Stefano Vicini

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons
    S Vicini
    Department of Physiology and Biophysics, Georgetown University Medical School, Washington, DC 20007, USA
    J Neurosci 21:3009-16. 2001
  2. pmc Desensitization and binding properties determine distinct alpha1beta2gamma2 and alpha3beta2gamma2 GABA(A) receptor-channel kinetic behavior
    Andrea Barberis
    Department of Physiology and Biophysics, Georgetown University School of Medicine, NW Washington, DC 20007, USA
    Eur J Neurosci 25:2726-40. 2007
  3. pmc Hilar somatostatin interneurons contribute to synchronized GABA activity in an in vitro epilepsy model
    Sabine Grosser
    Institute of Neurophysiology, Charite Universitatsmedizin Berlin, Germany Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Germany
    PLoS ONE 9:e86250. 2014
  4. ncbi request reprint Genetic manipulations of GABAA receptor in mice make inhibition exciting
    Stefano Vicini
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    Pharmacol Ther 103:109-20. 2004
  5. pmc A cerebellar synapse for "heavy duty" transmission
    Stefano Vicini
    Department of Physiology and Biophysics, Georgetown University School of Medicine, BSB225, 3900 Reservoir Rd NW, Washington, DC, USA
    Biophys J 88:1505-6. 2005
  6. ncbi request reprint GABA(A) receptor delta subunit deletion prevents neurosteroid modulation of inhibitory synaptic currents in cerebellar neurons
    Stefano Vicini
    Georgetown University, School of Medicine Department of Physiology and Biophysics, 3900 Reservoir Road NW, 20007 Washington DC, USA
    Neuropharmacology 43:646-50. 2002
  7. doi request reprint The FGIN period: electrophysiological studies
    Stefano Vicini
    Department of Physiology and Biophysics, Georgetown University Medical Center, room 225 3900 Reservoir Rd, N W, Washington DC 20057, United States
    Pharmacol Res 64:316-8. 2011
  8. pmc Cellular mechanisms of desynchronizing effects of hypothermia in an in vitro epilepsy model
    Gholam K Motamedi
    Department of Neurology, Georgetown University Hospital, Washington, DC 20007, USA
    Neurotherapeutics 9:199-209. 2012
  9. ncbi request reprint Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors
    Zhanyan Fu
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurophysiol 90:3950-7. 2003
  10. ncbi request reprint Deletion of the GABA(A) receptor alpha1 subunit increases tonic GABA(A) receptor current: a role for GABA uptake transporters
    Pavel I Ortinski
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurosci 26:9323-31. 2006

Research Grants

  1. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2004
  2. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2009
  3. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2010
  4. Cerebellar Inhibitory Synapses in GABAR subunits KO mice
    Stefano Vicini; Fiscal Year: 2006
  5. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2006
  6. Cerebellar Inhibitory Synapses in GABAR subunits KO mice
    Stefano Vicini; Fiscal Year: 2007
  7. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2009
  8. GABA channels and dopamine in striatum
    Stefano Vicini; Fiscal Year: 2010
  9. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2005
  10. Cerebellar Inhibitory Synapses in GABAR subunits KO mice
    Stefano Vicini; Fiscal Year: 2005

Detail Information

Publications77

  1. ncbi request reprint GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons
    S Vicini
    Department of Physiology and Biophysics, Georgetown University Medical School, Washington, DC 20007, USA
    J Neurosci 21:3009-16. 2001
    ..We propose that an increased alpha1 subunit assembly in postsynaptic receptors of cerebellar inhibitory synapses is responsible for the fast inhibitory synaptic currents that are normally observed during postnatal development...
  2. pmc Desensitization and binding properties determine distinct alpha1beta2gamma2 and alpha3beta2gamma2 GABA(A) receptor-channel kinetic behavior
    Andrea Barberis
    Department of Physiology and Biophysics, Georgetown University School of Medicine, NW Washington, DC 20007, USA
    Eur J Neurosci 25:2726-40. 2007
    ..Our work describes the mechanisms underlying the kinetic differences between two major GABA(A) receptor subtypes and provides a framework to interpret data from native GABA receptors...
