CHRISTOPHER WILCOX

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint Angiotensin-induced defects in renal oxygenation: role of oxidative stress
    William J Welch
    Division of Nephrology and Hypertension and Cardiovascular Kidney Institute, Georgetown University, Washington, DC, USA
    Am J Physiol Heart Circ Physiol 288:H22-8. 2005
  2. pmc Role of the kidneys in resistant hypertension
    Z Khawaja
    Division of Nephrology and Hypertension, Georgetown University Medical Center, 3800 Reservoir Road NW, PHC F6003, Washington, DC 20007, USA
    Int J Hypertens 2011:143471. 2011
  3. ncbi request reprint Endothelial dysfunction and enhanced contractility in microvessels from ovariectomized rats: roles of oxidative stress and perivascular adipose tissue
    Dan Wang
    Division of Nephrology and Hypertension, Georgetown University Medical Center, 6 PHC, Suite F6003, 3800 Reservoir Rd NW, Washington, DC 20007
    Hypertension 63:1063-9. 2014
  4. doi request reprint Renal oxygenation and function of the rat kidney: effects of inspired oxygen and preglomerular oxygen shunting
    Christopher S Wilcox
    Kidney and Vascular Research Center, Georgetown University Hypertension, Washington, DC 20007, USA
    Adv Exp Med Biol 765:329-34. 2013
  5. pmc Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass
    En Yin Lai
    Division of Nephrology and Hypertension, Center for Hypertension, Kidney and Vascular Research, Georgetown University, Washington, DC, USA
    Am J Physiol Renal Physiol 303:F64-74. 2012
  6. ncbi request reprint Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension?
    Christopher S Wilcox
    Division of Nephrology and Hypertension, Georgetown University Medical Center, 3800 Reservoir Rd, NW, Washington, DC 20007, USA
    Am J Physiol Regul Integr Comp Physiol 289:R913-35. 2005
  7. ncbi request reprint Special feature: cardiovascular-kidney interactions in health and disease
    Christopher S Wilcox
    George Division of Nephrology and Hypertension, Georgetown University Medical Center, PHC F6003, 3800 Reservoir Rd, NW, Washington, DC 20007, USA
    Am J Physiol Regul Integr Comp Physiol 290:R34-6. 2006
  8. pmc Chemistry and antihypertensive effects of tempol and other nitroxides
    Christopher S Wilcox
    Division of Nephrology and Hypertension, Kidney and Vascular Disorder Center, Georgetown University, Washington, DC 20007, USA
    Pharmacol Rev 60:418-69. 2008
  9. ncbi request reprint Acute antihypertensive action of nitroxides in the spontaneously hypertensive rat
    Kinjal Patel
    Georgetown University, Division of Nephrology and Hypertension, 3800 Reservoir Rd, NW, PHC F6003, Washington, DC 20007, USA
    Am J Physiol Regul Integr Comp Physiol 290:R37-43. 2006
  10. pmc Effects of tempol and redox-cycling nitroxides in models of oxidative stress
    Christopher S Wilcox
    Division of Nephrology and Hypertension, Department of Medicine and Center for Hypertension, Kidney and Vascular Health, Georgetown University, Washington, DC, United States
    Pharmacol Ther 126:119-45. 2010

Research Grants

  1. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2003
  2. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2007
  3. OXIDATIVE STRESS IN THE KIDNEY IN HYPERTENSION
    CHRISTOPHER WILCOX; Fiscal Year: 2007
  4. REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANE
    CHRISTOPHER WILCOX; Fiscal Year: 2007
  5. Nephrology and Hypertension Training Grant
    CHRISTOPHER WILCOX; Fiscal Year: 2007
  6. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2009
  7. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2006
  8. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2002
  9. REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANE
    CHRISTOPHER WILCOX; Fiscal Year: 1999
  10. REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANE
    CHRISTOPHER WILCOX; Fiscal Year: 2000

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Angiotensin-induced defects in renal oxygenation: role of oxidative stress
    William J Welch
    Division of Nephrology and Hypertension and Cardiovascular Kidney Institute, Georgetown University, Washington, DC, USA
    Am J Physiol Heart Circ Physiol 288:H22-8. 2005
    ..generation because they are prevented by an SOD mimetic...
