K J Meador

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint Differential cognitive and behavioral effects of topiramate and valproate
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta, USA
    Neurology 60:1483-8. 2003
  2. ncbi request reprint Neurodevelopmental outcomes of children born to mothers with epilepsy
    Kimford J Meador
    Department of Neurology, Georgetown University Hospital, 1st Floor Bles, 3800 Reservoir Rd, NW, Washington, DC 20007, USA
    Cleve Clin J Med 71:S38-41. 2004
  3. ncbi request reprint Ambiguous language in Wada evaluations
    Kimford J Meador
    Department of Neurology, Georgetown University Hospital, Washington, DC 20007, USA
    Epilepsia 45:24-5. 2004
  4. ncbi request reprint Role of cerebral lateralization in control of immune processes in humans
    Kimford J Meador
    Department of Neurology, Georgetown University, Washington, DC 20007, USA
    Ann Neurol 55:840-4. 2004
  5. pmc Effects of breastfeeding in children of women taking antiepileptic drugs
    K J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
    Neurology 75:1954-60. 2010
  6. ncbi request reprint Differential cognitive effects of carbamazepine and gabapentin
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta 30912, USA
    Epilepsia 40:1279-85. 1999
  7. ncbi request reprint Cognitive and behavioral effects of lamotrigine and topiramate in healthy volunteers
    K J Meador
    Department of Neurology, Georgetown University, Washington, DC, USA
    Neurology 64:2108-14. 2005
  8. ncbi request reprint Differential cognitive and behavioral effects of carbamazepine and lamotrigine
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta, 30912, USA
    Neurology 56:1177-82. 2001
  9. ncbi request reprint Results of lesional vs. nonlesional frontal lobe epilepsy surgery
    J R Smith
    Section of Neurosurgery, Medical College of Georgia, Augusta, USA
    Stereotact Funct Neurosurg 69:202-9. 1997
  10. pmc Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs
    Kimford J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Bldg, 101 Woodruff Cir, Suite 6000, Atlanta, GA 30322, USA
    N Engl J Med 360:1597-605. 2009

Detail Information

Publications61

  1. ncbi request reprint Differential cognitive and behavioral effects of topiramate and valproate
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta, USA
    Neurology 60:1483-8. 2003
    ..Cognitive effects have been reported during topiramate (TPM) treatment, but effects relative to standard antiepileptic drugs are unclear...
  2. ncbi request reprint Neurodevelopmental outcomes of children born to mothers with epilepsy
    Kimford J Meador
    Department of Neurology, Georgetown University Hospital, 1st Floor Bles, 3800 Reservoir Rd, NW, Washington, DC 20007, USA
    Cleve Clin J Med 71:S38-41. 2004
    ..Flaws in the methodology of some studies of these effects require that the results be interpreted cautiously and highlight the need for well-designed studies to explore this issue further...
  3. ncbi request reprint Ambiguous language in Wada evaluations
    Kimford J Meador
    Department of Neurology, Georgetown University Hospital, Washington, DC 20007, USA
    Epilepsia 45:24-5. 2004
    ..A case is presented with ambiguous cerebral language lateralization, as determined by the intracarotid amobarbital test. Reasons for ambiguous language findings for this test are discussed...
  4. ncbi request reprint Role of cerebral lateralization in control of immune processes in humans
    Kimford J Meador
    Department of Neurology, Georgetown University, Washington, DC 20007, USA
    Ann Neurol 55:840-4. 2004
    ..The findings demonstrate a differential role of the left and right cerebral hemispheres on immune functions in humans...
  5. pmc Effects of breastfeeding in children of women taking antiepileptic drugs
    K J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
    Neurology 75:1954-60. 2010
    ..Animal and human studies have demonstrated that some AEDs can adversely affect the immature brain. However, no investigation has examined effects of breastfeeding during AED therapy on subsequent cognitive abilities in children...
  6. ncbi request reprint Differential cognitive effects of carbamazepine and gabapentin
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta 30912, USA
    Epilepsia 40:1279-85. 1999
    ..The cognitive effects of the newer antiepileptic drugs (AEDs) compared with the older standard AEDs are uncertain...
  7. ncbi request reprint Cognitive and behavioral effects of lamotrigine and topiramate in healthy volunteers
    K J Meador
    Department of Neurology, Georgetown University, Washington, DC, USA
    Neurology 64:2108-14. 2005
    ..The relative cognitive and behavioral effects of lamotrigine (LTG) and topiramate (TPM) are unclear...
