Maddalena T Tilli

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. pmc Comparison of mouse mammary gland imaging techniques and applications: reflectance confocal microscopy, GFP imaging, and ultrasound
    Maddalena T Tilli
    Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    BMC Cancer 8:21. 2008
  2. ncbi request reprint Real-time imaging and characterization of human breast tissue by reflectance confocal microscopy
    Maddalena T Tilli
    Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Biomed Opt 12:051901. 2007
  3. ncbi request reprint Deregulated estrogen receptor alpha expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ
    M Silvina Frech
    Lombardi Comprehensive Cancer Center, Departments of Oncology and Pathology, Georgetown University, 3970 Reservoir Road, Washington, DC 20057, USA
    Cancer Res 65:681-5. 2005
  4. ncbi request reprint Overexpression of an N-terminally truncated isoform of the nuclear receptor coactivator amplified in breast cancer 1 leads to altered proliferation of mammary epithelial cells in transgenic mice
    Maddalena T Tilli
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Research Building, Room E307, 3970 Reservoir Road, Washington, D C 20057, USA
    Mol Endocrinol 19:644-56. 2005
  5. ncbi request reprint Reflectance confocal microscopy for characterization of mammary ductal structures and development of neoplasia in genetically engineered mouse models of breast cancer
    Angela Parrish
    Georgetown University, Lombardi Comprehensive Cancer Center, 3970 Reservoir Road NW, Washington, DC 20057, USA
    J Biomed Opt 10:051602. 2005
  6. pmc The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice
    Mark P Fereshteh
    Departments of Oncology and Pharmacology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
    Cancer Res 68:3697-706. 2008
  7. ncbi request reprint Explant-cell culture of primary mammary tumors from MMTV-c-Myc transgenic mice
    Xu Fang Pei
    Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, The Research Building, 3970 Reservoir Road, Washington, D C 20007, USA
    In Vitro Cell Dev Biol Anim 40:14-21. 2004
  8. ncbi request reprint Chemoprevention of mammary carcinogenesis in a transgenic mouse model by alpha-difluoromethylornithine (DFMO) in the diet is associated with decreased cyclin D1 activity
    Minglin Li
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057, USA
    Oncogene 22:2568-72. 2003
  9. pmc Introduction of estrogen receptor-alpha into the tTA/TAg conditional mouse model precipitates the development of estrogen-responsive mammary adenocarcinoma
    Maddalena T Tilli
    Program in Human Genetics, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA
    Am J Pathol 163:1713-9. 2003
  10. pmc Conditional mouse models demonstrate oncogene-dependent differences in tumor maintenance and recurrence
    Maddalena T Tilli
    Division of Human Genetics, University of Maryland, Baltimore, USA
    Breast Cancer Res 5:202-5. 2003