  2. pmc Role of the kidneys in resistant hypertension
    Z Khawaja
    Division of Nephrology and Hypertension, Georgetown University Medical Center, 3800 Reservoir Road NW, PHC F6003, Washington, DC 20007, USA
    Int J Hypertens 2011:143471. 2011
    ....
  3. ncbi request reprint Endothelial dysfunction and enhanced contractility in microvessels from ovariectomized rats: roles of oxidative stress and perivascular adipose tissue
    Dan Wang
    Division of Nephrology and Hypertension, Georgetown University Medical Center, 6 PHC, Suite F6003, 3800 Reservoir Rd NW, Washington, DC 20007
    Hypertension 63:1063-9. 2014
    ....
  4. doi request reprint Renal oxygenation and function of the rat kidney: effects of inspired oxygen and preglomerular oxygen shunting
    Christopher S Wilcox
    Kidney and Vascular Research Center, Georgetown University Hypertension, Washington, DC 20007, USA
    Adv Exp Med Biol 765:329-34. 2013
    ..Thus, the preglomerular diffusional shunt appeared to stabilize intrarenal PO(2) during changes in arterial oxygen and to protect NO signaling within the kidney...
  5. pmc Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass
    En Yin Lai
    Division of Nephrology and Hypertension, Center for Hypertension, Kidney and Vascular Research, Georgetown University, Washington, DC, USA
    Am J Physiol Renal Physiol 303:F64-74. 2012
    ..Thus hypoxia in RRM may be the outcome of NADPH oxidase-initiated ROS generation, leading to mitochondrial uncoupling counteracted by defense pathways coordinated by Nrf-2...
  6. ncbi request reprint Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension?
    Christopher S Wilcox
    Division of Nephrology and Hypertension, Georgetown University Medical Center, 3800 Reservoir Rd, NW, Washington, DC 20007, USA
    Am J Physiol Regul Integr Comp Physiol 289:R913-35. 2005
    ..This may place a break on further ROS generation yet could further enhance vasculopathy and hypertension. There is a tight relationship between oxidative stress in the kidney and the development and maintenance of hypertension...
  7. ncbi request reprint Special feature: cardiovascular-kidney interactions in health and disease
    Christopher S Wilcox
    George Division of Nephrology and Hypertension, Georgetown University Medical Center, PHC F6003, 3800 Reservoir Rd, NW, Washington, DC 20007, USA
    Am J Physiol Regul Integr Comp Physiol 290:R34-6. 2006
  8. pmc Chemistry and antihypertensive effects of tempol and other nitroxides
    Christopher S Wilcox
    Division of Nephrology and Hypertension, Kidney and Vascular Disorder Center, Georgetown University, Washington, DC 20007, USA
    Pharmacol Rev 60:418-69. 2008
    ..Thus, tempol is broadly effective in reducing blood pressure, whether given by acute intravenous injection or by prolonged administration, in a wide range of rodent models of hypertension...
  9. ncbi request reprint Acute antihypertensive action of nitroxides in the spontaneously hypertensive rat
    Kinjal Patel
    Georgetown University, Division of Nephrology and Hypertension, 3800 Reservoir Rd, NW, PHC F6003, Washington, DC 20007, USA
    Am J Physiol Regul Integr Comp Physiol 290:R37-43. 2006
    ..SOD exerts a delayed hypotensive action that is not enhanced by liposome encapsulation, suggesting it must diffuse to an extravascular site...
