..The fact that metabolites can affect the cancer process on so many levels suggests that the change in concentration of some metabolites that occurs in cancer cells could have an active role in the progress of the disease...
  10. doi request reprint Epigenetic regulation of transposable element derived human gene promoters
    Ahsan Huda
    School of Biology, Georgia Institute of Technology, 310 Ferst Drive, Atlanta, GA 30332, USA
    Gene 475:39-48. 2011
    ....
  11. pmc Homogeneous and organized differentiation within embryoid bodies induced by microsphere-mediated delivery of small molecules
    Richard L Carpenedo
    The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology Emory University, Atlanta, GA 30332 0535, USA
    Biomaterials 30:2507-15. 2009
    ....
  12. pmc LTR retrotransposons and the evolution of dosage compensation in Drosophila
    Lilya V Matyunina
    School of Biology and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    BMC Mol Biol 9:55. 2008
    ..While epigenetic mechanisms are hypothesized to have evolved originally to silence transposable elements, a connection between transposable elements and the evolution of dosage compensation has yet to be demonstrated...
  13. pmc A c-Myc regulatory subnetwork from human transposable element sequences
    Jianrong Wang
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Mol Biosyst 5:1831-9. 2009
    ..These data point to a substantial contribution of TEs to the regulation of human genes by c-Myc. Genes that are regulated by TE-derived c-Myc binding sites appear to form a distinct c-Myc regulatory subnetwork...
  14. pmc Identification, characterization and comparative genomics of chimpanzee endogenous retroviruses
    Nalini Polavarapu
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332 0230, USA
    Genome Biol 7:R51. 2006
    ....
  15. ncbi request reprint Mi-2/NuRD: multiple complexes for many purposes
    Nathan J Bowen
    Department of Genetics, University of Georgia, Athens, GA, USA
    Biochim Biophys Acta 1677:52-7. 2004
    ..We summarize evidence supporting the view that the alternative subunits of the complex that have arisen during vertebrate evolution endow unique functional properties...
  16. pmc Identification of candidate methylation-responsive genes in ovarian cancer
    Laura Menendez
    Department of Genetics, University of Georgia, Athens, GA 30605, USA
    Mol Cancer 6:10. 2007
    ..Genes associated with CpG islands (CGIs) are especially prone to methylation, but not all CGI-associated genes display changes in methylation patterns in cancers...
  17. pmc Retrotransposons and their recognition of pol II promoters: a comprehensive survey of the transposable elements from the complete genome sequence of Schizosaccharomyces pombe
    Nathan J Bowen
    Section on Eukaryotic Transposable Elements, Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Genome Res 13:1984-97. 2003
    ..Finally we describe a novel repetitive sequence, wtf, which was also preferentially located on chromosome III, and was often located near solo LTRs of Tf elements...
  18. pmc Newly identified families of human endogenous retroviruses
    Nalini Polavarapu
    J Virol 80:4640-2. 2006
  19. ncbi request reprint Multiple ribonuclease H-encoding genes in the Caenorhabditis elegans genome contrasts with the two typical ribonuclease H-encoding genes in the human genome
    Arulvathani Arudchandran
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Evol 19:1910-9. 2002
    ..elegans are quite unrelated to cellular RNases H1, but numerous RNase H domains of human endogenous retroviruses are more closely related to cellular RNases H...