Lopa Mishra

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi The role of PRAJA and ELF in TGF-beta signaling and gastric cancer
    Lopa Mishra
    Laboratory of GI Developmental Biology, Department of Surgery, Medicine and The Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007
    Cancer Biol Ther 4:694-9. 2005
  2. ncbi Cell cycle deregulation and loss of stem cell phenotype in the subventricular zone of TGF-beta adaptor elf-/- mouse brain
    Nady Golestaneh
    Laboratory of Developmental Neurobiology, Georgetown University School of Medicine, 3900 Reservoir Road NW, Medical Dental Building, Room NW 209 213, Washington, DC 20007, USA
    Brain Res 1108:45-53. 2006
  3. ncbi Role of transforming growth factor beta signaling and expansion of progenitor cells in regenerating liver
    Arun Thenappan
    Cancer Genetics, Digestive Diseases, and Developmental Molecular Biology, Department of Surgery, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
    Hepatology 51:1373-82. 2010
  4. ncbi Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling
    Yi Tang
    Cancer Genetics, Digestive Diseases and Developmental Molecular Biology, Institute of Transplant Surgery, Department of Surgery, Lombardi Comprehensive Cancer Center, Georgetown University, Medical Dental Building, Washington, DC 20007, USA
    Proc Natl Acad Sci U S A 105:2445-50. 2008
  5. ncbi TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF
    Sang Soo Kim
    Laboratory of Cancer Genetics, Digestive Diseases, and Developmental Molecular Biology, Department of Surgery, Medicine, Lombardi Cancer Center, Georgetown University, Washington, DC, USA
    Biochem Biophys Res Commun 344:1216-23. 2006
  6. ncbi Inactivation of TGF-beta signaling in lung cancer results in increased CDK4 activity that can be rescued by ELF
    Hye Jung Baek
    Department of Surgery, Laboratory of Cancer Genetics, Digestive Diseases, and Developmental Molecular Biology, Lombardi Cancer Center, Georgetown University, Washington, DC, USA
    Biochem Biophys Res Commun 346:1150-7. 2006
  7. ncbi Tgf-Beta signaling in development
    Krit Kitisin
    Laboratory of Cancer Genetics and Digestive Diseases, Department of Surgery, and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA
    Sci STKE 2007:cm1. 2007
  8. ncbi Loss of transforming growth factor β adaptor protein β-2 spectrin leads to delayed liver regeneration in mice
    Arun Thenappan
    Department of Surgery, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
    Hepatology 53:1641-50. 2011
  9. ncbi Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis
    Yi Tang
    Laboratory of GI Developmental Biology, Department of Surgery, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Cancer Res 65:4228-37. 2005
  10. ncbi Liver stem cells and hepatocellular carcinoma
    Lopa Mishra
    Laboratory of Cancer Genetics, Digestive Diseases, and Developmental Molecular Biology, Department of Surgery, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA
    Hepatology 49:318-29. 2009