  3. pmc Hilar somatostatin interneurons contribute to synchronized GABA activity in an in vitro epilepsy model
    Sabine Grosser
    Institute of Neurophysiology, Charite Universitatsmedizin Berlin, Germany Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Germany
    PLoS ONE 9:e86250. 2014
    ..Our results present evidence that the extensive synchronized activity of SST-expressing interneurons contribute to the generation of GABAergic LFPs in an in vitro model of temporal lobe seizures. ..
  4. ncbi request reprint Genetic manipulations of GABAA receptor in mice make inhibition exciting
    Stefano Vicini
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    Pharmacol Ther 103:109-20. 2004
    ..We review these findings and speculate on the new directions that the use of mice with altered expression of GABA(A) receptor subunits may provide...
  5. pmc A cerebellar synapse for "heavy duty" transmission
    Stefano Vicini
    Department of Physiology and Biophysics, Georgetown University School of Medicine, BSB225, 3900 Reservoir Rd NW, Washington, DC, USA
    Biophys J 88:1505-6. 2005
  6. ncbi request reprint GABA(A) receptor delta subunit deletion prevents neurosteroid modulation of inhibitory synaptic currents in cerebellar neurons
    Stefano Vicini
    Georgetown University, School of Medicine Department of Physiology and Biophysics, 3900 Reservoir Road NW, 20007 Washington DC, USA
    Neuropharmacology 43:646-50. 2002
    ..Phorbol-12-myristate-13-acetate (PMA) completely restored the action of the neurosteroid on synaptic currents in both granule and stellate neurons...
  7. doi request reprint The FGIN period: electrophysiological studies
    Stefano Vicini
    Department of Physiology and Biophysics, Georgetown University Medical Center, room 225 3900 Reservoir Rd, N W, Washington DC 20057, United States
    Pharmacol Res 64:316-8. 2011
    ....
  8. pmc Cellular mechanisms of desynchronizing effects of hypothermia in an in vitro epilepsy model
    Gholam K Motamedi
    Department of Neurology, Georgetown University Hospital, Washington, DC 20007, USA
    Neurotherapeutics 9:199-209. 2012
    ..Moreover, the persistence of action potential firing in interneurons would have additional antiepileptic effects through tonic γ-aminobutyric acid release...
  9. ncbi request reprint Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors
    Zhanyan Fu
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurophysiol 90:3950-7. 2003
    ....
  10. ncbi request reprint Deletion of the GABA(A) receptor alpha1 subunit increases tonic GABA(A) receptor current: a role for GABA uptake transporters
    Pavel I Ortinski
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurosci 26:9323-31. 2006
    ....
  11. ncbi request reprint NMDA receptor subtypes at autaptic synapses of cerebellar granule neurons
    Congyi Lu
    Department of Physiology and Biophysics, BSB225, Georgetown University School of Medicine, 3900 Reservoir Rd, Washington, DC 20007, USA
    J Neurophysiol 96:2282-94. 2006
    ..Thus solitary cerebellar granule neurons provide a novel model to investigate the role of receptor subtypes in the developmental changes of synaptic NMDA receptors...
  12. ncbi request reprint Long-lasting NMDA receptor-mediated EPSCs in mouse striatal medium spiny neurons
    Stephen M Logan
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurophysiol 98:2693-704. 2007
    ..Our data are consistent with the expression of a unique NMDA receptor complex in MSNs with very slow deactivation kinetics...
  13. pmc Presynaptic AMPA and kainate receptors increase the size of GABAergic terminals and enhance GABA release
    Monica L Fiszman
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    Neuropharmacology 52:1631-40. 2007
    ..Direct recordings from presynaptic GABAergic terminals suggest that AMPA and kainate receptors are present in developing GABAergic terminals and their activation affects the size of GABAergic terminals and spontaneous GABA release...
  14. pmc PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat
    Gabriele Losi
    Department of Physiology and Biophysics, Georgetown University, Washington, DC 20057, USA
    J Physiol 548:21-9. 2003
    ..These data suggest that PSD-95 overexpression in CGCs favours synaptic maturation by allowing synaptic insertion of NR2A and depressing expression of NR2B subunits...
  15. pmc Neonatal exposure to antiepileptic drugs disrupts striatal synaptic development
    Patrick A Forcelli
    Interdisciplinary Program in Neuroscience, Georgetown University, School of Medicine, Washington, DC, USA
    Ann Neurol 72:363-72. 2012
    ..The functional significance of the preclinical neurotoxicity has been questioned due to the absence of evidence for functional impairment associated with drug-induced developmental apoptosis...
