Anita Sidhu

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse?
    Anita Sidhu
    Department of Pediatrics, Georgetown University, Washington, DC, USA
    FASEB J 18:637-47. 2004
  2. pmc Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function
    Adam W Oaks
    Laboratory of Molecular Neurochemistry, Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA
    PLoS ONE 8:e60378. 2013
  3. pmc Tauopathic changes in the striatum of A53T α-synuclein mutant mouse model of Parkinson's disease
    Jonathan Wills
    Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Washington, DC, United States of America
    PLoS ONE 6:e17953. 2011
  4. pmc Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways
    Jonathan Wills
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Washington DC, United States of America
    PLoS ONE 7:e30745. 2012
  5. ncbi request reprint The role of alpha-synuclein in both neuroprotection and neurodegeneration
    Anita Sidhu
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    Ann N Y Acad Sci 1035:250-70. 2004
  6. ncbi request reprint alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease
    Anita Sidhu
    Laboratory of Molecular Neurochemistry, Department of Pediatrics, Georgetown University, The Research Building, Room W222, 3970 Reservoir Road, NW, Washington, DC 20007, USA
    FEBS Lett 565:1-5. 2004
  7. ncbi request reprint Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress
    Christophe Wersinger
    Department of Pediatrics, Georgetown University, Washington, DC, USA
    FASEB J 17:2151-3. 2003
  8. ncbi request reprint Mutations in the lipid-binding domain of alpha-synuclein confer overlapping, yet distinct, functional properties in the regulation of dopamine transporter activity
    Christophe Wersinger
    Department of Pediatrics, Georgetown University Medical Center, 3870 Reservoir Road NW, Washington, DC 20007, USA
    Mol Cell Neurosci 24:91-105. 2003
  9. pmc Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease
    Thomas Haggerty
    Laboratory of Molecular Neurochemistry, Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, The New Research Building, Room W222, Washington, DC 20007, USA
    Eur J Neurosci 33:1598-610. 2011
  10. pmc Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia
    Jonathan Wills
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    Exp Neurol 225:210-8. 2010

Research Grants

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse?
    Anita Sidhu
    Department of Pediatrics, Georgetown University, Washington, DC, USA
    FASEB J 18:637-47. 2004
    ....
  2. pmc Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function
    Adam W Oaks
    Laboratory of Molecular Neurochemistry, Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA
    PLoS ONE 8:e60378. 2013
    ..These findings highlight the involvement of the synuclein family of proteins and phosphorylation of Tau in the response to dopaminergic dysfunction of the nigrostriatal pathway...
  3. pmc Tauopathic changes in the striatum of A53T α-synuclein mutant mouse model of Parkinson's disease
    Jonathan Wills
    Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Washington, DC, United States of America
    PLoS ONE 6:e17953. 2011
    ..Together, these data demonstrate an elevated state of tauopathy in striata of the A53T α-Syn mutant mice, suggesting that tauopathy is a common feature of synucleinopathies...
  4. pmc Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways
    Jonathan Wills
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Washington DC, United States of America
    PLoS ONE 7:e30745. 2012
    ....
  5. ncbi request reprint The role of alpha-synuclein in both neuroprotection and neurodegeneration
    Anita Sidhu
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    Ann N Y Acad Sci 1035:250-70. 2004
    ....
  6. ncbi request reprint alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease
    Anita Sidhu
    Laboratory of Molecular Neurochemistry, Department of Pediatrics, Georgetown University, The Research Building, Room W222, 3970 Reservoir Road, NW, Washington, DC 20007, USA
    FEBS Lett 565:1-5. 2004
    ....
  7. ncbi request reprint Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress
    Christophe Wersinger
    Department of Pediatrics, Georgetown University, Washington, DC, USA
    FASEB J 17:2151-3. 2003
    ..These studies suggest a novel normative role for alpha-synuclein in regulating DA synaptic availability and homeostasis, which is relevant to the pathophysiology of PD...
