R E Tractenberg

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. pmc Using the Guttman scale to define and estimate measurement error in items over time: the case of cognitive decline and the meaning of "points lost"
    Rochelle E Tractenberg
    Department of Neurology, Georgetown University Medical Center, Washington, District of Columbia, United States of America
    PLoS ONE 7:e30019. 2012
  2. ncbi request reprint Characterizing sleep problems in persons with Alzheimer's disease and normal elderly
    Rochelle E Tractenberg
    Departments of Biostatistics, Biomathematics and Bioinformatics and Psychiatry, Georgetown University School of Medicine, Washington, DC, USA
    J Sleep Res 15:97-103. 2006
  3. ncbi request reprint Sleep and sleep disturbance: from genes to dreams
    R E Tractenberg
    Departments of Neurology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Cell Mol Life Sci 64:1171-3. 2007
  4. ncbi request reprint Symptoms of sleep disturbance in persons with Alzheimer's disease and normal elderly
    Rochelle E Tractenberg
    Department of Biomathematics and Biostatistics, Georgetown University School of Medicine, Georgetown University Hospital, Washington, DC 20007, USA
    J Sleep Res 14:177-85. 2005
  5. ncbi request reprint Independence of changes in behavior from cognition and function in community-dwelling persons with Alzheimer's disease: a factor analytic approach
    Rochelle E Tractenberg
    Department of Biomathematics and Biostatistics, Georgetown University School of Medicine, 7 East Main, M702, Georgetown University Hospital, 3800 Reservoir Rd, NW, Washington, DC 20007, USA
    J Neuropsychiatry Clin Neurosci 17:51-60. 2005
  6. pmc No cross-sectional influence of APOE epsilon4 dose on clinical tests in Alzheimer's disease
    Rochelle E Tractenberg
    Department of Neurology, Georgetown University School of Medicine, Washington, DC, USA
    Neurobiol Aging 30:1327-8. 2009
  7. ncbi request reprint Benchmarking a test of temporal orientation with data from american and taiwanese persons with Alzheimer's disease and american normal elderly
    Rochelle E Tractenberg
    Department of Biomathematics and Biostatistics, Georgetown University School of Medicine, Washington, DC 20008, USA
    Neuroepidemiology 24:110-6. 2005
  8. ncbi request reprint Benchmarking a computerized test of immediate verbal memory
    Rochelle E Tractenberg
    Department of Neurology, Georgetown University, Washington, DC 20057, USA
    Behav Res Methods 39:863-9. 2007
  9. pmc Sample size requirements for training to a kappa agreement criterion on clinical dementia ratings
    Rochelle E Tractenberg
    Department of Neurology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Alzheimer Dis Assoc Disord 24:264-8. 2010
  10. pmc Intra-individual variability in Alzheimer's disease and cognitive aging: definitions, context, and effect sizes
    Rochelle E Tractenberg
    Department of Neurology, Georgetown University School of Medicine, Washington, DC, United States of America
    PLoS ONE 6:e16973. 2011