  16. ncbi request reprint GABA(A) receptor beta3 subunit deletion decreases alpha2/3 subunits and IPSC duration
    Epolia Ramadan
    Department of Biology, Georgetown University School of Medicine, Washington, DC 20057, USA
    J Neurophysiol 89:128-34. 2003
    ....
  17. pmc Excitatory and inhibitory synapses in neuropeptide Y-expressing striatal interneurons
    John G Partridge
    Dept of Physiology and Biophysics, Stress Physiology and Research Center, BSB230, Georgetown Univ School of Medicine, 3900 Reservoir Rd, Washington, DC 20007, USA
    J Neurophysiol 102:3038-45. 2009
    ..On the contrary, evoked IPSCs decayed faster in NPY neurons than in other striatal neurons. These data report for the first time specific properties of synaptic transmission to NPY striatal interneurons...
  18. pmc GABAergic currents in RT and VB thalamic nuclei follow kinetic pattern of alpha3- and alpha1-subunit-containing GABAA receptors
    Jerzy W Mozrzymas
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    Eur J Neurosci 26:657-65. 2007
    ..The dissimilarity between stationary kinetics of neuronal and recombinant receptors probably reflects differences between GABAARs mediating phasic and tonic currents in these neurons...
  19. pmc Distinct roles of synaptic and extrasynaptic GABAAreceptors in striatal inhibition dynamics
    Ruixi Luo
    Department of Pharmacology and Physiology, Georgetown University School of Medicine Washington, DC, USA
    Front Neural Circuits 7:186. 2013
    ..Deletion of the β3 subunit from D2+ MSNs however, removed slow spontaneous IPSCs, implicating its role in mediating synaptic input from striatal neurogliaform interneurons. ..
  20. pmc The effects of amyloid precursor protein on postsynaptic composition and activity
    HYANG SOOK HOE
    Departments of Neuroscience, Physiology and Biophysics, Pharmacology, and Neurology, Georgetown University Medical Center, Washington, D C 20057 1464, USA
    J Biol Chem 284:8495-506. 2009
    ..These results demonstrate a novel physiological role of postsynaptic APP in enhancing NMDAR function...
  21. ncbi request reprint Developmental changes of GABA synaptic transient in cerebellar granule cells
    Andrea Barberis
    Department of Physiology and Biophysics, Georgetown University School of Medicine, 225 Basic Research Bldg 3900 Reservoir Road NW, Washington, DC 20007, USA
    Mol Pharmacol 67:1221-8. 2005
    ..Thus, we provide evidence that presynaptic GABA uniquantal release is developmentally regulated...
  22. ncbi request reprint Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor
    HYANG SOOK HOE
    Department of Neuroscience and Physiology, Georgetown University Medical Center, Washington, DC 20057 1464, USA
    J Biol Chem 281:3425-31. 2006
    ..These studies suggest that ApoEr2 can form a multiprotein complex with NMDA receptor subunits and PSD95...
  23. pmc Dopamine modulation of GABA tonic conductance in striatal output neurons
    Megan J Janssen
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurosci 29:5116-26. 2009
    ..Our results suggest that distinct phosphorylation of beta3-subunits may cause larger tonic current in D2+ striatopallidal MSNs, and proper intracellular conditions can reveal tonic current in D1+ cells...
  24. ncbi request reprint NMDA receptors increase the size of GABAergic terminals and enhance GABA release
    Monica L Fiszman
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurosci 25:2024-31. 2005
    ..These findings parallel changes in inhibitory synaptic efficacy seen in vivo in developing GABAergic interneurons of the molecular layer of the cerebellum...
  25. doi request reprint Differential tonic GABA conductances in striatal medium spiny neurons
    Kristen K Ade
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurosci 28:1185-97. 2008
    ....
  26. pmc Tonic GABAA receptor conductance in medial subnucleus of the tractus solitarius neurons is inhibited by activation of μ-opioid receptors
    Melissa A Herman
    Interdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia, USA
    J Neurophysiol 107:1022-31. 2012
    ..These data suggest that mNTS neurons possess a robust tonic inhibition that is mediated by GABA(A) receptors containing the δ-subunit, that determines membrane excitability, and that is partially regulated by μ-opioid receptors...
