Research Topics
Genomes and Genes | Christine MaricSummaryAffiliation: Georgetown University Country: USA Publications
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Publications
Changes in mean arterial pressure predict degranulation of renomedullary interstitial cellsChristine Maric
Departments of Anatomy, University of Melbourne, Parkville, Victoria, Australia
Clin Exp Pharmacol Physiol 29:1055-9. 2002....- Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17beta-estradiol in the aging Dahl salt sensitive ratChristine Maric
Center for the Study of Sex Differences in Health, Aging and Disease, Georgetown University Medical Center, 394 Building D, 4000 Reservoir Road NW, Washington, DC 20057, USA
J Am Soc Nephrol 15:1546-56. 2004..3 +/- 2.1; OVX, 32.6 +/- 5.1; OVX+E(2), 24.3 +/- 2.4 mg/dl). The authors conclude that E(2) is renoprotective in the aging DSS rat by attenuating glomerulosclerosis and tubulointerstitial fibrosis... 
Estrogens and the diabetic kidneyChristine Maric
Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
Gend Med 5:S103-13. 2008..These observations suggest that female sex may be renoprotective. In the setting of diabetes, however, this female protection against the development and progression of renal disease is diminished...- Interactions between angiotensin ll and atrial natriuretic peptide in renomedullary interstitial cells: the role of neutral endopeptidaseChristine Maric
Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
Nephron Physiol 103:p149-56. 2006..Neutral endopeptidase (NEP) inhibition attenuates renal damage in the diabetic kidney, but little is known about the mechanisms of this renoprotective effect... - Diabetic nephropathy is associated with decreased circulating estradiol levels and imbalance in the expression of renal estrogen receptorsCorinne C Wells
Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
Gend Med 2:227-37. 2005..We have recently reported that estrogen supplementation attenuates the progression of diabetic nephropathy, suggesting that lack of estrogen may nullify female sex as a protective factor against DM... - Imbalance in sex hormone levels exacerbates diabetic renal diseaseQin Xu
Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
Hypertension 51:1218-24. 2008..Most importantly, our results suggest an important role for sex hormones in the pathophysiology of diabetic renal complications... - Dose-dependent effects of dihydrotestosterone in the streptozotocin-induced diabetic rat kidneyQin Xu
Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia, USA
Am J Physiol Renal Physiol 297:F307-15. 2009..We conclude that the effects of DHT are dose dependent but caution should be taken when DHT supplementation is considered in the treatment of diabetic renal disease... - 17beta-Estradiol supplementation reduces tubulointerstitial fibrosis by increasing MMP activity in the diabetic kidneyRichard W Mankhey
Department of Medicine, Georgetown Univ Medical Center, 394 Bldg D, 4000 Reservoir Rd, NW, Washington, DC 20057, USA
Am J Physiol Regul Integr Comp Physiol 292:R769-77. 2007..66 +/- 0.35; MMP-9, 21.4 +/- 2.9 ROD). We conclude that E2 supplementation is renoprotective by attenuating glomerulosclerosis and tubulointerstitial fibrosis by reducing ECM synthesis and increasing ECM degradation... - 17beta-Estradiol attenuates diabetic kidney disease by regulating extracellular matrix and transforming growth factor-beta protein expression and signalingAlexis Dixon
Department of Medicine, Georgetown University Medical Center, 394 Bldg D, 4000 Reservoir Rd NW, Washington, DC 20057, USA
Am J Physiol Renal Physiol 293:F1678-90. 2007..These findings support the notion that sex hormones in general, and E2 in particular, are important regulators of renal function and may be novel targets for the treatment and prevention of diabetic renal disease... 
