Research Topics
Species | Steven J SoldinSummaryAffiliation: Georgetown University Country: USA Publications
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Publications
Analytic bias of thyroid function tests: analysis of a College of American Pathologists fresh frozen serum pool by 3900 clinical laboratoriesBernard W Steele
Department of Pathology, University of Miami School of Medicine, Miami, Fla, USA
Arch Pathol Lab Med 129:310-7. 2005..In proficiency testing surveys, there are differences in the values reported by users of various analytic methods. Two contributors to this variation are calibrator bias and matrix effects of proficiency testing materials...- Differences between measurements of T4 and T3 in pregnant and nonpregnant women using isotope dilution tandem mass spectrometry and immunoassays: are there clinical implications?Offie P Soldin
Division of Cancer Genetics and Epidemiology, Lombardi Cancer Center, Georgetown University School of Medicine, Room S 165A, 3800 Reservoir Road, NW, Washington, DC 20007 2197, USA
Clin Chim Acta 347:61-9. 2004..05) throughout pregnancy. In this study, we examined the clinical implications of these discrepancies... - Pediatric reference intervals for FSH, LH, estradiol, T3, free T3, cortisol, and growth hormone on the DPC IMMULITE 1000Offie P Soldin
Division of Endocrinology and Metabolism, Georgetown University School of Medicine, Washington DC 20057-1465, USA
Clin Chim Acta 355:205-10. 2005..These reference intervals provide the basis for clinical interpretation of laboratory results using the IMMULITE 1000 system and the assessment of child development... - The measurement of free thyroxine by isotope dilution tandem mass spectrometrySteven J Soldin
Bioanalytical Core Laboratory, Georgetown Clinical Research Center, Georgetown University, Washington, DC 20007 2197, USA
Clin Chim Acta 358:113-8. 2005..We developed a rapid, reliable free T4 method employing isotope dilution tandem mass spectrometry and compared our results with both the analogue (direct) free T4 and equilibrium dialysis procedures... - Simultaneous determination of 12 steroids by isotope dilution liquid chromatography-photospray ionization tandem mass spectrometryTiedong Guo
Bioanalytical Core Laboratory, General Clinical Research Center, Georgetown University, Washington, DC 20007-2197, USA
Clin Chim Acta 372:76-82. 2006..It can be routinely employed in a clinical environment and is attractive because of its simplicity in sample processing and high throughput... 
Comparison of FT4 with log TSH on the Abbott Architect ci8200: Pediatric reference intervals for free thyroxine and thyroid-stimulating hormoneSteven J Soldin
General Clinical Research Center, Georgetown University Medical Center, Washington, District of Columbia, USA
Clin Chim Acta 411:250-2. 2010..We evaluated the clinical validity of serum FT4 measurements by assessing its correlation with log TSH. To provide pediatric reference intervals (representative ranges) for FT4, and TSH on the Architect ci8200 integrated system...- Pediatric brain natriuretic peptide and N-terminal pro-brain natriuretic peptide reference intervalsSteven J Soldin
Departments of Medicine and Pharmacology, Georgetown University Medical Center, Washington DC 20007, USA
Clin Chim Acta 366:304-8. 2006..Previous studies lack large numbers in each group, have not covered all age ranges and have not compared results for BNP with NT-proBNP in simultaneously drawn samples... - Steroid hormone analysis by tandem mass spectrometrySteven J Soldin
Department of Medicine, Georgetown University, Washington, DC 20007, USA
Clin Chem 55:1061-6. 2009..New high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) methods are among the most successful approaches to improve specificity problems inherent in many immunoassays... - Results of phase 2 safety and feasibility study of treatment with levetiracetam for prevention of posttraumatic epilepsyPavel Klein
Department of Neurology, MedStar Research Institute, Washington, DC, USA
Arch Neurol 69:1290-5. 2012..To evaluate the safety and tolerability of treatment with levetiracetam and determine the trough levels of levetiracetam in patients with traumatic brain injury (TBI) who are at high risk for posttraumatic epilepsy (PTE)... - Changes in steroid concentrations with the timing of corticotropin stimulation testing in participants with adrenal sufficiencyJacqueline Jonklaas
Division of Endocrinology, Georgetown University Medical Center, Washington, DC 20007, USA
Endocr Pract 18:66-75. 2012..To determine whether the time of day at which corticotropin stimulation testing is performed influences the steroid concentrations observed in persons with normal adrenal function... - Nevirapine concentration in nonstimulated saliva: an alternative to plasma sampling in children with human immunodeficiency virus infectionNatella Y Rakhmanina
Division of Infectious Disease, The George Washington University School of Medicine, Washington, DC 20010, USA
Ther Drug Monit 29:110-7. 2007.... - Simultaneous quantification of free triiodothyronine and free thyroxine by isotope dilution tandem mass spectrometryJianghong Gu
Department of Laboratory Medicine, Children s National Medical Center, 111 Michigan Avenue, NW, Washington, DC, USA
Clin Biochem 40:1386-91. 2007.... 