  8. ncbi request reprint Differential cognitive and behavioral effects of carbamazepine and lamotrigine
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta, 30912, USA
    Neurology 56:1177-82. 2001
    ..The relative cognitive and behavioral effects of lamotrigine compared with the older standard antiepileptic drugs (AED) are uncertain...
  9. ncbi request reprint Results of lesional vs. nonlesional frontal lobe epilepsy surgery
    J R Smith
    Section of Neurosurgery, Medical College of Georgia, Augusta, USA
    Stereotact Funct Neurosurg 69:202-9. 1997
    ..Three of 20 cases with at least 90% reduction in seizures became SD > or = 2 years postresection. No case with < 90% seizure reduction at one year showed improvement with longer follow-up...
  10. pmc Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs
    Kimford J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Bldg, 101 Woodruff Cir, Suite 6000, Atlanta, GA 30322, USA
    N Engl J Med 360:1597-605. 2009
    ....
  11. ncbi request reprint Neuropsychological and neurophysiologic effects of carbamazepine and levetiracetam
    K J Meador
    Department of Neurology, University of Florida, McKnight Brain Institute L3 100, 100 South Newell Drive, Gainesville, FL 32610, USA
    Neurology 69:2076-84. 2007
    ..The relative effects of levetiracetam (LEV) and carbamazepine (CBZ) on cognitive and neurophysiologic measures are uncertain...
  12. ncbi request reprint The contribution of an imagery code to verbal memory
    R C Martin
    Department of Neurology, Medical College of Georgia
    Cortex 26:443-50. 1990
    ..Thus, reliance upon a left hemispheric mediated verbal encoding process may only allow for partial integration of linguistic and visuospatial properties...
  13. ncbi request reprint Time perception following unilateral amobarbital injection in patients with temporal lobe epilepsy
    D L Drane
    Medical College of Georgia, Department of Neurology, Gainesville, USA
    J Clin Exp Neuropsychol 21:385-96. 1999
    ..These findings are discussed in the context of the growing evidence for a right-hemispheric attentional network...
  14. pmc In utero antiepileptic drug exposure: fetal death and malformations
    K J Meador
    Department of Neurology, University of Florida, Gainesville 32610, USA
    Neurology 67:407-12. 2006
    ..Pregnancy outcomes following in utero exposure to antiepileptic drugs (AEDs) are uncertain, limiting an evidenced-based approach...
  15. ncbi request reprint A 13-year experience with epilepsy surgery
    J R Smith
    Section of Neurosurgery, Medical College of Georgia, Augusta 30912, USA
    Stereotact Funct Neurosurg 73:98-103. 1999
    ..Of 20 hemispherectomies, 65% were SF. Of 7 multiple subpial transections, 29% were SF...
  16. doi request reprint Pregnancy registries in epilepsy: a consensus statement on health outcomes
    K J Meador
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Neurology 71:1109-17. 2008
    ..There is a critical need for investigations to delineate the underlying mechanisms and explain the variance seen in outcomes across AEDs and within a single AED...
  17. pmc Topiramate dose effects on cognition: a randomized double-blind study
    D W Loring
    Department of Neurology, Emory University, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
    Neurology 76:131-7. 2011
    ..Topiramate (TPM), a broad-spectrum antiepileptic drug, has been associated with neuropsychological impairment in patients with epilepsy and in healthy volunteers...
  18. ncbi request reprint Limb and hemispatial hypometria
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta 30912 3280, USA
    J Int Neuropsychol Soc 6:71-5. 2000
    ..No effect was found for direction of sensory input. The results suggest that the directional hypometria is predominantly produced by hemispatial output deficits...
  19. ncbi request reprint Relationship of extinction to perceptual thresholds for single stimuli
    K J Meador
    Section of Behavioral Neurology, Department of Neurology, Medical College of Georgia, Augusta 30912-3280, USA
    Neurology 56:1044-7. 2001
    ..Asymmetries in mask and target intensities (relative to single-stimulus perceptual thresholds) affect extinction in RBS patients less for left targets but more for right targets as compared with control subjects...
  20. ncbi request reprint Epilepsy in cortical dysplasia: factors affecting surgical outcome
    K N Fountas
    Department of Neurosurgery, Medical College of Georgia, Augusta, GA, USA
    Stereotact Funct Neurosurg 82:26-30. 2004
    ..To determine the factors influencing the outcome of cortical dysplasia resection for medically refractory epilepsy...
  21. ncbi request reprint Clinical and physiological effects of stereotaxic bilateral amygdalotomy for intractable aggression
    G P Lee
    Section of Neurosurgery, Medical College of Georgia, Augusta 30912 4010, USA
    J Neuropsychiatry Clin Neurosci 10:413-20. 1998
    ..The "taming effect" reported after bilateral amygdalar destruction may be due to the amygdala's inadequate processing of perceived threat stimuli that would normally produce a fight-or-flight response...