  8. ncbi request reprint Mutations in the lipid-binding domain of alpha-synuclein confer overlapping, yet distinct, functional properties in the regulation of dopamine transporter activity
    Christophe Wersinger
    Department of Pediatrics, Georgetown University Medical Center, 3870 Reservoir Road NW, Washington, DC 20007, USA
    Mol Cell Neurosci 24:91-105. 2003
    ....
  9. pmc Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease
    Thomas Haggerty
    Laboratory of Molecular Neurochemistry, Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, The New Research Building, Room W222, Washington, DC 20007, USA
    Eur J Neurosci 33:1598-610. 2011
    ..The elevated state of tauopathy seen in these platelet-derived growth factor-α-synuclein mice provides further confirmation that PD may be a tauopathic disease...
  10. pmc Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia
    Jonathan Wills
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    Exp Neurol 225:210-8. 2010
    ....
  11. ncbi request reprint Trypsin disrupts the trafficking of the human dopamine transporter by alpha-synuclein and its A30P mutant
    Christophe Wersinger
    Department of Pediatrics, Georgetown University, Washington, D C 20007, USA
    Biochemistry 43:1242-53. 2004
    ..These results show that alpha-synuclein modulates hDAT function through trafficking of the transporter in a process that can be disrupted by trypsin...
  12. pmc Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades
    Jun Chen
    Department of Pediatrics, Georgetown University, Washington DC 20007, USA
    Eur J Neurosci 29:287-306. 2009
    ..These data provide unique insight into a novel role of p-ERK in striatal neurodegeneration...
  13. ncbi request reprint Bimodal induction of dopamine-mediated striatal neurotoxicity is mediated through both activation of D1 dopamine receptors and autoxidation
    Christophe Wersinger
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    Mol Cell Neurosci 25:124-37. 2004
    ..The reduction of DA striatal neurotoxicity through blockade of D1 DA receptors, suggests novel therapeutic approaches in the management of striatal neurodegeneration...
  14. ncbi request reprint Chronic stimulation of D1 dopamine receptors in human SK-N-MC neuroblastoma cells induces nitric-oxide synthase activation and cytotoxicity
    Jun Chen
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    J Biol Chem 278:28089-100. 2003
    ..These data demonstrate a novel pathway of dopamine-mediated postsynaptic oxidative stress and cell death through direct activation of NOS enzymes by D1 dopamine receptors and its associated signaling pathways...
  15. pmc Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases
    Valeriy Duka
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, District of Columbia, United States of America
    PLoS ONE 8:e75025. 2013
    ..We examined for the first time epitopes at which Tau is hyperphosphorylated in Parkinson's disease, dementia with Lewy bodies and Alzheimer's disease, and also select Tau kinases...
  16. ncbi request reprint Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism
    Tetyana Duka
    Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Washington, DC, USA
    FASEB J 20:2302-12. 2006
    ....
  17. ncbi request reprint Dopamine D1 receptor-mediated toxicity in human SK-N-MC neuroblastoma cells
    Charbel E H Moussa
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    Neurochem Int 48:226-34. 2006
    ..The present studies provide novel insight into a possible patho-physiological staging of cytotoxic events that are mediated by activation of D(1) receptor...
  18. ncbi request reprint The neurotoxin, MPP+, induces hyperphosphorylation of Tau, in the presence of alpha-Synuclein, in SH-SY5Y neuroblastoma cells
    Tetyana Duka
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington DC 20007, USA
    Neurotox Res 10:1-10. 2006
    ..These data indicate that alpha-Syn and p-Tau modulate the pathogenicity of one another, suggesting a novel convergent mechanism of neurodegeneration...
  19. ncbi request reprint Differential cytotoxicity of human wild type and mutant alpha-synuclein in human neuroblastoma SH-SY5Y cells in the presence of dopamine
    Charbel E H Moussa
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    Biochemistry 43:5539-50. 2004
    ..These findings suggest a specific sequence of events triggered by dopamine and differentially exacerbated by alpha-synuclein and the A30P mutant...
  20. ncbi request reprint Attenuation of the norepinephrine transporter activity and trafficking via interactions with alpha-synuclein
    Christophe Wersinger
    Department of Biochemistry, Molecular and Cell Biology, Georgetown University, Washington, DC 20007, USA
    Eur J Neurosci 24:3141-52. 2006
    ....