Pediatric reference intervals for free thyroxine and free triiodothyronineOffie P Soldin
Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA
Thyroid 19:699-702. 2009..We determined age- and sex-specific reference intervals for neonates, infants, and children 0-18 years of age for FT(4) and FT(3) using tandem mass spectrometry...- Tandem mass spectrometry improves the accuracy of free thyroxine measurements during pregnancyNatasa Kahric Janicic
Division of Endocrinology, Georgetown University Medical Center, Washington, DC, USA
Thyroid 17:303-11. 2007..The objective of this study was to characterize the performance of a novel tandem mass spectrometric assay for free thyroxine during the physiologic conditions of pregnancy... - Tandem mass spectrometry as a novel tool for elucidating pituitary-thyroid relationshipsJacqueline Jonklaas
Division of Endocrinology, Georgetown University Medical Center, Washington, District of Columbia 20007, USA
Thyroid 18:1303-11. 2008..Our objective was to determine the performance of liquid chromatography-tandem mass spectrometry (LC-MS/MS) in documenting both group and individual relationships between thyroid hormone and thyroid-stimulating hormone (TSH) concentrations... - Correlations of free thyroid hormones measured by tandem mass spectrometry and immunoassay with thyroid-stimulating hormone across 4 patient populationsJacqueline Jonklaas
Division of Endocrinology, Georgetown University Medical Center, Washington, DC 20007, USA
Clin Chem 55:1380-8. 2009..Our study was designed to compare free thyroid hormone measurements performed with immunoassay and LC-MS/MS... - Thyroid hormone levels associated with active and passive cigarette smokingOffie P Soldin
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
Thyroid 19:817-23. 2009..We use a comprehensive approach to assess the interrelationships between active and passive tobacco smoke exposure and thyroid hormone levels by employing innovative hormone analysis techniques... - Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometryOffie P Soldin
Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University Medical Center, Washington, DC 20057 1465, USA
Fertil Steril 84:701-10. 2005.... - Thyroid hormone testing by tandem mass spectrometryOffie P Soldin
Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA
Clin Biochem 44:89-94. 2011..These methods are especially important in states of disease and during pregnancy when protein binding is a factor that interferes with other methods for thyroid hormone analysis... - Steroid hormones: relevance and measurement in the clinical laboratoryJennifer P Holst
Division of Endocrinology and Metabolism, Georgetown University, 4000 Reservoir Road Northwest, Washington, DC 20007, USA
Clin Lab Med 24:105-18. 2004..This article addresses the relevance and methods of measurement of steroid hormones in the clinical laboratory... - Can therapeutic drug monitoring improve pharmacotherapy of HIV infection in adolescents?Natella Y Rakhmanina
Division of Infectious Disease, Children s National Medical Center, Washington, DC, USA
Ther Drug Monit 32:273-81. 2010..Finally, TDM in adolescents provides valuable information about the clinical pharmacology of ART during puberty... - Steroid hormone levels associated with passive and active smokingOffie P Soldin
Department of Oncology, Georgetown University Medical Center, Washington, DC, USA
Steroids 76:653-9. 2011..Cigarette tobacco smoke is a potent environmental contaminant known to adversely affect health including fertility and pregnancy... - Rapid measurement of estrogens and their metabolites in human serum by liquid chromatography-tandem mass spectrometry without derivatizationTiedong Guo
Bioanalytical Core Laboratory, General Clinical Research Center, Georgetown University Medical Center, Washington, DC, USA
Clin Biochem 41:736-41. 2008.... - Rapid measurement of plasma acylcarnitines by liquid chromatography-tandem mass spectrometry without derivatizationAmit K Ghoshal
Department of Laboratory Medicine, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010-2970, USA
Clin Chim Acta 358:104-12. 2005..It is thus ideal in a routine clinical setting where efficient processing of clinical samples is necessary to reduce turnaround time under conditions of high-throughput... - Safety and pharmacokinetics of antiretroviral therapy during pregnancyNatella Y Rakhmanina