  10. pmc Effects of tempol and redox-cycling nitroxides in models of oxidative stress
    Christopher S Wilcox
    Division of Nephrology and Hypertension, Department of Medicine and Center for Hypertension, Kidney and Vascular Health, Georgetown University, Washington, DC, United States
    Pharmacol Ther 126:119-45. 2010
    ..Indeed, tempol given from birth prolonged the life span of normal mice. However, presently tempol has been used only in human subjects as a topical agent to prevent radiation-induced alopecia...
  11. ncbi request reprint Thromboxane synthase and TP receptor mRNA in rat kidney and brain: effects of salt intake and ANG II
    Christopher S Wilcox
    Division of Nephrology and Hypertension and Center for Hypertension and Renal Disease Research, Georgetown University Medical Center, Washington, DC 20007, USA
    Am J Physiol Renal Physiol 284:F525-31. 2003
    ..Thus TP-Rs are strongly dependent on ANG II acting on AT(1)-Rs, whereas TxA(2)-S is regulated differentially in the kidney cortex and brain stem by salt intake...
  12. pmc Asymmetric dimethylarginine and reactive oxygen species: unwelcome twin visitors to the cardiovascular and kidney disease tables
    Christopher S Wilcox
    Division of Nephrology and Hypertension, Georgetown University Medical Center, 3800 Reservoir Rd, NW, 6 PHC Building, F6003, Washington, DC 20007, USA
    Hypertension 59:375-81. 2012
    ..Thus, we conclude that reactive oxygen species and asymmetric dimethylarginine form a tightly coupled amplification system that translates cardiovascular/kidney risk into overt disease...
  13. pmc p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice
    En Yin Lai
    Hypertension, Kidney, and Vascular Research Center, Georgetown University Medical Center, NW, Washington, DC 20007, USA
    Hypertension 59:415-20. 2012
    ..These effects likely contribute to hypertension and renal vasoconstriction during infusion of angiotensin II...
  14. ncbi request reprint Acute antihypertensive action of Tempol in the spontaneously hypertensive rat
    Xueguang Chen
    Division of Nephrology and Hypertension, Georgetown University, 3800 Reservoir Road N W, Washington, DC 20007, USA
    Am J Physiol Heart Circ Physiol 293:H3246-53. 2007
    ..The acute antihypertensive action of Tempol depends on the independent effects of potentiation of nitric oxide and inhibition of the peripheral SNS that involves the activation of K(ATP) channels...
  15. ncbi request reprint Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression
    Tina Chabrashvili
    Division of Nephrology and Hypertension, Georgetown Univ Hospital, 3800 Reservoir Rd, N W, PHC F6003, Washington, DC 20007, USA
    Am J Physiol Regul Integr Comp Physiol 285:R117-24. 2003
    ..This is offset by strong protective effects of AT2-R, which are accompanied by decreased expression of p22phox, Nox-1, and p67phox...
  16. pmc Blood pressure, blood flow, and oxygenation in the clipped kidney of chronic 2-kidney, 1-clip rats: effects of tempol and Angiotensin blockade
    Fredrik Palm
    Division of Nephrology and Hypertension, Hypertension, Kidney, and Vascular Center, and Angiogenesis Program of the Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Hypertension 55:298-304. 2010
    ..In conclusion, acute administration of Tempol is more effective than candesartan in reducing the mean arterial blood pressure and improving renal blood perfusion and oxygenation in the clipped kidney of chronic 2K,1C rats...
  17. ncbi request reprint Angiotensin II type 2 receptors and nitric oxide sustain oxygenation in the clipped kidney of early Goldblatt hypertensive rats
    Fredrik Palm
    Division of Nephrology and Hypertension, Cardiovascular Kidney Hypertension Institute, Georgetown University, 3800 Reservoir Rd, NW, PHC F6003, Washington, DC 20007, USA
    Hypertension 51:345-51. 2008
    ..This discloses a novel mechanism whereby angiotensin can prevent hypoxia in a kidney challenged with a reduced perfusion pressure...