Collaborators

Detail Information

Publications26

  1. ncbi The role of PRAJA and ELF in TGF-beta signaling and gastric cancer
    Lopa Mishra
    Laboratory of GI Developmental Biology, Department of Surgery, Medicine and The Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007
    Cancer Biol Ther 4:694-9. 2005
    ..These studies reveal a mechanism for gastric tumorigenesis whereby defects in adaptor proteins for Smads, such as ELF, can undergo degradation by PRAJA, through the ubiquitin-mediated pathway...
  2. ncbi Cell cycle deregulation and loss of stem cell phenotype in the subventricular zone of TGF-beta adaptor elf-/- mouse brain
    Nady Golestaneh
    Laboratory of Developmental Neurobiology, Georgetown University School of Medicine, 3900 Reservoir Road NW, Medical Dental Building, Room NW 209 213, Washington, DC 20007, USA
    Brain Res 1108:45-53. 2006
    ....
  3. ncbi Role of transforming growth factor beta signaling and expansion of progenitor cells in regenerating liver
    Arun Thenappan
    Cancer Genetics, Digestive Diseases, and Developmental Molecular Biology, Department of Surgery, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
    Hepatology 51:1373-82. 2010
    ....
  4. ncbi Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling
    Yi Tang
    Cancer Genetics, Digestive Diseases and Developmental Molecular Biology, Institute of Transplant Surgery, Department of Surgery, Lombardi Comprehensive Cancer Center, Georgetown University, Medical Dental Building, Washington, DC 20007, USA
    Proc Natl Acad Sci U S A 105:2445-50. 2008
    ..These experiments suggest an important therapeutic role for targeting IL-6 in HCCs lacking a functional TGF-beta pathway...
  5. ncbi TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF
    Sang Soo Kim
    Laboratory of Cancer Genetics, Digestive Diseases, and Developmental Molecular Biology, Department of Surgery, Medicine, Lombardi Cancer Center, Georgetown University, Washington, DC, USA
    Biochem Biophys Res Commun 344:1216-23. 2006
    ..Thus, in response to ELF deficiency, the abnormalities of G1/S checkpoint and senescence contribute their increment of susceptibility to malignant transformation...
  6. ncbi Inactivation of TGF-beta signaling in lung cancer results in increased CDK4 activity that can be rescued by ELF
    Hye Jung Baek
    Department of Surgery, Laboratory of Cancer Genetics, Digestive Diseases, and Developmental Molecular Biology, Lombardi Cancer Center, Georgetown University, Washington, DC, USA
    Biochem Biophys Res Commun 346:1150-7. 2006
    ....
  7. ncbi Tgf-Beta signaling in development
    Krit Kitisin
    Laboratory of Cancer Genetics and Digestive Diseases, Department of Surgery, and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA
    Sci STKE 2007:cm1. 2007
    ....
  8. ncbi Loss of transforming growth factor β adaptor protein β-2 spectrin leads to delayed liver regeneration in mice
    Arun Thenappan
    Department of Surgery, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
    Hepatology 53:1641-50. 2011
    ..2SP loss may increase susceptibility to DNA damage, impair cell cycle progression, and ultimately lead to hepatocellular cancer...
  9. ncbi Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis
    Yi Tang
    Laboratory of GI Developmental Biology, Department of Surgery, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Cancer Res 65:4228-37. 2005
    ..05) and of Smad4 in advanced colon cancers (P < 0.05). This study indicates that by modulating Smad 4, ELF has a key role in TGF-beta signaling in the suppression of early colon cancer...
  10. ncbi Liver stem cells and hepatocellular carcinoma
    Lopa Mishra
    Laboratory of Cancer Genetics, Digestive Diseases, and Developmental Molecular Biology, Department of Surgery, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA
    Hepatology 49:318-29. 2009
    ..This review provides a rationale for detecting and analyzing tumor stem cells as one of the most effective ways to treat cancers such as HCC...
  11. ncbi TGF-beta signaling in neuronal stem cells
    Chohee Yun
    Laboratory of Developmental Neurobiology, Department of Surgery, Medicine and Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Dis Markers 24:251-5. 2008
    ..Recent studies have suggested significant role of TGF-beta in stem/progenitor cell biology. Here in this review, we focus on the role of the TGF-beta superfamily in neuronal development...
  12. ncbi Inactivation of ELF/TGF-beta signaling in human gastrointestinal cancer
    Varalakshmi Katuri
    Laboratory of Developmental Molecular Biology, Department of Surgical Sciences, Medicine, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Oncogene 24:8012-24. 2005
    ..Furthermore, we demonstrate the rescue of E-cadherin-dependent homophilic cell-cell adhesion by ectopic expression of full-length elf. Our results suggest that ELF has an essential role in tumor suppression in GI cancers...
  13. ncbi Cancer stem cells and hepatocellular carcinoma
    Zhixing Yao