Special Immunology Program, Children s National Medical Center, Washington, DC 20010 2970, USA
Ther Drug Monit 26:110-5. 2004..The available pharmacokinetic data regarding the use of antiretroviral therapy in pregnancy is reviewed... - CYP3A5, ABCB1, and SLCO1B1 polymorphisms and pharmacokinetics and virologic outcome of lopinavir/ritonavir in HIV-infected childrenNatella Y Rakhmanina
Division of Infectious Diseases, Children s National Medical Center, Washington, DC, USA
Ther Drug Monit 33:417-24. 2011..The aim of this study was to investigate the influence of CYP3A5 A6986G, ABCB1 (C3435T and G2677T), and SLCO1B1 (T521C and A388AG) polymorphisms on the PK and virologic outcome of lopinavir/ritonavir (LPV/RTV) in HIV-infected children... - Therapeutic drug monitoring for patients with HIV infection: Children's National Medical Center, Washington DC experienceSteven J Soldin
Department of Pediatrics, The George Washington University School of Medicine, Washington, DC, USA
Ther Drug Monit 26:107-9. 2004..Also discussed are the preliminary new and original data on free antiretroviral drug measurement in both plasma and saliva... - Longitudinal comparison of thyroxine pharmacokinetics between pregnant and nonpregnant women: a stable isotope studyOffie P Soldin
Department of Medicine, Oncology, Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20057, USA
Ther Drug Monit 32:767-73. 2010..Future work should focus on the mechanisms responsible for the gestational differences in pharmacokinetics and whether these should necessitate dose schedule changes in pregnancy... - Results of phase II pharmacokinetic study of levetiracetam for prevention of post-traumatic epilepsyPavel Klein
Department of Neurology, MedStar Research Institute, Washington, D C 20010, USA
Epilepsy Behav 24:457-61. 2012..Treatment of TBI patients with high PTE risk with 55mg/kg/day LEV, a dose with antiepileptogenic effect in animals, results in plasma LEV levels comparable to those in animal studies... - Pediatric reference intervals for aldosterone, 17alpha-hydroxyprogesterone, dehydroepiandrosterone, testosterone and 25-hydroxy vitamin D3 using tandem mass spectrometryOffie P Soldin
Department of Oncology, Georgetown University Medical Center, USA
Clin Biochem 42:823-7. 2009..To determine age and sex-specific pediatric reference intervals for aldosterone, 17alpha-hydroxyprogesterone, dehydroepiandrosterone, testosterone, and 25-hydroxy vitamin D(3)... - Triiodothyronine levels in athyreotic individuals during levothyroxine therapyJacqueline Jonklaas
Division of Endocrinology, Georgetown University Medical Center, Washington, DC, USA
JAMA 299:769-77. 2008..However, trials evaluating therapy with combined LT4 and T3 have failed to demonstrate any consistent advantage of combination therapy... - Endogenous thyrotropin and triiodothyronine concentrations in individuals with thyroid cancerJacqueline Jonklaas
Division of Endocrinology, Georgetown University Medical Center, Washington, District of Columbia 20007, USA
Thyroid 18:943-52. 2008..We also sought to determine whether thyroid hormone levels were lower in the patients with malignancy... - Simultaneous determination of levetiracetam and its acid metabolite (ucb L057) in serum/plasma by liquid chromatography tandem mass spectrometryDamodara Rao Mendu
Department of Medicine, Bioanalytical Core Laboratory, Georgetown University, Washington, DC, USA
Clin Biochem 43:485-9. 2010..Levetiracetam and its acid metabolite have almost identical MRMs. They therefore need to be separated chromatographically prior to quantitation... - IMMULITE 2000 age and sex-specific reference intervals for alpha fetoprotein, homocysteine, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein-3, C-peptide, immunoglobulin E and intact parathyroid hormoneOffie P Soldin
Department of Oncology, Physiology, Georgetown University Medical Center, USA
Clin Biochem 41:937-42. 2008.... - Use of steroid profiles in determining the cause of adrenal insufficiencyJennifer P Holst
Center for Diabetes and Endocrinology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Steroids 72:71-84. 2007..The study objective was to determine whether a steroid profile, created by simultaneous measurement of 10 steroid hormones by tandem mass spectrometry, would help determine the cause of adrenal insufficiency... - Steroid profiles using liquid chromatography-tandem mass spectrometry with atmospheric pressure photoionization sourceTiedong Guo