  21. pmc Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behavior
    Dianca R Graham
    Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Washington, DC 20007, USA
    J Neurosci Res 88:1777-83. 2010
    ..These results indicate a possible role of the A53T alpha-Syn mutation in anxiety-like and hyperactive behaviors in a PD mouse model, suggesting that these behaviors might be comorbid with this disease...
  22. ncbi request reprint D1 dopamine receptor mediates dopamine-induced cytotoxicity via the ERK signal cascade
    Jun Chen
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    J Biol Chem 279:39317-30. 2004
    ..These data provide novel mechanistic insights into the role of ERK in the cytotoxicity mediated upon activation of the D1 dopamine receptor...
  23. pmc Partial regulation of serotonin transporter function by gamma-synuclein
    Christophe Wersinger
    Department of Biochemistry, Georgetown University, Washington, DC 20007, USA
    Neurosci Lett 453:157-61. 2009
    ..These studies document a novel physiological role for gamma-Syn in regulating 5-HT synaptic availability and homeostasis, and may be of relevance in depression and mood disorders, where SERT function is dysregulated...
  24. doi request reprint Desipramine modulation of alpha-, gamma-synuclein, and the norepinephrine transporter in an animal model of depression
    ALEXIS M JEANNOTTE
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Georgetown University, Washington, DC, USA
    Neuropsychopharmacology 34:987-98. 2009
    ..These results are the first to implicate alpha-Syn or gamma-Syn in the pathophysiology of depression and suggest that targeting synucleins may provide a new therapeutic option for depression...
  25. pmc Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models
    Tetyana Duka
    Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Washington, District of Columbia, USA
    FASEB J 23:2820-30. 2009
    ..These data unveil a previously unappreciated role of alpha-Syn in the induction of p-GSK-3beta, and demonstrate the importance of this kinase in the genesis and maintenance of neurodegenerative changes associated with PD...
  26. ncbi request reprint Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein
    Christophe Wersinger
    Department of Biochemistry, Molecular and Cell Biology, Georgetown University, The Research Building, Room W222, 3970 Reservoir Road, NW, Washington, DC 20007, USA
    Eur J Neurosci 24:55-64. 2006
    ..These studies suggest a novel physiological role for alpha-Syn in regulating SERT activity and may be of relevance in certain mental illnesses and in depression, in which SERT function is believed to be dysregulated...
  27. pmc Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease
    Tiffany Kaul
    Department of Biochemistry and Molecular and Cell Biology, University of California San Diego, La Jolla, California, USA
    BMC Neurosci 12:79. 2011
    ..The current studies were undertaken to analyze the distribution of tauopathy in different brain regions in a widely used mouse model of PD, the α-Syn overexpressing mouse...
  28. ncbi request reprint Attenuation of dopamine transporter activity by alpha-synuclein
    Christophe Wersinger
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    Neurosci Lett 340:189-92. 2003
    ..Thus, under normal (non-toxic) expression conditions, alpha-synuclein negatively modulates dopamine uptake by DAT...
  29. pmc Alterations of striatal glutamate transmission in rotenone-treated mice: MRI/MRS in vivo studies
    Charbel E H Moussa
    Laboratory of Molecular Neurochemistry, Department of Biochemistry, Molecular and Cell Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    Exp Neurol 209:224-33. 2008
    ..These studies provide novel insights on the effects of environmental toxins on glutamate and other amino acid neurotransmitters in human neurodegenerative diseases...
  30. doi request reprint Regulated interactions of the norepineprhine transporter by the actin and microtubule cytoskeletons
    ALEXIS M JEANNOTTE
    Interdisciplinary Program in Neuroscience, Department of Biochemistry and Molecular and Cell Biology, Georgetown University, Washington, DC 20007, USA
    J Neurochem 105:1668-82. 2008
    ..This is the first direct demonstration of NET activity being regulated via actin and modulated by interactions with alpha-Syn...