  27. pmc Soluble ICAM-5, a product of activity dependent proteolysis, increases mEPSC frequency and dendritic expression of GluA1
    Irina Lonskaya
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC, United States of America
    PLoS ONE 8:e69136. 2013
    ..We suggest that future studies are warranted to determine whether ICAM-5 is one of a select group of synaptic CAMs whose shedding contributes to MMP dependent effects on learning and memory. ..
  28. ncbi request reprint Expression of distinct alpha subunits of GABAA receptor regulates inhibitory synaptic strength
    Pavel I Ortinski
    Dept of Physiology and Biophysics, BSB225, Georgetown University School of Medicine, 3900 Reservoir Road, Washington, DC 20007, USA
    J Neurophysiol 92:1718-27. 2004
    ..Our results uncover a pattern of sequential expression of alpha subunits underlying the changes in functional efficacy of GABAergic networks with development...
  29. pmc Hippocampal neuron firing and local field potentials in the in vitro 4-aminopyridine epilepsy model
    Alfredo Gonzalez-Sulser
    Interdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia 20007, USA
    J Neurophysiol 108:2568-80. 2012
    ..Our findings reveal that neuronal subpopulations with interneuron properties are likely responsible for initiating synchronous activity in an in vitro model of epileptiform discharges...
  30. ncbi request reprint FE65 interaction with the ApoE receptor ApoEr2
    HYANG SOOK HOE
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057 1464, USA
    J Biol Chem 281:24521-30. 2006
    ..In addition, full-length FE65 decreased Abeta to a significantly greater extent than individual FE65 domains. These data suggest that FE65 can bind APP and ApoEr2 at the same time and affect the processing of each...
  31. pmc Deletion of the NR2A subunit prevents developmental changes of NMDA-mEPSCs in cultured mouse cerebellar granule neurones
    Zhanyan Fu
    Department of Physiology and Biophysics, BSB225 Georgetown University School of Medicine, 3900 Reservoir Rd, Washington, DC 20007, USA
    J Physiol 563:867-81. 2005
    ..Taken together, our results indicate that the NR2A subunit is mainly responsible for the developmental changes observed in the maturation of excitatory synapses...
  32. pmc EphA7 signaling guides cortical dendritic development and spine maturation
    Meredith A Clifford
    Departments of Biology and Pharmacology and Physiology, Interdisciplinary Program in Neuroscience, and Graduate Program in Physiology and Biophysics, Georgetown University, Washington, DC 20057
    Proc Natl Acad Sci U S A 111:4994-9. 2014
    ..These results provide evidence of roles for Eph signaling, first in limiting the elaboration of cortical neuronal dendrites and then in coordinating the maturation and function of synapses. ..
  33. pmc Labeling of dendritic spines with the carbocyanine dye DiI for confocal microscopic imaging in lightly fixed cortical slices
    Byung G Kim
    Department of Neuroscience, NRB Rm EP 04, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20007, USA
    J Neurosci Methods 162:237-43. 2007
    ..This method will thus be useful for studying structural synaptic plasticity...
  34. ncbi request reprint Distinct effect of pregnenolone sulfate on NMDA receptor subtypes
    M Ceccon
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington DC 20007, USA
    Neuropharmacology 40:491-500. 2001
    ....
  35. pmc Dopamine D2 receptors regulate collateral inhibition between striatal medium spiny neurons
    Rupa R Lalchandani
    Graduate Program in Physiology and Biophysics, Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20007, USA
    J Neurosci 33:14075-86. 2013
    ..As the D2 class of MSNs is highly implicated in Parkinson's disease and other neurological disorders, our findings may contribute to understanding and treating the changes that occur in these pathological states. ..
  36. pmc Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model
    Mary O Adedoyin
    Department of Biology, Georgetown University, Biology Reiss Building 37th and O St NW, Washington, D C 20057, USA
    Mol Pain 6:60. 2010
    ..Evoked excitatory postsynaptic currents (eEPSCs) were studied in neurons in the CeLC of mouse brain slices following stimulation of the spinoparabrachial amygdaloid afferents...
  37. ncbi request reprint Remodeling of synaptic structures in the motor cortex following spinal cord injury
    Byung G Kim
    Department of Neuroscience, NRB Rm EP 04, Georgetown University Medical Center, 3970 Reservoir Rd, NW, Washington, DC 20007, USA
    Exp Neurol 198:401-15. 2006
    ..Elongation of dendritic spines may indicate a more immature and modifiable pattern of synaptic connectivity in the motor cortex being reorganized following SCI...
