Offie P Soldin

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. pmc Thyroid function testing in pregnancy and thyroid disease: trimester-specific reference intervals
    Offie P Soldin
    Department of Medicine, Division of Endocrinology and Metabolism, Lombardi Cancer Center, Washington, DC 20057 1465, USA
    Ther Drug Monit 28:8-11. 2006
  2. pmc IMMULITE 2000 age and sex-specific reference intervals for alpha fetoprotein, homocysteine, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein-3, C-peptide, immunoglobulin E and intact parathyroid hormone
    Offie P Soldin
    Department of Oncology, Physiology, Georgetown University Medical Center, USA
    Clin Biochem 41:937-42. 2008
  3. pmc Gestation-specific thyroxine and thyroid stimulating hormone levels in the United States and worldwide
    Offie P Soldin
    Department of Oncology, Center for Sex Differences, Washington, DC, USA
    Ther Drug Monit 29:553-9. 2007
  4. pmc Prenatal exposure of a girl with autism spectrum disorder to 'horsetail' (Equisetum arvense) herbal remedy and alcohol: a case report
    Juan A Ortega García
    Pediatric Environmental Health Specialty Unit, Neuropediatric Unit, Department of Pediatrics, University Hospital Virgen of Arrixaca, Murcia, Spain
    J Med Case Reports 5:129. 2011
  5. pmc Therapeutic drug monitoring during pregnancy and lactation: thyroid function assessment in pregnancy-challenges and solutions
    Offie P Soldin
    Department of Oncology, Lombardi Comprehensive Cancer Center, Washington, DC, USA
    Ther Drug Monit 32:265-8. 2010
  6. pmc Effects of manganese on thyroid hormone homeostasis: potential links
    O P Soldin
    Department of Oncology and Medicine, The Center for Study of Sex Differences, Georgetown University Medical Center, Washington, DC, USA
    Neurotoxicology 28:951-6. 2007
  7. pmc Pediatric reference intervals for free thyroxine and free triiodothyronine
    Offie P Soldin
    Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA
    Thyroid 19:699-702. 2009
  8. pmc Triptans in pregnancy
    Offie P Soldin
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Ther Drug Monit 30:5-9. 2008
  9. pmc Pediatric acute lymphoblastic leukemia and exposure to pesticides
    Offie P Soldin
    Department of Oncology, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    Ther Drug Monit 31:495-501. 2009
  10. pmc Thyroid hormone levels associated with active and passive cigarette smoking
    Offie P Soldin
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    Thyroid 19:817-23. 2009