  22. ncbi request reprint Gamma coherence and conscious perception
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta, USA
    Neurology 59:847-54. 2002
    ..In addition, controversy exists as to whether the primary sensory cortices are involved directly in the mechanisms of conscious perception or just in processes prior to conscious awareness...
  23. ncbi request reprint Pre-surgical evaluation for epilepsy surgery
    D W Loring
    Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912 3275, USA
    Saudi Med J 21:609-16. 2000
    ....
  24. ncbi request reprint Negative seizures
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta 30912, USA
    J Int Neuropsychol Soc 6:731-3. 2000
    ..One had repeated episodes with PLEDs but no parenchymal lesions. Clinicians should consider seizures in the setting of unexplained deficits, even if there are no positive ictal phenomena...
  25. doi request reprint A test of the mechanisms of sensory extinction to simultaneous stimulation
    B M Kluger
    Department of Neurology, University of Florida College of Medicine, Box 100236, Gainesville, FL 32610 0236, USA
    Neurology 70:1644-5. 2008
  26. ncbi request reprint Arrhythmias in neurofibromatosis. A case report and review of the literature
    S Verma
    Section of Cardiology, Medical College of Georgia, Augusta, GA 30912-3105, USA
    Cardiology 95:167-9. 2001
    ..Complete resolution of symptoms occurred after a permanent pacemaker implantation. We believe this is the first reported case of sinus node dysfunction associated with neurofibromatosis...
  27. ncbi request reprint Pathophysiology of altered consciousness during seizures: Subtraction SPECT study
    K H Lee
    Department of Neurology, Medical College of Georgia, Augusta, GA, USA
    Neurology 59:841-6. 2002
    ..The mechanisms underlying altered consciousness during seizures are poorly understood. Previous clinicopathologic studies suggest a role for the thalamus and upper brainstem in consciousness mechanisms...
  28. ncbi request reprint Topography of somatosensory processing: cerebral lateralization and focused attention
    K J Meador
    Department of Neurology, Medical College of Georgia, Augusta 30912, USA
    J Int Neuropsychol Soc 8:349-59. 2002
    ..Unattended stimuli activate the contralateral primary somatosensory area. Left/right asymmetries were demonstrated consistent with cerebral lateralization...
  29. pmc Structured cueing on a semantic fluency task differentiates patients with temporal versus frontal lobe seizure onset
    Daniel L Drane
    Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA
    Epilepsy Behav 9:339-44. 2006
    ....
  30. ncbi request reprint Distinct cognitive neurophysiologic profiles for lamotrigine and topiramate
    Michael E Smith
    San Francisco Brain Research Institute and SAM Technology, San Francisco, California 94108, USA
    Epilepsia 47:695-703. 2006
    ..To contrast the effects of lamotrigine (LTG) and topiramate (TPM) on cognitive task-related and resting-state EEG and evoked potential (EP) measures...
  31. ncbi request reprint Subjective preference for lamotrigine or topiramate in healthy volunteers: relationship to cognitive and behavioral functioning
    Mary Ann Werz
    Department of Neurology, University Hospitals of Cleveland and Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Epilepsy Behav 8:181-91. 2006
    ..Additionally, drug preference was related to effects of lamotrigine and topiramate on objective neuropsychological tests as well as self-perception on behavioral instruments...
  32. ncbi request reprint Victoria Symptom Validity Test performance in a heterogenous clinical sample
    David W Loring
    Department of Neurology, University of Florida, Gainesville, FL 2610 0236, USA
    Clin Neuropsychol 21:522-31. 2007
    ..These data suggest that intentional response distortion in patients referred for non-forensic neuropsychological evaluation is rare. Performances by specific diagnosis using different classification criteria are also presented...
  33. ncbi request reprint Afterdischarges during cortical stimulation at different frequencies and intensities
    Gholam K Motamedi
    Department of Neurology, PHC 7, Georgetown University Hospital, 3800 Reservior Rd, NW, Washington, DC 20007, USA
    Epilepsy Res 77:65-9. 2007
    ..The occurrence of unwanted afterdischarges (ADs) impedes cortical stimulation for mapping purposes. We investigated the safety of several stimulation paradigms...
  34. ncbi request reprint Neuropsychological and behavioral effects of antiepilepsy drugs
    David W Loring
    Department of Neurology, University of Florida, Gainesville, USA
    Neuropsychol Rev 17:413-25. 2007
    ..The present article serves to provide an overview of our current understanding regarding the risks of antiepilepsy drug use for both cognitive and behavioral side effects...
