Lixin Mi

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint Self-assembling protein hydrogels with modular integrin binding domains
    Lixin Mi
    Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Biomacromolecules 7:38-47. 2006
  2. ncbi request reprint The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20057, USA
    Cancer Res 67:6409-16. 2007
  3. pmc Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Biol Chem 283:22136-46. 2008
  4. pmc A cautionary note on using N-acetylcysteine as an antagonist to assess isothiocyanate-induced reactive oxygen species-mediated apoptosis
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Anal Biochem 405:269-71. 2010
  5. pmc Proteomic identification of binding targets of isothiocyanates: A perspective on techniques
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Proteomics 74:1036-44. 2011
  6. pmc Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D C 20057, USA
    J Biol Chem 284:17039-51. 2009
  7. pmc Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Biochem Biophys Res Commun 388:456-62. 2009
  8. pmc Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Carcinogenesis 32:216-23. 2011
  9. pmc Proteins as binding targets of isothiocyanates in cancer prevention
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Carcinogenesis 32:1405-13. 2011
  10. pmc Identification of potential protein targets of isothiocyanates by proteomics
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, Washington, D C 20057, United States
    Chem Res Toxicol 24:1735-43. 2011

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Self-assembling protein hydrogels with modular integrin binding domains
    Lixin Mi
    Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Biomacromolecules 7:38-47. 2006
    ..Such hydrogel-forming bioactive proteins have potential for cell and tissue culture applications...
  2. ncbi request reprint The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20057, USA
    Cancer Res 67:6409-16. 2007
    ..Because PEITC is a stronger inducer of apoptosis than SFN, these results indicate that direct covalent binding to cellular proteins is an important early event in the induction of apoptosis by the ITCs...
  3. pmc Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Biol Chem 283:22136-46. 2008
    ..This is the first study directly linking tubulin-ITC adduct formation to cell growth inhibition...
  4. pmc A cautionary note on using N-acetylcysteine as an antagonist to assess isothiocyanate-induced reactive oxygen species-mediated apoptosis
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Anal Biochem 405:269-71. 2010
    ..The study provides a cautionary note on the assay in studying mechanisms of apoptosis by ITCs and other electrophilic and thiol-reactive compounds...
  5. pmc Proteomic identification of binding targets of isothiocyanates: A perspective on techniques
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Proteomics 74:1036-44. 2011
    ..The advantages and limitations of each method are discussed to facilitate future studies on target discovery of ITCs and perhaps other compounds...
  6. pmc Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D C 20057, USA
    J Biol Chem 284:17039-51. 2009
    ..This is the first report that tubulin, a stable and abundant cytoskeleton protein required for cell cycle progression, can be selectively degraded by a small molecule...
  7. pmc Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Biochem Biophys Res Commun 388:456-62. 2009
    ..ITC-induced ALS is a proteasome-dependent assembly for emergent removal of misfolded proteins, suggesting that the cell may have a previously unknown strategy to cope with misfolded proteins...
  8. pmc Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Carcinogenesis 32:216-23. 2011
    ..It also supports the future studies of ITCs as therapeutic and preventive agents for MM...
  9. pmc Proteins as binding targets of isothiocyanates in cancer prevention
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Carcinogenesis 32:1405-13. 2011
    ..In the end, we also offer discussions to shed light onto the relationship between protein binding and reactive oxygen species generation by ITCs...
  10. pmc Identification of potential protein targets of isothiocyanates by proteomics
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, Washington, D C 20057, United States
    Chem Res Toxicol 24:1735-43. 2011
    ..The discovery of the protein targets may facilitate studies of the mechanisms by which ITCs exert their cancer preventive activity and provide the molecular basis for designing more efficacious ITC compounds...
  11. doi request reprint Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells
    Lixin Mi
    Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
    Nutr Cancer 60:12-20. 2008
    ..These results collectively suggest that the covalent binding to protein targets, such as tubulin, by ITCs is an important chemical event in apoptosis induction by ITCs in human lung A549 cells...
  12. pmc Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships
    Xiantao Wang
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, LL 128A, Box 571465, Washington, DC 20057, USA
    J Med Chem 54:809-16. 2011
    ..Collectively, this study shows that mutant p53 depletion may be an important novel target for cancer chemoprevention and therapy by natural and synthetic ITCs...
  13. pmc Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin
    Xiantao Wang
    Lombardi Comprehensive Cancer Center, Georgetown University, 3800Reservoir Road NW, Washington, DC 20057, USA
    Mol Nutr Food Res 55:1572-81. 2011
    ..In this study, we examined the potential of PEITC in enhancing cisplatin-induced apoptosis in cervical cancer cells and its mechanisms...
  14. pmc Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27
    Nanqin Gan
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Biol Chem 285:35528-36. 2010
    ..This is the first report to show that heat shock response by SFN, in addition to the antioxidant response mediated by the Keap1-Nrf2 pathway, may contribute to cytoprotection...
  15. pmc Sensitization of non-small cell lung cancer cells to cisplatin by naturally occurring isothiocyanates
    Anthony J Di Pasqua
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, Washington DC 20057, USA
    Chem Res Toxicol 23:1307-9. 2010
    ..Neither cellular platinum accumulation nor DNA platination account for this increased cytotoxicity. BITC and PEITC deplete beta-tubulin, but SFN does not; this correlates with and may be important for sensitization...