Research Topics
| CHRISTOPHER WILCOXSummaryAffiliation: Georgetown University Country: USA Publications
Research Grants
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Detail Information
Publications
Angiotensin-induced defects in renal oxygenation: role of oxidative stressWilliam J Welch
Division of Nephrology and Hypertension and Cardiovascular Kidney Institute, Georgetown University, Washington, DC, USA
Am J Physiol Heart Circ Physiol 288:H22-8. 2005..generation because they are prevented by an SOD mimetic...
Renal oxygenation and function of the rat kidney: effects of inspired oxygen and preglomerular oxygen shuntingChristopher S Wilcox
Kidney and Vascular Research Center, Georgetown University Hypertension, Washington, DC 20007, USA
Adv Exp Med Biol 765:329-34. 2013..Thus, the preglomerular diffusional shunt appeared to stabilize intrarenal PO(2) during changes in arterial oxygen and to protect NO signaling within the kidney...
Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal massEn Yin Lai
Division of Nephrology and Hypertension, Center for Hypertension, Kidney and Vascular Research, Georgetown University, Washington, DC, USA
Am J Physiol Renal Physiol 303:F64-74. 2012..Thus hypoxia in RRM may be the outcome of NADPH oxidase-initiated ROS generation, leading to mitochondrial uncoupling counteracted by defense pathways coordinated by Nrf-2...- p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in miceEn Yin Lai
Hypertension, Kidney, and Vascular Research Center, Georgetown University Medical Center, NW, Washington, DC 20007, USA
Hypertension 59:415-20. 2012..These effects likely contribute to hypertension and renal vasoconstriction during infusion of angiotensin II... - Effects of tempol and redox-cycling nitroxides in models of oxidative stressChristopher S Wilcox
Division of Nephrology and Hypertension, Department of Medicine and Center for Hypertension, Kidney and Vascular Health, Georgetown University, Washington, DC, United States
Pharmacol Ther 126:119-45. 2010..Indeed, tempol given from birth prolonged the life span of normal mice. However, presently tempol has been used only in human subjects as a topical agent to prevent radiation-induced alopecia... - Asymmetric dimethylarginine and reactive oxygen species: unwelcome twin visitors to the cardiovascular and kidney disease tablesChristopher S Wilcox
Division of Nephrology and Hypertension, Georgetown University Medical Center, 3800 Reservoir Rd, NW, 6 PHC Building, F6003, Washington, DC 20007, USA
Hypertension 59:375-81. 2012..Thus, we conclude that reactive oxygen species and asymmetric dimethylarginine form a tightly coupled amplification system that translates cardiovascular/kidney risk into overt disease... - Chemistry and antihypertensive effects of tempol and other nitroxidesChristopher S Wilcox
Division of Nephrology and Hypertension, Kidney and Vascular Disorder Center, Georgetown University, Washington, DC 20007, USA
Pharmacol Rev 60:418-69. 2008..Thus, tempol is broadly effective in reducing blood pressure, whether given by acute intravenous injection or by prolonged administration, in a wide range of rodent models of hypertension... - Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension?Christopher S Wilcox
Division of Nephrology and Hypertension, Georgetown University Medical Center, 3800 Reservoir Rd, NW, Washington, DC 20007, USA
Am J Physiol Regul Integr Comp Physiol 289:R913-35. 2005..This may place a break on further ROS generation yet could further enhance vasculopathy and hypertension. There is a tight relationship between oxidative stress in the kidney and the development and maintenance of hypertension... - Special feature: cardiovascular-kidney interactions in health and diseaseChristopher S Wilcox
George Division of Nephrology and Hypertension, Georgetown University Medical Center, PHC F6003, 3800 Reservoir Rd, NW, Washington, DC 20007, USA
Am J Physiol Regul Integr Comp Physiol 290:R34-6. 2006 - Thromboxane synthase and TP receptor mRNA in rat kidney and brain: effects of salt intake and ANG IIChristopher S Wilcox
Division of Nephrology and Hypertension and Center for Hypertension and Renal Disease Research, Georgetown University Medical Center, Washington, DC 20007, USA
