Christine Maric

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi Changes in mean arterial pressure predict degranulation of renomedullary interstitial cells
    Christine Maric
    Departments of Anatomy, University of Melbourne, Parkville, Victoria, Australia
    Clin Exp Pharmacol Physiol 29:1055-9. 2002
  2. ncbi Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17beta-estradiol in the aging Dahl salt sensitive rat
    Christine Maric
    Center for the Study of Sex Differences in Health, Aging and Disease, Georgetown University Medical Center, 394 Building D, 4000 Reservoir Road NW, Washington, DC 20057, USA
    J Am Soc Nephrol 15:1546-56. 2004
  3. pmc Estrogens and the diabetic kidney
    Christine Maric
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Gend Med 5:S103-13. 2008
  4. ncbi Interactions between angiotensin ll and atrial natriuretic peptide in renomedullary interstitial cells: the role of neutral endopeptidase
    Christine Maric
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Nephron Physiol 103:p149-56. 2006
  5. ncbi Diabetic nephropathy is associated with decreased circulating estradiol levels and imbalance in the expression of renal estrogen receptors
    Corinne C Wells
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Gend Med 2:227-37. 2005
  6. pmc Imbalance in sex hormone levels exacerbates diabetic renal disease
    Qin Xu
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Hypertension 51:1218-24. 2008
  7. pmc Dose-dependent effects of dihydrotestosterone in the streptozotocin-induced diabetic rat kidney
    Qin Xu
    Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia, USA
    Am J Physiol Renal Physiol 297:F307-15. 2009
  8. ncbi 17beta-Estradiol supplementation reduces tubulointerstitial fibrosis by increasing MMP activity in the diabetic kidney
    Richard W Mankhey
    Department of Medicine, Georgetown Univ Medical Center, 394 Bldg D, 4000 Reservoir Rd, NW, Washington, DC 20057, USA
    Am J Physiol Regul Integr Comp Physiol 292:R769-77. 2007
  9. pmc 17beta-Estradiol attenuates diabetic kidney disease by regulating extracellular matrix and transforming growth factor-beta protein expression and signaling
    Alexis Dixon
    Department of Medicine, Georgetown University Medical Center, 394 Bldg D, 4000 Reservoir Rd NW, Washington, DC 20057, USA
    Am J Physiol Renal Physiol 293:F1678-90. 2007
  10. doi Effect of dietary sodium on estrogen regulation of blood pressure in Dahl salt-sensitive rats
    Wei Zheng
    Georgetown University, NW, Washington, DC 20057, USA
    Am J Physiol Heart Circ Physiol 294:H1508-13. 2008