  35. doi request reprint Differential neuropsychological test sensitivity to left temporal lobe epilepsy
    David W Loring
    Department of Neurology, University of Florida, Gainesville, Florida 32610, USA
    J Int Neuropsychol Soc 14:394-400. 2008
    ....
  36. ncbi request reprint The basic science of memory as it applies to epilepsy
    Kimford J Meador
    Department of Neurology, University of Florida, McKnight Brain Institute, Gainesville, FL 32610, USA
    Epilepsia 48:23-5. 2007
    ..The hippocampus contributes to both through its role in memory formation and its low seizure threshold...
  37. pmc Cognitive/behavioral teratogenetic effects of antiepileptic drugs
    Kimford J Meador
    Department of Neurology, University of Florida, Gainesville, FL, USA
    Epilepsy Behav 11:292-302. 2007
    ..The risks of AEDs in humans are less clear, but recent studies raise concerns, especially for valproate. There is a critical need for well-designed systematic research to improve our understanding of AED effects on the fetal brain...
  38. pmc Teratogenicity of antiepileptic medications
    Benzi M Kluger
    Department of Neurology, University of Florida, Gainesville, Florida 32610, USA
    Semin Neurol 28:328-35. 2008
    ..Management of women with epilepsy should include a discussion of these risks, prophylactic treatment with folic acid, and the minimal use of polypharmacy and valproate needed to maintain optimum seizure control...
  39. ncbi request reprint Cognitive and memory effects of the new antiepileptic drugs
    Kimford J Meador
    Epilepsy Res 68:63-7. 2006
    ..The available data suggest that some of the new AEDs have fewer effects on cognition and memory than the older AEDs, and these differences can have clinical impact...
  40. ncbi request reprint The Wada test for language and memory lateralization
    Kimford J Meador
    Neurology 65:659. 2005
  41. ncbi request reprint Victoria symptom validity test performance in non-litigating epilepsy surgery candidates
    David W Loring
    Department of Neurology, Georgetown University Medical Center, Washington, DC 20057, USA
    J Clin Exp Neuropsychol 27:610-7. 2005
    ....
  42. ncbi request reprint Newer anticonvulsants: dosing strategies and cognition in treating patients with mood disorders and epilepsy
    Kimford J Meador
    Department of Neurology, Medical College of Georgia, Augusta, USA
    J Clin Psychiatry 64:30-4. 2003
    ..Since multiple new anticonvulsants have been introduced in recent years, the question arises as to the frequency and magnitude of their cognitive side effects...
  43. ncbi request reprint Neurodevelopmental effects of antiepileptic drugs
    Kimford J Meador
    Department of Neurology, Medical College of Georgia, 1120 15th Street BA3410, Augusta, GA 30912, USA
    Curr Neurol Neurosci Rep 2:373-8. 2002
    ..Prenatal folate and multivitamins should also be given routinely to women of childbearing age who require AED therapy...
  44. ncbi request reprint Cognitive side effects of antiepileptic drugs in children
    David W Loring
    Department of Neurology, Georgetown University Medical Center, Washington, DC, USA
    Neurology 62:872-7. 2004
    ....
  45. ncbi request reprint Structural versus functional prediction of memory change following anterior temporal lobectomy
    David W Loring
    Department of Neurology, Georgetown University Medical Center, Building D, Suite 207, 4000 Reservoir Road, NW, Washington, DC 22057, USA
    Epilepsy Behav 5:264-8. 2004
    ..In the present case, behavioral measures were superior to structural measures in predicting cognitive change following surgery...
  46. ncbi request reprint Antiepileptic drugs and memory
    Gholam K Motamedi
    Department of Neurology, Georgetown University School of Medicine, Washington, DC, USA
    Epilepsy Behav 5:435-9. 2004
    ..Well-controlled studies are needed to understand the underlying mechanisms and to further delineate the magnitude and relative effects of AEDs on memory...
  47. ncbi request reprint Cognitive outcomes and predictive factors in epilepsy
    Kimford J Meador
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Neurology 58:S21-6. 2002
    ..Patients who are refractory or intolerant to AED therapy should be referred for video EEG monitoring to confirm the seizure diagnosis and determine if the patient is a candidate for epilepsy surgery...
  48. ncbi request reprint Determinants of quality of life in epilepsy
    David W Loring
    Department of Neurology, University of Florida, Gainesville, FL 32610, USA
    Epilepsy Behav 5:976-80. 2004
    ..Although quality of life has multiple determinants, symptoms of depression and seizure worry are the most important factors affecting QOL in patients with intractable epilepsy...