Am J Physiol Renal Physiol 284:F525-31. 2003..Thus TP-Rs are strongly dependent on ANG II acting on AT(1)-Rs, whereas TxA(2)-S is regulated differentially in the kidney cortex and brain stem by salt intake... - Acute antihypertensive action of nitroxides in the spontaneously hypertensive ratKinjal Patel
Georgetown University, Division of Nephrology and Hypertension, 3800 Reservoir Rd, NW, PHC F6003, Washington, DC 20007, USA
Am J Physiol Regul Integr Comp Physiol 290:R37-43. 2006..SOD exerts a delayed hypotensive action that is not enhanced by liposome encapsulation, suggesting it must diffuse to an extravascular site... - Acute antihypertensive action of Tempol in the spontaneously hypertensive ratXueguang Chen
Division of Nephrology and Hypertension, Georgetown University, 3800 Reservoir Road N W, Washington, DC 20007, USA
Am J Physiol Heart Circ Physiol 293:H3246-53. 2007..The acute antihypertensive action of Tempol depends on the independent effects of potentiation of nitric oxide and inhibition of the peripheral SNS that involves the activation of K(ATP) channels... - Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expressionTina Chabrashvili
Division of Nephrology and Hypertension, Georgetown Univ Hospital, 3800 Reservoir Rd, N W, PHC F6003, Washington, DC 20007, USA
Am J Physiol Regul Integr Comp Physiol 285:R117-24. 2003..This is offset by strong protective effects of AT2-R, which are accompanied by decreased expression of p22phox, Nox-1, and p67phox... - Blood pressure, blood flow, and oxygenation in the clipped kidney of chronic 2-kidney, 1-clip rats: effects of tempol and Angiotensin blockadeFredrik Palm
Division of Nephrology and Hypertension, Hypertension, Kidney, and Vascular Center, and Angiogenesis Program of the Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
Hypertension 55:298-304. 2010..In conclusion, acute administration of Tempol is more effective than candesartan in reducing the mean arterial blood pressure and improving renal blood perfusion and oxygenation in the clipped kidney of chronic 2K,1C rats... - Angiotensin II type 2 receptors and nitric oxide sustain oxygenation in the clipped kidney of early Goldblatt hypertensive ratsFredrik Palm
Division of Nephrology and Hypertension, Cardiovascular Kidney Hypertension Institute, Georgetown University, 3800 Reservoir Rd, NW, PHC F6003, Washington, DC 20007, USA
Hypertension 51:345-51. 2008..This discloses a novel mechanism whereby angiotensin can prevent hypoxia in a kidney challenged with a reduced perfusion pressure... - Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systemsFredrik Palm
Division of Nephrology and Hypertension, Georgetown University, 3800 Reservoir Road N W, Washington, DC 20007, USA
Am J Physiol Heart Circ Physiol 293:H3227-45. 2007.... - Enhanced contractility of renal afferent arterioles from angiotensin-infused rabbits: roles of oxidative stress, thromboxane prostanoid receptors, and endotheliumDan Wang
Division of Nephrology and Hypertension and the Cardiovascular-Kidney Institute, Georgetown University, Washington, DC 20007-2197, USA
Circ Res 94:1436-42. 2004.... - Asymmetric dimethylarginine, oxidative stress, and vascular nitric oxide synthase in essential hypertensionDan Wang
Georgetown University Hypertension, Kidney and Vascular Disorders Center, Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007 USA
Am J Physiol Regul Integr Comp Physiol 296:R195-200. 2009..In conclusion, elevated levels of ADMA and oxidative stress in a group of hypertensive patients could contribute to the associated microvascular endothelial dysfunction and elevated blood pressure... - RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor responsePaul Modlinger
Division of Nephrology and Hypertension, Georgetown University, Washington, DC, USA
Hypertension 47:238-44. 2006..005). An increase in p22phox is required for increased renal NADPH oxidase activity, expression of Nox proteins and oxidative stress, and contributes < or =50% to hypertension during an Ang II slow-pressor response... - beta(1) Receptors protect the renal afferent arteriole of angiotensin-infused rabbits from norepinephrine-induced oxidative stressDan Wang