  31. pmc Desipramine induced changes in the norepinephrine transporter, alpha- and gamma-synuclein in the hippocampus, amygdala and striatum
    ALEXIS M JEANNOTTE
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Georgetown University, Washington, DC 20007, United States
    Neurosci Lett 467:86-9. 2009
    ....
  32. ncbi request reprint Comparative analyses of alpha-synuclein expression levels in rat brain tissues and transfected cells
    Christophe Wersinger
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    Neurosci Lett 358:95-8. 2004
    ....
  33. pmc Synucleins antagonize endoplasmic reticulum function to modulate dopamine transporter trafficking
    Adam W Oaks
    Laboratory of Molecular Neurochemistry, Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA
    PLoS ONE 8:e70872. 2013
    ....
  34. ncbi request reprint Differential cytotoxicity of dopamine and H2O2 in a human neuroblastoma divided cell line transfected with alpha-synuclein and its familial Parkinson's disease-linked mutants
    Christophe Wersinger
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    Neurosci Lett 342:124-8. 2003
    ..These results show an absence of protective effects for the A30P/A53T mutants, and a differential cytoprotective role of alpha-synuclein against oxidants, which varies according to expression levels...
  35. ncbi request reprint Disruption of the interaction of alpha-synuclein with microtubules enhances cell surface recruitment of the dopamine transporter
    Christophe Wersinger
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    Biochemistry 44:13612-24. 2005
    ....
  36. ncbi request reprint Dopamine differentially induces aggregation of A53T mutant and wild type alpha-synuclein: insights into the protein chemistry of Parkinson's disease
    Charbel E H Moussa
    Department of Biochemistry, Molecular and Cell Biology, and Georgetown University, Washington, DC 20007, USA
    Biochem Biophys Res Commun 365:833-9. 2008
    ..The present data indicate that mutation in the alpha-synuclein gene may predispose the protein to dopamine-induced aggregation, thereby contributing to disease pathogenesis...
  37. ncbi request reprint Abnormal migration of human wild-type alpha-synuclein upon gel electrophoresis
    Charbel E H Moussa
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    Neurosci Lett 371:239-43. 2004
    ..These studies raise important considerations about the type of protein gel electrophoresis system suitable to study the alterations of alpha-synuclein associated with neurodegeneration, PD and other synucleinopathies...
  38. ncbi request reprint Regulation of the norepinephrine transporter by alpha-synuclein-mediated interactions with microtubules
    ALEXIS M JEANNOTTE
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University, Washington, DC 20007, USA
    Eur J Neurosci 26:1509-20. 2007
    ..These findings suggest that the surface localization and activity of NET is modulated by alpha-Syn in a manner that is both dependent on interactions with the MT cytoskeleton and varies across brain regions...
  39. ncbi request reprint Inflammation and Parkinson's disease
    Christophe Wersinger
    Laboratory of Molecular Neurochemistry, Department of Pediatrics, Georgetown University Medical Center, 3970 Reservoir Road, NW, Washington, DC 20007, USA
    Curr Drug Targets Inflamm Allergy 1:221-42. 2002
    ..The major similarities and differences between PD and other neurodegenerative disorders are discussed...
  40. ncbi request reprint An inflammatory pathomechanism for Parkinson's disease?
    Christophe Wersinger
    Laboratory of Molecular Neurochemistry, Department of Pediatrics, Georgetown University Medical Center, 3970 Reservoir Road, NW, Washington, DC 20007, USA
    Curr Med Chem 13:591-602. 2006
    ..The current status of anti-inflammatory agents, either already tried in PD clinical trials or putatively usefull as adjuvant therapies for PD, is also discussed...
  41. pmc Synuclein modulation of monoamine transporters
    Adam W Oaks
    Department of Biochemistry, Molecular, Cellular Biology and Lombardi Cancer Center, Georgetown University, Washington, DC 20007, United States
    FEBS Lett 585:1001-6. 2011
    ....
