ALEXEI D KONDRATYEV

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint Electroconvulsive shock exposure prevents neuronal apoptosis after kainic acid-evoked status epilepticus
    A Kondratyev
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA
    Brain Res Mol Brain Res 91:1-13. 2001
  2. ncbi request reprint Status epilepticus leads to the degradation of the endogenous inhibitor of caspase-activated DNase in rats
    Alexei Kondratyev
    Department of Pharmacology, Georgetown University Medical Center, The Research Building, Room W217, 3970 Reservoir Road, Washington, DC 20007, USA
    Neurosci Lett 319:145-8. 2002
  3. ncbi request reprint Latency to onset of status epilepticus determines molecular mechanisms of seizure-induced cell death
    Alexei Kondratyev
    Department of Pharmacology, Georgetown University, Washington, DC, USA
    Brain Res Mol Brain Res 121:86-94. 2004
  4. pmc Phosphorylation of histone H2A.X as an early marker of neuronal endangerment following seizures in the adult rat brain
    Samantha L Crowe
    Interdisciplinary Program in Neuroscience and Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    J Neurosci 31:7648-56. 2011
  5. ncbi request reprint AMPA receptor desensitization as a determinant of vulnerability to focally evoked status epilepticus
    Francesco Fornai
    Department of Pharmacology, W215 Research Bldg, 3970 Reservoir Road NW, Georgetown University, Washington, DC 20057, USA
    Eur J Neurosci 21:455-63. 2005
  6. pmc Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy
    Jinsook Kim
    Interdisciplinary Program in Neuroscience, Georgetown University, W215 Research Building, 3970 Reservoir Road, N W, Washington, DC 20057, USA
    J Pharmacol Exp Ther 323:165-73. 2007
  7. ncbi request reprint Neurodevelopmental impact of antiepileptic drugs and seizures in the immature brain
    Jin Sook Kim
    Interdisciplinary Program in Neuroscience and Department of Pharmacology, Georgetown University, Washington, DC, USA
    Epilepsia 48:19-26. 2007
  8. pmc Rapid phosphorylation of histone H2A.X following ionotropic glutamate receptor activation
    Samantha L Crowe
    Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC, USA
    Eur J Neurosci 23:2351-61. 2006
  9. pmc Immunohistochemical evaluation of the protein expression of nerve growth factor and its TrkA receptor in rat limbic regions following electroshock seizures
    Giuseppe Conti
    Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    Neurosci Res 65:201-9. 2009
  10. pmc Effects of repeated minimal electroshock seizures on NGF, BDNF and FGF-2 protein in the rat brain during postnatal development
    Jinsook Kim
    Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Int J Dev Neurosci 28:227-32. 2010

Research Grants

  1. MECHANISMS OF NEUROPROTECTION IN LIMBIC SYSTEM
    Alexei Kondratyev; Fiscal Year: 2005
  2. Neonatal Seizure Therapy and Susceptibility to Schizophrenia
    Alexei Kondratyev; Fiscal Year: 2007
  3. Epigenetic control of apoptotic susceptibility
    Alexei Kondratyev; Fiscal Year: 2007

Collaborators

  • F Fornai
  • Karen Gale
  • Jinsook Kim
  • Samantha L Crowe
  • Giuseppe Conti
  • Timothy J Jorgensen
  • Jin Sook Kim
  • Irina Katz
  • Susanna Tsukerman
  • York Tomita
  • Vilen A Movsesyan