Division of Nephrology and Hypertension and the Cardiovascular-Kidney Institute, Georgetown University Medical Center, Washington, DC 20007, USA
J Am Soc Nephrol 17:3347-54. 2006..Aff have robust alpha(1)-receptor contraction and beta(1)-receptor dilation. NE elicits beta(1) signaling via cAMP that moderates oxidative stress and contractions in Aff from AngII-infused rabbits... - Angiotensin II and NADPH oxidase increase ADMA in vascular smooth muscle cellsZaiming Luo
Division of Nephrology and Hypertension, Georgetown University Medical Center, 6 PHC, Suite F6003, 3800 Reservoir Rd, NW, Washington DC 20007, USA
Hypertension 56:498-504. 2010..This could underlie increases in cellular asymmetrical dimethylarginine during oxidative stress... - Nitric oxide, oxidative stress, and progression of chronic renal failurePaul S Modlinger
Division of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC 20007, USA
Semin Nephrol 24:354-65. 2004..Therapy for oxidative stress has focused on antioxidants and agents that modify the renin-angiotensin system. The effects of such treatments are more compelling in animal models than in human studies... - A mouse model of angiotensin II slow pressor response: role of oxidative stressNoritaka Kawada
Center for Hypertension and Renal Disease Research, Georgetown University Medical Center, 3800 Reservoir Road NE, Washington, DC 20007-2197, USA
J Am Soc Nephrol 13:2860-8. 2002..There is evidence of increased oxidative stress that is implicated in the increase in the BP and RVR in this model... - TP receptors regulate renal hemodynamics during angiotensin II slow pressor responseNoritaka Kawada
Cardiovascular Kidney Institute and Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007, USA
Am J Physiol Renal Physiol 287:F753-9. 2004..TP-Rs mediate all of the increase in RVR and FF, part of the increase in MAP, but are not implicated in the suppression of ANG I or increase in aldosterone. TP -/- mice have a basal increase in RVR and FF associated with ROS... - Impaired endothelial function and microvascular asymmetrical dimethylarginine in angiotensin II-infused rats: effects of tempolDan Wang
Division of Nephrology and Hypertension, Georgetown University, Washington, DC, USA
Hypertension 56:950-5. 2010..These effects were dependent on reactive oxygen species and could, therefore, be targeted with effective antioxidant therapy... - p22phox in the macula densa regulates single nephron GFR during angiotensin II infusion in ratsPouneh Nouri
Department of Medicine, Georgetown University, Washington, District of Columbia 20057, USA
Am J Physiol Heart Circ Physiol 292:H1685-9. 2007..05). We conclude that p22(phox) and NADPH oxidase regulate the SNGFR during ANG II infusion via MD-dependent mechanisms... - Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NODan Wang
Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007, USA
Circ Res 101:627-35. 2007..This implies specific functions of DDAH isoforms... - Role of oxidative stress in endothelial dysfunction and enhanced responses to angiotensin II of afferent arterioles from rabbits infused with angiotensin IIDan Wang
Division of Nephrology and Hypertension and Center for Hypertension and Renal Disease Research, Georgetown University, Washington, DC 20007, USA
J Am Soc Nephrol 14:2783-9. 2003..A subpressor dose of AngII enhances Aff responses to AngII independent of O(2)(.-)... - Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arteriolesDan Wang
Division of Nephrology and Hypertension, Center for Renal Disease and Hypertension Research, Department of Medicine, Georgetown University, Washington, D.C. 20007, USA
Kidney Int 63:2187-93. 2003..CONCLUSION: Acetylcholine-induced afferent arteriolar relaxation depends strongly on both nitric oxide, acting via soluble guanylate cyclase, and on an EDHF, likely 14,15-EET, acting via KCa... - Cyclooxygenase-1-deficient mice have high sleep-to-wake blood pressure ratios and renal vasoconstrictionNoritaka Kawada
Cardiovascular Kidney Institute, Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007 2197, USA