Bioanalytical Core Laboratory, Georgetown University and Georgetown Clinical Research Center, Washington, DC, USA
Arch Pathol Lab Med 128:469-75. 2004 - Steroid profiles in serum by liquid chromatography-tandem mass spectrometry in infants with genital hairPaul Kaplowitz
Department of Endocrinolog, Children s National Medical Center, Washington, DC 20010, USA
J Pediatr Endocrinol Metab 20:597-605. 2007..In recent years, an increasing number of infants have been seen with fine hair in the genital area and no other signs of androgen excess, but the hormonal basis of this finding is unknown... - Serum iron, ferritin, transferrin, total iron binding capacity, hs-CRP, LDL cholesterol and magnesium in children; new reference intervals using the Dade Dimension Clinical Chemistry SystemOffie P Soldin
Cancer, Genetics and Epidemiology and Endocrinology and Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA
Clin Chim Acta 342:211-7. 2004.... - Determination of levetiracetam in human plasma/serum/saliva by liquid chromatography-electrospray tandem mass spectrometryTiedong Guo
Bioanalytical Core Laboratory, General Clinical Research Center, Georgetown University, Washington, DC, USA
Clin Chim Acta 375:115-8. 2007..We developed and describe a simple and rapid high performance liquid chromatography-electrospray tandem mass spectrometry (HPLC-ESI-MS/MS) assay for the determination of levetiracetam in human matrix (plasma, serum, or saliva)... - Isotope dilution tandem mass spectrometric method for T4/T3Nadia Soukhova
Bioanalytical Core Laboratory, Georgetown Clinical Research Center, Georgetown University, Washington, DC 20007-2197, USA
Clin Chim Acta 343:185-90. 2004..RESULTS AND CONCLUSIONS: An isotope dilution tandem mass spectrometry method for the simultaneous determination of total T4 and T3 in serum is described which is accurate, specific, precise (%CVs 3.5-9.0), simple and fast (<7 min)... - Therapeutic drug monitoring of antiretroviral therapyNatella Y Rakhmanina
Special Immunology Program, Children s National Medical Center, Washington, DC 20010 2970, USA
AIDS Patient Care STDS 18:7-14. 2004..This review includes an illustrative case report of measuring concentrations of antiretroviral drugs in a pediatric patient... - Improved method for concurrent quantification of antiretrovirals by liquid chromatography-tandem mass spectrometryAmit K Ghoshal
Department of Laboratory Medicine, Children's National Medical Center, Washington, DC, USA
Ther Drug Monit 25:541-3. 2003..997 for all drugs). Accuracy was assessed by correlation of the calibrators with proficiency testing samples spiked with known drug concentrations and yielded results within 8% of the target values... - An improved application for the enzyme multipled immunoassay technique for caffeine, amikacin, and methotrexate assays on the Dade-Behring Dimension RxL Max clinical chemistry systemDamodara Rao Mendu
Department of Medicine, Georgetown University and Georgetown Clinical Research Center, Washington, DC, USA
Ther Drug Monit 29:632-7. 2007..The new Dimension RxL Max method parameters provide greatly improved precision and also meet today's clinical sensitivity guidelines (0.05 micromol/L) for MTX... - Simultaneous quantification of GM1 and GM2 gangliosides by isotope dilution tandem mass spectrometryJianghong Gu
Department of Laboratory Medicine, Children s National Medical Center, 111 Michigan Avenue, NW, Washington, DC, USA
Clin Biochem 41:413-7. 2008.... - Performance evaluation of the new ADVIA Centaur system cyclosporine assay (single-step extraction)Steven J Soldin
Georgetown University, Washington, DC, USA
Clin Chim Acta 411:806-11. 2010..Cyclosporine (CsA) monitoring is essential for transplant success. We report a performance study of the recently released, fully automated Siemens ADVIA Centaur CsA assay... - Circadian disruption alters mouse lung clock gene expression and lung mechanicsHélène Hadden
Lung Regeneration Laboratory, Department of Medicine, Georgetown University School of Medicine, Washington, District of Columbia, USA
J Appl Physiol 113:385-92. 2012..Among CJL males, expression of Clock was decreased; Per 2 and Rev-erb alpha expression was increased. We conclude circadian disruption alters lung mechanics and clock gene expression and does so in a sexually dimorphic manner... - Evaluation of the Dade Behring Dimension RxL: integrated chemistry system-pediatric reference rangesAmit K Ghoshal