  38. pmc Distinct roles for somatically and dendritically synthesized brain-derived neurotrophic factor in morphogenesis of dendritic spines
    Lauren L Orefice
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA
    J Neurosci 33:11618-32. 2013
    ..These results indicate that somatically synthesized BDNF promotes spine formation, whereas dendritically synthesized BDNF is a key regulator of spine head growth and spine pruning. ..
  39. ncbi request reprint The nicotinic receptor in the rat pineal gland is an alpha3beta4 subtype
    Susan C Hernandez
    Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Mol Pharmacol 66:978-87. 2004
    ....
  40. pmc Mossy fiber-CA3 synapses mediate homeostatic plasticity in mature hippocampal neurons
    Kea Joo Lee
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA
    Neuron 77:99-114. 2013
    ....
  41. pmc Therapeutic strategies to avoid long-term adverse outcomes of neonatal antiepileptic drug exposure
    Patrick A Forcelli
    Department of Pharmacology, Georgetown University, Washington, District of Columbia 20057, USA
    Epilepsia 51:18-23. 2010
    ..In addition, our findings identify early exposure to certain AEDs as an important potential risk factor contributing to psychiatric and neurologic abnormalities later in life...
  42. ncbi request reprint Phenotypic changes in NG2+ cells after spinal cord injury
    Judith M Lytle
    Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC, USA
    J Neurotrauma 23:1726-38. 2006
    ..Our results indicate that the adult NG2(+) cell pool is antigenically and physiologically different than the early postnatal pool, and that contusive injury induces changes in adult NG2(+) cells...
  43. ncbi request reprint Exacerbation of neuronal cell death by activation of group I metabotropic glutamate receptors: role of NMDA receptors and arachidonic acid release
    J W Allen
    Institute for Cognitive and Computational Sciences, Department of Neuroscience, Georgetown University, 3970 Reservoir Road NW, Washington, DC 20007, USA
    Exp Neurol 169:449-60. 2001
    ..Thus, activation of group I mGluR may exacerbate neuronal injury through multiple mechanisms, which include positive modulation of NMDA receptors and enhanced release of arachidonic acid...
  44. pmc Direct and GABA-mediated indirect effects of nicotinic ACh receptor agonists on striatal neurones
    Ruixi Luo
    Department of Pharmacology and Physiology, Basic Science Building, Rm 225, Georgetown University School of Medicine, 3900 Reservoir Rd, Washington, DC 20007, USA
    J Physiol 591:203-17. 2013
    ....
  45. ncbi request reprint Silent synapses in developing cerebellar granule neurons
    Gabriele Losi
    Departments of Physiology and Biophysics, Georgetown University School of Medicine, 3900 Reservoir Road, Washington, DC 20007, USA
    J Neurophysiol 87:1263-70. 2002
    ..We suggest that the prevalence of synaptic NR2A subunits that confer faster kinetics is paralleled by the disappearance of silent synapses early in cerebellar development...
  46. ncbi request reprint Neuronal and glial mGluR5 modulation prevents stretch-induced enhancement of NMDA receptor current
    Paul M Lea
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007 2197, USA
    Pharmacol Biochem Behav 73:287-98. 2002
    ..Neither CHPG nor MPEP had any direct effects upon the NMDA receptor. We conclude that mGluR5 regulates NMDAR activity during mild stretch injury, but not severe injury, by modulating both the Mg2+ block and I(NMDA)...
  47. pmc The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array
    Alfredo Gonzalez-Sulser
    Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC, USA
    Neuropharmacology 60:1142-53. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  48. pmc Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability
    Li Rebekah Feng
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Eur J Neurosci 32:10-7. 2010
    ....
  49. ncbi request reprint Developmental changes in localization of NMDA receptor subunits in primary cultures of cortical neurons
    J H Li
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    Eur J Neurosci 10:1704-15. 1998
    ..Our data indicate that excitatory synapse formation occurs when NMDA receptors comprise NR1 and NR2B subunits, and that NR2A subunits cluster preferentially at synaptic sites...
  50. pmc A slow NMDA channel: in search of a role
    S Vicini
    Department of Physiology, Georgetown University School of Medicine, Washington DC 20007, USA
    J Physiol 525:283. 2000
    ..1994). This property has now been identified for the first time by Misra et al. (this issue of The Journal of Physiology, Misra et al. 2000b) for native NMDA channels in mammalian neurons...