Research Grants

Collaborators

Detail Information

Publications24

  1. ncbi Changes in mean arterial pressure predict degranulation of renomedullary interstitial cells
    Christine Maric
    Departments of Anatomy, University of Melbourne, Parkville, Victoria, Australia
    Clin Exp Pharmacol Physiol 29:1055-9. 2002
    ....
  2. ncbi Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17beta-estradiol in the aging Dahl salt sensitive rat
    Christine Maric
    Center for the Study of Sex Differences in Health, Aging and Disease, Georgetown University Medical Center, 394 Building D, 4000 Reservoir Road NW, Washington, DC 20057, USA
    J Am Soc Nephrol 15:1546-56. 2004
    ..3 +/- 2.1; OVX, 32.6 +/- 5.1; OVX+E(2), 24.3 +/- 2.4 mg/dl). The authors conclude that E(2) is renoprotective in the aging DSS rat by attenuating glomerulosclerosis and tubulointerstitial fibrosis...
  3. pmc Estrogens and the diabetic kidney
    Christine Maric
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Gend Med 5:S103-13. 2008
    ..These observations suggest that female sex may be renoprotective. In the setting of diabetes, however, this female protection against the development and progression of renal disease is diminished...
  4. ncbi Interactions between angiotensin ll and atrial natriuretic peptide in renomedullary interstitial cells: the role of neutral endopeptidase
    Christine Maric
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Nephron Physiol 103:p149-56. 2006
    ..Neutral endopeptidase (NEP) inhibition attenuates renal damage in the diabetic kidney, but little is known about the mechanisms of this renoprotective effect...
  5. ncbi Diabetic nephropathy is associated with decreased circulating estradiol levels and imbalance in the expression of renal estrogen receptors
    Corinne C Wells
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Gend Med 2:227-37. 2005
    ..We have recently reported that estrogen supplementation attenuates the progression of diabetic nephropathy, suggesting that lack of estrogen may nullify female sex as a protective factor against DM...
  6. pmc Imbalance in sex hormone levels exacerbates diabetic renal disease
    Qin Xu
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Hypertension 51:1218-24. 2008
    ..Most importantly, our results suggest an important role for sex hormones in the pathophysiology of diabetic renal complications...
  7. pmc Dose-dependent effects of dihydrotestosterone in the streptozotocin-induced diabetic rat kidney
    Qin Xu
    Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia, USA
    Am J Physiol Renal Physiol 297:F307-15. 2009
    ..We conclude that the effects of DHT are dose dependent but caution should be taken when DHT supplementation is considered in the treatment of diabetic renal disease...
  8. ncbi 17beta-Estradiol supplementation reduces tubulointerstitial fibrosis by increasing MMP activity in the diabetic kidney
    Richard W Mankhey
    Department of Medicine, Georgetown Univ Medical Center, 394 Bldg D, 4000 Reservoir Rd, NW, Washington, DC 20057, USA
    Am J Physiol Regul Integr Comp Physiol 292:R769-77. 2007
    ..66 +/- 0.35; MMP-9, 21.4 +/- 2.9 ROD). We conclude that E2 supplementation is renoprotective by attenuating glomerulosclerosis and tubulointerstitial fibrosis by reducing ECM synthesis and increasing ECM degradation...
  9. pmc 17beta-Estradiol attenuates diabetic kidney disease by regulating extracellular matrix and transforming growth factor-beta protein expression and signaling
    Alexis Dixon
    Department of Medicine, Georgetown University Medical Center, 394 Bldg D, 4000 Reservoir Rd NW, Washington, DC 20057, USA
    Am J Physiol Renal Physiol 293:F1678-90. 2007
    ..These findings support the notion that sex hormones in general, and E2 in particular, are important regulators of renal function and may be novel targets for the treatment and prevention of diabetic renal disease...
  10. doi Effect of dietary sodium on estrogen regulation of blood pressure in Dahl salt-sensitive rats
    Wei Zheng
    Georgetown University, NW, Washington, DC 20057, USA
    Am J Physiol Heart Circ Physiol 294:H1508-13. 2008
    ..These findings have implications for women with salt-sensitive hypertension and women who are E(2) deficient, such as postmenopausal women...
  11. pmc Age-related renal disease in female Dahl salt-sensitive rats is attenuated with 17 beta-estradiol supplementation by modulating nitric oxide synthase expression
    Christine Maric
    Department of Medicine, Georgetown University Medical Center, Washington, DC, USA
    Gend Med 5:147-59. 2008
    ..However, the mechanisms by which sex hormones, particularly estrogens, contribute to the disease process are unclear...
  12. ncbi Effect of sex hormones on renal estrogen and angiotensin type 1 receptors in female and male rats
    Jennifer L Rogers
    Department of Physiology and Biophysics, Georgetown University, Medical Center, Washington, DC 20057, USA
    Am J Physiol Regul Integr Comp Physiol 292:R794-9. 2007