  18. ncbi request reprint Enhanced contractility of renal afferent arterioles from angiotensin-infused rabbits: roles of oxidative stress, thromboxane prostanoid receptors, and endothelium
    Dan Wang
    Division of Nephrology and Hypertension and the Cardiovascular Kidney Institute, Georgetown University, Washington, DC 20007 2197, USA
    Circ Res 94:1436-42. 2004
    ....
  19. ncbi request reprint Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems
    Fredrik Palm
    Division of Nephrology and Hypertension, Georgetown University, 3800 Reservoir Road N W, Washington, DC 20007, USA
    Am J Physiol Heart Circ Physiol 293:H3227-45. 2007
    ....
  20. ncbi request reprint beta(1) Receptors protect the renal afferent arteriole of angiotensin-infused rabbits from norepinephrine-induced oxidative stress
    Dan Wang
    Division of Nephrology and Hypertension and the Cardiovascular Kidney Institute, Georgetown University Medical Center, Washington, DC 20007, USA
    J Am Soc Nephrol 17:3347-54. 2006
    ..Aff have robust alpha(1)-receptor contraction and beta(1)-receptor dilation. NE elicits beta(1) signaling via cAMP that moderates oxidative stress and contractions in Aff from AngII-infused rabbits...
  21. ncbi request reprint RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response
    Paul Modlinger
    Division of Nephrology and Hypertension, Georgetown University, Washington, DC, USA
    Hypertension 47:238-44. 2006
    ..005). An increase in p22phox is required for increased renal NADPH oxidase activity, expression of Nox proteins and oxidative stress, and contributes < or =50% to hypertension during an Ang II slow-pressor response...
  22. ncbi request reprint A mouse model of angiotensin II slow pressor response: role of oxidative stress
    Noritaka Kawada
    Center for Hypertension and Renal Disease Research, Georgetown University Medical Center, 3800 Reservoir Road NE, Washington, DC 20007 2197, USA
    J Am Soc Nephrol 13:2860-8. 2002
    ..There is evidence of increased oxidative stress that is implicated in the increase in the BP and RVR in this model...
  23. pmc Asymmetric dimethylarginine, oxidative stress, and vascular nitric oxide synthase in essential hypertension
    Dan Wang
    Georgetown University Hypertension, Kidney and Vascular Disorders Center, Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007 USA
    Am J Physiol Regul Integr Comp Physiol 296:R195-200. 2009
    ..In conclusion, elevated levels of ADMA and oxidative stress in a group of hypertensive patients could contribute to the associated microvascular endothelial dysfunction and elevated blood pressure...
  24. ncbi request reprint Nitric oxide, oxidative stress, and progression of chronic renal failure
    Paul S Modlinger
    Division of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC 20007, USA
    Semin Nephrol 24:354-65. 2004
    ..Therapy for oxidative stress has focused on antioxidants and agents that modify the renin-angiotensin system. The effects of such treatments are more compelling in animal models than in human studies...
  25. pmc Angiotensin II and NADPH oxidase increase ADMA in vascular smooth muscle cells
    Zaiming Luo
    Division of Nephrology and Hypertension, Georgetown University Medical Center, 6 PHC, Suite F6003, 3800 Reservoir Rd, NW, Washington DC 20007, USA
    Hypertension 56:498-504. 2010
    ..This could underlie increases in cellular asymmetrical dimethylarginine during oxidative stress...
  26. ncbi request reprint TP receptors regulate renal hemodynamics during angiotensin II slow pressor response
    Noritaka Kawada
    Cardiovascular Kidney Institute and Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007, USA
    Am J Physiol Renal Physiol 287:F753-9. 2004
    ..TP-Rs mediate all of the increase in RVR and FF, part of the increase in MAP, but are not implicated in the suppression of ANG I or increase in aldosterone. TP -/- mice have a basal increase in RVR and FF associated with ROS...
  27. pmc Impaired endothelial function and microvascular asymmetrical dimethylarginine in angiotensin II-infused rats: effects of tempol
    Dan Wang
    Division of Nephrology and Hypertension, Georgetown University, Washington, DC, USA
    Hypertension 56:950-5. 2010
    ..These effects were dependent on reactive oxygen species and could, therefore, be targeted with effective antioxidant therapy...