  51. ncbi request reprint NAAG fails to antagonize synaptic and extrasynaptic NMDA receptors in cerebellar granule neurons
    G Losi
    Department of Physiology, Georgetown University, Washington, D C 20057 1229 USA
    Neuropharmacology 46:490-6. 2004
    ..Recent reports indicate that enhancing the activity of endogenous NAAG may be an important therapeutic approach to excitotoxicity and chronic pain perception. These effects are likely mediated by group II mGluRs, not NMDA receptors...
  52. pmc Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons
    G Stocca
    Department of Physiology and Biophysics, Georgetown University School of Medicine, 3900 Reservoir Road NW, Washington, DC 20007, USA
    J Physiol 507:13-24. 1998
    ..Moreover, the consistent blockade seen in outside out patches might be ascribed to the confinement of NR1/NR2B receptors to an extrasynaptic population...
  53. ncbi request reprint Interleukin-10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3-like activity
    A Bachis
    Departments of Neuroscience and Physiology, Georgetown University, Washington, DC 20007, USA
    J Neurosci 21:3104-12. 2001
    ..IL-10 blocked both the glutamate-mediated induction of caspase-3 as well as NF-kappaB DNA binding activity, suggesting that the neuroprotective properties of IL-10 may rely on its ability to block the activity of proapoptotic proteins...
  54. pmc Melanocortin signaling in the brainstem influences vagal outflow to the stomach
    Janell Richardson
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA
    J Neurosci 33:13286-99. 2013
    ....
  55. ncbi request reprint Association of NR3A with the N-methyl-D-aspartate receptor NR1 and NR2 subunits
    Rana A Al-Hallaq
    Department of Pharmacology, Georgetown University Medical Center, Washington DC, USA
    Mol Pharmacol 62:1119-27. 2002
    ....
  56. pmc Acetylsalicylic acid enhances purinergic receptor-mediated outward currents in rat megakaryocytes
    José P Young
    Dept of Physiology and Biophysics, Georgetown Univ, Columbia, Washington, DC 20057, USA
    Am J Physiol Cell Physiol 298:C602-10. 2010
    ..These findings may be relevant to ASA resistance, because individual variations in sensitivity to the multiple effects of ASA on signaling pathways could result in insensitivity to its antiplatelet effects in some patients...
  57. pmc Nicotinic ACh receptor subtypes on gastrointestinally projecting neurones in the dorsal motor vagal nucleus of the rat
    Niaz Sahibzada
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA
    J Physiol 545:1007-16. 2002
    ..In addition, we obtained evidence for the co-expression of the alpha4beta2 nAChR subtype on DMV neurones projecting to the fundus and antrum, and the alpha3beta4 nAChR subtype on DMV neurones projecting to the caecum...
  58. pmc GABA(A) Receptor β3 Subunit Expression Regulates Tonic Current in Developing Striatopallidal Medium Spiny Neurons
    Megan J Janssen
    Department of Pharmacology and Physiology, Georgetown University School of Medicine Washington, DC, USA
    Front Cell Neurosci 5:15. 2011
    ..These results offer insight for target mechanisms in Parkinson's disease, where symptoms arise due to the imbalance in striatal D1+ and D2+ MSN excitability and output...
  59. ncbi request reprint Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors
    S Vicini
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurophysiol 79:555-66. 1998
    ....
  60. doi request reprint Therapeutic brain hypothermia, its mechanisms of action, and its prospects as a treatment for epilepsy
    Gholam K Motamedi
    Department of Neurology, Georgetown University Hospital, Washington, District of Columbia 20007, USA
    Epilepsia 54:959-70. 2013
    ..This article reviews currently available clinical and laboratory data with a focus on cellular mechanisms of action and prospects of hypothermia as a treatment for intractable seizures...
  61. ncbi request reprint Ribozyme-mediated reduction of the GABA(A) receptor alpha1 subunit
    J R Subramaniam
    Department of Biology, Georgetown University, Washington, DC 20057-1229, USA
    Brain Res Mol Brain Res 92:149-56. 2001
    ....
  62. ncbi request reprint Functional expression of distinct NMDA channel subunits tagged with green fluorescent protein in hippocampal neurons in culture
    J H Luo
    Department of Physiology and Biophysics, Georgetown University School of Medicine, 3900 Reservoir Road NW, Washington, DC 20007, USA
    Neuropharmacology 42:306-18. 2002
    ..Our report provides the basis for studies of NMDA receptor location together with dendritic dynamics in living neurons during synaptogenesis in vitro...