Hypertension 45:1131-8. 2005..COX-1 contributes to the normal nocturnal BP dipping phenomenon... - Reactive oxygen species: roles in blood pressure and kidney functionChristopher S Wilcox
Division of Nephrology and Hypertension, Georgetown University Hospital, 3800 Reservoir Rd, NW PHC F6003, Washington, DC 20007, USA
Curr Hypertens Rep 4:160-6. 2002..Much progress has been made in defining the pathways that intervene between agonist stimulation of blood vessels and reactive oxygen species-mediated contractile and renal functional responses in animal models in hypertension... - New insights into diuretic use in patients with chronic renal diseaseChristopher S Wilcox
Division of Nephrology and Hypertension and Center for Hypertension and Renal Disease Research, Georgetown University, Washington DC, USA
J Am Soc Nephrol 13:798-805. 2002..These measures are more logical, effective, and less expensive than infusion of albumin solutions... - Asymmetric dimethylarginine and lipid peroxidation products in early autosomal dominant polycystic kidney diseaseDan Wang
Cardiovascular Kidney Hypertension Institute, Division of Nephrology and Hypertension and Angiogenesis Section, Lombardi Cancer Institute, Georgetown University, Washington, DC 20007, USA
Am J Kidney Dis 51:184-91. 2008.... - Roles of oxidative stress and AT1 receptors in renal hemodynamics and oxygenation in the postclipped 2K,1C kidneyWilliam J Welch
Division of Nephrology and Hypertension and Center for Hypertension and Renal Disease Research, Georgetown University Medical Center, Washington, DC 20007, USA
Hypertension 41:692-6. 2003..5+/-1.6). We conclude that the correction of oxidative stress in the 2K,1C model partially corrects renal cortical hypoxia and inefficient utilization of O2 for Na+ transport, independent of the fall in blood pressure... - Adenosine A(2) receptors modulate tubuloglomerular feedbackMattias Carlström
Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia, USA
Am J Physiol Renal Physiol 299:F412-7. 2010..Simultaneous application of A(1) and A(2) antagonists abolished the TGF response (DeltaP(SF): 0.4 +/- 0.3 mmHg). In conclusion, adenosine A(2) receptors modulate the TGF response by counteracting the effects of adenosine A(1) receptors... - Renal oxygenation defects in the spontaneously hypertensive rat: role of AT1 receptorsWilliam J Welch
Division of Nephrology and Hypertension and Center for Hypertension and Renal Disease Research, Georgetown University, Washington, DC, USA
Kidney Int 63:202-8. 2003..Therefore, we investigated the hypothesis that AT1-Rs mediate the inefficient renal oxygenation in the SHR... - Hydrogen peroxide mediates a transient vasorelaxation with tempol during oxidative stressYifan Chen
Cardiovascular Kidney Hypertension Institute, Division of Nephrology and Hypertension, Georgetown Univ, 4000 Reservoir Road, NW, Bldg D 399, Washington, DC 20057, USA
Am J Physiol Heart Circ Physiol 293:H2085-92. 2007.... - Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidneyTinatin Chabrashvili
Division of Nephrology and Hypertension and Center for Hypertension and Renal Disease Research, Georgetown University Medical Center, Washington, DC 20007 2197, USA
Hypertension 39:269-74. 2002..There is a prominent increase in the SHR kidney of the mRNA, and protein expression of p47phox in the vasculature, macula densa, and distal nephron, which precedes development of hypertension... - Aberrant D1 and D3 dopamine receptor transregulation in hypertensionChunyu Zeng
Department of Pediatrics, PHC 2, Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 20007, USA
Hypertension 43:654-60. 2004..Altered interactions between D(1) and D(3) receptors may play a role in the pathogenesis of genetic hypertension, including human hypertension, because these receptors also interact in human vascular smooth muscle cells... - Performing laparoscopic adrenalectomy safelyMohammed M H Kalan
Department of Surgery, Georgetown University Medical Center, Washington, DC 20007, USA
Arch Surg 139:1243-7. 2004 - Controlled trials of very high dose folic acid, vitamins B12 and B6, intravenous folinic acid and serine for treatment of hyperhomocysteinemia in ESRDJoyce M Gonin