    Laboratory of Cancer Genetics, Digestive Diseases and Developmental Molecular Biology, Georgetown University, Washington, DC 20007, USA
    Cancer Biol Ther 8:1691-8. 2009
    ..This review provides a rationale for detecting and analyzing tumor stem cells as one of the most effective ways to treat cancers such as hepatocellular cancer...
  14. ncbi Transforming growth factor-beta signaling in stem cells and cancer
    Lopa Mishra
    Cancer Genetics and Digestive Diseases, Medicine and Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Science 310:68-71. 2005
    ..Here we illustrate their roles in embryonic stem cells and in the differentiation of neural, hematopoietic, mesenchymal, and gastrointestinal epithelial stem cells...
  15. ncbi The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer
    Lopa Mishra
    Department of Surgery, Medicine, The Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
    Oncogene 24:5775-89. 2005
    ....
  16. ncbi Adaptor proteins and ubiquinators in TGF-beta signaling
    Lopa Mishra
    Laboratory of Digestive Diseases, Department of Surgery, Medicine and Lombardi Cancer Center, Georgetown University, Washington, DC, USA
    Cytokine Growth Factor Rev 17:75-87. 2006
    ..Delineating these key interactions of the TGF-beta signaling pathway could yield powerful new therapeutics aimed at treating hitherto difficult to treat cancers...
  17. ncbi Transforming growth factor-beta signaling and ubiquitinators in cancer
    Eric Glasgow
    Laboratory of Cancer Genetics, Digestive Diseases, and GI Developmental Biology, Department of Surgery, Medicine and Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Endocr Relat Cancer 15:59-72. 2008
    ..Delineating the role of ubiquitinators in the TGF-beta signaling pathway could yield powerful novel therapeutic targets for designing new cancer treatments...
  18. ncbi Stem cells in gastrointestinal cancers
    Aiwu Ruth He
    Division of Hematology/Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA
    Dis Markers 24:217-22. 2008
  19. ncbi Transforming growth factor-beta and wound healing
    Byron J Faler
    Department of Surgery, Veterans Affairs Medical Center, Washington, DC, USA
    Perspect Vasc Surg Endovasc Ther 18:55-62. 2006
    ..From illustrating these cellular actions of TGF-beta, we summarize its multipotent role in the process of wound repair. As a clinical correlation, we also review research dedicated to the involvement of TGF-beta in venous stasis ulcers...
  20. ncbi Molecular biology of colorectal cancer: new targets
    Krit Kitisin
    Department of Surgery, Laboratory of Digestive Diseases, Georgetown University, Washington, DC 20007, USA
    Semin Oncol 33:S14-23. 2006
    ....
  21. ncbi Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice
    Yi Tang
    Laboratory of Developmental Biology, Department of Medicine, Georgetown University, Washington, DC 20007, USA
    Science 299:574-7. 2003
    ..This study reveals an unexpected molecular link between a major dynamic scaffolding protein and a key signaling pathway...
  22. ncbi Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis
    Hye Jung Baek
    Radiation Medicine Branch, National Cancer Center, Goyang, Korea
    Hepatology 48:1128-37. 2008
    ..Our studies propose that ELF is potentially a powerful target for mimetics enhancing the TGF-beta pathway tumor suppression of HCC...
  23. ncbi Loss of cooperative function of transforming growth factor-beta signaling proteins, smad3 with embryonic liver fodrin, a beta-spectrin, in primary biliary cirrhosis
    Bibhuti Mishra
    GI Developmental Biology, Medicine, Surgical Sciences, Lombardi Cancer Center, Georgetown University and DVAMC, Washington, DC, USA
    Liver Int 24:637-45. 2004
    ..CONCLUSIONS: These results suggest that a compromised cytoarchitecture and polarized trafficking of TGF-beta signaling molecules, ELF and Smad3 are involved in the pathogenesis of PBC as well as HCC...
  24. ncbi Orofacial and gastrointestinal hyperplasia and neoplasia in smad4+/- and elf+/-/smad4+/- mutant mice
    Robert S Redman
    Oral Pathology Research Laboratory, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
    J Oral Pathol Med 34:23-9. 2005
    ..The embryonic liver fodrin (ELF) is a beta-spectrin that facilitates the nuclear translocation of activated Smad4...
  25. ncbi A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
    Rui Hong Wang
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Metab 2:399-409. 2005
    ..Our study uncovers a novel role of TGF-beta/SMAD4 in regulating hepcidin expression and thus intestinal iron transport and iron homeostasis...
  26. ncbi ELF a beta-spectrin is a neuronal precursor cell marker in developing mammalian brain; structure and organization of the elf/beta-G spectrin gene
    Yi Tang
    Laboratory of Development Molecular Biology, DVAMC, Washington, District of Columbia, DC 20422, USA
    Oncogene 21:5255-67. 2002
    ..Based on its expression pattern, ELF may have a role in neural stem cell development and is a marker of axonal sprouting in mid stages of embryonic development...