    ..Furthermore, E2 regulates ERalpha and is inversely associated with glomerular AT1R binding, supporting our hypothesis that E2 tonically suppresses AT1Rs and suggesting a potential mechanism for the protective effects of estrogen...
  13. pmc Expression of aromatase, androgen and estrogen receptors in peripheral target tissues in diabetes
    Anjali Prabhu
    Department of Medicine, Georgetown University Medical Center, 4000 Reservoir Road NW, Washington, DC 20057, United States
    Steroids 75:779-87. 2010
    ..Overall, our data provides evidence for the extra-testicular source of estradiol that in males, through an intracrine mechanism, may contribute to the development and/or progression of end-organ damage associated with diabetes...
  14. ncbi Mechanisms of antioxidant and pro-oxidant effects of alpha-lipoic acid in the diabetic and nondiabetic kidney
    Faizah Bhatti
    Department of Medicine, Division of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC 20057, USA
    Kidney Int 67:1371-80. 2005
    ..alpha-Lipoic acid is a potent antioxidant that improves renal function in diabetes by lowering glycemia, however, the mechanisms by which alpha-lipoic acid exerts its antioxidant effects are not completely understood...
  15. ncbi 17beta-Estradiol replacement improves renal function and pathology associated with diabetic nephropathy
    Richard W Mankhey
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Am J Physiol Renal Physiol 288:F399-405. 2005
    ..08 AU). We conclude that E2 deficiency increases the severity of renal disease in a diabetic animal model and that E2 replacement is renoprotective by attenuating the decline in renal function and pathology associated with diabetes...
  16. ncbi Posttranscriptional mechanisms contribute to osmotic regulation of ANG type 1 receptors in cultured rat renomedullary interstitial cells
    Sunghou Lee
    Department of Medicine, 394 Bldg D, 4000 Reservoir Rd, NW, Washington, DC 20057, USA
    Am J Physiol Regul Integr Comp Physiol 290:R44-9. 2006
    ..The downregulation of AT(1a)R expression under hyperosmotic conditions may be an important mechanism by which the activity of ANG II is regulated in the hyperosmotic renal medulla...
  17. ncbi Estrogen regulates adrenal angiotensin AT1 receptors by modulating AT1 receptor translation
    Zheng Wu
    Department of Physiology and Biophysics, Georgetown University Medical Center, 4000 Reservoir Road NW, Washington, D C 20007, USA
    Endocrinology 144:3251-61. 2003
    ..Dysregulation of this posttranscriptional mechanism may contribute to the increased incidence of cardiovascular disease associated with menopause...
  18. pmc Renoprotective effects of a selective estrogen receptor modulator, raloxifene, in an animal model of diabetic nephropathy
    Alexis Dixon
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Am J Nephrol 27:120-8. 2007
    ..RAL activates estrogen receptors and estrogen-receptor-mediated cellular events without the side effects of E2...
  19. ncbi Cutting edge: developmental up-regulation of IFN-gamma-inducible lysosomal thiol reductase expression leads to reduced T cell sensitivity and less severe autoimmunity
    Maja Maric
    Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington, DC 20057, USA
    J Immunol 182:746-50. 2009
    ..GILT expression levels progressively increase in T cells with maturation. These data suggest that regulation of GILT expression may be a mechanism of T cell differentiation-associated changes in sensitivity to TCR engagement...
  20. doi Vasoactive hormones and the diabetic kidney
    Christine Maric
    Department of Medicine, Georgetown University Medical Center, Washington, DC, USA
    ScientificWorldJournal 8:470-85. 2008
    ....
  21. ncbi Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis
    Maciej Tomaszewski
    British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Circulation 116:1915-24. 2007
    ..The distal portion of the long arm of chromosome 5 is linked to hypertension and contains functional candidate blood pressure-regulating genes...
  22. pmc Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
    Robson A S Santos
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, 31270, Minas Gerais, Brazil
    Proc Natl Acad Sci U S A 100:8258-63. 2003
    ..Collectively, these findings identify Mas as a functional receptor for Ang-(1-7) and provide a clear molecular basis for the physiological actions of this biologically active peptide...
  23. ncbi Mechanisms of fetal programming of adult hypertension: role of sex hormones
    Christine Maric
    Hypertension 50:605-6. 2007
  24. ncbi Rofecoxib decreases renal injury in obese Zucker rats
    Aparajita Dey
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Clin Sci (Lond) 107:561-70. 2004
    ..These results suggest that altered vascular arachidonic acid enzymes contribute to the renal damage, and that COX-2 inhibition decreases glomerular injury in obese Zucker rats...

Research Grants2

  1. Estrogen in pathogenesis of tubulointerstitial disease
    Christine Maric; Fiscal Year: 2003
    ..abstract_text> ..
  2. ESTROGEN AND INFLAMMATION IN DIABETIC NEPHROPATHY
    Christine Maric; Fiscal Year: 2007
    ....