Research Grants

Detail Information

Publications35

  1. pmc Using the Guttman scale to define and estimate measurement error in items over time: the case of cognitive decline and the meaning of "points lost"
    Rochelle E Tractenberg
    Department of Neurology, Georgetown University Medical Center, Washington, District of Columbia, United States of America
    PLoS ONE 7:e30019. 2012
    ..We found that measurement error, as we defined it, was inconsistent over time and across cognitive functioning levels, violating the theory underlying reliability and other psychometric characteristics, and key regression assumptions...
  2. ncbi request reprint Characterizing sleep problems in persons with Alzheimer's disease and normal elderly
    Rochelle E Tractenberg
    Departments of Biostatistics, Biomathematics and Bioinformatics and Psychiatry, Georgetown University School of Medicine, Washington, DC, USA
    J Sleep Res 15:97-103. 2006
    ..Within-cohort differences reflect a clear distinction between persons with and without sleep problems, regardless of the reporter...
  3. ncbi request reprint Sleep and sleep disturbance: from genes to dreams
    R E Tractenberg
    Departments of Neurology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Cell Mol Life Sci 64:1171-3. 2007
  4. ncbi request reprint Symptoms of sleep disturbance in persons with Alzheimer's disease and normal elderly
    Rochelle E Tractenberg
    Department of Biomathematics and Biostatistics, Georgetown University School of Medicine, Georgetown University Hospital, Washington, DC 20007, USA
    J Sleep Res 14:177-85. 2005
    ..There was no association between subjective perception of 'sleep problems', the number and frequency of sleep disturbance symptoms, and estimated TIB in either group...
  5. ncbi request reprint Independence of changes in behavior from cognition and function in community-dwelling persons with Alzheimer's disease: a factor analytic approach
    Rochelle E Tractenberg
    Department of Biomathematics and Biostatistics, Georgetown University School of Medicine, 7 East Main, M702, Georgetown University Hospital, 3800 Reservoir Rd, NW, Washington, DC 20007, USA
    J Neuropsychiatry Clin Neurosci 17:51-60. 2005
    ..Cognitive and functional subscores for the CDR were supported. These findings suggest that changes in behavior and cognition in dementia may have distinct pathophysiologies...
  6. pmc No cross-sectional influence of APOE epsilon4 dose on clinical tests in Alzheimer's disease
    Rochelle E Tractenberg
    Department of Neurology, Georgetown University School of Medicine, Washington, DC, USA
    Neurobiol Aging 30:1327-8. 2009
    ..No significant influence of epsilon4 was detected. APOE's effect in AD may occur prior to clinical symptoms, or may simply be more subtle than these instruments can detect...
  7. ncbi request reprint Benchmarking a test of temporal orientation with data from american and taiwanese persons with Alzheimer's disease and american normal elderly
    Rochelle E Tractenberg
    Department of Biomathematics and Biostatistics, Georgetown University School of Medicine, Washington, DC 20008, USA
    Neuroepidemiology 24:110-6. 2005
    ..TTO may be a useful component of cognitive screening efforts...
  8. ncbi request reprint Benchmarking a computerized test of immediate verbal memory
    Rochelle E Tractenberg
    Department of Neurology, Georgetown University, Washington, DC 20057, USA
    Behav Res Methods 39:863-9. 2007
    ..The online version of the digit span task is comparable to the traditional version in assessing verbal span capacity; the code with which to implement the task is available at www.psychonomic.org/archive...
  9. pmc Sample size requirements for training to a kappa agreement criterion on clinical dementia ratings
    Rochelle E Tractenberg
    Department of Neurology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Alzheimer Dis Assoc Disord 24:264-8. 2010
    ..80; fewer test cases increases the standard error and unequal distribution of test cases across CDR stages will lower kappa and increase error...
  10. pmc Intra-individual variability in Alzheimer's disease and cognitive aging: definitions, context, and effect sizes
    Rochelle E Tractenberg
    Department of Neurology, Georgetown University School of Medicine, Washington, DC, United States of America
    PLoS ONE 6:e16973. 2011
    ....
  11. pmc Analytic methods for factors, dimensions and endpoints in clinical trials for Alzheimer's disease
    R E Tractenberg
    Department of Neurology, Georgetown University School of Medicine, Washington, DC 20057, USA
    J Nutr Health Aging 13:249-55. 2009
    ..It is not recommended as a method to build BMMIs, which will be useful in establishing diagnostic criteria, creating and evaluating benchmarks, and monitoring progression in clinical trials...
  12. ncbi request reprint The Sleep Disorders Inventory: an instrument for studies of sleep disturbance in persons with Alzheimer's disease