Division of Nephrology and Hypertension, Georgetown University Hospital, Washington, DC 20007, USA
J Nephrol 16:522-34. 2003..We undertook a fully controlled trial with abnormally high doses of folic acid alone or with supplemental vitamin B6 and B12 compared with active folate alone or with serine... - What is brain nitric oxide synthase doing in the kidney?William J Welch
Center for Hypertension and Renal Diseases Research Center, Georgetown University, Washington, DC 20007, USA
Curr Opin Nephrol Hypertens 11:109-15. 2002..Nitric oxide synthase type I in the macula densa probably adapts renal hemodynamics and possibly renin secretion to changes in blood pressure and salt intake... - Endothelial dysfunction and reduced nitric oxide in resistance arteries in autosomal-dominant polycystic kidney diseaseDan Wang
Department of Nephrology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
Kidney Int 64:1381-8. 2003..We investigated the relationship between endothelial dysfunction and nitric oxide generation in hypertension and chronic renal insufficiency (CRI) in ADPKD... - Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertensionWilliam J Welch
Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007, USA
Am J Physiol Heart Circ Physiol 293:H2644-9. 2007..2K,1C hypertension in rats activates renin, O(2)*(-), and vasoconstrictor PGs. Hypertension is maintained by AT(1)Rs and by COX-1, but not COX-2, products that activate TPRs... - NADPH oxidases in the kidneyPritmohinder S Gill
Angiogenesis Section, Lombardi Cancer Center, Cardiovascular-Kidney Institute and Division of Nephrology and Hypertension, Georgetown University, Washington, District of Columbia 20007, USA
Antioxid Redox Signal 8:1597-607. 2006..Experimental studies of the distribution, signaling, and function of NADPH oxidases in the kidney are described... - Role of extracellular superoxide dismutase in the mouse angiotensin slow pressor responseWilliam J Welch
Cardiovascular Kidney Institute and Division of Nephrology and Hypertension, Georgetown University, Washington, DC, USA
Hypertension 48:934-41. 2006.... - Dopamine D1 receptor augmentation of D3 receptor action in rat aortic or mesenteric vascular smooth musclesChunyu Zeng
Department of Pediatrics, PHC 2 Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 20007, USA
Hypertension 43:673-9. 2004..D(1) receptor stimulation augments D(3) receptor vasorelaxant effects. An interaction of D(1) and D(3) receptors may be involved in the regulation of blood pressure... - Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutaseChagriya Kitiyakara
Division of Nephrology and Hypertension and Cardiovascular-Kidney Institute, Georgetown University, Washington, DC 20007, USA
J Am Soc Nephrol 14:2775-82. 2003..Thus, salt intake enhances generation of O(2)(.-) accompanied by enhanced renal expression and activity of NAD(P)H oxidase with diminished renal expression of IC- and Mn-SOD... - Myogenic responses of mouse isolated perfused renal afferent arterioles: effects of salt intake and reduced renal massEn Yin Lai
Division of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC 20007, USA
Hypertension 55:983-9. 2010..This myogenic response is impaired substantially in the mouse model of prolonged reduced renal mass, especially during high salt intake... - Role of thromboxane receptors in the dipsogenic response to central angiotensin IIChagriya Kitiyakara
Division of Nephrology and Hypertension, and Center for Hypertension and Renal Disease Research, Georgetown University, Washington, District of Columbia 20007, USA
Am J Physiol Regul Integr Comp Physiol 282:R865-9. 2002..1 +/- 0.7 vs. ANG II + U-46,619, 4.5 +/- 0.9 ml; n = 5 rats; P < 0.01). We conclude that central TP receptors contribute to the dipsogenic response to ANG II... - Superoxide modulates myogenic contractions of mouse afferent arteriolesEn Yin Lai
Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007, USA
Hypertension 58:650-6. 2011.... - Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARBMaristela Lika Onozato
Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