  63. ncbi request reprint Contrasting actions of group I metabotropic glutamate receptors in distinct mouse striatal neurones
    John G Partridge
    Department of Pharmacology and Physiology, Georgetown University School of Medicine, Washington, DC, 20007, USA Interdisciplinary Program in Neuroscience, Georgetown University School of Medicine, Washington, DC, 20007, USA
    J Physiol 592:2721-33. 2014
    ....
  64. ncbi request reprint NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR
    Rafal T Olszewski
    Department of Biology, Georgetown University, Washington, DC, USA
    J Neurochem 89:876-85. 2004
    ..These data support the view that NAAG peptidase inhibitors may represent a new therapeutic approach to some of the components of schizophrenia that are modeled by PCP...
  65. ncbi request reprint Characterization of NMDA receptor subunit-specific antibodies: distribution of NR2A and NR2B receptor subunits in rat brain and ontogenic profile in the cerebellum
    Y H Wang
    Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurochem 65:176-83. 1995
    ..At the same time (P12), levels of NR2B protein begin to decline rapidly to reach undetectable levels by 22 days after birth.(ABSTRACT TRUNCATED AT 250 WORDS)..
  66. pmc Brain-derived neurotrophic factor and nerve growth factor potentiate excitatory synaptic transmission in the rat visual cortex
    G Carmignoto
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington DC, USA
    J Physiol 498:153-64. 1997
    ..6. The probability of neurotransmitter release represents a rapidly modifiable synaptic feature by which neurotrophins can potentiate the efficacy of excitatory synaptic transmission in the visual cortex...
  67. ncbi request reprint The pheromone androstenol (5 alpha-androst-16-en-3 alpha-ol) is a neurosteroid positive modulator of GABAA receptors
    Rafal M Kaminski
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Pharmacol Exp Ther 317:694-703. 2006
    ..GABA(A) receptors could represent a target for androstenol as a pheromone, for which it is well suited because of high volatility and lipophilicity, or as a conventional hormonal neurosteroid...
  68. ncbi request reprint GABA comes first to newly generated neurons. Focus on "GABAergic signal to newborn neurons in dentate gyrus"
    Stefano Vicini
    J Neurophysiol 94:3661. 2005
  69. pmc The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2
    Kate Prybylowski
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, Room 4148 Bldg 50, National Institutes of Health, Bethesda Maryland 20892, USA
    Neuron 47:845-57. 2005
    ..This study identifies a dynamic regulation of synaptic NR2B-containing NMDARs through PDZ protein-mediated stabilization and AP-2-mediated internalization that is modulated by phosphorylation by Fyn kinase...
  70. ncbi request reprint Repeated electroconvulsive stimulation impairs long-term depression in the neostriatum
    Marco De Murtas
    Clinica Psichiatrica II Universitá di Roma la Sapienza MDM, RT, PG, Rome, Italy
    Biol Psychiatry 55:472-6. 2004
    ..Therefore, the beneficial effect of electroconvulsive stimulation (ECS) treatment of acute state of mood disorder may relate to changes in striatal synaptic plasticity...
  71. ncbi request reprint GABA-induced neurite outgrowth of cerebellar granule cells is mediated by GABA(A) receptor activation, calcium influx and CaMKII and erk1/2 pathways
    Laura N Borodinsky
    Instituto de Investigaciones Farmacológicas CONICET, Buenos Aires, Argentina
    J Neurochem 84:1411-20. 2003
    ..These data demonstrate that GABA exerts a stimulatory role on cerebellar granule cell neuritogenesis through calcium influx and activation of calcium-dependent kinases...
  72. pmc Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice
    Christopher D Toscano
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9 Memorial Drive, Bethesda, MD 20892, USA
    Brain Res Bull 75:598-609. 2008
    ..Our results suggest that PTGS-2 activity and its specific products may modulate neuronal excitability by affecting GABAergic neurotransmission. Further, inhibition of PTGS-2, but not PTGS-1, may increase the susceptibility to seizures...