Collaborators

Detail Information

Publications12

  1. pmc Comparison of mouse mammary gland imaging techniques and applications: reflectance confocal microscopy, GFP imaging, and ultrasound
    Maddalena T Tilli
    Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    BMC Cancer 8:21. 2008
    ..However, traditional whole mount and histological imaging modalities are only applicable to non-viable tissue...
  2. ncbi request reprint Real-time imaging and characterization of human breast tissue by reflectance confocal microscopy
    Maddalena T Tilli
    Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Biomed Opt 12:051901. 2007
    ..RCM data are comparable to data from H and E sections. Epithelial cell nuclear size is measured on stored digital RCM images. We compare RCM and H and E images from 16 patients and 25 core needle biopsy samples...
  3. ncbi request reprint Deregulated estrogen receptor alpha expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ
    M Silvina Frech
    Lombardi Comprehensive Cancer Center, Departments of Oncology and Pathology, Georgetown University, 3970 Reservoir Road, Washington, DC 20057, USA
    Cancer Res 65:681-5. 2005
    ....
  4. ncbi request reprint Overexpression of an N-terminally truncated isoform of the nuclear receptor coactivator amplified in breast cancer 1 leads to altered proliferation of mammary epithelial cells in transgenic mice
    Maddalena T Tilli
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Research Building, Room E307, 3970 Reservoir Road, Washington, D C 20057, USA
    Mol Endocrinol 19:644-56. 2005
    ..These results are consistent with the hypothesis that the N-terminally deleted isoform of AIB1 can play a role in breast cancer development and/or progression...
  5. ncbi request reprint Reflectance confocal microscopy for characterization of mammary ductal structures and development of neoplasia in genetically engineered mouse models of breast cancer
    Angela Parrish
    Georgetown University, Lombardi Comprehensive Cancer Center, 3970 Reservoir Road NW, Washington, DC 20057, USA
    J Biomed Opt 10:051602. 2005
    ..In summary, reflectance confocal microscopy is a tool that can be used to rapidly and accurately analyze mammary gland structure...
  6. pmc The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice
    Mark P Fereshteh
    Departments of Oncology and Pharmacology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
    Cancer Res 68:3697-706. 2008
    ..We predict that reducing AIB1/SRC-3 levels or activity in the mammary epithelium could potentiate therapies aimed at inhibiting HER2/neu signaling in breast cancer...
  7. ncbi request reprint Explant-cell culture of primary mammary tumors from MMTV-c-Myc transgenic mice
    Xu Fang Pei
    Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, The Research Building, 3970 Reservoir Road, Washington, D C 20007, USA
    In Vitro Cell Dev Biol Anim 40:14-21. 2004
    ..This culture system provides a useful tool for studying the biology of mouse mammary gland tumors and possibly tumors from other organ sites...
  8. ncbi request reprint Chemoprevention of mammary carcinogenesis in a transgenic mouse model by alpha-difluoromethylornithine (DFMO) in the diet is associated with decreased cyclin D1 activity
    Minglin Li
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057, USA
    Oncogene 22:2568-72. 2003
    ..Alterations in cyclin D1 activity in preneoplastic cells could represent an early biomarker of chemopreventive action and are consistent with a mechanistic role for cyclin D1 in progression of mammary cancer...
  9. pmc Introduction of estrogen receptor-alpha into the tTA/TAg conditional mouse model precipitates the development of estrogen-responsive mammary adenocarcinoma
    Maddalena T Tilli
    Program in Human Genetics, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA
    Am J Pathol 163:1713-9. 2003
    ..014, chi-square test). These experiments demonstrate that the introduction of an ER-alpha transgene targeted to mammary epithelial cells can be used to develop mouse models of ER-alpha-responsive mammary cancer...
  10. pmc Conditional mouse models demonstrate oncogene-dependent differences in tumor maintenance and recurrence
    Maddalena T Tilli
    Division of Human Genetics, University of Maryland, Baltimore, USA
    Breast Cancer Res 5:202-5. 2003
    ..Finally, they exemplify the power of conditional mouse models for elucidating how specific molecular mechanisms give rise to the complexity of human cancer...
  11. ncbi request reprint Loss of protein phosphatase 2A expression correlates with phosphorylation of DP-1 and reversal of dysplasia through differentiation in a conditional mouse model of cancer progression
    Maddalena T Tilli
    Graduate Program in Human Genetics, University of Maryland at Baltimore, Baltimore, MD, USA
    Cancer Res 63:7668-73. 2003
    ..Results are consistent with the hypothesis that persistent PP2A expression prevented the appearance of the phosphorylated form of DP-1 required for cellular differentiation and reversal of dysplasia after loss of oncogene expression...
  12. ncbi request reprint Conditional over-expression of estrogen receptor alpha in a transgenic mouse model
    Kathleen S Hruska
    Department of Epidemiology and Preventive Medicine, School of Medicine, University of Maryland, Baltimore 21201, USA
    Transgenic Res 11:361-72. 2002
    ....