Research Grants

Collaborators

Detail Information

Publications43

  1. pmc Thyroid function testing in pregnancy and thyroid disease: trimester-specific reference intervals
    Offie P Soldin
    Department of Medicine, Division of Endocrinology and Metabolism, Lombardi Cancer Center, Washington, DC 20057 1465, USA
    Ther Drug Monit 28:8-11. 2006
    ..Gestational age-specific reference intervals are now available for thyroid function tests. Knowing the expected normal changes in hormone concentrations throughout pregnancy allows individualized supplementation when necessary...
  2. pmc IMMULITE 2000 age and sex-specific reference intervals for alpha fetoprotein, homocysteine, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein-3, C-peptide, immunoglobulin E and intact parathyroid hormone
    Offie P Soldin
    Department of Oncology, Physiology, Georgetown University Medical Center, USA
    Clin Biochem 41:937-42. 2008
    ....
  3. pmc Gestation-specific thyroxine and thyroid stimulating hormone levels in the United States and worldwide
    Offie P Soldin
    Department of Oncology, Center for Sex Differences, Washington, DC, USA
    Ther Drug Monit 29:553-9. 2007
    ..Therefore, gestation-specific reference intervals assist in appropriate clinical management of thyroid disease in pregnancy to ensure maternal and fetal health...
  4. pmc Prenatal exposure of a girl with autism spectrum disorder to 'horsetail' (Equisetum arvense) herbal remedy and alcohol: a case report
    Juan A Ortega García
    Pediatric Environmental Health Specialty Unit, Neuropediatric Unit, Department of Pediatrics, University Hospital Virgen of Arrixaca, Murcia, Spain
    J Med Case Reports 5:129. 2011
    ..abstract:..
  5. pmc Therapeutic drug monitoring during pregnancy and lactation: thyroid function assessment in pregnancy-challenges and solutions
    Offie P Soldin
    Department of Oncology, Lombardi Comprehensive Cancer Center, Washington, DC, USA
    Ther Drug Monit 32:265-8. 2010
    ....
  6. pmc Effects of manganese on thyroid hormone homeostasis: potential links
    O P Soldin
    Department of Oncology and Medicine, The Center for Study of Sex Differences, Georgetown University Medical Center, Washington, DC, USA
    Neurotoxicology 28:951-6. 2007
    ....
  7. pmc Pediatric reference intervals for free thyroxine and free triiodothyronine
    Offie P Soldin
    Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA
    Thyroid 19:699-702. 2009
    ..We determined age- and sex-specific reference intervals for neonates, infants, and children 0-18 years of age for FT(4) and FT(3) using tandem mass spectrometry...
  8. pmc Triptans in pregnancy
    Offie P Soldin
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Ther Drug Monit 30:5-9. 2008
    ..There are no data to suggest teratogenicity for any of the triptans, although preterm birth rates appear to be elevated...
  9. pmc Pediatric acute lymphoblastic leukemia and exposure to pesticides
    Offie P Soldin
    Department of Oncology, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    Ther Drug Monit 31:495-501. 2009
    ..03) and diethyldithiophosphate (P < 0.05). The association of ALL risk with pesticide exposure merits further studies to confirm the association...
  10. pmc Thyroid hormone levels associated with active and passive cigarette smoking
    Offie P Soldin
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    Thyroid 19:817-23. 2009
    ..We use a comprehensive approach to assess the interrelationships between active and passive tobacco smoke exposure and thyroid hormone levels by employing innovative hormone analysis techniques...
  11. pmc Sex differences in pharmacokinetics and pharmacodynamics
    Offie P Soldin
    Departments of Medicine, Oncology and Physiology, Center for the Study of Sex Differences, Georgetown University Medical Center, Washington, DC, USA
    Clin Pharmacokinet 48:143-57. 2009
    ..Since this is a rapidly evolving area, it is essential for the practitioner to review drug prescribing information and recent literature in order to fully understand the impact of these differences on clinical therapeutics...
  12. pmc Thyroid hormones and methylmercury toxicity
    Offie P Soldin
    Department of Medicine, Oncology and Physiology, Center for Sex Differences, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 20057, USA
    Biol Trace Elem Res 126:1-12. 2008
    ..This review addresses the possibility that high exposures to the organometal, methylmercury (MeHg), may perturb neurodevelopmental processes by selectively affecting thyroid hormone homeostasis and function...
  13. pmc Differences between measurements of T4 and T3 in pregnant and nonpregnant women using isotope dilution tandem mass spectrometry and immunoassays: are there clinical implications?
    Offie P Soldin
    Division of Cancer Genetics and Epidemiology, Lombardi Cancer Center, Georgetown University School of Medicine, Room S 165A, 3800 Reservoir Road, NW, Washington, DC 20007 2197, USA
    Clin Chim Acta 347:61-9. 2004
    ..05) throughout pregnancy. In this study, we examined the clinical implications of these discrepancies...
  14. pmc Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry
    Offie P Soldin
    Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University Medical Center, Washington, DC 20057 1465, USA
    Fertil Steril 84:701-10. 2005
    ....
  15. pmc Innovative studies in women by use of stabilized isotopes in pregnancy
    Offie P Soldin
    PregnaTox, Georgetown University Medical Center, Washington, DC, USA
    J Popul Ther Clin Pharmacol 18:e528-32. 2011