  73. pmc The role of GABA and glutamate on adult neurogenesis
    Stefano Vicini
    J Physiol 586:3737-8. 2008
  74. ncbi request reprint Kainate-induced excitotoxicity is dependent upon extracellular potassium concentrations that regulate the activity of AMPA/KA type glutamate receptors
    Byeong Keun Ha
    Department of Neuroscience, Ohio State University, Columbus, Ohio 43210, USA
    J Neurochem 83:934-45. 2002
    ..This study suggests that KA-induced excitotoxicity in mature CGCs is dependent upon the extracellular potassium concentration, which modulates functional expression and excitability of AMPA/KA receptors...
  75. ncbi request reprint Relationship between availability of NMDA receptor subunits and their expression at the synapse
    Kate Prybylowski
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 22:8902-10. 2002
    ..Therefore, the entry of NMDA receptors into the synapse requires a PDZ binding domain and is limited by means other than receptor subunit availability...
  76. ncbi request reprint NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex
    Nathalie Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 50, Room 4146, 50 South Drive, Bethesda, MD 20892 8027, USA
    Nat Cell Biol 5:520-30. 2003
    ..Furthermore, they suggest that an exocyst-SAP102-NMDAR complex is an important component of NMDAR trafficking...
  77. ncbi request reprint Termination of epileptiform activity by cooling in rat hippocampal slice epilepsy models
    Gholam K Motamedi
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 3702, USA
    Epilepsy Res 70:200-10. 2006
    ..Practical devices to inhibit seizure activity may only need to induce small temperature drops, if the cooling can be applied sufficiently rapidly...

Research Grants21

  1. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2004
    ..Thus, the results we will derive, although clearly related to basic neuroscience, will have notable applications to neurological disorders and to mental health ..
  2. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2009
    ..abstract_text> ..
  3. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2010
    ....
  4. Cerebellar Inhibitory Synapses in GABAR subunits KO mice
    Stefano Vicini; Fiscal Year: 2006
    ..The goal is to identify native subunit combinations and ultimately link these different receptor combinations to their particular role in GABA-mediated inhibition in cerebellar neurons. ..
  5. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2006
    ..Thus, the results we will derive, although clearly related to basic neuroscience, will have notable applications to neurological disorders and to mental health ..
  6. Cerebellar Inhibitory Synapses in GABAR subunits KO mice
    Stefano Vicini; Fiscal Year: 2007
    ..The goal is to identify native subunit combinations and ultimately link these different receptor combinations to their particular role in GABA-mediated inhibition in cerebellar neurons. ..
  7. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2009
    ....
  8. GABA channels and dopamine in striatum
    Stefano Vicini; Fiscal Year: 2010
    ....
  9. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2005
    ..Thus, the results we will derive, although clearly related to basic neuroscience, will have notable applications to neurological disorders and to mental health ..
  10. Cerebellar Inhibitory Synapses in GABAR subunits KO mice
    Stefano Vicini; Fiscal Year: 2005
    ..The goal is to identify native subunit combinations and ultimately link these different receptor combinations to their particular role in GABA-mediated inhibition in cerebellar neurons. ..
  11. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 1999
    ..Data obtained from these specific aims will permit the understanding of the molecular determinant responsible for synaptic plasticity in CNS. ..
  12. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2000
    ..Data obtained from these specific aims will permit the understanding of the molecular determinant responsible for synaptic plasticity in CNS. ..
  13. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2001
    ..Data obtained from these specific aims will permit the understanding of the molecular determinant responsible for synaptic plasticity in CNS. ..
  14. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2002
    ..Data obtained from these specific aims will permit the understanding of the molecular determinant responsible for synaptic plasticity in CNS. ..
  15. Cerebellar Inhibitory Synapses in GABAR subunits KO mice
    Stefano Vicini; Fiscal Year: 2003
    ..The goal is to identify native subunit combinations and ultimately link these different receptor combinations to their particular role in GABA-mediated inhibition in cerebellar neurons. ..
  16. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2003
    ..Data obtained from these specific aims will permit the understanding of the molecular determinant responsible for synaptic plasticity in CNS possibly relevant o for the understanding of neuropsychiatric disorders. ..
  17. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2003
    ..Thus, the results we will derive, although clearly related to basic neuroscience, will have notable applications to neurological disorders and to mental health ..
  18. Cerebellar Inhibitory Synapses in GABAR subunits KO mice
    Stefano Vicini; Fiscal Year: 2004
    ..The goal is to identify native subunit combinations and ultimately link these different receptor combinations to their particular role in GABA-mediated inhibition in cerebellar neurons. ..
  19. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2010
    ....