  28. ncbi request reprint p22phox in the macula densa regulates single nephron GFR during angiotensin II infusion in rats
    Pouneh Nouri
    Department of Medicine, Georgetown University, Washington, District of Columbia 20057, USA
    Am J Physiol Heart Circ Physiol 292:H1685-9. 2007
    ..05). We conclude that p22(phox) and NADPH oxidase regulate the SNGFR during ANG II infusion via MD-dependent mechanisms...
  29. ncbi request reprint Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arterioles
    Dan Wang
    Division of Nephrology and Hypertension, Center for Renal Disease and Hypertension Research, Department of Medicine, Georgetown University, Washington, D C 20007, USA
    Kidney Int 63:2187-93. 2003
    ....
  30. ncbi request reprint Role of oxidative stress in endothelial dysfunction and enhanced responses to angiotensin II of afferent arterioles from rabbits infused with angiotensin II
    Dan Wang
    Division of Nephrology and Hypertension and Center for Hypertension and Renal Disease Research, Georgetown University, Washington, DC 20007, USA
    J Am Soc Nephrol 14:2783-9. 2003
    ..A subpressor dose of AngII enhances Aff responses to AngII independent of O(2)(.-)...
  31. ncbi request reprint Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO
    Dan Wang
    Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007, USA
    Circ Res 101:627-35. 2007
    ..This implies specific functions of DDAH isoforms...
  32. ncbi request reprint Cyclooxygenase-1-deficient mice have high sleep-to-wake blood pressure ratios and renal vasoconstriction
    Noritaka Kawada
    Cardiovascular Kidney Institute, Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007 2197, USA
    Hypertension 45:1131-8. 2005
    ..COX-1 contributes to the normal nocturnal BP dipping phenomenon...
  33. ncbi request reprint New insights into diuretic use in patients with chronic renal disease
    Christopher S Wilcox
    Division of Nephrology and Hypertension and Center for Hypertension and Renal Disease Research, Georgetown University, Washington DC, USA
    J Am Soc Nephrol 13:798-805. 2002
    ..These measures are more logical, effective, and less expensive than infusion of albumin solutions...
  34. ncbi request reprint Endothelial dysfunction and reduced nitric oxide in resistance arteries in autosomal-dominant polycystic kidney disease
    Dan Wang
    Department of Nephrology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Kidney Int 64:1381-8. 2003
    ..We investigated the relationship between endothelial dysfunction and nitric oxide generation in hypertension and chronic renal insufficiency (CRI) in ADPKD...
  35. doi request reprint Asymmetric dimethylarginine and lipid peroxidation products in early autosomal dominant polycystic kidney disease
    Dan Wang
    Cardiovascular Kidney Hypertension Institute, Division of Nephrology and Hypertension and Angiogenesis Section, Lombardi Cancer Institute, Georgetown University, Washington, DC 20007, USA
    Am J Kidney Dis 51:184-91. 2008
    ....
  36. ncbi request reprint What is brain nitric oxide synthase doing in the kidney?
    William J Welch
    Center for Hypertension and Renal Diseases Research Center, Georgetown University, Washington, DC 20007, USA
    Curr Opin Nephrol Hypertens 11:109-15. 2002
    ..Nitric oxide synthase type I in the macula densa probably adapts renal hemodynamics and possibly renin secretion to changes in blood pressure and salt intake...
  37. ncbi request reprint Roles of oxidative stress and AT1 receptors in renal hemodynamics and oxygenation in the postclipped 2K,1C kidney
    William J Welch
    Division of Nephrology and Hypertension and Center for Hypertension and Renal Disease Research, Georgetown University Medical Center, Washington, DC 20007, USA
    Hypertension 41:692-6. 2003
    ..5+/-1.6). We conclude that the correction of oxidative stress in the 2K,1C model partially corrects renal cortical hypoxia and inefficient utilization of O2 for Na+ transport, independent of the fall in blood pressure...