Effect of dietary sodium on estrogen regulation of blood pressure in Dahl salt-sensitive ratsWei Zheng
Georgetown University, NW, Washington, DC 20057, USA
Am J Physiol Heart Circ Physiol 294:H1508-13. 2008..These findings have implications for women with salt-sensitive hypertension and women who are E(2) deficient, such as postmenopausal women...- Age-related renal disease in female Dahl salt-sensitive rats is attenuated with 17 beta-estradiol supplementation by modulating nitric oxide synthase expressionChristine Maric
Department of Medicine, Georgetown University Medical Center, Washington, DC, USA
Gend Med 5:147-59. 2008..However, the mechanisms by which sex hormones, particularly estrogens, contribute to the disease process are unclear... - Effect of sex hormones on renal estrogen and angiotensin type 1 receptors in female and male ratsJennifer L Rogers
Department of Physiology and Biophysics, Georgetown University, Medical Center, Washington, DC 20057, USA
Am J Physiol Regul Integr Comp Physiol 292:R794-9. 2007..Furthermore, E2 regulates ERalpha and is inversely associated with glomerular AT1R binding, supporting our hypothesis that E2 tonically suppresses AT1Rs and suggesting a potential mechanism for the protective effects of estrogen... - Expression of aromatase, androgen and estrogen receptors in peripheral target tissues in diabetesAnjali Prabhu
Department of Medicine, Georgetown University Medical Center, 4000 Reservoir Road NW, Washington, DC 20057, United States
Steroids 75:779-87. 2010..Overall, our data provides evidence for the extra-testicular source of estradiol that in males, through an intracrine mechanism, may contribute to the development and/or progression of end-organ damage associated with diabetes... - Mechanisms of antioxidant and pro-oxidant effects of alpha-lipoic acid in the diabetic and nondiabetic kidneyFaizah Bhatti
Department of Medicine, Division of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC 20057, USA
Kidney Int 67:1371-80. 2005..CONCLUSION: We conclude that alpha-lipoic acid improves albuminuria and pathology in diabetes by reducing oxidative stress, while in healthy animals, alpha-lipoic acid may act as a pro-oxidant, contributing to renal dysfunction... - 17beta-Estradiol replacement improves renal function and pathology associated with diabetic nephropathyRichard W Mankhey
Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
Am J Physiol Renal Physiol 288:F399-405. 2005..08 AU). We conclude that E2 deficiency increases the severity of renal disease in a diabetic animal model and that E2 replacement is renoprotective by attenuating the decline in renal function and pathology associated with diabetes... - Posttranscriptional mechanisms contribute to osmotic regulation of ANG type 1 receptors in cultured rat renomedullary interstitial cellsSunghou Lee
Department of Medicine, 394 Bldg D, 4000 Reservoir Rd, NW, Washington, DC 20057, USA
Am J Physiol Regul Integr Comp Physiol 290:R44-9. 2006..The downregulation of AT(1a)R expression under hyperosmotic conditions may be an important mechanism by which the activity of ANG II is regulated in the hyperosmotic renal medulla... - Estrogen regulates adrenal angiotensin AT1 receptors by modulating AT1 receptor translationZheng Wu
Department of Physiology and Biophysics, Georgetown University Medical Center, 4000 Reservoir Road NW, Washington, D C 20007, USA
Endocrinology 144:3251-61. 2003..Dysregulation of this posttranscriptional mechanism may contribute to the increased incidence of cardiovascular disease associated with menopause... - Renoprotective effects of a selective estrogen receptor modulator, raloxifene, in an animal model of diabetic nephropathyAlexis Dixon
Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
Am J Nephrol 27:120-8. 2007..RAL activates estrogen receptors and estrogen-receptor-mediated cellular events without the side effects of E2... - Cutting edge: developmental up-regulation of IFN-gamma-inducible lysosomal thiol reductase expression leads to reduced T cell sensitivity and less severe autoimmunityMaja Maric
Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington, DC 20057, USA
J Immunol 182:746-50. 2009..GILT expression levels progressively increase in T cells with maturation. These data suggest that regulation of GILT expression may be a mechanism of T cell differentiation-associated changes in sensitivity to TCR engagement... - Vasoactive hormones and the diabetic kidneyChristine Maric
Department of Medicine, Georgetown University Medical Center, Washington, DC, USA
ScientificWorldJournal 8:470-85. 2008.... - Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysisMaciej Tomaszewski
British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
Circulation 116:1915-24. 2007..The distal portion of the long arm of chromosome 5 is linked to hypertension and contains functional candidate blood pressure-regulating genes... - Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor MasRobson A S Santos
Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, 31270, Minas Gerais, Brazil
Proc Natl Acad Sci U S A 100:8258-63. 2003..Collectively, these findings identify Mas as a functional receptor for Ang-(1-7) and provide a clear molecular basis for the physiological actions of this biologically active peptide... - Mechanisms of fetal programming of adult hypertension: role of sex hormonesChristine Maric
Hypertension 50:605-6. 2007 - Rofecoxib decreases renal injury in obese Zucker ratsAparajita Dey
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
Clin Sci (Lond) 107:561-70. 2004..These results suggest that altered vascular arachidonic acid enzymes contribute to the renal damage, and that COX-2 inhibition decreases glomerular injury in obese Zucker rats...
Research Grants
- Estrogen in pathogenesis of tubulointerstitial diseaseChristine Maric; Fiscal Year: 2003..abstract_text> ..
- ESTROGEN AND INFLAMMATION IN DIABETIC NEPHROPATHYChristine Maric; Fiscal Year: 2007....