  42. ncbi request reprint Modulation of D1-like dopamine receptor function by aldehydic products of lipid peroxidation
    Yangmee Shin
    Department of Pediatrics, Georgetown University Medical Center, 3970 Reservoir Road, N W, 20057, Washington, DC, USA
    Brain Res 968:102-13. 2003
    ..Our data suggests that aldehydic products of lipid peroxidation can directly modulate the binding and functional properties of D1/D5 receptors, as well as effector proteins within their signaling pathway...
  43. ncbi request reprint The degeneration of dopamine neurons in Parkinson's disease: insights from embryology and evolution of the mesostriatocortical system
    Philippe Vernier
    Development, Evolution, Plasticity of the Nervous System, Institute of Neurobiology A Fessard, CNRS, Gif sur Yvette, France
    Ann N Y Acad Sci 1035:231-49. 2004
    ....
  44. ncbi request reprint Delineation of the conserved functional properties of D1A, D1B and D1C dopamine receptor subtypes in vertebrates
    Stephane Le Crom
    Developpement, Evolution, Plasticité du Système Nerveux UPR2197, Institut de Neurobiologie Alfred Fessard, CNRS, Gif sur Yvette, 91198, France
    Biol Cell 96:383-94. 2004
    ..These properties have been instrumental to adapt dopamine system to the physiology of the numerous neuronal networks and functions they control in the large and complex brains of vertebrates...
  45. ncbi request reprint Highly potent and specific GSK-3beta inhibitors that block tau phosphorylation and decrease alpha-synuclein protein expression in a cellular model of Parkinson's disease
    Alan P Kozikowski
    Drug Discovery Program, College of Pharmacy, University of Illinois at Chicago, 833 S Wood St, Chicago, Illinois 60612, USA
    ChemMedChem 1:256-66. 2006
    ....

Research Grants35

  1. Dopamine and Oxidative Stress in Parkinson's Disease.
    Anita Sidhu; Fiscal Year: 2006
    ....
  2. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
    ..This grant is also relevant for the ARRA in that it will immediately create 3 new professional jobs. ..
  3. SYNUCLEOPATHIES IN NEURODEGENERATION
    Anita Sidhu; Fiscal Year: 2006
    ..Studies will be conducted to determine if changes in alpha-synuclein/DAT interactions will reduce oxidative stress and cell death. ..
  4. SYNUCLEOPATHIES IN NEURODEGENERATION
    Anita Sidhu; Fiscal Year: 2005
    ..Studies will be conducted to determine if changes in alpha-synuclein/DAT interactions will reduce oxidative stress and cell death. ..
  5. DOPAMINERGIC SIGNALING IN NEUROLOGICAL DISORDERS
    Anita Sidhu; Fiscal Year: 2005
    ....
  6. SYNUCLEOPATHIES IN NEURODEGENERATION
    Anita Sidhu; Fiscal Year: 2006
    ..Studies will be conducted to determine if changes in alpha-synuclein/DAT interactions will reduce oxidative stress and cell death. ..
  7. SYNUCLEOPATHIES IN NEURODEGENERATION
    Anita Sidhu; Fiscal Year: 2003
    ..Studies will be conducted to determine if changes in alpha-synuclein/DAT interactions will reduce oxidative stress and cell death. ..
  8. DOPAMINERGIC SYSTEMS IN HYPERTENSIVE
    Anita Sidhu; Fiscal Year: 2002
    ..It is likely that RAS blockers will normalize the redox state of the SHR kidney, and that upon such normalization, Dl DA receptor function may also be normalized, restoring the ability of DA and the Dl DA receptors to excrete sodium. ..
  9. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2009
    ..This grant is also relevant for the ARRA in that it will immediately create 3 new professional jobs. ..
  10. DOPAMINERGIC SIGNALING IN NEUROLOGICAL DISORDERS
    Anita Sidhu; Fiscal Year: 2002
    ....
  11. Mechanisms of Tauopathies and Synucleopathies
    Anita Sidhu; Fiscal Year: 2010
    ..From such studies, it will be possible to understand the overlapping pathology and mechanisms of tauopathies and synucleopathies, and to develop common targeted therapies. ..