    Rochelle E Tractenberg
    Department of Biomathematics and Biostatistics, Georgetown University School of Medicine, Washington, DC 20057, USA
    J Sleep Res 12:331-7. 2003
    ..The SDI covers a wide range of sleep behaviors and provides information independent of sleep time and SQR...
  13. ncbi request reprint Comorbidity of psychopathological domains in community-dwelling persons with Alzheimer's disease
    Rochelle E Tractenberg
    Center for Population and Health, Georgetown University, Washington, DC 20057 1197, USA
    J Geriatr Psychiatry Neurol 16:94-9. 2003
    ..Significant psychopathological comorbidity should be considered in the design of clinical trials targeting particular psychopathology in this disease population...
  14. pmc Agreement in cognitive and clinical assessments in Alzheimer's disease
    Rochelle E Tractenberg
    Departments of Neurology, Biostatistics, Bioinformatics and Biomathematics, and Psychiatry, Georgetown University School of Medicine, Washington, D C 20057, USA
    Dement Geriatr Cogn Disord 27:344-52. 2009
    ..To estimate agreement among scores on three common assessments of cognitive function...
  15. ncbi request reprint Executive dysfunction in Alzheimer disease
    Margaret M Swanberg
    Department of Neurology, David Geffen School of Medicine at UCLA, 90095 1769, USA
    Arch Neurol 61:556-60. 2004
    ..Executive dysfunction (EDF) is common in Alzheimer disease (AD); however, its relationship to other symptoms is difficult to assess in patients with AD...
  16. pmc Trimester-specific changes in maternal thyroid hormone, thyrotropin, and thyroglobulin concentrations during gestation: trends and associations across trimesters in iodine sufficiency
    O P Soldin
    Division of Cancer Genetics and Epidemiology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20057 1465, USA
    Thyroid 14:1084-90. 2004
    ..To describe the interrelationships of thyroid functions based on trimester-specific concentrations in healthy, iodine-sufficient pregnant women across trimesters, and postpartum...
  17. pmc Do thyroxine and thyroid-stimulating hormone levels reflect urinary iodine concentrations?
    Offie P Soldin
    Division of Endocrinology and Metabolism, Georgetown University School of Medicine, Washington, DC 20057, USA
    Ther Drug Monit 27:178-85. 2005
    ..Monitoring the status of iodine nutrition of individuals in the United States may be important because serum TSH and T4 concentrations do not indicate low iodine status...
  18. ncbi request reprint Promoting self-awareness and reflection through an experiential mind-body skills course for first year medical students
    Pamela A Saunders
    Department of Neurology, Georgetown University, Washington, DC 20057, USA
    Med Teach 29:778-84. 2007
    ..This research examines student evaluations of their experience and attitudes in an 11 week mind-body skills course for first year medical students...
  19. pmc Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry
    Offie P Soldin
    Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University Medical Center, Washington, DC 20057 1465, USA
    Fertil Steril 84:701-10. 2005
    ....
  20. pmc Differences between measurements of T4 and T3 in pregnant and nonpregnant women using isotope dilution tandem mass spectrometry and immunoassays: are there clinical implications?
    Offie P Soldin
    Division of Cancer Genetics and Epidemiology, Lombardi Cancer Center, Georgetown University School of Medicine, Room S 165A, 3800 Reservoir Road, NW, Washington, DC 20007 2197, USA
    Clin Chim Acta 347:61-9. 2004
    ..05) throughout pregnancy. In this study, we examined the clinical implications of these discrepancies...
  21. ncbi request reprint The smallpox vaccine: a multidimensional model of choice
    Stacey Kaltman
    Department of Psychiatry, Georgetown University Medical Center, Washington, DC 2007, USA
    Biosecur Bioterror 4:64-73. 2006
    ..g., first responders, healthcare workers). A multidimensional modeling approach should facilitate these and other studies of choice...
  22. ncbi request reprint Modeling dimensions of choice in accepting the smallpox vaccine
    Stacey Kaltman
    Department of Psychiatry, Biomathematics and Bioinformatics, Washington, DC, USA
    Am J Health Behav 30:513-24. 2006
    ..To model the dimensionality of understanding refusal to be vaccinated against smallpox...
  23. pmc Use of steroid profiles in determining the cause of adrenal insufficiency
    Jennifer P Holst
    Center for Diabetes and Endocrinology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Steroids 72:71-84. 2007
    ..The study objective was to determine whether a steroid profile, created by simultaneous measurement of 10 steroid hormones by tandem mass spectrometry, would help determine the cause of adrenal insufficiency...
  24. pmc Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative
    Owen Carmichael
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Arch Neurol 67:1370-8. 2010
    ....