    ..In order to solidify these findings, a larger group of patients is required. In addition, the mechanisms responsible for the gestational differences in pharmacokinetics need to be investigated...
  16. pmc Sex differences in drug disposition
    Offie P Soldin
    Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA
    J Biomed Biotechnol 2011:187103. 2011
    ..This paper summarizes sex differences that impact drug disposition and includes a general comparison of clinical pharmacology as it applies to men and women...
  17. pmc Thyroid hormone testing by tandem mass spectrometry
    Offie P Soldin
    Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA
    Clin Biochem 44:89-94. 2011
    ..These methods are especially important in states of disease and during pregnancy when protein binding is a factor that interferes with other methods for thyroid hormone analysis...
  18. pmc Trimester-specific reference intervals for thyroxine and triiodothyronine in pregnancy in iodine-sufficient women using isotope dilution tandem mass spectrometry and immunoassays
    O P Soldin
    Division of Cancer Genetics and Epidemiology, Lombardi Cancer Center, Georgetown University Medical Center, Room S 165 A, Washington, DC 20007 2197, USA
    Clin Chim Acta 349:181-9. 2004
    ..We used a novel isotope dilution tandem mass spectrometry (LC/MS/MS) method, and compare these to reference intervals obtained by immunoassays (IAs) performed on the same samples...
  19. pmc Trimester-specific changes in maternal thyroid hormone, thyrotropin, and thyroglobulin concentrations during gestation: trends and associations across trimesters in iodine sufficiency
    O P Soldin
    Division of Cancer Genetics and Epidemiology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20057 1465, USA
    Thyroid 14:1084-90. 2004
    ..To describe the interrelationships of thyroid functions based on trimester-specific concentrations in healthy, iodine-sufficient pregnant women across trimesters, and postpartum...
  20. pmc Do thyroxine and thyroid-stimulating hormone levels reflect urinary iodine concentrations?
    Offie P Soldin
    Division of Endocrinology and Metabolism, Georgetown University School of Medicine, Washington, DC 20057, USA
    Ther Drug Monit 27:178-85. 2005
    ..Monitoring the status of iodine nutrition of individuals in the United States may be important because serum TSH and T4 concentrations do not indicate low iodine status...
  21. pmc Steroid hormone levels associated with passive and active smoking
    Offie P Soldin
    Department of Oncology, Georgetown University Medical Center, Washington, DC, USA
    Steroids 76:653-9. 2011
    ..Cigarette tobacco smoke is a potent environmental contaminant known to adversely affect health including fertility and pregnancy...
  22. pmc Longitudinal comparison of thyroxine pharmacokinetics between pregnant and nonpregnant women: a stable isotope study
    Offie P Soldin
    Department of Medicine, Oncology, Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20057, USA
    Ther Drug Monit 32:767-73. 2010
    ..Future work should focus on the mechanisms responsible for the gestational differences in pharmacokinetics and whether these should necessitate dose schedule changes in pregnancy...
  23. pmc Pediatric reference intervals for aldosterone, 17alpha-hydroxyprogesterone, dehydroepiandrosterone, testosterone and 25-hydroxy vitamin D3 using tandem mass spectrometry
    Offie P Soldin
    Department of Oncology, Georgetown University Medical Center, USA
    Clin Biochem 42:823-7. 2009
    ..To determine age and sex-specific pediatric reference intervals for aldosterone, 17alpha-hydroxyprogesterone, dehydroepiandrosterone, testosterone, and 25-hydroxy vitamin D(3)...
  24. pmc The measurement of free thyroxine by isotope dilution tandem mass spectrometry
    Steven J Soldin
    Bioanalytical Core Laboratory, Georgetown Clinical Research Center, Georgetown University, Washington, DC 20007 2197, USA
    Clin Chim Acta 358:113-8. 2005
    ..We developed a rapid, reliable free T4 method employing isotope dilution tandem mass spectrometry and compared our results with both the analogue (direct) free T4 and equilibrium dialysis procedures...
  25. pmc Tandem mass spectrometry improves the accuracy of free thyroxine measurements during pregnancy
    Natasa Kahric-Janicic
    Division of Endocrinology, Georgetown University Medical Center, Washington, DC, USA
    Thyroid 17:303-11. 2007
    ..The objective of this study was to characterize the performance of a novel tandem mass spectrometric assay for free thyroxine during the physiologic conditions of pregnancy...
  26. pmc Correlations of free thyroid hormones measured by tandem mass spectrometry and immunoassay with thyroid-stimulating hormone across 4 patient populations
    Jacqueline Jonklaas
    Division of Endocrinology, Georgetown University Medical Center, Washington, DC 20007, USA
    Clin Chem 55:1380-8. 2009
    ..Our study was designed to compare free thyroid hormone measurements performed with immunoassay and LC-MS/MS...
  27. ncbi Simultaneous quantification of free triiodothyronine and free thyroxine by isotope dilution tandem mass spectrometry
    Jianghong Gu
    Department of Laboratory Medicine, Children s National Medical Center, 111 Michigan Avenue, NW, Washington, DC, USA
    Clin Biochem 40:1386-91. 2007
    ....
  28. pmc The effect of secondhand smoke exposure on markers of elastin degradation
    Natalie Slowik
    Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10019, USA
    Chest 140:946-53. 2011
    ..This study determined whether exposure to SHS affects elastin degradation in asymptomatic individuals...
  29. pmc Isotope dilution tandem mass spectrometric method for T4/T3