Detail Information

Publications11

  1. ncbi request reprint Electroconvulsive shock exposure prevents neuronal apoptosis after kainic acid-evoked status epilepticus
    A Kondratyev
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA
    Brain Res Mol Brain Res 91:1-13. 2001
    ....
  2. ncbi request reprint Status epilepticus leads to the degradation of the endogenous inhibitor of caspase-activated DNase in rats
    Alexei Kondratyev
    Department of Pharmacology, Georgetown University Medical Center, The Research Building, Room W217, 3970 Reservoir Road, Washington, DC 20007, USA
    Neurosci Lett 319:145-8. 2002
    ..Our results support the proposal that CAD participates in caspase-3-mediated internucleosomal DNA fragmentation in the aftermath of SE...
  3. ncbi request reprint Latency to onset of status epilepticus determines molecular mechanisms of seizure-induced cell death
    Alexei Kondratyev
    Department of Pharmacology, Georgetown University, Washington, DC, USA
    Brain Res Mol Brain Res 121:86-94. 2004
    ..It is possible that the absence of such "preconditioning" period in short-latency SE favors predominantly necrotic profile...
  4. pmc Phosphorylation of histone H2A.X as an early marker of neuronal endangerment following seizures in the adult rat brain
    Samantha L Crowe
    Interdisciplinary Program in Neuroscience and Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    J Neurosci 31:7648-56. 2011
    ..This demonstrates that DNA DSB damage is an especially sensitive indicator of neuronal endangerment and that it is responsive to neuroprotective intervention...
  5. ncbi request reprint AMPA receptor desensitization as a determinant of vulnerability to focally evoked status epilepticus
    Francesco Fornai
    Department of Pharmacology, W215 Research Bldg, 3970 Reservoir Road NW, Georgetown University, Washington, DC 20057, USA
    Eur J Neurosci 21:455-63. 2005
    ....
  6. pmc Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy
    Jinsook Kim
    Interdisciplinary Program in Neuroscience, Georgetown University, W215 Research Building, 3970 Reservoir Road, N W, Washington, DC 20057, USA
    J Pharmacol Exp Ther 323:165-73. 2007
    ..The latter drugs, as monotherapy or in combination, may be promising candidates for the treatment of women during pregnancy and for preterm and neonatal infants...
  7. ncbi request reprint Neurodevelopmental impact of antiepileptic drugs and seizures in the immature brain
    Jin Sook Kim
    Interdisciplinary Program in Neuroscience and Department of Pharmacology, Georgetown University, Washington, DC, USA
    Epilepsia 48:19-26. 2007
    ..It is now important to evaluate the long-term consequences of the changes in PCD in infancy by examining behavioral outcomes and seizure susceptibility in the AED- and seizure-exposed neonates when they reach adulthood...
  8. pmc Rapid phosphorylation of histone H2A.X following ionotropic glutamate receptor activation
    Samantha L Crowe
    Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC, USA
    Eur J Neurosci 23:2351-61. 2006
    ....
  9. pmc Immunohistochemical evaluation of the protein expression of nerve growth factor and its TrkA receptor in rat limbic regions following electroshock seizures
    Giuseppe Conti
    Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    Neurosci Res 65:201-9. 2009
    ..Our results demonstrate that repeated exposure to ECS causes an upregulation of TrkA and NGF proteins in several limbic areas in which neuroprotective effects are observed suggesting that NGF contributes to ECS-evoked neuroprotection...
  10. pmc Effects of repeated minimal electroshock seizures on NGF, BDNF and FGF-2 protein in the rat brain during postnatal development
    Jinsook Kim
    Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Int J Dev Neurosci 28:227-32. 2010
    ..This maturation of seizure-evoked changes in trophic factors may be important for understanding the impact of ECT and seizures in childhood...
  11. ncbi request reprint Effects of lamotrigine alone and in combination with MK-801, phenobarbital, or phenytoin on cell death in the neonatal rat brain
    Irina Katz
    Departments of Pediatrics, Georgetown University, Washington, DC 20057, USA
    J Pharmacol Exp Ther 322:494-500. 2007
    ..However, because AEDs are often introduced as add-on medication, careful selection of drug combinations and doses may be required to avoid developmental neurotoxicity when lamotrigine is used in polytherapy...

Research Grants4

  1. MECHANISMS OF NEUROPROTECTION IN LIMBIC SYSTEM
    Alexei Kondratyev; Fiscal Year: 2005
    ..Structured mentored activities and short courses will guide the development of expertise in these areas necessary for the proposed studies and for the long-term career advancement of the applicant as a versatile neuroscientist. ..
  2. Neonatal Seizure Therapy and Susceptibility to Schizophrenia
    Alexei Kondratyev; Fiscal Year: 2007
    ..This study also aims at identifying AEDs that will not predispose the neonates and pregnant women afflicted with seizures to schizophrenia- like disorders. ..
  3. Epigenetic control of apoptotic susceptibility
    Alexei Kondratyev; Fiscal Year: 2007
    ....