  49. ncbi request reprint Dimensions of the epilepsy foundation concerns index
    David W Loring
    Department of Neurology, University of Florida, Gainesville, FL, USA
    Epilepsy Behav 6:348-52. 2005
    ..We conclude that the Epilepsy Foundation Concerns Index is multidimensional, and using a global score based on all items may mask specific concerns that may be relevant when applied to individual patients...
  50. ncbi request reprint Cognitive side effects of antiepileptic drugs
    Pavel Ortinski
    Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC 20007, USA
    Epilepsy Behav 5:S60-5. 2004
    ..AEDs can have positive or negative effects on mood, providing another consideration in choosing the course of treatment...
  51. ncbi request reprint Lateralized changes in autonomic arousal during emotional processing in patients with unilateral temporal lobe seizure onset
    Gregory P Lee
    Department of Occupational Therapy, School of Allied Health, Department of Neurology, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA
    Int J Neurosci 112:743-57. 2002
    ..Dysfunction of left mesial temporal lobe structures may result in autonomic hyperarousal and a release of the unrestrained negative emotional tendencies of the right hemisphere...
  52. ncbi request reprint Antiepileptic drugs and neurodevelopment
    Gholam K Motamedi
    Georgetown University Hospital, Department of Neurology, PHC 7, 3800 Reservoir Road, NW, Washington, DC 20007, USA
    Curr Neurol Neurosci Rep 6:341-6. 2006
    ..Prospective clinical studies seem necessary in order to better understand the long-term neurodevelopmental effects of in utero exposure to AEDs...
  53. ncbi request reprint Lamotrigine therapy in patients requiring a change in antiepileptic drug regimen
    Robert P Kustra
    Epilepsy Clinical Development, GlaxoSmithKline, P O Box 13398, Research Triangle Park, NC 27709, USA
    Seizure 14:254-61. 2005
    ..Open-label studies conducted in the clinic setting may provide additional drug tolerability and effectiveness information that may not be evident in pre-approval clinical trials...
  54. ncbi request reprint Neural substrates of emotion as revealed by functional magnetic resonance imaging
    Gregory P Lee
    Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912 3275, USA
    Cogn Behav Neurol 17:9-17. 2004
    ..To examine the brain circuitry involved in emotional experience and determine whether the cerebral hemispheres are specialized for positive and negative emotional experience...
  55. ncbi request reprint Epilepsy and reproductive function in women
    Kimford J Meador
    Ann Neurol 52:696-7. 2002
  56. ncbi request reprint Rates and risk factors for suicide, suicidal ideation, and suicide attempts in chronic epilepsy
    Jana E Jones
    Department of Neurology, University of Wisconsin Madison, Madison, WI, USA
    Epilepsy Behav 4:S31-8. 2003
    ..Assessing severity of risk helps to determine the appropriate level of intervention. The suicidality module of the Mini-International Neuropsychiatric Interview is a practical tool to help quantify current suicide risk...
  57. ncbi request reprint What is the risk of orofacial clefts from lamotrigine exposure during pregnancy?
    Kimford J Meador
    Neurology 71:706-7. 2008
  58. ncbi request reprint Rapid detection of major depression in epilepsy: a multicentre study
    Frank G Gilliam
    Department of Neurology, The Neurological Institute, Columbia University, New York, USA
    Lancet Neurol 5:399-405. 2006
    ..Depression is a common comorbid disorder in epilepsy but is not routinely assessed in neurology clinics. We aimed to create a rapid yet accurate screening instrument for major depression in people with epilepsy...
  59. ncbi request reprint Screening for major depression in epilepsy with common self-report depression inventories
    Jana E Jones
    Department of Neurology, University of Wisconsin Madison, 53792, USA
    Epilepsia 46:731-5. 2005
    ..The purpose of this study was to determine the ability of two common depressive symptom inventories to identify major depression in people with epilepsy...
  60. ncbi request reprint The neuropsychology of epilepsy: what are the factors involved?
    Albert P Aldenkamp
    Department of Behavioral Sciences, Epilepsy Center Kempenhaeghe, PO Box 61, NL 5590 A B Heeze, The Netherlands
    Epilepsy Behav 5:S1-2. 2004
  61. ncbi request reprint Clinical assessment of Axis I psychiatric morbidity in chronic epilepsy: a multicenter investigation
    Jana E Jones
    Department of Neurology, University of Wisconsin Madison, 53792 6180, USA
    J Neuropsychiatry Clin Neurosci 17:172-9. 2005
    ..Issues regarding recognition and treatment of psychiatric morbidity in epilepsy are discussed...