    Nadia Soukhova
    Bioanalytical Core Laboratory, Georgetown Clinical Research Center, Georgetown University, Washington, DC 20007 2197, USA
    Clin Chim Acta 343:185-90. 2004
    ..To compare the results obtained by this MS/MS method with those obtained by an immunoassay procedure on the same samples (DPC Immulite for T3, Diagnostics Product, and Dade RxL Dimension for T4, Dade-Behring)...
  30. pmc Comparison of FT4 with log TSH on the Abbott Architect ci8200: Pediatric reference intervals for free thyroxine and thyroid-stimulating hormone
    Steven J Soldin
    General Clinical Research Center, Georgetown University Medical Center, Washington, District of Columbia, USA
    Clin Chim Acta 411:250-2. 2010
    ..We evaluated the clinical validity of serum FT4 measurements by assessing its correlation with log TSH. To provide pediatric reference intervals (representative ranges) for FT4, and TSH on the Architect ci8200 integrated system...
  31. pmc Rapid measurement of estrogens and their metabolites in human serum by liquid chromatography-tandem mass spectrometry without derivatization
    Tiedong Guo
    Bioanalytical Core Laboratory, General Clinical Research Center, Georgetown University Medical Center, Washington, DC, USA
    Clin Biochem 41:736-41. 2008
    ....
  32. pmc Pediatric reference intervals for FSH, LH, estradiol, T3, free T3, cortisol, and growth hormone on the DPC IMMULITE 1000
    Offie P Soldin
    Division of Endocrinology and Metabolism, Georgetown University School of Medicine, Washington DC 20057 1465, USA
    Clin Chim Acta 355:205-10. 2005
    ..Our objective was to obtain reference intervals for the 7 serum analytes for our pediatric population using the IMMULITE 1000 system...
  33. pmc Steroid hormones: relevance and measurement in the clinical laboratory
    Jennifer P Holst
    Division of Endocrinology and Metabolism, Georgetown University, 4000 Reservoir Road Northwest, Washington, DC 20007, USA
    Clin Lab Med 24:105-18. 2004
    ..This article addresses the relevance and methods of measurement of steroid hormones in the clinical laboratory...
  34. pmc Steroid hormone analysis by tandem mass spectrometry
    Steven J Soldin
    Department of Medicine, Georgetown University, Washington, DC 20007, USA
    Clin Chem 55:1061-6. 2009
    ..New high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) methods are among the most successful approaches to improve specificity problems inherent in many immunoassays...
  35. pmc Teratology public affairs committee position paper: iodine deficiency in pregnancy
    Sarah G Obican
    Department of Obstetrics and Gynecology, George Washington University, Washington, DC, USA
    Birth Defects Res A Clin Mol Teratol 94:677-82. 2012
    ..To achieve this goal, we recommend that all pregnant and lactating women take daily iodine supplementation of 150 micrograms...
  36. pmc Pediatric brain natriuretic peptide and N-terminal pro-brain natriuretic peptide reference intervals
    Steven J Soldin
    Departments of Medicine and Pharmacology, Georgetown University Medical Center, Washington DC 20007, USA
    Clin Chim Acta 366:304-8. 2006
    ..Previous studies lack large numbers in each group, have not covered all age ranges and have not compared results for BNP with NT-proBNP in simultaneously drawn samples...
  37. doi Thyrotropin isoforms: implications for thyrotropin analysis and clinical practice
    Joshua M Estrada
    1 Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia
    Thyroid 24:411-23. 2014
    ..This review focuses on the dissociation between the clinical state and serum TSH concentrations and addresses clinically important aspects of TSH analysis. ..
  38. doi P450 oxidoreductase *28 (POR*28) and tacrolimus disposition in pediatric kidney transplant recipients--a pilot study
    Violette M G J Gijsen
    Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Rotterdam, the Netherlands Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, Canada Department of Clinical Chemistry, Erasmus MC, Rotterdam, The Netherlands Departments of Oncology Medicine Pharmacology Physiology Biophysics, Georgetown University Medical Center, Washington, DC and Department of Medicine, University of Western Ontario, London, ON, Canada
    Ther Drug Monit 36:152-8. 2014
    ..The authors aimed to evaluate the additional contribution of POR*28 to early tacrolimus disposition in pediatric kidney transplant recipients...
  39. pmc Serum iron, ferritin, transferrin, total iron binding capacity, hs-CRP, LDL cholesterol and magnesium in children; new reference intervals using the Dade Dimension Clinical Chemistry System
    Offie P Soldin
    Cancer, Genetics and Epidemiology and Endocrinology and Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA
    Clin Chim Acta 342:211-7. 2004
    ....
  40. pmc Hypothyroidism during pregnancy
    Alejandro A Nava-Ocampo
    Can Fam Physician 50:549-51. 2004
    ..Another study has shown that even if levothyroxine therapy is started after the first trimester, there is an excellent chance children will have normal neuropsychologic development...
  41. pmc Hypothyroxinemia, iodine deficiency, and subtle changes in migration and cytoarchitecture
    Offie P Soldin
    Environ Health Perspect 112:A268-9; author reply A269. 2004
  42. doi Serotonin syndrome associated with triptan monotherapy
    Offie P Soldin
    N Engl J Med 358:2185-6. 2008

Research Grants1

  1. Hyopthyroidism Treatment in Aging and Thyroid Cancer
    Offie P Soldin; Fiscal Year: 2010
    ..This will help in setting therapeutic goals and help millions in diagnosis, treatment and management of thyroid disease in aging. ..