Department of Laboratory Medicine, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010-2970, USA
Clin Chim Acta 331:135-46. 2003..Since a good correlation was observed with the alternate platforms, consolidation of these various workstations into one unit would contribute to decreased turnaround time and greatly improved staff efficiency... - Dipeptidyl peptidases as survival factors in Ewing sarcoma family of tumors: implications for tumor biology and therapyCongyi Lu
Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC 20057, USA
J Biol Chem 286:27494-505. 2011..This is the first demonstration that intracellular DPPs are involved in regulation of ESFT growth and may become potential therapeutic targets for these tumors... - Determination of total and free plasma carnitine concentrations on the Dade Behring Dimension RxL: integrated chemistry systemAmit K Ghoshal
Department of Laboratory Medicine, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010-2970, USA
Clin Chim Acta 361:80-5. 2005..It also avoids the use of radioisotopes and is appropriate in labs where access to reference methods such as tandem mass spectrometry and HPLC is limited or unavailable... - Lack of specificity of cyclosporine immunoassays. Results of a College of American Pathologists StudySteven J Soldin
Department of Pathology, The George Washington University School of Medicine, Children s National Medical Center, Washington, DC 20010, USA
Arch Pathol Lab Med 127:19-22. 2003..To evaluate the cross-reactivity of the 6 most abundant cyclosporine A (CsA) metabolites in commonly used assays for CsA... - Phenytoin overview--metabolite interference in some immunoassays could be clinically important: results of a College of American Pathologists studySteven J Soldin
Department of Pathology, The George Washington University School of Medicine, Children's National Medical Center, Washington, DC 20010, USA
Arch Pathol Lab Med 127:1623-5. 2003 - Simple rapid method for quantification of antiretrovirals by liquid chromatography-tandem mass-spectrometryAndrew Volosov
Children's National Medical Center, Washington, DC, USA
Clin Biochem 35:99-103. 2002..CONCLUSIONS: The simplicity, universality and high throughput of the method make it suitable for application in a clinical laboratory. The method has been implemented in our laboratory for routine use... - Pediatric reference ranges for zinc protoporphyrinOffie Porat Soldin
Soldin Research and Consultants, Inc, Bethesda, MD, USA
Clin Biochem 36:21-5. 2003..To determine pediatric reference ranges for zinc protoporphyrin (ZPP)... - A longitudinal replicate study of immunosuppressive drugs: a College of American Pathologists studyBernard W Steele
Department of Pathology, University of Miami School of Medicine, Miami, FL, USA. bsteele;camed.miami.edu
Arch Pathol Lab Med 127:283-8. 2003..The finding that 85% of the total variance was due to within-laboratory variation is similar to other therapeutic drugs... - Comparison of pooled fresh frozen serum to proficiency testing material in College of American Pathologists surveys: cortisol and immunoglobulin EDarryl Erik Palmer-Toy
Department of Pathology, Massachusetts General Hospital and Harvard Partners Center for Genetics and Genomics, Boston, Mass, USA
Arch Pathol Lab Med 129:305-9. 2005..The College of American Pathologists (CAP) provides proficiency testing (PT) surveys to laboratories around the world... - Adrenocortical hormone abnormalities in men with chronic prostatitis/chronic pelvic pain syndromeJordan Dimitrakov
Harvard Urological Diseases Research Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Urology 71:261-6. 2008..To identify adrenocortical hormone abnormalities as indicators of endocrine dysfunction in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)... - Age specific reference intervals for soluble transferrin receptor (sTfR)Tonya Kratovil
Clin Chim Acta 380:222-4. 2007 - Modified and improved method for the measurement of plasma acylcarnitines by online extraction coupled to liquid chromatography-tandem mass spectrometry without derivatizationAmit K Ghoshal
Clin Chim Acta 365:352-3. 2006 - Blood lead concentrations in children: new rangesOffie Porat Soldin
Soldin Research and Consultants, Inc, Bethesda, MD 20816, USA
Clin Chim Acta 327:109-13. 2003..Using a large hospital population (n=11145), we define more specific ranges for pediatric blood lead concentrations...