David A Solomon

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. pmc Dynamic targeting of the replication machinery to sites of DNA damage
    David A Solomon
    Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, 3125 Eden Ave, Cincinnati, OH 45267, USA
    J Cell Biol 166:455-63. 2004
  2. ncbi request reprint Hierarchical requirement of SWI/SNF in retinoblastoma tumor suppressor-mediated repression of Plk1
    Ranjaka W Gunawardena
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0521, USA
    J Biol Chem 279:29278-85. 2004
  3. pmc Retinoblastoma tumor suppressor: analyses of dynamic behavior in living cells reveal multiple modes of regulation
    Steven P Angus
    Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Mol Cell Biol 23:8172-88. 2003
  4. ncbi request reprint Analysis of RB action in DNA damage checkpoint response
    Christopher N Mayhew
    Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, OH, USA
    Methods Mol Biol 281:3-16. 2004
  5. pmc RB reversibly inhibits DNA replication via two temporally distinct mechanisms
    Steven P Angus
    Department of Cell Biology, University of Cincinnati College of Medicine, OH 45267, USA
    Mol Cell Biol 24:5404-20. 2004
  6. ncbi request reprint Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation
    David A Solomon
    Department of Cell Biology, University of Cincinnati, Vontz Center for Molecular Studies, Cincinnati, Ohio 45267 0521, USA
    J Biol Chem 278:30339-47. 2003
  7. pmc Histone deacetylation of RB-responsive promoters: requisite for specific gene repression but dispensable for cell cycle inhibition
    Hasan Siddiqui
    Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0521, USA
    Mol Cell Biol 23:7719-31. 2003

Detail Information

Publications7

  1. pmc Dynamic targeting of the replication machinery to sites of DNA damage
    David A Solomon
    Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, 3125 Eden Ave, Cincinnati, OH 45267, USA
    J Cell Biol 166:455-63. 2004
    ..Together, these findings support a dynamic exchange model in which multiple repair factors regulated by specific modifications have access to and rapidly turn over at sites of DNA damage...
  2. ncbi request reprint Hierarchical requirement of SWI/SNF in retinoblastoma tumor suppressor-mediated repression of Plk1
    Ranjaka W Gunawardena
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0521, USA
    J Biol Chem 279:29278-85. 2004
    ..In summary, these data demonstrate that Plk1 is a target of the RB pathway. Moreover, these findings demonstrate a hierarchical role for SWI/SNF in the control of promoter activity through histone modification...
  3. pmc Retinoblastoma tumor suppressor: analyses of dynamic behavior in living cells reveal multiple modes of regulation
    Steven P Angus
    Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Mol Cell Biol 23:8172-88. 2003
    ..Together, these results elucidate the kinetic framework of RB tumor suppressor action in transcriptional repression and cell cycle regulation...
  4. ncbi request reprint Analysis of RB action in DNA damage checkpoint response
    Christopher N Mayhew
    Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, OH, USA
    Methods Mol Biol 281:3-16. 2004
    ..X detection). Together, this combination of techniques allows the evaluation of RB action in the coordinated checkpoint response to DNA damage...
  5. pmc RB reversibly inhibits DNA replication via two temporally distinct mechanisms
    Steven P Angus
    Department of Cell Biology, University of Cincinnati College of Medicine, OH 45267, USA
    Mol Cell Biol 24:5404-20. 2004
    ..Strikingly, attenuation of RB activity reversed both acute and chronic replication blocks. Thus, continued RB action is required for the maintenance of two kinetically and functionally distinct modes of replication inhibition...
  6. ncbi request reprint Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation
    David A Solomon
    Department of Cell Biology, University of Cincinnati, Vontz Center for Molecular Studies, Cincinnati, Ohio 45267 0521, USA
    J Biol Chem 278:30339-47. 2003
    ..In summary, we demonstrate that cyclin D1b specifically disrupts contact inhibition in a manner distinct from cyclin D1a. These data reveal novel roles for d-type cyclins in tumorigenesis...
  7. pmc Histone deacetylation of RB-responsive promoters: requisite for specific gene repression but dispensable for cell cycle inhibition
    Hasan Siddiqui
    Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0521, USA
    Mol Cell Biol 23:7719-31. 2003
    ..Thus, while HDACs do play a major role in RB-mediated repression, they are dispensable for the repression of critical targets leading to cell cycle arrest...