  25. ncbi request reprint Regression to the mean: implications for clinical trials of psychotropic agents in dementia
    Jeffrey L Cummings
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
    Curr Alzheimer Res 1:323-8. 2004
    ..Research design adjustments such as collection of both screening and baseline measures to determine eligibility may limit the effects of regression to the mean on trial outcomes and reduce this challenge to clinical trials...
  26. ncbi request reprint A large-sample survey of first- and second-year medical student attitudes toward complementary and alternative medicine in the curriculum and in practice
    Ranjana Chaterji
    Georgetown University School of Medicine, Washington, DC, USA
    Altern Ther Health Med 13:30-5. 2007
    ..To assess attitudes toward complementary and alternative medicine (CAM) and its place in the medical school curriculum and medical practice among preclinical students at Georgetown University School of Medicine (GUSOM), Washington, DC...
  27. ncbi request reprint One-trial 10-item free-recall performance in Taiwanese elderly and near-elderly: A potential screen for cognitive decline
    Rochelle E Tractenberg
    Department of Biomathematics and Biostatistics, Georgetown University School of Medicine, Washington, DC, USA
    Am J Alzheimers Dis Other Demen 20:239-47. 2005
    ....
  28. ncbi request reprint Estimating the prevalence of agitation in community-dwelling persons with Alzheimer's disease
    Rochelle E Tractenberg
    Alzheimer s Disease Cooperative Study, Department of Neurosciences, University of California, San Diego, La Jolla 92093 0949, USA
    J Neuropsychiatry Clin Neurosci 14:11-8. 2002
    ..The authors conclude that the best estimate of prevalence of excessive agitation in this population is 67.5%, and that individuals with CMAI scores of 0 to 14 probably should not be considered to have excessive agitation...
  29. ncbi request reprint Emergent psychopathology in Alzheimer's disease patients over 12 months associated with functional, not cognitive, changes
    Rochelle E Tractenberg
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0949, USA
    J Geriatr Psychiatry Neurol 15:110-7. 2002
    ....
  30. ncbi request reprint No long-term effect of behavioral treatment on psychotropic drug use for agitation in Alzheimer's disease patients
    Myron F Weiner
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA
    J Geriatr Psychiatry Neurol 15:95-8. 2002
    ..0 for subjects in each drug arm or placebo arm versus BMTs. We concluded that teaching caregivers BMTs did not diminish long-term prescription of psychotropic drugs...
  31. ncbi request reprint A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease
    Clifford Singer
    Department of Psychiatry, Oregon Health and Science University, Portland, USA
    Sleep 26:893-901. 2003
    ..To determine the safety and efficacy of 2 dose formulations of melatonin for the treatment of insomnia in patients with Alzheimer's disease...
  32. ncbi request reprint Assessing Alzheimer's disease patients with the Cohen-Mansfield Agitation Inventory: scoring and clinical implications
    Myron F Weiner
    Departments of Psychiatry and Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    J Psychiatr Res 36:19-25. 2002
    ....
  33. ncbi request reprint Investigating emergent symptomatology as an outcome measure in a behavioral study of Alzheimer's disease
    Rochelle E Tractenberg
    Alzheimer s Disease Cooperative Study, Department of Neurosciences, University of California, San Diego 92093 0949, USA
    J Neuropsychiatry Clin Neurosci 14:303-10. 2002
    ..The ratio of expected to observed emergence provides an intuitively appealing quantification of treatment efficacy and can be used with any instrument that uses categorical or frequency ratings...
  34. ncbi request reprint Exploring hypotheses about phonological awareness, memory, and reading achievement
    Rochelle E Tractenberg
    Alzheimer s Disease Cooperative Study, University of California, San Diego School of Medicine, 92093 0949, USA
    J Learn Disabil 35:407-24. 2002
    ..The results support other studies suggesting that processes dependent on memory, not solely phonological awareness, may contribute to determining reading achievement...
  35. ncbi request reprint Reliability of monitoring the clinical dementia rating in multicenter clinical trials
    Kimberly A Schafer
    Department of Neurosciences, University of California, San Diego, CA, USA
    Alzheimer Dis Assoc Disord 18:219-22. 2004
    ..An abbreviated version, with formal monitoring for consistency across sites and raters, is currently used in the Alzheimer's Disease Cooperative Study (ADCS)...

Research Grants2

  1. Latent variable analysis in cognitive aging and executive function
    ROCHELLE TRACTENBERG; Fiscal Year: 2007
    ..This K01 award will achieve these and so will move the PI closer to her long-term goal of becoming an independent researcher in cognitive aging and AD. ..