  12. Modulation of Serotonergic Transporters
    Anita Sidhu; Fiscal Year: 2010
    ..The identification of a-synuclein as a regulatory protein partner of SERT holds promise in the development of novel therapeutic strategies in the treatment of depression and drug addiction. ..
  13. DOPAMINERGIC SYSTEMS IN HYPERTENSIVE
    Anita Sidhu; Fiscal Year: 2001
    ..It is likely that RAS blockers will normalize the redox state of the SHR kidney, and that upon such normalization, Dl DA receptor function may also be normalized, restoring the ability of DA and the Dl DA receptors to excrete sodium. ..
  14. Mechanisms of Tauopathies and Synucleopathies
    Anita Sidhu; Fiscal Year: 2007
    ..From such studies, it will be possible to understand the overlapping pathology and mechanisms of tauopathies and synucleopathies, and to develop common targeted therapies. ..
  15. Modulation of Serotonergic Transporters
    Anita Sidhu; Fiscal Year: 2007
    ..The identification of a-synuclein as a regulatory protein partner of SERT holds promise in the development of novel therapeutic strategies in the treatment of depression and drug addiction. ..
  16. SYNUCLEOPATHIES IN NEURODEGENERATION
    Anita Sidhu; Fiscal Year: 2005
    ..Studies will be conducted to determine if changes in alpha-synuclein/DAT interactions will reduce oxidative stress and cell death. ..
  17. Mechanisms of Tauopathies and Synucleopathies
    Anita Sidhu; Fiscal Year: 2009
    ..From such studies, it will be possible to understand the overlapping pathology and mechanisms of tauopathies and synucleopathies, and to develop common targeted therapies. ..
  18. DOPAMINERGIC SIGNALING IN NEUROLOGICAL DISORDERS
    Anita Sidhu; Fiscal Year: 2003
    ....
  19. Dopamine and Oxidative Stress in Parkinson's Disease.
    Anita Sidhu; Fiscal Year: 2005
    ....
  20. Dopamine and Oxidative Stress in Parkinson's Disease.
    Anita Sidhu; Fiscal Year: 2004
    ....
  21. REGULATION OF DOPAMINE RECEPTOR FUNCTION AND EXPRESSION
    Anita Sidhu; Fiscal Year: 1999
    ..The information obtained after tetanic stimulation of cells will be correlated with the results obtained from biochemical studies, and will provide unique insight to the DA-mediated processes underlying neuronal cell firing. ..
  22. Dopamine and Oxidative Stress in Parkinson's Disease.
    Anita Sidhu; Fiscal Year: 2003
    ....
  23. Dopamine and Oxidative Stress in Parkinson's Disease.
    Anita Sidhu; Fiscal Year: 2002
    ....
  24. DOPAMINERGIC SYSTEMS IN HYPERTENSIVE RATS
    Anita Sidhu; Fiscal Year: 2000
    ..It is likely that RAS blockers will normalize the redox state of the SHR kidney, and that upon such normalization, Dl DA receptor function may also be normalized, restoring the ability of DA and the Dl DA receptors to excrete sodium. ..
  25. DOPAMINERGIC SYSTEMS IN HYPERTENSIVE
    Anita Sidhu; Fiscal Year: 2003
    ..It is likely that RAS blockers will normalize the redox state of the SHR kidney, and that upon such normalization, Dl DA receptor function may also be normalized, restoring the ability of DA and the Dl DA receptors to excrete sodium. ..
  26. DOPAMINERGIC SIGNALING IN NEUROLOGICAL DISORDERS
    Anita Sidhu; Fiscal Year: 2004
    ....
  27. Modulation of Serotonergic Transporters
    Anita Sidhu; Fiscal Year: 2009
    ..The identification of a-synuclein as a regulatory protein partner of SERT holds promise in the development of novel therapeutic strategies in the treatment of depression and drug addiction. ..
  28. SYNUCLEOPATHIES IN NEURODEGENERATION
    Anita Sidhu; Fiscal Year: 2004
    ..Studies will be conducted to determine if changes in alpha-synuclein/DAT interactions will reduce oxidative stress and cell death. ..