Kidney Int 61:186-94. 2002..This finding indicates a pathogenic role for AT1 receptors in the development of oxidative damage in the kidneys during early DM... - Chronic ANG II infusion increases NO generation by rat descending vasa rectaZhong Zhang
Division of Nephrology, Department of Physiology, University of MarylandSchool of Medicine, Baltimore, MD, USA
Am J Physiol Heart Circ Physiol 288:H29-36. 2005..DVR superoxide is unlikely to be an important mediator of chronic ANG II slow pressor hypertension in rats... - Effects of NADPH oxidase inhibitor in diabetic nephropathyKensuke Asaba
Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
Kidney Int 67:1890-8. 2005..Apocynin prevents these changes and the associated proteinuria... - Renal function and outcome of PTRA and stenting for atherosclerotic renal artery stenosisFelipe Ramos
Instituto de Cardiologia y Cirugia Cardiovascular ICYCC, Fundacion Favaloro, Buenos Aires, Argentina
Kidney Int 63:276-82. 2003..The factors predicting benefit remain controversial. We tested the hypothesis that the baseline glomerular filtration rate (GFR) predicts the changes in GFR and blood pressure (BP) after PTRAS... - High-dose angiotensin-converting enzyme inhibition restores body fluid homeostasis in heart-transplant recipientsRandy W Braith
Center for Exercise Science, College of Health and Human Performance, PO Box 118206, University of Florida, Gainesville, FL 32611, USA
J Am Coll Cardiol 41:426-32. 2003..We tested the hypothesis that salt and fluid retention in heart-transplant recipients (HTRs) is caused by a failure to reflexively suppress the renin-angiotensin-aldosterone system (RAAS)... - Expression of NG,NG-dimethylarginine dimethylaminohydrolase and protein arginine N-methyltransferase isoforms in diabetic rat kidney: effects of angiotensin II receptor blockersMaristela L Onozato
Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
Diabetes 57:172-80. 2008..We tested the hypothesis that increased serum ADMA (S(ADMA)) in the streptozotocin (STZ)-induced diabetic rat model of diabetes is mediated by an angiotensin receptor blocker-sensitive change in DDAH or PRMT expression... - Antihypertensive response to prolonged tempol in the spontaneously hypertensive ratWilliam J Welch
School of Pharmacy, University of Missouri, Kansas City, Missouri, USA
Kidney Int 68:179-87. 2005..The response is independent of nitric oxide, endothelin, or catecholamines and occurs despite increased PRA. It is accompanied by a reduction in oxidative stress and is maintained during increased salt intake... - Focus on oxidative stress in the cardiovascular and renal systemsChristopher S Wilcox
Am J Physiol Heart Circ Physiol 288:H3-6. 2005 - Omapatrilat: still a promise in salt-sensitive hypertension?Akihiro Tojo
J Hypertens 21:31-2. 2003
Research Grants
- NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUSCHRISTOPHER WILCOX; Fiscal Year: 2003..abstract_text> ..
- OXIDATIVE STRESS IN THE KIDNEY IN HYPERTENSIONCHRISTOPHER WILCOX; Fiscal Year: 2007..The goal of this work is to provide a basis for better understanding of the role of ROS in hypertension and its consequences and thereby providing a rational basis for new forms of prevention or treatment. ..
- REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANECHRISTOPHER WILCOX; Fiscal Year: 2007..These studies are focused on the roles of COX-1 versus -2, and TP-R in mediating renal mechanism of homeostasis and their dysregulation during Ang II hypertension. ..
- Nephrology and Hypertension Training GrantCHRISTOPHER WILCOX; Fiscal Year: 2007..The aim is to train physicians and post doctoral scientists, for a career in academic nephrology and hypertension. ..
- NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUSCHRISTOPHER WILCOX; Fiscal Year: 2009..abstract_text> ..
- REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANECHRISTOPHER WILCOX; Fiscal Year: 2002....
- NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUSChristopher S Wilcox; Fiscal Year: 2010..They could identify new molecular mechanisms that underlie endothelial and kidney dysfunction, and could provide new targets for therapy for patients with these conditions. ..