  38. ncbi request reprint Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney
    Tinatin Chabrashvili
    Division of Nephrology and Hypertension and Center for Hypertension and Renal Disease Research, Georgetown University Medical Center, Washington, DC 20007 2197, USA
    Hypertension 39:269-74. 2002
    ..There is a prominent increase in the SHR kidney of the mRNA, and protein expression of p47phox in the vasculature, macula densa, and distal nephron, which precedes development of hypertension...
  39. ncbi request reprint Renal oxygenation defects in the spontaneously hypertensive rat: role of AT1 receptors
    William J Welch
    Division of Nephrology and Hypertension and Center for Hypertension and Renal Disease Research, Georgetown University, Washington, DC, USA
    Kidney Int 63:202-8. 2003
    ..Therefore, we investigated the hypothesis that AT1-Rs mediate the inefficient renal oxygenation in the SHR...
  40. ncbi request reprint Reactive oxygen species: roles in blood pressure and kidney function
    Christopher S Wilcox
    Division of Nephrology and Hypertension, Georgetown University Hospital, 3800 Reservoir Rd, NW PHC F6003, Washington, DC 20007, USA
    Curr Hypertens Rep 4:160-6. 2002
    ..Much progress has been made in defining the pathways that intervene between agonist stimulation of blood vessels and reactive oxygen species-mediated contractile and renal functional responses in animal models in hypertension...
  41. pmc Adenosine A(2) receptors modulate tubuloglomerular feedback
    Mattias Carlström
    Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia, USA
    Am J Physiol Renal Physiol 299:F412-7. 2010
    ..Simultaneous application of A(1) and A(2) antagonists abolished the TGF response (DeltaP(SF): 0.4 +/- 0.3 mmHg). In conclusion, adenosine A(2) receptors modulate the TGF response by counteracting the effects of adenosine A(1) receptors...
  42. ncbi request reprint Aberrant D1 and D3 dopamine receptor transregulation in hypertension
    Chunyu Zeng
    Department of Pediatrics, PHC 2, Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 20007, USA
    Hypertension 43:654-60. 2004
    ..Altered interactions between D(1) and D(3) receptors may play a role in the pathogenesis of genetic hypertension, including human hypertension, because these receptors also interact in human vascular smooth muscle cells...
  43. ncbi request reprint Controlled trials of very high dose folic acid, vitamins B12 and B6, intravenous folinic acid and serine for treatment of hyperhomocysteinemia in ESRD
    Joyce M Gonin
    Division of Nephrology and Hypertension, Georgetown University Hospital, Washington, DC 20007, USA
    J Nephrol 16:522-34. 2003
    ..We undertook a fully controlled trial with abnormally high doses of folic acid alone or with supplemental vitamin B6 and B12 compared with active folate alone or with serine...
  44. ncbi request reprint Performing laparoscopic adrenalectomy safely
    Mohammed M H Kalan
    Department of Surgery, Georgetown University Medical Center, Washington, DC 20007, USA
    Arch Surg 139:1243-7. 2004
  45. ncbi request reprint Hydrogen peroxide mediates a transient vasorelaxation with tempol during oxidative stress
    Yifan Chen
    Cardiovascular Kidney Hypertension Institute, Division of Nephrology and Hypertension, Georgetown Univ, 4000 Reservoir Road, NW, Bldg D 399, Washington, DC 20057, USA
    Am J Physiol Heart Circ Physiol 293:H2085-92. 2007
    ....
  46. ncbi request reprint Role of extracellular superoxide dismutase in the mouse angiotensin slow pressor response
    William J Welch
    Cardiovascular Kidney Institute and Division of Nephrology and Hypertension, Georgetown University, Washington, DC, USA
    Hypertension 48:934-41. 2006
    ....
