Michael Zasloff

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. doi request reprint The antibacterial shield of the human urinary tract
    Michael Zasloff
    Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC 20007, USA
    Kidney Int 83:548-50. 2013
  2. pmc Defending the cornea with antibacterial fragments of keratin
    Michael Zasloff
    Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Clin Invest 122:3471-3. 2012
  3. pmc Commentary. On the epidemiology of influenza: reply to Radonovich et al
    John J Cannell
    Department of Psychiatry, Atascadero State Hospital, 10333 El Camino Real, Atascadero, CA 93423, USA
    Virol J 6:121. 2009
  4. pmc On the epidemiology of influenza
    John J Cannell
    Department of Psychiatry, Atascadero State Hospital, 10333 El Camino Real, Atascadero, CA 93423, USA
    Virol J 5:29. 2008
  5. doi request reprint Antimicrobial RNases of human skin
    Michael Zasloff
    Transplant Institute, Department of Surgery, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Invest Dermatol 129:2091-3. 2009
  6. doi request reprint Antimicrobial peptides and suppression of apoptosis in human skin
    Michael Zasloff
    Transplant Institute, Department of Surgery, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Invest Dermatol 129:824-6. 2009
  7. ncbi request reprint Antimicrobial peptides, innate immunity, and the normally sterile urinary tract
    Michael Zasloff
    Division of Surgical Immunology, Department of Surgery, Georgetown University School of Medicine, Washington, DC, USA
    J Am Soc Nephrol 18:2810-6. 2007
  8. pmc Inducing endogenous antimicrobial peptides to battle infections
    Michael Zasloff
    Departments of Surgery and Pediatrics, Georgetown University School of Medicine, Washington, DC 20007, USA
    Proc Natl Acad Sci U S A 103:8913-4. 2006
  9. ncbi request reprint Antimicrobial peptides of multicellular organisms
    Michael Zasloff
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104 6059, USA
    Nature 415:389-95. 2002
  10. ncbi request reprint Innate immunity, antimicrobial peptides, and protection of the oral cavity
    Michael Zasloff
    Georgetown University Medical Center, 3900 Reservoir Road, Washington, DC 20007, USA
    Lancet 360:1116-7. 2002