  47. ncbi request reprint NADPH oxidases in the kidney
    Pritmohinder S Gill
    Angiogenesis Section, Lombardi Cancer Center, Cardiovascular Kidney Institute and Division of Nephrology and Hypertension, Georgetown University, Washington, District of Columbia 20007, USA
    Antioxid Redox Signal 8:1597-607. 2006
    ..Experimental studies of the distribution, signaling, and function of NADPH oxidases in the kidney are described...
  48. ncbi request reprint Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension
    William J Welch
    Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007, USA
    Am J Physiol Heart Circ Physiol 293:H2644-9. 2007
    ..2K,1C hypertension in rats activates renin, O(2)*(-), and vasoconstrictor PGs. Hypertension is maintained by AT(1)Rs and by COX-1, but not COX-2, products that activate TPRs...
  49. ncbi request reprint Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase
    Chagriya Kitiyakara
    Division of Nephrology and Hypertension and Cardiovascular Kidney Institute, Georgetown University, Washington, DC 20007, USA
    J Am Soc Nephrol 14:2775-82. 2003
    ..Thus, salt intake enhances generation of O(2)(.-) accompanied by enhanced renal expression and activity of NAD(P)H oxidase with diminished renal expression of IC- and Mn-SOD...
  50. ncbi request reprint Dopamine D1 receptor augmentation of D3 receptor action in rat aortic or mesenteric vascular smooth muscles
    Chunyu Zeng
    Department of Pediatrics, PHC 2 Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 20007, USA
    Hypertension 43:673-9. 2004
    ..D(1) receptor stimulation augments D(3) receptor vasorelaxant effects. An interaction of D(1) and D(3) receptors may be involved in the regulation of blood pressure...
  51. ncbi request reprint Role of thromboxane receptors in the dipsogenic response to central angiotensin II
    Chagriya Kitiyakara
    Division of Nephrology and Hypertension, and Center for Hypertension and Renal Disease Research, Georgetown University, Washington, District of Columbia 20007, USA
    Am J Physiol Regul Integr Comp Physiol 282:R865-9. 2002
    ..1 +/- 0.7 vs. ANG II + U-46,619, 4.5 +/- 0.9 ml; n = 5 rats; P < 0.01). We conclude that central TP receptors contribute to the dipsogenic response to ANG II...
  52. pmc Myogenic responses of mouse isolated perfused renal afferent arterioles: effects of salt intake and reduced renal mass
    En Yin Lai
    Division of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC 20007, USA
    Hypertension 55:983-9. 2010
    ..This myogenic response is impaired substantially in the mouse model of prolonged reduced renal mass, especially during high salt intake...
  53. pmc Superoxide modulates myogenic contractions of mouse afferent arterioles
    En Yin Lai
    Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007, USA
    Hypertension 58:650-6. 2011
    ....
  54. ncbi request reprint Effects of NADPH oxidase inhibitor in diabetic nephropathy
    Kensuke Asaba
    Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
    Kidney Int 67:1890-8. 2005
    ..We used apocynin to test the hypothesis that superoxide anion (O(-) (2)) from nicotinamide adenine dinucleotide phosphate (NADPH) oxidase underlies the development of diabetic nephropathy in the rat...
  55. ncbi request reprint Renal function and outcome of PTRA and stenting for atherosclerotic renal artery stenosis
    Felipe Ramos
    Instituto de Cardiologia y Cirugia Cardiovascular ICYCC, Fundacion Favaloro, Buenos Aires, Argentina
    Kidney Int 63:276-82. 2003
    ..The factors predicting benefit remain controversial. We tested the hypothesis that the baseline glomerular filtration rate (GFR) predicts the changes in GFR and blood pressure (BP) after PTRAS...
  56. ncbi request reprint High-dose angiotensin-converting enzyme inhibition restores body fluid homeostasis in heart-transplant recipients
    Randy W Braith
    Center for Exercise Science, College of Health and Human Performance, PO Box 118206, University of Florida, Gainesville, FL 32611, USA
    J Am Coll Cardiol 41:426-32. 2003
    ..We tested the hypothesis that salt and fluid retention in heart-transplant recipients (HTRs) is caused by a failure to reflexively suppress the renin-angiotensin-aldosterone system (RAAS)...
  57. ncbi request reprint Chronic ANG II infusion increases NO generation by rat descending vasa recta
    Zhong Zhang
    Division of Nephrology, Department of Physiology, University of MarylandSchool of Medicine, Baltimore, MD, USA
    Am J Physiol Heart Circ Physiol 288:H29-36. 2005
    ..DVR superoxide is unlikely to be an important mediator of chronic ANG II slow pressor hypertension in rats...
  58. ncbi request reprint Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB
    Maristela Lika Onozato
    Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
    Kidney Int 61:186-94. 2002
    ..We tested the hypothesis that Ang II subtype 1 (AT1) receptor activation enhances oxidative stress and nitrotyrosine deposition in the kidneys of rats with diabetes mellitus (DM)...
  59. ncbi request reprint Antihypertensive response to prolonged tempol in the spontaneously hypertensive rat
    William J Welch
    School of Pharmacy, University of Missouri, Kansas City, Missouri, USA
    Kidney Int 68:179-87. 2005
    ....
  60. ncbi request reprint Expression of NG,NG-dimethylarginine dimethylaminohydrolase and protein arginine N-methyltransferase isoforms in diabetic rat kidney: effects of angiotensin II receptor blockers
    Maristela L Onozato
    Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
    Diabetes 57:172-80. 2008
    ..We tested the hypothesis that increased serum ADMA (S(ADMA)) in the streptozotocin (STZ)-induced diabetic rat model of diabetes is mediated by an angiotensin receptor blocker-sensitive change in DDAH or PRMT expression...
  61. ncbi request reprint Focus on oxidative stress in the cardiovascular and renal systems
    Christopher S Wilcox
    Am J Physiol Heart Circ Physiol 288:H3-6. 2005
  62. ncbi request reprint Omapatrilat: still a promise in salt-sensitive hypertension?
    Akihiro Tojo
    J Hypertens 21:31-2. 2003

Research Grants29

  1. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2003
    ..abstract_text> ..
  2. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2007
    ..abstract_text> ..
  3. OXIDATIVE STRESS IN THE KIDNEY IN HYPERTENSION
    CHRISTOPHER WILCOX; Fiscal Year: 2007
    ..The goal of this work is to provide a basis for better understanding of the role of ROS in hypertension and its consequences and thereby providing a rational basis for new forms of prevention or treatment. ..
  4. REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANE
    CHRISTOPHER WILCOX; Fiscal Year: 2007
    ..These studies are focused on the roles of COX-1 versus -2, and TP-R in mediating renal mechanism of homeostasis and their dysregulation during Ang II hypertension. ..
  5. Nephrology and Hypertension Training Grant
    CHRISTOPHER WILCOX; Fiscal Year: 2007
    ..The aim is to train physicians and post doctoral scientists, for a career in academic nephrology and hypertension. ..
  6. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2009
    ..abstract_text> ..
  7. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2006
    ..abstract_text> ..
  8. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2002
    ..abstract_text> ..
  9. REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANE
    CHRISTOPHER WILCOX; Fiscal Year: 1999
    ....
  10. REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANE
    CHRISTOPHER WILCOX; Fiscal Year: 2000
    ....
  11. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2000
    ..abstract_text> ..
  12. REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANE
    CHRISTOPHER WILCOX; Fiscal Year: 2001
    ....
  13. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2001
    ..abstract_text> ..
  14. REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANE
    CHRISTOPHER WILCOX; Fiscal Year: 2002
    ....
  15. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    Christopher S Wilcox; Fiscal Year: 2010
    ..They could identify new molecular mechanisms that underlie endothelial and kidney dysfunction, and could provide new targets for therapy for patients with these conditions. ..