Research Grants

  1. Electronic IRB for GU Cooperative Oncology Research
    Michael Zasloff; Fiscal Year: 2002

Collaborators

Detail Information

Publications21

  1. doi request reprint The antibacterial shield of the human urinary tract
    Michael Zasloff
    Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC 20007, USA
    Kidney Int 83:548-50. 2013
    ....
  2. pmc Defending the cornea with antibacterial fragments of keratin
    Michael Zasloff
    Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Clin Invest 122:3471-3. 2012
    ..In this issue of the JCI, Tam et al. describe the unexpected role of a structural protein, cytokeratin 6A, in this process...
  3. pmc Commentary. On the epidemiology of influenza: reply to Radonovich et al
    John J Cannell
    Department of Psychiatry, Atascadero State Hospital, 10333 El Camino Real, Atascadero, CA 93423, USA
    Virol J 6:121. 2009
    ..On the epidemiology of influenza: reply to Radonovich LJ, Martinello RA, Hodgson M, Milton DK, Nardell EA. Influenza and ultraviolet germicidal irradiation. Virol J. 2008, 5:149...
  4. pmc On the epidemiology of influenza
    John J Cannell
    Department of Psychiatry, Atascadero State Hospital, 10333 El Camino Real, Atascadero, CA 93423, USA
    Virol J 5:29. 2008
    ..quot; If true, our revision of Edgar Hope-Simpson's theory has profound implications for the prevention of influenza...
  5. doi request reprint Antimicrobial RNases of human skin
    Michael Zasloff
    Transplant Institute, Department of Surgery, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Invest Dermatol 129:2091-3. 2009
    ..Elsewhere in the epidermis RNases are complexed with an inhibitory protein. In the stratum corneum proteases degrade the inhibitor, freeing the RNase and liberating it to function in antimicrobial defense...
  6. doi request reprint Antimicrobial peptides and suppression of apoptosis in human skin
    Michael Zasloff
    Transplant Institute, Department of Surgery, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Invest Dermatol 129:824-6. 2009
    ..In this issue Chammoro et al. (2009) describe a novel mechanism involving prostaglandin PGE2 that appears to explain how the keratinocyte, which secretes AMPs, can remain immune to self-inflicted AMP-induced apoptosis...
  7. ncbi request reprint Antimicrobial peptides, innate immunity, and the normally sterile urinary tract
    Michael Zasloff
    Division of Surgical Immunology, Department of Surgery, Georgetown University School of Medicine, Washington, DC, USA
    J Am Soc Nephrol 18:2810-6. 2007
    ..As more knowledge accrues, vitamin D supplementation may someday be useful as adjuvant therapy in this setting...
  8. pmc Inducing endogenous antimicrobial peptides to battle infections
    Michael Zasloff
    Departments of Surgery and Pediatrics, Georgetown University School of Medicine, Washington, DC 20007, USA
    Proc Natl Acad Sci U S A 103:8913-4. 2006
  9. ncbi request reprint Antimicrobial peptides of multicellular organisms
    Michael Zasloff
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104 6059, USA
    Nature 415:389-95. 2002
    ..What sorts of molecules are they? How are they employed by animals in their defence? As our need for new antibiotics becomes more pressing, could we design anti-infective drugs based on the design principles these molecules teach us?..
  10. ncbi request reprint Innate immunity, antimicrobial peptides, and protection of the oral cavity
    Michael Zasloff
    Georgetown University Medical Center, 3900 Reservoir Road, Washington, DC 20007, USA
    Lancet 360:1116-7. 2002
  11. ncbi request reprint Vernix, the newborn, and innate defense
    Michael Zasloff
    Georgetown University Medical Center, Department of Pediatrics, Washington, DC 20007, USA
    Pediatr Res 53:203-4. 2003
  12. ncbi request reprint Sunlight, vitamin D, and the innate immune defenses of the human skin
    Michael Zasloff
    Georgetown University Hospital, Washington, District of Columbia, USA
    J Invest Dermatol 125:xvi-xvii. 2005
  13. ncbi request reprint Regression of retinopathy by squalamine in a mouse model
    Rosemary D Higgins
    Department of Pediatrics, Georgetown University, Wshington, DC 20007, USA
    Pediatr Res 56:144-9. 2004
    ..Further, squalamine given late in the course of OIR improves retinopathy by inducing regression of retinal neovessels and abrogating invasion of new vessels beyond the inner-limiting membrane of the retina...
  14. ncbi request reprint Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis
    Yi Tang
    Laboratory of GI Developmental Biology, Department of Surgery, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Cancer Res 65:4228-37. 2005
    ..05) and of Smad4 in advanced colon cancers (P < 0.05). This study indicates that by modulating Smad 4, ELF has a key role in TGF-beta signaling in the suppression of early colon cancer...
  15. ncbi request reprint Defending the epithelium
    Michael Zasloff
    Nat Med 12:607-8. 2006
  16. ncbi request reprint The nervous system and innate immunity: the neuropeptide connection
    Kim A Brogden
    Department of Periodontics and Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52252, USA
    Nat Immunol 6:558-64. 2005
    ..As examples, we have chosen five well described, locally produced neuropeptides that may serve a previously unrecognized, direct antimicrobial, innate immune function in four anatomical sites...
  17. ncbi request reprint Hagfish intestinal antimicrobial peptides are ancient cathelicidins
    Thomas Uzzell
    Academy of Natural Sciences, 1900 Benjamin Franklin Parkway, Philadelphia, PA 19103, USA
    Peptides 24:1655-67. 2003
    ..We suggest that this tissue organization provides local defense of the hagfish gastrointestinal tract via innate immunity and possibly served as the architectural plan upon which the adaptive immune system evolved...
  18. ncbi request reprint Fighting infections with vitamin D
    Michael Zasloff
    Nat Med 12:388-90. 2006
  19. ncbi request reprint Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus
    Per H Mygind
    Novozymes A S, 2880 Bagsvaerd, Denmark
    Nature 437:975-80. 2005
    ..These findings identify fungi as a novel source of antimicrobial defensins, and show the therapeutic potential of plectasin. They also suggest that the defensins of insects, molluscs and fungi arose from a common ancestral gene...
  20. ncbi request reprint Antimicrobial peptides in health and disease
    Michael Zasloff
    N Engl J Med 347:1199-200. 2002
  21. pmc Experimental evolution of resistance to an antimicrobial peptide
    Gabriel G Perron
    Department of Biology, McGill University, 1205 Avenue Dr Penfield, Montreal, Que H3A 1B1, Canada
    Proc Biol Sci 273:251-6. 2006
    ....

Research Grants1

  1. Electronic IRB for GU Cooperative Oncology Research
    Michael Zasloff; Fiscal Year: 2002
    ..Effectiveness of the project activities will be evaluated through self-report user surveys that include both structured and open-ended questions. ..